PT762901E - Peptidos marcados com tecnecio-99m para imagiologia. - Google Patents

Peptidos marcados com tecnecio-99m para imagiologia.

Info

Publication number
PT762901E
PT762901E PT95922946T PT95922946T PT762901E PT 762901 E PT762901 E PT 762901E PT 95922946 T PT95922946 T PT 95922946T PT 95922946 T PT95922946 T PT 95922946T PT 762901 E PT762901 E PT 762901E
Authority
PT
Portugal
Prior art keywords
peptides
methods
imagiology
technology
relates
Prior art date
Application number
PT95922946T
Other languages
English (en)
Original Assignee
Berlex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Berlex Inc filed Critical Berlex Inc
Publication of PT762901E publication Critical patent/PT762901E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/083—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being octreotide or a somatostatin-receptor-binding peptide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PT95922946T 1994-06-03 1995-06-01 Peptidos marcados com tecnecio-99m para imagiologia. PT762901E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/253,678 US5997844A (en) 1991-02-08 1994-06-03 Technetium-99m labeled peptides for imaging

Publications (1)

Publication Number Publication Date
PT762901E true PT762901E (pt) 2006-08-31

Family

ID=22961259

Family Applications (1)

Application Number Title Priority Date Filing Date
PT95922946T PT762901E (pt) 1994-06-03 1995-06-01 Peptidos marcados com tecnecio-99m para imagiologia.

Country Status (14)

Country Link
US (2) US5997844A (pt)
EP (1) EP0762901B9 (pt)
JP (1) JPH10501241A (pt)
KR (1) KR100235136B1 (pt)
CN (1) CN1090973C (pt)
AT (1) ATE323511T1 (pt)
AU (1) AU697048B2 (pt)
CA (1) CA2191950C (pt)
DE (1) DE69534943T2 (pt)
DK (1) DK0762901T3 (pt)
ES (1) ES2263153T3 (pt)
PT (1) PT762901E (pt)
WO (1) WO1995033498A1 (pt)
ZA (1) ZA954547B (pt)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
US5965107A (en) * 1992-03-13 1999-10-12 Diatide, Inc. Technetium-99m labeled peptides for imaging
US5645815A (en) 1991-02-08 1997-07-08 Diatide, Inc. Radiolabled compounds for thrombus imaging
JP2774378B2 (ja) * 1991-02-08 1998-07-09 ダイアテク，インコーポレイテッド 映像用テクネチウム−９９ｍ標識化ポリペプチド
US5736122A (en) * 1991-02-08 1998-04-07 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
US5783170A (en) * 1991-11-27 1998-07-21 Diatide, Inc. Peptide-metal chelate conjugates
DE69332879T2 (de) * 1992-03-13 2004-02-19 Diatide, Inc. Technetium-99-markierte peptide zur visualisierung vom entzuendungen
US5989519A (en) * 1992-03-13 1999-11-23 Diatide, Inc. Technetium-99m labeled peptides for imaging inflammation
US5508020A (en) * 1992-06-05 1996-04-16 Diatech, Inc. Technetium-99M labeled peptides for imaging
US5968476A (en) * 1992-05-21 1999-10-19 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
US6017512A (en) * 1992-06-23 2000-01-25 Diatide, Inc. Radiolabeled peptides
JP2005514335A (ja) * 2001-10-19 2005-05-19 トマス ジェファソン ユニバーシティ 腫瘍イメージング及び治療のためのｐａｃａｐ組成物及び方法
US7122189B2 (en) 2002-08-13 2006-10-17 Enzon, Inc. Releasable polymeric conjugates based on aliphatic biodegradable linkers
WO2006116634A2 (en) * 2005-04-26 2006-11-02 Novadaq Technologies, Inc. Method and apparatus for vasculature visualization with applications in neurosurgery and neurology
EP1717247A1 (en) * 2005-04-28 2006-11-02 Schering AG Cyclic peptides binding to the somatostatin receptor
WO2006114324A1 (en) * 2005-04-28 2006-11-02 Schering Ag Compounds comprising cyclized somatostatin receptor binding peptides
US20070122344A1 (en) 2005-09-02 2007-05-31 University Of Rochester Medical Center Office Of Technology Transfer Intraoperative determination of nerve location
AT502987A1 (de) * 2005-12-23 2007-07-15 Fibrex Medical Res & Dev Gmbh Pharmazeutische zusammensetzung zur behandlung von hämorrhagischem schock und seinen folgeerscheinungen
US20080161744A1 (en) 2006-09-07 2008-07-03 University Of Rochester Medical Center Pre-And Intra-Operative Localization of Penile Sentinel Nodes
JP2010533202A (ja) * 2007-07-11 2010-10-21 エンゾン ファーマシューティカルズ，インコーポレーテッド 多置換芳香族部分を含むポリマー性薬剤送達システム
US8406860B2 (en) 2008-01-25 2013-03-26 Novadaq Technologies Inc. Method for evaluating blush in myocardial tissue
US10219742B2 (en) 2008-04-14 2019-03-05 Novadaq Technologies ULC Locating and analyzing perforator flaps for plastic and reconstructive surgery
WO2009135178A2 (en) 2008-05-02 2009-11-05 Flower Robert W Methods for production and use of substance-loaded erythrocytes (s-les) for observation and treatment of microvascular hemodynamics
AU2009246397B2 (en) 2008-05-13 2013-01-17 University Of Kansas Metal abstraction peptide (MAP) tag and associated methods
US10492671B2 (en) 2009-05-08 2019-12-03 Novadaq Technologies ULC Near infra red fluorescence imaging for visualization of blood vessels during endoscopic harvest
WO2013181461A2 (en) 2012-06-01 2013-12-05 University Of Kansas Metal abstraction peptide with superoxide dismutase activity
EP2863801B8 (en) 2012-06-21 2024-06-12 Stryker Corporation Quantification and analysis of angiography and perfusion
DE102013113156A1 (de) 2013-11-28 2015-05-28 Freie Universität Berlin Verbindung und Verfahren zur selektiven Radiomarkierung von Polypeptiden mittels Festphasensynthese
EP3201607B1 (en) 2014-09-29 2020-12-30 Novadaq Technologies ULC Imaging a target fluorophore in a biological material in the presence of autofluorescence
EP3203902B1 (en) 2014-10-09 2021-07-07 Novadaq Technologies ULC Quantification of absolute blood flow in tissue using fluorescence-mediated photoplethysmography
CA3049922A1 (en) 2017-02-10 2018-08-16 Novadaq Technologies ULC Open-field handheld fluorescence imaging systems and methods
GB201918559D0 (en) * 2019-12-16 2020-01-29 Bicycle Tx Ltd Bicyclic peptide ligands specific for IL-17

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4427646A (en) * 1981-04-02 1984-01-24 Research Corporation Use of radiolabeled peptide derived from crosslinked fibrin to locate thrombi in vivo
US4444690A (en) * 1982-02-25 1984-04-24 University Patents, Inc. Technetium chelates
US4472509A (en) * 1982-06-07 1984-09-18 Gansow Otto A Metal chelate conjugated monoclonal antibodies
US4575556A (en) * 1982-11-08 1986-03-11 Medi-Physics, Inc. Bifunctional chelating agents
US4571430A (en) * 1982-11-08 1986-02-18 Medi-Physics, Inc. Homocysteine and homocysteinamide derivatives
US4434151A (en) * 1982-11-08 1984-02-28 Medi-Physics, Inc. Bifunctional chelating agents
US4615876A (en) * 1983-04-25 1986-10-07 Curators Of The University Of Missouri Macrocyclic complexes of technetium-99m for use as diagnostic radionuclides
US4673562A (en) * 1983-08-19 1987-06-16 The Children's Medical Center Corporation Bisamide bisthiol compounds useful for making technetium radiodiagnostic renal agents
US4638051A (en) * 1984-04-30 1987-01-20 The Johns Hopkins University Brain imaging radiopharmaceuticals
US4837003A (en) * 1984-09-13 1989-06-06 Mallinckrodt, Inc. Radiolabeled antibody fragments
ATE66469T1 (de) * 1985-01-14 1991-09-15 Neorx Corp Metall-radionuklid markiertes protein fuer diagnose und therapie.
ZA863205B (en) * 1985-05-01 1987-08-26 Univ New York State Res Found Diagnostic radiopharmaceutical compounds
GB8525974D0 (en) * 1985-10-22 1985-11-27 Nyegaard & Co As Chemical substance
US4861869A (en) * 1986-05-29 1989-08-29 Mallinckrodt, Inc. Coupling agents for joining radionuclide metal ions with biologically useful proteins
FR2604371B1 (fr) * 1986-09-30 1990-07-06 Toulouse Inst Nal Sciences App Procede et dispositif d'echange entre un gaz et un liquide
US4731506A (en) * 1986-10-29 1988-03-15 Noel Lee Signal cable assembly
US5279811A (en) * 1987-02-18 1994-01-18 The Du Pont Merck Pharmaceutical Company Ester-substituted diaminedithiols and radiolabeled complexes thereof
US4965392A (en) * 1987-03-26 1990-10-23 Neorx Corporation Chelating compounds for metal-radionuclide labeled proteins
WO1989000051A1 (en) * 1987-07-07 1989-01-12 Cytrx Biopool Ltd. Fibrin-binding compound and method
DE3730057C1 (de) * 1987-08-22 1989-02-09 Hans Wahlers Vorschubwalze fuer eine Vorrichtung zum Bearbeiten von Baumstaemmen
WO1989002634A1 (en) * 1987-09-10 1989-03-23 Dennison Manufacturing Company Multipurpose labeling and inventory control
DE3731266A1 (de) * 1987-09-17 1989-04-06 Kernforschungsz Karlsruhe Huellmaterial fuer supraleitende draehte
CA1335725C (en) * 1987-09-25 1995-05-30 Stephen W. Hadley Method of diagnosing blood clots using fibrin-binding proteins
IL89222A (en) * 1988-02-09 1995-03-30 Mallinckrodt Inc Preparation of metal-radionuclide-labelled proteins, certain novel compounds used therein and radiopharmaceutical compositions containing the labelled proteins
US5061641A (en) * 1988-04-01 1991-10-29 Immunomedics, Inc. Method for radiolabeling proteins
EP0381713B1 (en) * 1988-04-29 1994-01-19 Mallinckrodt, Inc. Diaminedithiol chelating agents for radiopharmaceuticals
JPH03505094A (ja) * 1988-05-02 1991-11-07 ニュー　イングランド　ディーコネス　ホスピタル　コーポレイション 動脈映像のための合成ペプチド
US4988496A (en) * 1988-05-31 1991-01-29 Neorx Corporation Metal radionuclide chelating compounds for improved chelation kinetics
US5218128A (en) * 1988-06-15 1993-06-08 Centocor, Inc. Bifunctional coupling agents and radionuclide labeled compositions prepared therefrom
WO1989012680A1 (en) * 1988-06-20 1989-12-28 Washington University USE OF MODIFIED tPA TO DETECT BLOOD CLOTS
FR2634400B1 (fr) * 1988-07-19 1991-12-06 Becker Arnaud Broyeur a marteaux pour le dechiquetage d'objets metalliques muni d'un dispositif de protection du tambour d'entrainement des marteaux
US5196510A (en) * 1988-12-29 1993-03-23 Cytogen Corporation Molecular recognition units
US4986979A (en) * 1989-03-14 1991-01-22 Neorx Corporation Imaging tissue sites of inflammation
DE3908997A1 (de) * 1989-03-18 1990-09-20 Huels Chemische Werke Ag Verfahren zur herstellung immobilisierter hefen fuer die sektgaerung
CA2016235C (en) * 1989-05-09 2002-03-12 Alan J. Fischman Labeled chemotactic peptides to image focal sites of infection or inflammation
DE69023394T2 (de) * 1989-06-16 1996-07-04 Merck Frosst Canada Inc Chelat-Derivate von atrialnatriurethischem Faktor (ANF).
GB8914020D0 (en) * 1989-06-19 1989-08-09 Antisoma Ltd Synthetic peptides for use in thrombus detection
ATE120374T1 (de) * 1989-07-20 1995-04-15 Sandoz Ag Markierte polypeptidderivate.
US5686410A (en) * 1989-07-20 1997-11-11 Novartis Ag Polypeptide derivatives
FR2650672A1 (fr) * 1989-08-02 1991-02-08 Medgenix Group Sa Procede de marquage de proteines ou polypeptides au technetium-99m, conjugue obtenu, utilisation a titre d'agent d'imagerie, kit de reconstitution desdits conjugues
US5759515A (en) * 1989-08-09 1998-06-02 Rhomed Incorporated Polyvalent peptide pharmaceutical applications
US5700444A (en) * 1992-02-20 1997-12-23 Rhomed Incorporated Chemotactic peptide pharmaceutical applications
FR2651077B1 (fr) * 1989-08-18 1994-06-10 Letourneur Gregoire Dispositif de traitement d'echo notamment acoustique dans une ligne telephonique
CA2080493A1 (en) * 1990-05-03 1991-11-04 Robert S. Lees Synthetic peptides for arterial imaging
US5382654A (en) * 1992-02-05 1995-01-17 Mallinckrodt Medical, Inc. Radiolabelled peptide compounds
US5965107A (en) * 1992-03-13 1999-10-12 Diatide, Inc. Technetium-99m labeled peptides for imaging
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
JP2774378B2 (ja) * 1991-02-08 1998-07-09 ダイアテク，インコーポレイテッド 映像用テクネチウム−９９ｍ標識化ポリペプチド
US5552525A (en) * 1991-02-08 1996-09-03 Diatech Inc. Technetium-99m labeled peptides for imaging inflammation
US5225180A (en) * 1991-09-10 1993-07-06 Diatech, Inc. Technetium-99m labeled somatostatin-derived peptides for imaging
US5783170A (en) * 1991-11-27 1998-07-21 Diatide, Inc. Peptide-metal chelate conjugates
DE69332879T2 (de) * 1992-03-13 2004-02-19 Diatide, Inc. Technetium-99-markierte peptide zur visualisierung vom entzuendungen
AU687080B2 (en) * 1993-04-08 1998-02-19 Cis Bio International Radiolabeled compounds for thrombus imaging
US5508020A (en) * 1992-06-05 1996-04-16 Diatech, Inc. Technetium-99M labeled peptides for imaging
DE69334033D1 (de) * 1992-05-21 2006-07-27 Diatide Inc Technetium-99M markierte Peptide zur Bilderzeugung von Thrombus
US5620675A (en) * 1992-06-23 1997-04-15 Diatech, Inc. Radioactive peptides
US5716596A (en) * 1992-06-23 1998-02-10 Diatide, Inc. Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses
DE69426673T2 (de) * 1993-06-23 2001-09-20 Diatide, Inc. Radiomarkierte somatostatin derivate zur abbildung und zur therapeutischen verwendung
EP0772459B1 (en) * 1994-05-02 2003-03-19 Diatide, Inc. TECHNETIUM-99m LABELED IMAGING AGENTS

Also Published As

Publication number Publication date
EP0762901A1 (en) 1997-03-19
EP0762901B1 (en) 2006-04-19
JPH10501241A (ja) 1998-02-03
CA2191950A1 (en) 1995-12-14
KR970703171A (ko) 1997-07-03
WO1995033498A1 (en) 1995-12-14
ES2263153T3 (es) 2006-12-01
CA2191950C (en) 2003-01-28
US6074627A (en) 2000-06-13
CN1090973C (zh) 2002-09-18
KR100235136B1 (ko) 1999-12-15
AU697048B2 (en) 1998-09-24
DE69534943D1 (de) 2006-05-24
DE69534943T2 (de) 2007-03-08
ATE323511T1 (de) 2006-05-15
DK0762901T3 (da) 2006-08-21
AU2778395A (en) 1996-01-04
US5997844A (en) 1999-12-07
EP0762901B9 (en) 2007-01-17
CN1154072A (zh) 1997-07-09
ZA954547B (en) 1996-01-24

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