ES2106573T3 - Composicion oftalmica que contiene un derivado de 1,5-benzoxatiepina para tratar glaucoma. - Google Patents

Composicion oftalmica que contiene un derivado de 1,5-benzoxatiepina para tratar glaucoma.

Info

Publication number
ES2106573T3
ES2106573T3 ES95100934T ES95100934T ES2106573T3 ES 2106573 T3 ES2106573 T3 ES 2106573T3 ES 95100934 T ES95100934 T ES 95100934T ES 95100934 T ES95100934 T ES 95100934T ES 2106573 T3 ES2106573 T3 ES 2106573T3
Authority
ES
Spain
Prior art keywords
optionally substituted
hydrogen
ophthalmic composition
benzoxatiepina
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95100934T
Other languages
English (en)
Inventor
Takahiro Ogawa
Takaaki Deguchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Senju Pharmaceutical Co Ltd
Original Assignee
Senju Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senju Pharmaceutical Co Ltd filed Critical Senju Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2106573T3 publication Critical patent/ES2106573T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE PRESENTA UNA COMPOSICION OFTALMOLOGICA QUE COMPRENDE UN COMPUESTO DE LA FORMULA (I) EN LA QUE R1 Y R2 SON CADA UNA UN HIDROGENO, UN HALOGENO, UN HIDROXILO, UN ALQUILO INFERIOR O UN ALCOXIDO INFERIOR, R3 Y R4 SON CADA UNA UN HIDROGENO, UN ALQUIL INFERIOR OPCIONALMENTE SUSTITUIDO, UN CICLOALQUILO OPCIONALMENTE SUSTITUIDO O UN ARALQUILO OPCIONALMENTE SUSTITUIDO, O FORMAN, JUNTO CON EL ATOMO DE NITROGENO ADYACENTE, UN ANILLO OPCIONALMENTE SUSTITUIDO, X ES UN HIDROGENO, UN ALQUILO INFERIOR OPCIONALMENTE SUSTITUIDO, O UN CARBOXILO OPCIONALMENTE ESTERIFICADO O AMIDADO, Y ES >C=O O >CH-OR5 EN DONDE R5 ES HIDROGENO, UN ACILO O UN CARBAMOILO OPCIONALMENTE SUSTITUIDO, M ES UN ENTERO ENTRE 0 Y 2, N ES 1 Y 6, TAMBIEN SE PRESENTA UNA SAL DEL COMPUESTO Y UN METODO PARA LA PREVENCION Y EL TRATAMIENTO DE ENFERMEDADES DE LOS OJOS, QUE COMPRENDE LA ADMINISTRACION DE DICHO COMPUESTO O DE LA SAL DEL MISMO.
ES95100934T 1994-01-27 1995-01-25 Composicion oftalmica que contiene un derivado de 1,5-benzoxatiepina para tratar glaucoma. Expired - Lifetime ES2106573T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP747094 1994-01-27

Publications (1)

Publication Number Publication Date
ES2106573T3 true ES2106573T3 (es) 1997-11-01

Family

ID=11666688

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95100934T Expired - Lifetime ES2106573T3 (es) 1994-01-27 1995-01-25 Composicion oftalmica que contiene un derivado de 1,5-benzoxatiepina para tratar glaucoma.

Country Status (9)

Country Link
US (1) US5538974A (es)
EP (1) EP0667156B1 (es)
KR (1) KR950032169A (es)
CN (1) CN1116928A (es)
AT (1) ATE157870T1 (es)
CA (1) CA2141176A1 (es)
DE (1) DE69500660T2 (es)
ES (1) ES2106573T3 (es)
TW (1) TW316235B (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6960579B1 (en) * 1998-05-19 2005-11-01 Alcon Manufacturing, Ltd. Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders
AU755119B2 (en) 1998-09-18 2002-12-05 Alcon Laboratories, Inc. Serotonergic 5HT2 agonists for treating glaucoma
DE60117247D1 (de) * 2000-03-31 2006-04-20 Purdue Research Foundation West Lafayette Phosphoramidat-prodrugs
FR2822467B1 (fr) * 2001-03-22 2003-12-12 Pf Medicament Derives benzoxathiepines et leur utilisation comme medicaments
JP2005511764A (ja) * 2001-12-14 2005-04-28 アルコン，インコーポレイテッド 緑内障の処置のためのアミノアルキルベンゾフラン−５−オール化合物
TW593302B (en) * 2001-12-20 2004-06-21 Alcon Inc Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma
DK1534391T3 (da) * 2002-07-19 2007-06-11 Biovitrum Ab Nye piperazinyl-pyrazinonderivater til behandling af 5-HT2A-recptor-relaterede forstyrrelser
JP2006501245A (ja) * 2002-08-30 2006-01-12 アルコン，インコーポレイテッド 置換された５−クロマン−５−イル−エチルアミン化合物および緑内障の治療のためのその使用
BR0316775A (pt) * 2002-12-13 2005-11-01 Alcon Inc Novos análogos de benzopirano e seu uso para o tratamento de glaucoma
US20060286173A1 (en) * 2003-08-20 2006-12-21 Kazuhito Yamada Drug delivery system for sub-tenon s capsule adminstration of fine grains
US7476687B2 (en) * 2003-11-26 2009-01-13 Alcon, Inc. Substituted furo[2,3-g]indazoles for the treatment of glaucoma
US7338972B1 (en) 2003-12-15 2008-03-04 Alcon, Inc. Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma
AR046890A1 (es) * 2003-12-15 2005-12-28 Alcon Inc [1,4] oxazino [2,3-g] indazoles sustituidos para el tratamiento del glaucoma.
US7129257B1 (en) * 2003-12-15 2006-10-31 Alcon, Inc. Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma
US20050276867A1 (en) * 2004-06-09 2005-12-15 Allergan, Inc. Stabilized compositions comprising a therapeutically active agent and an oxidizing preservative
WO2006062839A1 (en) * 2004-12-08 2006-06-15 Alcon, Inc. Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma
TW200744567A (en) * 2005-09-23 2007-12-16 Alcon Inc Phenylethylamine analogs and their use for treating glaucoma
WO2007149728A2 (en) * 2006-06-20 2007-12-27 Alcon Research, Ltd. Aryl and heteroaryl tetrahydrobenzazepine derivatives and their use for treating glaucoma
EP2095713A1 (en) * 2006-10-20 2009-09-02 Limited Liability Company "Mitotechnology" Composition for regenerating and stimulating growth of plants and for adapting plants to different stress factors
EA200900582A1 (ru) * 2006-10-20 2009-08-28 Общество С Ограниченной Ответственностью "Митотехнология" Фармацевтические композиции для профилактики и лечения глазных патологий
EP2145623A4 (en) * 2007-01-29 2010-10-27 Ltd Liability Company Mitotech PHARMACEUTICAL AND COSMETIC COMPOSITIONS FOR ACCELERATING THE PROCESS OF WOUND HEALING AND OTHER SURFACE INJURIES
WO2008094062A1 (en) 2007-01-29 2008-08-07 Limited Liability Company 'mitotechnology' Pharmaceutical compositions useful for preventing and treating oncological diseases
EA016723B1 (ru) * 2007-02-27 2012-07-30 Дели Инститьют Оф Фармасьютикал Сайнсиз Энд Рисерч (Дипсар) Синергетическая травяная композиция, применяемая при глаукоме, и способ ее получения
WO2008127138A1 (fr) * 2007-04-11 2008-10-23 Limited Liability Company 'mitotechnology' Composition visant à ralentir le vieillissement et à allonger la durée de vie de l'organisme et utilisation de cette composition
US8518915B2 (en) 2007-06-29 2013-08-27 Mitotech Sa Use of mitochondrially-addressed compounds for preventing and treating cardiovascular diseases
US9308214B2 (en) 2008-11-12 2016-04-12 Mitotech S.A. Method for moderately increasing the proton conductivity of biological membranes with the aid of mitochondria-targeted delocalized cations
EA025414B1 (ru) * 2009-06-10 2016-12-30 Общество С Ограниченной Ответственностью "Митотех" Фармацевтическая композиция для применения в медицинской и ветеринарной офтальмологии
MX2012005356A (es) 2009-11-13 2013-01-29 Obschestvo S Ogranichennoi Otvetstvennostyu Mitotekh Substancias farmaceuticas basadas en antioxidantes dirigidos a mitocondria.
CN103260466B (zh) 2010-12-20 2016-08-17 高露洁-棕榄公司 含有亲水性活性物质、疏水性结构化剂和油载体的明胶包囊的口腔护理组合物
ES2704064T3 (es) 2011-06-03 2019-03-14 Mitotech Sa Formulaciones orales de antioxidantes dirigidos mitocondrialmente y su preparación y uso
CN112439071B (zh) * 2019-09-04 2022-05-20 武汉科福新药有限责任公司 透皮促渗组合物及其在噻吗洛尔制剂中的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK166779B1 (da) * 1983-12-14 1993-07-12 Takeda Chemical Industries Ltd 1,5-benzoxatiepinderivater eller farmaceutisk acceptable salte deraf, samt farmaceutisk praeparat indeholdende en saadan forbindelse
EP0229467A1 (en) * 1985-12-10 1987-07-22 Takeda Chemical Industries, Ltd. 1,5-Benzoxathiepin derivatives, their production and use

Also Published As

Publication number Publication date
DE69500660D1 (de) 1997-10-16
DE69500660T2 (de) 1998-02-26
CA2141176A1 (en) 1995-07-28
CN1116928A (zh) 1996-02-21
EP0667156B1 (en) 1997-09-10
ATE157870T1 (de) 1997-09-15
EP0667156A1 (en) 1995-08-16
KR950032169A (ko) 1995-12-20
TW316235B (es) 1997-09-21
US5538974A (en) 1996-07-23

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