ES2106739T3 - Procedimiento para la preparacion selectiva de cristales de hidrato. - Google Patents

Procedimiento para la preparacion selectiva de cristales de hidrato.

Info

Publication number
ES2106739T3
ES2106739T3 ES91103032T ES91103032T ES2106739T3 ES 2106739 T3 ES2106739 T3 ES 2106739T3 ES 91103032 T ES91103032 T ES 91103032T ES 91103032 T ES91103032 T ES 91103032T ES 2106739 T3 ES2106739 T3 ES 2106739T3
Authority
ES
Spain
Prior art keywords
methyl
procedure
hydrate crystals
selective preparation
benzoxazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91103032T
Other languages
English (en)
Inventor
Yukio Sato
Atsushi Sato
Tatsuro Sumikawa
Tazuo Uemura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2106739T3 publication Critical patent/ES2106739T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

UN PROCESO PARA PRODUCIR SELECTIVAMENTE UN ACIDO (S)-9-FLUORO-3-METILO-10 -(4-METILO-1-PIPERAZINILO)-7-OXO-2, 3 DIHIDRO-7H-PIRIDO(1, 2, 3-DE) (1, 4) BENZOXAZINA-6-CARBOXILICO HEMIHIDRATADO O MONOHIDRATADO, QUE COMPRENDE EL CONTROL DEL CONTENIDO DE AGUA DE UN DISOLVENTE ACUOSO EN EL QUE SE DISUELVE UN ACIDO DE LA FORMULA ANTERIOR DURANTE LA CRISTALIZACION.
ES91103032T 1990-03-01 1991-02-28 Procedimiento para la preparacion selectiva de cristales de hidrato. Expired - Lifetime ES2106739T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5045490 1990-03-01

Publications (1)

Publication Number Publication Date
ES2106739T3 true ES2106739T3 (es) 1997-11-16

Family

ID=12859314

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91103032T Expired - Lifetime ES2106739T3 (es) 1990-03-01 1991-02-28 Procedimiento para la preparacion selectiva de cristales de hidrato.

Country Status (12)

Country Link
US (1) US5545737A (es)
EP (1) EP0444678B1 (es)
KR (1) KR970000045B1 (es)
AT (1) ATE157666T1 (es)
DE (1) DE69127485T2 (es)
ES (1) ES2106739T3 (es)
GR (1) GR3025276T3 (es)
IE (1) IE910692A1 (es)
IN (1) IN172207B (es)
PT (1) PT96917B (es)
TW (1) TW208013B (es)
YU (1) YU48328B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA946853B (en) * 1993-09-10 1995-04-24 Daiichi Seiyaku Co Crystals of antimicrobial compound.
US6410520B2 (en) 2000-02-01 2002-06-25 The Procter & Gamble Company Selective crystallization of 3-pyridyl-1-hydroxyethylidene-1, 1-bisphosphonic acid sodium as the hemipentahydrate or monohydrate
US6562974B2 (en) 2000-02-01 2003-05-13 The Procter & Gamble Company Process for making geminal bisphosphonates
US7629458B2 (en) * 2001-10-03 2009-12-08 Teva Pharmaceutical Industries Ltd. Preparation of levofloxacin and hemihydrate thereof
US7425628B2 (en) * 2001-10-03 2008-09-16 Teva Pharmaceutical Industries Ltd. Methods for the purification of levofloxacin
EP1460997A4 (en) * 2001-11-29 2005-06-15 Teva Pharma METHODS OF PURIFYING LEVOFLOXACIN
US20060276463A1 (en) * 2002-12-16 2006-12-07 Sharma Tarun K Pure levofloxacin hemihydrate and processes for preparation thereof
KR100704641B1 (ko) * 2004-07-21 2007-04-06 주식회사유한양행 고순도의 레보플록사신 제조방법
US7678903B2 (en) * 2004-09-17 2010-03-16 Matrix Laboratories Limited Process for the preparation of levofloxacin hemihydrate
US20070244318A1 (en) * 2004-11-08 2007-10-18 Rao Davuluri R Process for the Preparation of Levofloxacin Hemihydrate
ES2255871B1 (es) * 2004-12-31 2007-08-16 Quimica Sintetica, S.A. Procedimiento para la obtencion de levofloxacino exento de sales.
CN1321121C (zh) * 2005-04-21 2007-06-13 浙江医药股份有限公司新昌制药厂 左氧氟沙星制备及后处理方法
US7964723B2 (en) * 2008-08-02 2011-06-21 Apeloa-Kangyu And practical process for exclusively producing (S)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido-[1,2,3,de][1,4]benzoxazine-6-carboxylic acid hemihydrate
CN101863904A (zh) * 2010-07-08 2010-10-20 浙江东亚药业有限公司 一种高纯度左氧氟沙星半水合物的制备方法
CN117341268B (zh) * 2022-11-24 2026-03-03 华夏生生药业(北京)有限公司 一种制备氧氟沙星和左氧氟沙星的方法及设备

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE203719C (es) * 1907-11-02 1908-10-20
JPS5746986A (en) * 1980-09-02 1982-03-17 Dai Ichi Seiyaku Co Ltd Pyrido(1,2,3-de)(1,4)benzoxazine derivative
JPS57131769A (en) * 1981-02-10 1982-08-14 Kissei Pharmaceut Co Ltd 4-(1-imidazolylmethyl)cinnamic acid hydrochloride monohydrate, its preparation and drug containing the same
JPS5843977A (ja) * 1981-09-09 1983-03-14 Dai Ichi Seiyaku Co Ltd ピリドベンズオキサジン誘導体の製法
JPS60226855A (ja) * 1984-04-26 1985-11-12 Nippon Kayaku Co Ltd Ｎ−ベンジルオキシカルボニル−ｌ−スレオニンアミド・１／２水和物およびその製造法
NO166131C (no) * 1985-06-20 1991-06-05 Daiichi Seiyaku Co Analogifremgangsmaate for fremstilling av s(-)-pyridobenzoksazinforbindelser.
ZA864518B (en) * 1985-06-20 1987-03-25 Daiichi Seiyaku Co Optically active pyridobenzoxazine derivatives and intermediates thereof
MY104139A (en) * 1988-08-09 1994-02-28 Daiichi Seiyaku Co Antimicrobial agent for animals
FI82240C (fi) * 1988-10-20 1991-02-11 Huhtamaeki Oy Foerfarande foer framstaellning av farmakologiskt vaerdefullt s-timolol-hemihydrat.
MTP1076B (en) * 1990-01-12 1991-09-30 Ciba Geigy Ag Hemihydrate

Also Published As

Publication number Publication date
EP0444678B1 (en) 1997-09-03
US5545737A (en) 1996-08-13
HK1002730A1 (en) 1998-09-11
PT96917B (pt) 1998-07-31
KR910016748A (ko) 1991-11-05
TW208013B (es) 1993-06-21
GR3025276T3 (en) 1998-02-27
DE69127485T2 (de) 1998-04-02
IE910692A1 (en) 1991-09-11
IN172207B (es) 1993-05-01
EP0444678A1 (en) 1991-09-04
YU35491A (sh) 1994-04-05
KR970000045B1 (ko) 1997-01-04
PT96917A (pt) 1991-10-31
ATE157666T1 (de) 1997-09-15
YU48328B (sh) 1998-05-15
DE69127485D1 (de) 1997-10-09

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