ES2105332T3 - Polimeros quelantes. - Google Patents
Polimeros quelantes.Info
- Publication number
- ES2105332T3 ES2105332T3 ES93923302T ES93923302T ES2105332T3 ES 2105332 T3 ES2105332 T3 ES 2105332T3 ES 93923302 T ES93923302 T ES 93923302T ES 93923302 T ES93923302 T ES 93923302T ES 2105332 T3 ES2105332 T3 ES 2105332T3
- Authority
- ES
- Spain
- Prior art keywords
- polymer
- chelating polymers
- diagnostic
- pursuant
- poly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229920000642 polymer Polymers 0.000 title abstract 3
- 239000002216 antistatic agent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000002059 diagnostic imaging Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229920000233 poly(alkylene oxides) Polymers 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
- C08G65/332—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof
- C08G65/3324—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof cyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Polyamides (AREA)
- Polyethers (AREA)
Abstract
SEGUN ESTA INVENCION, SE PRESENTA UN POLIMERO QUE CONTIENE UNIDADES QUE CONTIENEN EL RESIDUO DE UN AGENTE QUELANTE ENLAZADO A UNA UNIDAD DE POLI(OXIDO DE ALQUILENO) Y UN METODO PARA LA PREPARACION DEL MISMO. EL POLIMERO ES PARTICULARMENTE UTIL PARA COMPOSICIONES FORMADORAS DE IMAGENES TERAPEUTICAS Y DE DIAGNOSTICO Y COMO AGENTE ANTIESTATICO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96114692A | 1992-10-14 | 1992-10-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2105332T3 true ES2105332T3 (es) | 1997-10-16 |
Family
ID=25504123
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES93923302T Expired - Lifetime ES2105332T3 (es) | 1992-10-14 | 1993-10-07 | Polimeros quelantes. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5583206A (es) |
| EP (1) | EP0664819B1 (es) |
| JP (1) | JPH08502528A (es) |
| KR (1) | KR950703582A (es) |
| AU (1) | AU5323794A (es) |
| CA (1) | CA2146990A1 (es) |
| DE (1) | DE69312951T2 (es) |
| ES (1) | ES2105332T3 (es) |
| HK (1) | HK1001498A1 (es) |
| WO (1) | WO1994009056A1 (es) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5559214A (en) | 1993-05-28 | 1996-09-24 | Sterling Winthrop Inc. | Unsymmetrical complexing agents and targeting immunoreagents useful in thearpeutic and diagnostic compositions and methods |
| US5730968A (en) * | 1994-03-31 | 1998-03-24 | Sterling Winthrop Inc. | Segmented chelating polymers as imaging and therapeutic agents |
| US5801228A (en) * | 1995-06-07 | 1998-09-01 | Nycomed Imaging As | Polymeric contrast agents for medical imaging |
| US5859215A (en) * | 1995-10-25 | 1999-01-12 | Wallac Oy | Biospecific binding reactants labelled with luminescent lanthanide chelates and their use |
| ATE253943T1 (de) * | 1996-09-12 | 2003-11-15 | Amersham Health As | Markerzusammensetzungen |
| US6153655A (en) * | 1998-04-17 | 2000-11-28 | Enzon, Inc. | Terminally-branched polymeric linkers and polymeric conjugates containing the same |
| US6361759B1 (en) * | 1998-05-26 | 2002-03-26 | Wisconsin Alumni Research Foundation | MR signal-emitting coatings |
| US6896874B2 (en) * | 1998-05-26 | 2005-05-24 | Wisconsin Alumni Research Foundation | MR-signal emitting coatings |
| EP1063254A1 (de) * | 1999-06-25 | 2000-12-27 | Technische Uni München, Klinikum rechts der Isar, Inst. für Experiment. Onkoligie und Therapieforschung | Copolymere für den Transport von Nukleinsäuren in die Zelle |
| EP1198489B1 (de) * | 1999-06-25 | 2004-04-28 | Christian Plank | Kombinationen zur einführung von nucleinsäuren in zellen |
| US6777387B2 (en) | 2000-03-31 | 2004-08-17 | Enzon Pharmaceuticals, Inc. | Terminally-branched polymeric linkers containing extension moieties and polymeric conjugates containing the same |
| US6756037B2 (en) | 2000-03-31 | 2004-06-29 | Enzon, Inc. | Polymer conjugates of biologically active agents and extension moieties for facilitating conjugation of biologically active agents to polymeric terminal groups |
| US20060177416A1 (en) | 2003-10-14 | 2006-08-10 | Medivas, Llc | Polymer particle delivery compositions and methods of use |
| CA2437989A1 (en) * | 2001-02-20 | 2002-08-29 | Enzon, Inc. | Terminally-branched polymeric linkers and polymeric conjugates containing the same |
| US20040253292A1 (en) * | 2003-04-23 | 2004-12-16 | Wisconsin Alumni Research Foundation | MR-signal emitting coatings |
| US8765263B2 (en) | 2005-04-29 | 2014-07-01 | 3M Innovative Properties Company | Multilayer polyurethane protective films |
| EP1926780B1 (en) | 2005-09-22 | 2013-08-14 | Medivas, LLC | Bis-( -amino)-diol-diester-containing poly(ester amide) and poly(ester urethane) compositions and methods of use |
| JP5178520B2 (ja) | 2005-09-22 | 2013-04-10 | メディバス エルエルシー | 固体ポリマー送達組成物およびその使用法 |
| US8457712B2 (en) * | 2005-12-30 | 2013-06-04 | Wisconsin Alumni Research Foundation | Multi-mode medical device system and methods of manufacturing and using same |
| US20070156042A1 (en) * | 2005-12-30 | 2007-07-05 | Orhan Unal | Medical device system and method for tracking and visualizing a medical device system under MR guidance |
| TW200738752A (en) | 2006-01-31 | 2007-10-16 | Bayer Schering Pharma Ag | Modulation of MDL-1 activity for treatment of inflammatory disease |
| US8532742B2 (en) * | 2006-11-15 | 2013-09-10 | Wisconsin Alumni Research Foundation | System and method for simultaneous 3DPR device tracking and imaging under MR-guidance for therapeutic endovascular interventions |
| WO2008066787A2 (en) * | 2006-11-27 | 2008-06-05 | E. I. Du Pont De Nemours And Company | Multi-functional polyalkylene oxides, hydrogels and tissue adhesives |
| US20080183070A1 (en) * | 2007-01-29 | 2008-07-31 | Wisconsin Alumni Research Foundation | Multi-mode medical device system with thermal ablation capability and methods of using same |
| US8412306B2 (en) * | 2007-02-28 | 2013-04-02 | Wisconsin Alumni Research Foundation | Voltage standing wave suppression for MR-guided therapeutic interventions |
| EP2005970A1 (de) | 2007-06-22 | 2008-12-24 | Berlin Science Partners GmbH i.V. | Bildgebende Diagnostik durch Kombination von Kontrastmitteln |
| EP2072060A1 (en) | 2007-12-18 | 2009-06-24 | Institut Curie | Methods and compositions for the preparation and use of toxin conjugates. |
| WO2009108891A2 (en) * | 2008-02-29 | 2009-09-03 | Egen, Inc. | Modified poloxamers for gene expression and associated methods |
| CA2723721A1 (en) * | 2008-05-07 | 2009-11-12 | Medivas, Llc | Biodegradable metal-chelating polymers and vaccines |
| EP2161020A1 (en) * | 2008-09-09 | 2010-03-10 | Koninklijke Philips Electronics N.V. | Chelating amphiphilic polymers |
| WO2010045241A1 (en) * | 2008-10-15 | 2010-04-22 | Medivas, Llc | Biodegradable proline-based polymers |
| US8524457B2 (en) | 2009-09-22 | 2013-09-03 | William Patterson | Method for the selection of specific affinity binders by homogeneous noncompetitive assay |
| US9125942B2 (en) | 2010-01-19 | 2015-09-08 | Northwestern University | Paramagnetic metal-nanodiamond conjugates |
| US20120277517A1 (en) * | 2011-04-08 | 2012-11-01 | The Johns Hopkins University | Formulation and Methods for Enhanced Interventional Image-Guided Therapy of Cancer |
| US20120271100A1 (en) | 2011-04-14 | 2012-10-25 | Northwestern University | Compositions and methods for the detection of zinc |
| EP4406558A3 (en) | 2011-06-23 | 2024-10-23 | DSM IP Assets B.V. | New biodegradable polyesteramide copolymers for drug delivery |
| US9873765B2 (en) | 2011-06-23 | 2018-01-23 | Dsm Ip Assets, B.V. | Biodegradable polyesteramide copolymers for drug delivery |
| WO2013134686A1 (en) | 2012-03-09 | 2013-09-12 | Promega Corporation | pH SENSORS |
| US20140134665A1 (en) | 2012-11-15 | 2014-05-15 | Northwestern University | Compositions and methods for the detection of zinc |
| BR112015013715A2 (pt) | 2012-12-12 | 2017-09-26 | Promega Corp | sistema, método para capturar o alvo celular, lisado celular e ligante de captura. |
| AU2014236949C1 (en) | 2013-03-15 | 2018-11-29 | Promega Corporation | Activation of bioluminescence by structural complementation |
| US10168323B2 (en) | 2013-03-15 | 2019-01-01 | Promega Corporation | Compositions and methods for capture of cellular targets of bioactive agents |
| US9310353B2 (en) | 2014-02-27 | 2016-04-12 | The Procter & Gamble Company | Method for evaluating bioavailable zinc |
| WO2015175864A1 (en) | 2014-05-15 | 2015-11-19 | Cleveland Heartlab, Inc. | Compositions and methods for purification and detection of hdl and apoa1 |
| WO2016004333A2 (en) | 2014-07-02 | 2016-01-07 | Promega Corporation | Reversible metal ion chelators |
| EP4219736A1 (en) | 2014-09-12 | 2023-08-02 | Promega Corporation | Internal protein tags |
| US10434071B2 (en) | 2014-12-18 | 2019-10-08 | Dsm Ip Assets, B.V. | Drug delivery system for delivery of acid sensitivity drugs |
| RU2602502C2 (ru) * | 2015-03-05 | 2016-11-20 | Федеральное государственное бюджетное учреждение науки Институт высокомолекулярных соединений Российской академии наук | Способ получения радиофармпрепаратов класса поли-n-виниламидов с металлами группы марганца |
| CN107531859B (zh) | 2015-04-28 | 2020-02-14 | 罗门哈斯电子材料有限责任公司 | 作为电镀浴添加剂的双酸酐与二胺的反应产物 |
| WO2016210290A1 (en) | 2015-06-26 | 2016-12-29 | Northwestern University | Gd(III)-DITHIOLANE GOLD NANOPARTICLE CONJUGATES |
| US12344643B2 (en) | 2016-12-07 | 2025-07-01 | The University Of Chicago | Compositions and methods for inhibition of FOXP3 |
| WO2018156602A1 (en) | 2017-02-21 | 2018-08-30 | The Regents Of The University Of Michigan | Il-22bp compositions and method for the treatment of disease therewith |
| NL2020578B1 (en) * | 2018-03-13 | 2019-09-20 | Xeikon Mfg Nv | A metal compound, use of the metal compound as a charge control agent composition and a chargeable toner composition |
| WO2020191339A1 (en) | 2019-03-20 | 2020-09-24 | Promega Corporation | Photoaffinity probes |
| US11360096B2 (en) | 2019-05-16 | 2022-06-14 | Duke University | Complex BRET technique for measuring biological interactions |
| WO2021094468A1 (en) | 2019-11-12 | 2021-05-20 | Dsm Ip Assets B.V. | Polyesteramide copolymers possessing high glass transition temperatures |
| US12241839B2 (en) | 2019-11-27 | 2025-03-04 | Promega Corporation | Multipartite luciferase peptides and polypeptides |
| EP4519385A2 (en) | 2022-05-04 | 2025-03-12 | Promega Corporation | Bioluminescence-triggered photocatalytic labeling |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3562161A (en) * | 1968-10-08 | 1971-02-09 | Atlantic Richfield Co | Polyalkylene glycol esters of ethylene-diaminetetraacetic acid as lubricant dispersants |
| US3859337A (en) * | 1969-06-11 | 1975-01-07 | Stauffer Chemical Co | Ethylenediaminetetraacetic acid anhydride derivatives |
| USRE30885E (en) * | 1981-03-13 | 1982-03-23 | Cincinnati Milacron Inc. | Novel diamide and lubricants containing same |
| US4859777A (en) * | 1981-07-01 | 1989-08-22 | Eastman Kodak Company | Terpyridine chelating agents |
| US4647447A (en) * | 1981-07-24 | 1987-03-03 | Schering Aktiengesellschaft | Diagnostic media |
| US4957939A (en) * | 1981-07-24 | 1990-09-18 | Schering Aktiengesellschaft | Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging |
| CS226911B1 (en) * | 1981-10-28 | 1984-04-16 | Jaroslav Kahovec | Polymere polydonor komplexons and method of their manufacture polymere polydonor |
| US4423158A (en) * | 1983-01-27 | 1983-12-27 | Gelinnovation Handelsaktiebolag | Ion adsorbent for metals having a coordination number greater than two |
| US4972837A (en) * | 1983-04-26 | 1990-11-27 | Regents Of The University Of California | Contrast agents for nuclear magnetic resonance imaging |
| JPS59215321A (ja) * | 1983-05-23 | 1984-12-05 | Sumitomo Chem Co Ltd | 二官能性配位子化合物を結合した反応性高分子 |
| FR2550449B1 (fr) * | 1983-08-12 | 1986-01-31 | Commissariat Energie Atomique | Agents de relaxation specifiques d'organes ou de pathologies, utilisables pour modifier les contrastes en imagerie medicale par resonance magnetique nucleaire |
| US4615879A (en) * | 1983-11-14 | 1986-10-07 | Vanderbilt University | Particulate NMR contrast agents for gastrointestinal application |
| US4943523A (en) * | 1984-01-30 | 1990-07-24 | Enzo Biochem, Inc. | Detectable molecules, method of preparation and use |
| US4602097A (en) * | 1984-06-11 | 1986-07-22 | Ulano Corporation | Water soluble photoinitiator benzophenone and thioxanthenone ethoxy-ether derivatives |
| US4859451A (en) * | 1984-10-04 | 1989-08-22 | Salutar, Inc. | Paramagnetic contrast agents for MR imaging |
| US4687659A (en) * | 1984-11-13 | 1987-08-18 | Salutar, Inc. | Diamide-DTPA-paramagnetic contrast agents for MR imaging |
| US4687658A (en) * | 1984-10-04 | 1987-08-18 | Salutar, Inc. | Metal chelates of diethylenetriaminepentaacetic acid partial esters for NMR imaging |
| SE465907B (sv) * | 1984-11-01 | 1991-11-18 | Nyegaard & Co As | Diagnosticeringsmedel innehaallande en paramagnetisk metall |
| DE3577185D1 (de) * | 1984-11-01 | 1990-05-23 | Nycomed As | Paramagnetische kontrastmittel fuer die anwendung in "in vivo" nmr-diagnostischen methoden und die herstellung davon. |
| US4826673A (en) * | 1985-01-09 | 1989-05-02 | Mallinckrodt, Inc. | Methods and compositions for enhancing magnetic resonance imaging |
| US4980148A (en) * | 1985-02-06 | 1990-12-25 | Mallinckrodt, Inc. | Methods for enhancing magnetic resonance imaging |
| US4746507A (en) * | 1985-04-02 | 1988-05-24 | Salutar, Inc. | EDHPA based contrast agents for MR imaging, apparatus and methods |
| JPH084504B2 (ja) * | 1985-04-26 | 1996-01-24 | 味の素株式会社 | 安定化ス−パ−オキサイドジスムタ−ゼ |
| SE8502573D0 (sv) * | 1985-05-23 | 1985-05-23 | Jouko Kanakre | Fluorescent lanthanide chelates useful as labels of physiologically active materials |
| IT1213029B (it) * | 1986-01-30 | 1989-12-07 | Bracco Ind Chimica Spa | Chelati di ioni metallici paramagnetici. |
| US4909257A (en) * | 1986-05-01 | 1990-03-20 | The Regents Of The University Of California | Method for attaining in vivo tissue-specific contrast by nuclear magnetic resonance imaging |
| US4814098A (en) * | 1986-09-06 | 1989-03-21 | Bellex Corporation | Magnetic material-physiologically active substance conjugate |
| JPS63112622A (ja) * | 1986-10-30 | 1988-05-17 | Agency Of Ind Science & Technol | 多塩基酸ポリエ−テル誘導体及びそれからなる界面活性剤 |
| US4933441A (en) * | 1987-01-27 | 1990-06-12 | Gibby Wendell A | Contrast enhancing agents for magnetic resonance images |
| US4822594A (en) * | 1987-01-27 | 1989-04-18 | Gibby Wendell A | Contrast enhancing agents for magnetic resonance images |
| US5057302A (en) * | 1987-02-13 | 1991-10-15 | Abbott Laboratories | Bifunctional chelating agents |
| DE3869251D1 (de) * | 1987-07-16 | 1992-04-23 | Nycomed As | Aminopolycarbonsaeure und ihre derivate. |
| US5202423A (en) * | 1988-07-08 | 1993-04-13 | Wallac Oy | Terpyridine derivatives |
| US5137711A (en) * | 1988-07-19 | 1992-08-11 | Mallickrodt Medical, Inc. | Paramagnetic dtpa and edta alkoxyalkylamide complexes as mri agents |
| GB8824593D0 (en) * | 1988-10-20 | 1988-11-23 | Royal Free Hosp School Med | Liposomes |
| GB8923843D0 (en) * | 1989-10-23 | 1989-12-13 | Salutar Inc | Compounds |
| DE3938992A1 (de) * | 1989-11-21 | 1991-05-23 | Schering Ag | Kaskadenpolymer-gebundene komplexbildner, deren komplexe und konjugate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| SE465155B (sv) * | 1989-12-19 | 1991-08-05 | Exploaterings Ab Tbf | Metallkelatbildande hydrofil polymer foer adsorption etc samt ett saett foer framstaellning av polymeren |
| DE4011684A1 (de) * | 1990-04-06 | 1991-10-10 | Schering Ag | Dtpa-monoamide, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung |
| ATE153860T1 (de) * | 1990-04-10 | 1997-06-15 | Imarx Pharmaceutical Corp | Polymere und ihre verwendung als kontrastmittel bei der bilderzeugung mit magnetischer resonanz |
| ATE115864T1 (de) * | 1990-05-30 | 1995-01-15 | Deutsches Krebsforsch | Polyethersubstituierte tumormittel. |
| US5077037A (en) * | 1990-08-03 | 1991-12-31 | Mallinckrodt Medical, Inc. | Novel compositions for magnetic resonance imaging |
| US5367080A (en) * | 1990-11-08 | 1994-11-22 | Sterling Winthrop Inc. | Complexing agents and targeting radioactive immunoreagents useful in therapeutic and diagnostic imaging compositions and methods |
| US5385719A (en) * | 1991-09-24 | 1995-01-31 | Unger; Evan C. | Copolymers and their use as contrast agents in magnetic resonance imaging and in other applications |
| US5285719A (en) * | 1992-09-11 | 1994-02-15 | Gas Research Institute | Rapid frozen food thawing system |
| US5407657A (en) * | 1992-09-22 | 1995-04-18 | Unger; Evan C. | Hybrid magnetic resonance contrast agents |
-
1993
- 1993-10-07 WO PCT/US1993/009587 patent/WO1994009056A1/en not_active Ceased
- 1993-10-07 DE DE69312951T patent/DE69312951T2/de not_active Expired - Fee Related
- 1993-10-07 JP JP6510122A patent/JPH08502528A/ja active Pending
- 1993-10-07 AU AU53237/94A patent/AU5323794A/en not_active Abandoned
- 1993-10-07 EP EP93923302A patent/EP0664819B1/en not_active Expired - Lifetime
- 1993-10-07 CA CA002146990A patent/CA2146990A1/en not_active Abandoned
- 1993-10-07 ES ES93923302T patent/ES2105332T3/es not_active Expired - Lifetime
- 1993-10-07 KR KR1019950701430A patent/KR950703582A/ko not_active Withdrawn
- 1993-10-07 HK HK98100427A patent/HK1001498A1/en not_active IP Right Cessation
-
1994
- 1994-11-28 US US08/348,197 patent/US5583206A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0664819A1 (en) | 1995-08-02 |
| US5583206A (en) | 1996-12-10 |
| CA2146990A1 (en) | 1994-04-28 |
| AU5323794A (en) | 1994-05-09 |
| EP0664819B1 (en) | 1997-08-06 |
| HK1001498A1 (en) | 1998-06-19 |
| DE69312951T2 (de) | 1997-12-11 |
| WO1994009056A1 (en) | 1994-04-28 |
| JPH08502528A (ja) | 1996-03-19 |
| DE69312951D1 (de) | 1997-09-11 |
| KR950703582A (ko) | 1995-09-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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