ES2106018T3 - Procedimiento para la preparacion de derivados de 1,5-benzotiazepina. - Google Patents

Procedimiento para la preparacion de derivados de 1,5-benzotiazepina.

Info

Publication number
ES2106018T3
ES2106018T3 ES90304299T ES90304299T ES2106018T3 ES 2106018 T3 ES2106018 T3 ES 2106018T3 ES 90304299 T ES90304299 T ES 90304299T ES 90304299 T ES90304299 T ES 90304299T ES 2106018 T3 ES2106018 T3 ES 2106018T3
Authority
ES
Spain
Prior art keywords
formula
benzotiazepine
derivatives
procedure
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90304299T
Other languages
English (en)
Inventor
Hironori Hayashi
Shigeru Nishimoto
Tamotsu Okuno
Masashi Kitano
Sadao Maeda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Pharma Corp
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Application granted granted Critical
Publication of ES2106018T3 publication Critical patent/ES2106018T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

Abstract

SE REVELA UN PROCESO PARA LA PREPARACION DE DERIVADOS DE 1,5-BENZOTIACEPINA MEDIANTE LA FORMULA: EN DONDE R ES UN GRUPO ALQUILO INFERIOR, SOMETIENDO UN COMPUESTO ACIDO PROPIONICO REPRESENTADO POR LA FORMULA: EN DONDE R TIENE EL MISMO SIGNIFICADO QUE EL QUE SE DEFINE ANTERIORMENTE, A UNA REACCION DE CIERRE DE ANILLO INTRAMOLECULAR CON PRESENCIA DE UN COMPUESTO DE ACIDO SULFONICO REPRESENTADO POR LA FORMULA: R1SO3H (III) EN DONDE R1 REPRESENTA UN GRUPO ALQUILO INFERIOR O UN GRUPO FENILO SUSTITUIDO O SIN SUSTITUIR.
ES90304299T 1989-04-28 1990-04-20 Procedimiento para la preparacion de derivados de 1,5-benzotiazepina. Expired - Lifetime ES2106018T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1109795A JPH0798813B2 (ja) 1989-04-28 1989-04-28 １，５―ベンゾチアゼピン誘導体の製法

Publications (1)

Publication Number Publication Date
ES2106018T3 true ES2106018T3 (es) 1997-11-01

Family

ID=14519414

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90304299T Expired - Lifetime ES2106018T3 (es) 1989-04-28 1990-04-20 Procedimiento para la preparacion de derivados de 1,5-benzotiazepina.

Country Status (16)

Country Link
EP (1) EP0395323B1 (es)
JP (1) JPH0798813B2 (es)
KR (1) KR970002466B1 (es)
CN (3) CN1031708C (es)
AT (1) ATE154348T1 (es)
AU (1) AU616351B2 (es)
DE (1) DE69030897T2 (es)
DK (1) DK0395323T3 (es)
ES (1) ES2106018T3 (es)
FI (1) FI109533B (es)
FR (1) FR2646424B1 (es)
GR (1) GR3023767T3 (es)
HK (1) HK1003789A1 (es)
HU (1) HU203882B (es)
IL (1) IL94208A0 (es)
SG (1) SG47004A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69015682T2 (de) * 1989-04-28 1995-05-11 Tanabe Seiyaku Co Verfahren zur Herstellung von 1,5-Benzothiazepinderivaten.
IT1234387B (it) * 1989-07-12 1992-05-18 Zambon Spa Processo di purificazione di intermedi utili nella preparazione del diltiazem
AU628217B2 (en) * 1989-08-31 1992-09-10 Marion Merrell Dow Inc. Heterogeneous synthesis of azepinones from esters
JPH085869B2 (ja) * 1990-03-08 1996-01-24 田辺製薬株式会社 １，５−ベンゾチアゼピン誘導体の製法
IT1249318B (it) * 1991-05-23 1995-02-22 Zambon Spa Processo per la preparazione di benzotiazepine per ciclizzazione con acidi fosfonici
DE4206714A1 (de) * 1992-03-04 1993-09-09 Sandoz Ag Wachsdispersionen, deren herstellung und verwendung
NL1002687C2 (nl) * 1996-03-22 1997-09-23 Dsm Nv Werkwijze voor de bereiding van een benzothiazepine.
TW438787B (en) 1997-02-27 2001-06-07 Tanabe Seiyaku Co Process for preparing optically active trans-3-substituted glycidic acid ester
IT1295376B1 (it) * 1997-10-22 1999-05-12 Zambon Spa Processo per il riciclo di un sottoprodotto della sintesi del diltiazem
CN116143723A (zh) * 2022-12-07 2023-05-23 海南锦瑞制药有限公司 一种盐酸地尔硫卓的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3374865D1 (en) * 1982-07-07 1988-01-21 Siegfried Ag Process for preparing 4-hydroxy-2-methyl-n-2-pyridyl-2h-1,2-benzothiazine-3-carboxamide 1,1-dioxide
US4552695A (en) * 1983-04-21 1985-11-12 Shionogi & Co., Ltd. Process for production of diltiazem hydrochloride
ZA893392B (en) * 1988-05-24 1990-01-31 Hoffmann La Roche Process for the manufacture of optically active naphthothiazepinones
FR2641535B1 (fr) * 1989-01-11 1991-03-15 Synthelabo Procede de preparation de (+) - (2s, 3s)-hydroxy-3 (methoxy-4 phenyl)-2 dihydro-2,3 5h-benzothiazepine-1,5 one-4
DE69015682T2 (de) * 1989-04-28 1995-05-11 Tanabe Seiyaku Co Verfahren zur Herstellung von 1,5-Benzothiazepinderivaten.
JPH085869B2 (ja) * 1990-03-08 1996-01-24 田辺製薬株式会社 １，５−ベンゾチアゼピン誘導体の製法

Also Published As

Publication number Publication date
FR2646424B1 (fr) 1994-05-20
CN1110684A (zh) 1995-10-25
DE69030897T2 (de) 1997-09-25
AU5385690A (en) 1990-11-01
KR900016171A (ko) 1990-11-12
HK1003789A1 (en) 1998-11-06
DE69030897D1 (de) 1997-07-17
AU616351B2 (en) 1991-10-24
CN1031708C (zh) 1996-05-01
DK0395323T3 (da) 1997-09-08
HU203882B (en) 1991-10-28
JPH02286672A (ja) 1990-11-26
GR3023767T3 (en) 1997-09-30
CN1245802A (zh) 2000-03-01
CN1136205C (zh) 2004-01-28
ATE154348T1 (de) 1997-06-15
CN1052479C (zh) 2000-05-17
FI109533B (fi) 2002-08-30
EP0395323A1 (en) 1990-10-31
EP0395323B1 (en) 1997-06-11
HUT55373A (en) 1991-05-28
FI902030A0 (fi) 1990-04-23
FR2646424A1 (fr) 1990-11-02
JPH0798813B2 (ja) 1995-10-25
KR970002466B1 (ko) 1997-03-05
HU902607D0 (en) 1990-09-28
IL94208A0 (en) 1991-01-31
SG47004A1 (en) 1998-03-20
CN1046901A (zh) 1990-11-14

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