ES2107422T3 - Moleculas de adn recombinante, huespedes, procedimientos y polipeptidos similares a proteinas portadoras de somatomedina humana. - Google Patents
Moleculas de adn recombinante, huespedes, procedimientos y polipeptidos similares a proteinas portadoras de somatomedina humana.Info
- Publication number
- ES2107422T3 ES2107422T3 ES90901407T ES90901407T ES2107422T3 ES 2107422 T3 ES2107422 T3 ES 2107422T3 ES 90901407 T ES90901407 T ES 90901407T ES 90901407 T ES90901407 T ES 90901407T ES 2107422 T3 ES2107422 T3 ES 2107422T3
- Authority
- ES
- Spain
- Prior art keywords
- dna molecules
- polypeptides
- carrier protein
- human
- hosts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 8
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 8
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 8
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 title abstract 6
- 102000013275 Somatomedins Human genes 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 6
- 108020004511 Recombinant DNA Proteins 0.000 title abstract 4
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 102000014914 Carrier Proteins Human genes 0.000 abstract 4
- 108010078791 Carrier Proteins Proteins 0.000 abstract 4
- 108020004414 DNA Proteins 0.000 abstract 4
- 230000004071 biological effect Effects 0.000 abstract 1
- 238000011210 chromatographic step Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4743—Insulin-like growth factor binding protein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Molecular Biology (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Nutrition Science (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
ESTA INVENCION SE REFIERE A POLIPEPTIDOS QUE SON SUBUNIDADES DE PROTEINA QUE TRANSPORTAN SOMATOMEDINA HUMANA, Y A PROCESOS PARA PRODUCIRLOS. LAS SUBMIDADES DE PROTEINA TRANSPORTADORA SE UNEN A POLIPEPTIDOS EN FORMA DE PROTEINA HUMANA, TAMBIEN CONOCIDOS COMO FACTORES DE CRECIMIENTO DE TIPO DE INSULINA. EL PROCESO INCLUYE LA PREPARACION A PARTIR DE UNA FRACCION DE SUERO HUMANO, COHN+V-1, POR UNA MOLECULA DE VARIOS PASOS CROMATOGRAFICOS. ESTA INVENCION TAMBIEN SE REFIERE A MOLECULAS DE ADN QUE CODIFICAN POLIPEPTIDOS EN FORMA DE PROTEINA TRANSPORTADORES DE SOMATOMEDINA HUMANA, MOLECULAS DE ADN RECOMBINANTES, RECEPTORES, PROCESOS PARA PRODUCIR POLIPEPTIDOS EN FORMA DE PROTEINA TRANSPORTADORA, POLIPEPTIDOS EN FORMA DE PROTEINA TRANSPORTADORES DE SOMATOMEDINA HUMANA PRODUCIDOS UTILIZANDO AQUELLAS MOLECULAS, RECEPTORES Y PROCESOS. LA INVENCION SE REFIERE A MOLECULAS DE ADN Y SU EXPRESION EN RECEPTORES APROPIADOS. LAS MOLECULAS DE ADN RECOMBINANTES CONTIENEN MOLECULAS DE ADN QUE CODIFICAN PARA POLIPEPTIDOS QUE TIENEN UNA ACTIVIDAD BIOLOGICA DE LA PROTEINA TRANSPORTADORA HUMANA O UNA SUBUNIDAD DE PROTEINA TRANSPORTADORA HUMANA CAPAZ DE LIGAR SOMATOMEDINAS. LAS MOLECULAS DE ADN, MOLECULAS DE ADN, RECOMBINANTES, RECEPTORES Y PROCESOS DE ESTA INVENCION PUDEN UTILIZARSE EN LA PRODUCCION DE POLIPEPTIDOS UTILES PARA VARIAS APLICACIONES TERAPEUTICAS, DIAGNOSTICOS Y OTRAS APLICACIONES UTILES.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29025088A | 1988-12-22 | 1988-12-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2107422T3 true ES2107422T3 (es) | 1997-12-01 |
Family
ID=23115154
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES90901407T Expired - Lifetime ES2107422T3 (es) | 1988-12-22 | 1989-12-21 | Moleculas de adn recombinante, huespedes, procedimientos y polipeptidos similares a proteinas portadoras de somatomedina humana. |
Country Status (13)
| Country | Link |
|---|---|
| EP (2) | EP0375438A3 (es) |
| JP (2) | JPH04503352A (es) |
| KR (1) | KR910700261A (es) |
| AT (1) | ATE155793T1 (es) |
| AU (1) | AU4836890A (es) |
| CA (1) | CA2006322C (es) |
| DE (1) | DE68928203T2 (es) |
| DK (1) | DK95291A (es) |
| ES (1) | ES2107422T3 (es) |
| GR (1) | GR3025094T3 (es) |
| IL (1) | IL92816A0 (es) |
| WO (1) | WO1990006950A1 (es) |
| ZA (1) | ZA899832B (es) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5258287A (en) * | 1988-03-22 | 1993-11-02 | Genentech, Inc. | DNA encoding and methods of production of insulin-like growth factor binding protein BP53 |
| US5198340A (en) * | 1991-01-17 | 1993-03-30 | Genentech, Inc. | Assay for free igf-i, igf-ii, and gh levels in body fluids |
| US5187151A (en) * | 1991-02-12 | 1993-02-16 | Genentech, Inc. | Use of binding protein with igf-i as an anabolic growth promoting agent |
| US5643867A (en) * | 1992-08-26 | 1997-07-01 | Celtrix Pharmaceuticals, Inc. | Method for treating catabolic conditions |
| EP0800530A4 (en) * | 1994-07-20 | 1998-12-02 | Celtrix Pharma | IGF / IGFBP COMPLEX FOR PROMOTING BONE TRAINING AND REGULATING BONE REMODELING |
| US5565204A (en) * | 1994-08-24 | 1996-10-15 | American Cyanamid Company | Pneumococcal polysaccharide-recombinant pneumolysin conjugate vaccines for immunization against pneumococcal infections |
| US6420518B1 (en) | 1997-04-04 | 2002-07-16 | Genetech, Inc. | Insulin-like growth factor agonist molecules |
| US20030069177A1 (en) | 2000-05-16 | 2003-04-10 | Genentech, Inc. | Method for treating cartilage disorders |
| US6121416A (en) | 1997-04-04 | 2000-09-19 | Genentech, Inc. | Insulin-like growth factor agonist molecules |
| DE60042550D1 (de) | 1999-01-06 | 2009-08-27 | Genentech Inc | Mutierte varianten des insulin-ähnlichen wachstumsfaktor i (igf-i) |
| CA2356109C (en) | 1999-01-06 | 2008-04-22 | Genentech, Inc. | Insulin-like growth factor (igf) i mutant variants |
| US7071300B2 (en) | 2001-03-14 | 2006-07-04 | Genentech, Inc. | IGF antagonist peptides |
| CA2524305C (en) | 2003-05-01 | 2015-12-08 | Imclone Systems Incorporated | Fully human antibodies directed against the human insulin-like growth factor-1 receptor |
| DK2274978T3 (en) | 2003-09-12 | 2015-06-15 | Ipsen Biopharmaceuticals Inc | Methods of treating an insulin-like growth factor-I (IGF-I) deficiency |
| EP1670822A2 (en) | 2003-10-03 | 2006-06-21 | Genentech, Inc. | Igf binding proteins |
| KR101246504B1 (ko) | 2005-06-17 | 2013-03-26 | 임클론 엘엘씨 | 항－ＰＤＧＦＲα 항체 |
| KR101353706B1 (ko) | 2006-02-03 | 2014-02-18 | 유니버시티 오브 워싱톤 | 전립선 암 치료용 보강제로서의 ⅰｇｆ-ⅰｒ 길항제 |
| KR20200097679A (ko) | 2017-09-11 | 2020-08-19 | 샤이어 휴먼 지네틱 테라피즈 인크. | 만성 폐 질환 치료를 위한 방법 및 조성물 |
| ES3005966T3 (en) | 2020-10-19 | 2025-03-17 | Oak Hill Bio Ltd | Compositions suitable for use in neonates |
| JP2025502349A (ja) | 2022-01-19 | 2025-01-24 | オーク ヒル バイオ リミテッド | Ｉｇｆ－１／ｉｇｆｂｐの酸化を低減するための組成物および方法 |
| WO2023242439A1 (en) | 2022-06-17 | 2023-12-21 | Oak Hill Bio Limited | Vascular stabilisation (preterm infants) |
| WO2023242442A1 (en) | 2022-06-17 | 2023-12-21 | Oak Hill Bio Limited | Method of maturing/differentiating neurons and/or modulating the vagus nerve |
| WO2023242440A1 (en) | 2022-06-17 | 2023-12-21 | Oak Hill Bio Limited | Treament of lungs in infants |
| IL322721A (en) | 2023-02-14 | 2025-10-01 | Oak Hill Bio Ltd | Treatment of healing dysregulation in digestive tract tissue |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL68218A (en) * | 1983-03-23 | 1985-12-31 | Univ Ramot | Compositions for cartilage repair comprising embryonal chondrocytes |
| US4738921A (en) * | 1984-09-27 | 1988-04-19 | Eli Lilly And Company | Derivative of the tryptophan operon for expression of fused gene products |
| CA1322714C (en) * | 1986-11-14 | 1993-10-05 | Harry N. Antoniades | Wound healing and bone regeneration |
| US4885163A (en) * | 1987-02-24 | 1989-12-05 | Eli Lilly And Company | Topical use of IGF-II for wound healing |
| AU617795B2 (en) * | 1988-03-17 | 1991-12-05 | Leukotech A/S | Heparin-binding proteins, dna coding for them, processes for producing them as well as therapeutic preparations containing them |
| US5258287A (en) * | 1988-03-22 | 1993-11-02 | Genentech, Inc. | DNA encoding and methods of production of insulin-like growth factor binding protein BP53 |
| DE3854842T2 (de) * | 1988-04-12 | 1996-06-13 | Amgen Boulder Inc | Verfahren zur steigerung und zur hemmung der wirkung eines insulinähnlichen wachstumfaktors |
-
1989
- 1989-12-20 IL IL92816A patent/IL92816A0/xx unknown
- 1989-12-21 AT AT90901407T patent/ATE155793T1/de not_active IP Right Cessation
- 1989-12-21 ZA ZA899832A patent/ZA899832B/xx unknown
- 1989-12-21 EP EP19890313463 patent/EP0375438A3/en active Pending
- 1989-12-21 DE DE68928203T patent/DE68928203T2/de not_active Revoked
- 1989-12-21 CA CA002006322A patent/CA2006322C/en not_active Expired - Fee Related
- 1989-12-21 AU AU48368/90A patent/AU4836890A/en not_active Abandoned
- 1989-12-21 WO PCT/US1989/005791 patent/WO1990006950A1/en not_active Ceased
- 1989-12-21 KR KR1019900701824A patent/KR910700261A/ko not_active Withdrawn
- 1989-12-21 JP JP2501912A patent/JPH04503352A/ja active Pending
- 1989-12-21 ES ES90901407T patent/ES2107422T3/es not_active Expired - Lifetime
- 1989-12-21 EP EP90901407A patent/EP0451194B1/en not_active Revoked
-
1991
- 1991-05-21 DK DK095291A patent/DK95291A/da unknown
-
1997
- 1997-10-20 GR GR970402735T patent/GR3025094T3/el unknown
-
1998
- 1998-10-23 JP JP10303047A patent/JPH11236400A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU4836890A (en) | 1990-07-10 |
| DK95291A (da) | 1991-08-16 |
| EP0451194B1 (en) | 1997-07-23 |
| JPH04503352A (ja) | 1992-06-18 |
| CA2006322A1 (en) | 1990-06-22 |
| IL92816A0 (en) | 1990-09-17 |
| ATE155793T1 (de) | 1997-08-15 |
| EP0375438A3 (en) | 1992-03-25 |
| EP0451194A1 (en) | 1991-10-16 |
| HK1000826A1 (en) | 1998-05-01 |
| GR3025094T3 (en) | 1998-01-30 |
| EP0451194A4 (en) | 1992-09-02 |
| EP0375438A2 (en) | 1990-06-27 |
| CA2006322C (en) | 2000-08-01 |
| DE68928203T2 (de) | 1998-01-15 |
| DK95291D0 (da) | 1991-05-21 |
| DE68928203D1 (de) | 1997-09-04 |
| WO1990006950A1 (en) | 1990-06-28 |
| KR910700261A (ko) | 1991-03-14 |
| ZA899832B (en) | 1990-10-31 |
| JPH11236400A (ja) | 1999-08-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK95291A (da) | Rekombinante dna-molekyler | |
| DK677688A (da) | Humane somatomedinbaererproteinunderenheder og fremgangsmaade til fremstilling af saadanne | |
| DE68926888D1 (de) | Verfahren zur Herstellung von sekretierten Rezeptoranalogen | |
| FI102768B1 (fi) | Hybridi-DNA-molekyyli ja menetelmä fibronektiiniä sitovan proteiinin valmistamiseksi | |
| ATE83801T1 (de) | Verfahren und mittel zur herstellung eines proteins mit der gleichen igg-spezifizitaet wie protein g. | |
| IL92257A0 (en) | Binding proteins for insulin-like growth factors,pharmaceutical compositions containing them and dna fragments encoding them | |
| DE69637148D1 (de) | Nukleinsäuremoleküle, proteine und peptide, die im zusammenhang stehen mit dickdarmzellen und dickdarm-krebszellen | |
| ATE380867T1 (de) | Lactoferrinrezeptorgen von moraxella | |
| FI103892B1 (fi) | Rekombinantti-DNA-molekyyli, joka koodaa polypeptidiä/proteiinia, jolla on oleellisesti vaskulaaristen antikoaguloivien proteiinien biologiset ominaisuudet sekä niiden valmistus | |
| DE3855084D1 (de) | Herstellung und Reinigung eines Proteins, das mit einem Bindungsprotein fusioniert ist | |
| ATE290087T1 (de) | Neue signalsequenzen | |
| DE69132813D1 (de) | Genetisches igfbp-5 rodierendes material | |
| FI921600A0 (fi) | Bjoerkpollenallergen p14 foer diagnos och behandling av allergiska sjukdomar. | |
| PT98804A (pt) | Processo de preparacao de igfbp-4 ou um fragmento da mesma | |
| CA2128215C (en) | Autotaxin: motility stimulating protein useful in cancer diagnosis and therapy | |
| SE8801723D0 (sv) | Fibronectin binding protein as well as its preparation | |
| WO1995008628A3 (en) | Nucleic acids encoding merosin, merosin fragments and uses thereof | |
| DK595187D0 (da) | Minactivin og fremgangsmaade til fremstilling deraf | |
| IL78278A0 (en) | Process for the production of polypeptides,dna sequence encoding desired polypeptide human somatomedin c polypeptide and recombinant dna molecules | |
| Spencer et al. | Uses for antibodies which bind to human somatomedin carrier protein subunits |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
Ref document number: 451194 Country of ref document: ES |