IT1248011B - Procedimento per la preparazione dell'acido 9-fluoro-10- (4-metil-1-piperazinil)-7-oxo-2,3-diidro-7h-pirido (1,2,3-de) (1,4)benzotiadin-6-carbossilico cloridrato. - Google Patents

Procedimento per la preparazione dell'acido 9-fluoro-10- (4-metil-1-piperazinil)-7-oxo-2,3-diidro-7h-pirido (1,2,3-de) (1,4)benzotiadin-6-carbossilico cloridrato.

Info

Publication number
IT1248011B
IT1248011B ITMI911577A ITMI911577A IT1248011B IT 1248011 B IT1248011 B IT 1248011B IT MI911577 A ITMI911577 A IT MI911577A IT MI911577 A ITMI911577 A IT MI911577A IT 1248011 B IT1248011 B IT 1248011B
Authority
IT
Italy
Prior art keywords
methyl
piperazinyl
dihydro
oxo
fluoro
Prior art date
Application number
ITMI911577A
Other languages
English (en)
Inventor
Violetta Cecchetti
Arnaldo Fravolini
Pier Giuseppe Pagella
Fausto Schiaffella
Original Assignee
Mediolanum Farmaceutici Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mediolanum Farmaceutici Spa filed Critical Mediolanum Farmaceutici Spa
Priority to ITMI911577A priority Critical patent/IT1248011B/it
Publication of ITMI911577A0 publication Critical patent/ITMI911577A0/it
Priority to EP92109079A priority patent/EP0522277A1/en
Priority to US07/889,797 priority patent/US5221741A/en
Priority to JP4171500A priority patent/JPH05194535A/ja
Publication of ITMI911577A1 publication Critical patent/ITMI911577A1/it
Application granted granted Critical
Publication of IT1248011B publication Critical patent/IT1248011B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

Procedimento per la preparazione dell'acido 9-fluoro-10-(4-metil-l-piperazinil)-7-oxo-2,3-diidro-7H-pirido [1, 2, 3-de] [1, 4] benzotiazin-6-carbossilico cloridrato (Rufloxacina) mediante reazione del 2, 3, 5-trifluro-4-(4-metil-1-piperazinil benzoilacetato di etile con N, N-dimetilformammide dimetilacetale, seguita da reazione con 2-amminoetantiolo, ciclizzazione intramolecolare mediante trattamento con NaH, idrolisi con H2O e salificazione con HCl.
ITMI911577A 1991-06-07 1991-06-07 Procedimento per la preparazione dell'acido 9-fluoro-10- (4-metil-1-piperazinil)-7-oxo-2,3-diidro-7h-pirido (1,2,3-de) (1,4)benzotiadin-6-carbossilico cloridrato. IT1248011B (it)

Priority Applications (4)

Application Number Priority Date Filing Date Title
ITMI911577A IT1248011B (it) 1991-06-07 1991-06-07 Procedimento per la preparazione dell'acido 9-fluoro-10- (4-metil-1-piperazinil)-7-oxo-2,3-diidro-7h-pirido (1,2,3-de) (1,4)benzotiadin-6-carbossilico cloridrato.
EP92109079A EP0522277A1 (en) 1991-06-07 1992-05-29 Process for the preparation of 9-fluoro-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzothiazine-6-carboxylic acid hydrochloride
US07/889,797 US5221741A (en) 1991-06-07 1992-05-29 Process for the preparation of 9-fluoro-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzothiazine-6-carboxylic acid hydrochloride
JP4171500A JPH05194535A (ja) 1991-06-07 1992-06-08 ９−フルオロ−１０−（４−メチル−１−ピペラジニル）−７−オキソ−２，３−ジヒドロ−７Ｈ−ピリド［１，２，３−ｄ，ｅ［１，４ベンゾチアジン−６−カルボン酸塩酸塩の製造方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI911577A IT1248011B (it) 1991-06-07 1991-06-07 Procedimento per la preparazione dell'acido 9-fluoro-10- (4-metil-1-piperazinil)-7-oxo-2,3-diidro-7h-pirido (1,2,3-de) (1,4)benzotiadin-6-carbossilico cloridrato.

Publications (3)

Publication Number Publication Date
ITMI911577A0 ITMI911577A0 (it) 1991-06-07
ITMI911577A1 ITMI911577A1 (it) 1992-12-07
IT1248011B true IT1248011B (it) 1995-01-05

Family

ID=11360072

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI911577A IT1248011B (it) 1991-06-07 1991-06-07 Procedimento per la preparazione dell'acido 9-fluoro-10- (4-metil-1-piperazinil)-7-oxo-2,3-diidro-7h-pirido (1,2,3-de) (1,4)benzotiadin-6-carbossilico cloridrato.

Country Status (4)

Country Link
US (1) US5221741A (it)
EP (1) EP0522277A1 (it)
JP (1) JPH05194535A (it)
IT (1) IT1248011B (it)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1270836B (it) * 1993-10-27 1997-05-13 Archimica Spa Procedimento per la preparazione di rufloxacina e suoi sali
IT1270834B (it) * 1993-10-27 1997-05-13 Archimica Spa Disolfuro chinolico
FI970427A7 (fi) * 1994-08-02 1997-03-26 Procter & Gamble Menetelmä mikrobinvastaisten yhdisteiden valmistamiseksi
NZ290722A (en) * 1994-08-02 1999-03-29 Procter & Gamble A process for making derivatives of quinolonyl lactam (qla's); intermediates

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1173374B (it) * 1984-02-24 1987-06-24 Mediolanum Farmaceutici Srl Derivati pirido-benzotiazinici ad elevata attivita' antimicrobica
JPS62216591A (ja) * 1986-03-18 1987-09-24 Toshiba Corp メモリ制御回路
JPS63179856A (ja) * 1987-01-21 1988-07-23 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体の製造方法並びにその中間体
JPH0228178A (ja) * 1988-04-23 1990-01-30 Toyama Chem Co Ltd 新規なピリドンカルボン酸誘導体およびその塩並びにそれらの製造法

Also Published As

Publication number Publication date
US5221741A (en) 1993-06-22
ITMI911577A1 (it) 1992-12-07
JPH05194535A (ja) 1993-08-03
EP0522277A1 (en) 1993-01-13
ITMI911577A0 (it) 1991-06-07

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Effective date: 19960628