ES2107454T3 - Segmentos extracelulares de peptidos de anclaje de la inmunoglobulina ige humana, y anticuerpos especificos para los mismos. - Google Patents

Segmentos extracelulares de peptidos de anclaje de la inmunoglobulina ige humana, y anticuerpos especificos para los mismos.

Info

Publication number
ES2107454T3
ES2107454T3 ES91904413T ES91904413T ES2107454T3 ES 2107454 T3 ES2107454 T3 ES 2107454T3 ES 91904413 T ES91904413 T ES 91904413T ES 91904413 T ES91904413 T ES 91904413T ES 2107454 T3 ES2107454 T3 ES 2107454T3
Authority
ES
Spain
Prior art keywords
ige
membrane
specific antibodies
human ige
extracellular segments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91904413T
Other languages
English (en)
Inventor
Tse Wen Chang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanox Inc
Original Assignee
Tanox Biosystems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/468,766 external-priority patent/US5260416A/en
Priority claimed from US07/515,604 external-priority patent/US5274075A/en
Application filed by Tanox Biosystems Inc filed Critical Tanox Biosystems Inc
Application granted granted Critical
Publication of ES2107454T3 publication Critical patent/ES2107454T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

SE PRESENTAN EPITOPOS ANTIGENICOS ASOCIADOS CON SEGMENTOS EXTRACELULARES DEL DOMINANTE QUE UNE LAS INMUNOGLUBULINAS A LA MEMBRANA DE LA CELULA B. PARA IGE, LOS EPITOPOS ESTAN PRESENTES SOBRE LAS CELULAS B QUE SOPORTAN IGE PERO NO ESTAN PRESENTES LOS BASOFILOS O LA FORMA SECRETADA, SOLUBLE DE IGE. LOS EPITOPOS PUEDEN USARSE PARA TERAPIA Y DIAGNOSIS. POR EJEMPLO, LOS ANTICUERPOS O INMUNOTOXINAS ESPECIFICAS PARA LOS EPITOPOS ASOCIADOS CON EL DOMINANTE QUE SE UNE AL IGE PUEDEN USARSE PARA DESTRUIR SELECTIVAMENTE O REGULAR LOS LINFOCITOS QUE SOPORTAN IGE, BLOQUEANDO ASI LAS REACCIONES ALERGICAS EN LAS QUE INTERVIENE IGE. SE HAN DESCUBIERTO TRES ISOFORMAS DIFERENTES DEL SEGMENTO TERMINAL C DE LA CADENA EPSILON HUMANA QUE RESULTA DE LAS UNIONES ALTERNATIVAS DEL MRNA EN LA ZONA EXON DE LA MEMBRANA, UNA DE LAS CUALES ES SECRETADA Y NO SE ENCUENTRA UNIDA A LA MEMBRANA.
ES91904413T 1990-01-23 1991-01-23 Segmentos extracelulares de peptidos de anclaje de la inmunoglobulina ige humana, y anticuerpos especificos para los mismos. Expired - Lifetime ES2107454T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/468,766 US5260416A (en) 1987-12-31 1990-01-23 Antigenic epitopes present on membrane-bound but not secreted IgE
US07/515,604 US5274075A (en) 1987-12-31 1990-04-27 Newly identified human epsilon immunoglobulin peptides and related products
US63007790A 1990-12-19 1990-12-19

Publications (1)

Publication Number Publication Date
ES2107454T3 true ES2107454T3 (es) 1997-12-01

Family

ID=27413084

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91904413T Expired - Lifetime ES2107454T3 (es) 1990-01-23 1991-01-23 Segmentos extracelulares de peptidos de anclaje de la inmunoglobulina ige humana, y anticuerpos especificos para los mismos.

Country Status (11)

Country Link
EP (1) EP0512064B1 (es)
JP (1) JP3449712B2 (es)
AT (1) ATE154637T1 (es)
AU (2) AU645783B2 (es)
CA (1) CA2074089C (es)
DE (1) DE69126607T2 (es)
DK (1) DK0512064T3 (es)
ES (1) ES2107454T3 (es)
GR (1) GR3024563T3 (es)
SG (1) SG70982A1 (es)
WO (1) WO1991011456A1 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0673427T3 (da) * 1992-07-08 2003-07-21 Unilever Nv Enzymatisk proces under anvendelse af enzymer immobiliseret på cellevæggen af en eukaryotisk mikrobiel celle ved fremstilling af et fusionsprotein
AU4661293A (en) * 1993-03-11 1994-09-26 Tanox Biosystems, Inc. Peptides representing antigenic epitopes of ige present on b cell but not basophil surface
US5552537A (en) * 1993-03-24 1996-09-03 The Regents Of The University Of California IgE isoforms and methods of use
US6685940B2 (en) 1995-07-27 2004-02-03 Genentech, Inc. Protein formulation
US6267958B1 (en) 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
IL116436A (en) 1995-12-18 2006-12-31 Yissum Res Dev Co Fc?Á-PE CHIMERIC PROTEIN FOR TARGETED TREATMENT OF ALLERGY RESPONSES AND
CA2245497C (en) 1996-03-01 2009-02-24 Novartis Ag Peptide immunogens for vaccination against and treatment of allergy
US6913749B2 (en) * 1998-11-02 2005-07-05 Resistentia Pharmaceuticals Ab Immunogenic polypeptides for inducing anti-self IgE responses
GB9908533D0 (en) 1999-04-14 1999-06-09 Novartis Ag Organic compounds
US7754208B2 (en) 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
CA2486464A1 (en) * 2002-05-21 2003-11-27 Resistentia Pharmaceuticals Ab Chimeric ige polypeptides and host cells
EP2295080A3 (en) 2005-07-25 2011-06-22 Emergent Product Development Seattle, LLC B-cell reduction using CD37-specific and CD20-specific binding molecules
EP1941275B1 (en) 2005-09-29 2013-07-24 Medimmune, Inc. Method of identifying membrane lg specific antibodies and use thereof for targeting immunoglobulin-producing precursor cells
WO2007131129A2 (en) * 2006-05-03 2007-11-15 Guthrie Foundation For Education & Research Immunoglobulin associated cell-surface determinants in the treatment of b-cell disorders
CN105837690A (zh) 2006-06-12 2016-08-10 新兴产品开发西雅图有限公司 具有效应功能的单链多价结合蛋白
AR065368A1 (es) 2007-02-15 2009-06-03 Astrazeneca Ab Anticuerpos para moleculas de ige
SI2132230T1 (sl) 2007-03-22 2014-07-31 Genentech, Inc. Apoptotska protitelesa, ki veĹľejo membransko-vezan IgE
PT2132228E (pt) 2008-04-11 2011-10-11 Emergent Product Dev Seattle Imunoterapia de cd37 e sua combinação com um quimioterápico bifuncional
SG174161A1 (en) 2009-02-25 2011-11-28 Tsewen Chang ANTI-CemX ANTIBODIES CAPABLE OF BINDING TO HUMAN mIgE ON B LYMPHOCYTES
CA2832443C (en) * 2011-04-06 2020-08-25 The Board Of Regents Of The University Of Texas System Modulating bacterial mam polypeptides in pathogenic disease
CN104603150A (zh) 2012-04-20 2015-05-06 中央研究院 与CH4和CεmX结构域之间的连接处结合的抗mIgE抗体
US10196458B2 (en) * 2013-07-26 2019-02-05 The Regents Of The University Of California Anti-immunoglobulin E antibodies and methods of using thereof
TWI603979B (zh) * 2013-12-05 2017-11-01 中央研究院 抗人類膜錨定型免疫球蛋白a抗體能夠溶解帶有膜錨定型免疫球蛋白a的b淋巴球與降低免疫球蛋白a 的生產
KR102784293B1 (ko) 2015-09-21 2025-03-20 압테보 리서치 앤드 디벨롭먼트 엘엘씨 Cd3 결합 폴리펩타이드
EP3703753A4 (en) 2017-10-31 2021-08-18 Oneness Biotech Co., Ltd. TREATMENT OF ALLERGIC DISEASES MEDIA BY IGE

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT89107A (pt) * 1987-11-30 1989-11-30 Idec Pharma Corp Metodo e meios para a seleccao de anticorpos anti-idiotipos e seu uso para o diagnostico, monitorizacao, tratamento e/ou prevencao de doencas cancerosas, da autoimunidade ou infecciosas
DE122006000007I2 (de) * 1987-12-31 2008-03-27 Tanox Inc -tragenden b-lymphocyten befinden.

Also Published As

Publication number Publication date
DK0512064T3 (da) 1997-12-15
AU5214893A (en) 1994-03-03
DE69126607T2 (de) 1998-01-15
SG70982A1 (en) 2000-03-21
EP0512064A1 (en) 1992-11-11
HK1002034A1 (en) 1998-07-24
WO1991011456A1 (en) 1991-08-08
ATE154637T1 (de) 1997-07-15
AU7317991A (en) 1991-08-21
AU645783B2 (en) 1994-01-27
EP0512064B1 (en) 1997-06-18
GR3024563T3 (en) 1997-12-31
DE69126607D1 (de) 1997-07-24
CA2074089C (en) 2001-04-10
JP3449712B2 (ja) 2003-09-22
JPH05504482A (ja) 1993-07-15
CA2074089A1 (en) 1991-07-24
EP0512064A4 (en) 1993-02-17

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