ES2107776T3 - Procedimiento y dispositivo de inyeccion de un liquido esteril y apirogeno obtenido por filtracion. - Google Patents
Procedimiento y dispositivo de inyeccion de un liquido esteril y apirogeno obtenido por filtracion.Info
- Publication number
- ES2107776T3 ES2107776T3 ES94420131T ES94420131T ES2107776T3 ES 2107776 T3 ES2107776 T3 ES 2107776T3 ES 94420131 T ES94420131 T ES 94420131T ES 94420131 T ES94420131 T ES 94420131T ES 2107776 T3 ES2107776 T3 ES 2107776T3
- Authority
- ES
- Spain
- Prior art keywords
- liquid
- injection
- apirogen
- filtration
- procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D65/00—Accessories or auxiliary operations, in general, for separation processes or apparatus using semi-permeable membranes
- B01D65/10—Testing of membranes or membrane apparatus; Detecting or repairing leaks
- B01D65/102—Detection of leaks in membranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1654—Dialysates therefor
- A61M1/1656—Apparatus for preparing dialysates
- A61M1/1672—Apparatus for preparing dialysates using membrane filters, e.g. for sterilising the dialysate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/342—Adding solutions to the blood, e.g. substitution solutions
- A61M1/3424—Substitution fluid path
- A61M1/3437—Substitution fluid path downstream of the filter, e.g. post-dilution with filtrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/342—Adding solutions to the blood, e.g. substitution solutions
- A61M1/3455—Substitution fluids
- A61M1/3462—Circuits for the preparation thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/342—Adding solutions to the blood, e.g. substitution solutions
- A61M1/3455—Substitution fluids
- A61M1/3465—Substitution fluids using dialysate as substitution fluid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D65/00—Accessories or auxiliary operations, in general, for separation processes or apparatus using semi-permeable membranes
- B01D65/10—Testing of membranes or membrane apparatus; Detecting or repairing leaks
- B01D65/104—Detection of leaks in membrane apparatus or modules
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/44—Treatment of water, waste water, or sewage by dialysis, osmosis or reverse osmosis
- C02F1/444—Treatment of water, waste water, or sewage by dialysis, osmosis or reverse osmosis by ultrafiltration or microfiltration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/17—General characteristics of the apparatus with redundant control systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/70—General characteristics of the apparatus with testing or calibration facilities
- A61M2205/705—Testing of filters for leaks
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/70—General characteristics of the apparatus with testing or calibration facilities
- A61M2205/707—Testing of filters for clogging
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Hydrology & Water Resources (AREA)
- Environmental & Geological Engineering (AREA)
- Water Supply & Treatment (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- External Artificial Organs (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Abstract
EL DISPOSITIVO DE INYECCION DE UN LIQUIDO ESTERIL Y APIROGENO COMPRENDE: UN PRIMER Y UN SEGUNDO COMPARTIMENTOS (16, 17) SEPARADOS POR UNA MEMBRANA POROSA (18), TENIENDO EL PRIMER COMPARTIMENTO (16) UNA ENTRADA CONECTABLE A UNA FUENTE (11) QUE TIENE UNA SALIDA CONECTADA A UNA CANALIZACION DE INYECCION (22). PARA HACER CIRCULAR EL LIQUIDO A TRAVES DEL FILTRO PRINCIPAL (15) Y EN LA CANALIZACION DE INYECCION (22), 27) DE VERIFICACION DE LA INTEGRIDAD DEL FILTRO PRINCIPAL QUE COMPRENDE: RIAS Y ELEMENTOS PYROGENOS DISPUESTO SOBRE LA CANALIZACION DE INYECCION (22), Y IAMIENTO DEL FILTRO SECUNDARIO (24) DURANTE LA INYECCION DE LIQUIDO. LA INVENCION ENCUENTRA UNA APLICACION PARTICULAR EN EL CASO EN QUE EL LIQUIDO INYECTADO ES LIQUIDO DE DIALISIS ESTERILIZADO EN LINEA PARA SER INYECTADO COMO LIQUIDO DE SUSTITUCION.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9305198A FR2704432B1 (fr) | 1993-04-27 | 1993-04-27 | Dispositif d'injection de liquide dans un circuit extracorporel de sang. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2107776T3 true ES2107776T3 (es) | 1997-12-01 |
Family
ID=9446658
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES94420131T Expired - Lifetime ES2107776T3 (es) | 1993-04-27 | 1994-04-27 | Procedimiento y dispositivo de inyeccion de un liquido esteril y apirogeno obtenido por filtracion. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5476592A (es) |
| EP (1) | EP0622087B1 (es) |
| JP (1) | JP3553637B2 (es) |
| CN (1) | CN1117588C (es) |
| AT (1) | ATE157015T1 (es) |
| CA (1) | CA2122207C (es) |
| DE (1) | DE69405038T2 (es) |
| ES (1) | ES2107776T3 (es) |
| FR (1) | FR2704432B1 (es) |
| WO (1) | WO1994025085A1 (es) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0692268B2 (de) * | 1994-07-13 | 2005-02-09 | Fresenius Medical Care Deutschland GmbH | Substituataufbereitung bei der Hämofiltration oder Hämodiafiltration |
| FR2723002B1 (fr) * | 1994-07-26 | 1996-09-06 | Hospal Ind | Dispositif et procede pour preparer un liquide de traitement par filtration |
| DE19607162C2 (de) * | 1996-02-26 | 1998-01-15 | Fresenius Ag | Verwendung eines Dialysators mit zwei Modulen zur Durchführung eines Verfahrens zum Filtrieren und sofortigen Verwenden von Substituatflüssigkeit in einer Hämodialfiltrationsvorrichtung |
| DE19700466A1 (de) | 1997-01-09 | 1998-07-16 | Polaschegg Hans Dietrich Dr | Einrichtung und Verfahren zur Hämodiafiltration |
| US6852090B2 (en) | 1997-02-14 | 2005-02-08 | Nxstage Medical, Inc. | Fluid processing systems and methods using extracorporeal fluid flow panels oriented within a cartridge |
| WO2001037899A2 (en) * | 1997-02-14 | 2001-05-31 | Nxstage Medical, Inc. | Extracorporeal circuits for performing hemofiltration employing pressure sensing without an air interface |
| DE69940608D1 (de) * | 1998-07-31 | 2009-04-30 | Nephros Inc | Vorrichtung zur effizienten hämodiafiltration |
| ATE346677T1 (de) | 1998-10-30 | 2006-12-15 | Nephros Inc | Anlage zur nicht-isosmotischen diafiltration |
| US6818179B1 (en) * | 1999-03-30 | 2004-11-16 | Gambro Lundia Ab | Method and apparatus for sterilizing a heat sensitive fluid |
| FR2791574B1 (fr) * | 1999-03-30 | 2002-06-14 | Hospal Ind | Procede et dispositif pour steriliser et dispenser un liquide a usage medical |
| US6579494B1 (en) | 1999-03-30 | 2003-06-17 | Hospal Industrie | Process and device for sterilizing and dispensing a liquid for medical use |
| FR2791575B1 (fr) * | 1999-03-30 | 2002-06-28 | Hospal Ind | Procede et dispositif pour steriliser et dispenser un liquide a usage medical |
| FR2791576B1 (fr) * | 1999-03-30 | 2002-06-14 | Hospal Ind | Procede et dispositif pour steriliser et dispenser un liquide a usage medical |
| US6406631B1 (en) | 1999-07-30 | 2002-06-18 | Nephros, Inc. | Two stage diafiltration method and apparatus |
| AU769507B2 (en) | 1999-08-12 | 2004-01-29 | Aker Kvaerner Process Systems As | Protection system to prevent damage to a gas diffusion membrane |
| US6635026B1 (en) | 1999-11-08 | 2003-10-21 | Hospal Industrie | Haemofiltration machine for independently controlling the concentration of a least two ionic substances in a patient's internal medium |
| FR2800618B1 (fr) | 1999-11-08 | 2002-02-22 | Bert Christophe | Appareil d'hemofiltration permettant de controler, de facon independante, la concentration d'au moins deux substances ioniques dans le milieu interieur d'un patient |
| US7780619B2 (en) | 1999-11-29 | 2010-08-24 | Nxstage Medical, Inc. | Blood treatment apparatus |
| US6635179B1 (en) | 1999-12-30 | 2003-10-21 | Nephros, Inc. | Sterile fluid filtration cartridge and method for using same |
| WO2001051185A1 (en) | 2000-01-11 | 2001-07-19 | Nephros, Inc. | Thermally enhanced dialysis/diafiltration system |
| IL155408A0 (en) | 2000-10-30 | 2003-11-23 | Nephros Inc | Dual-stage filtration cartridge |
| MXPA03007068A (es) * | 2001-02-07 | 2003-11-18 | Nephros Inc | Metodo y aparato para un modulo de administracion de hemodiafiltracion. |
| US20050010158A1 (en) * | 2001-05-24 | 2005-01-13 | Brugger James M. | Drop-in blood treatment cartridge with filter |
| US6649063B2 (en) | 2001-07-12 | 2003-11-18 | Nxstage Medical, Inc. | Method for performing renal replacement therapy including producing sterile replacement fluid in a renal replacement therapy unit |
| US7112273B2 (en) * | 2002-09-27 | 2006-09-26 | Nxstage Medical, Inc. | Volumetric fluid balance control for extracorporeal blood treatment |
| WO2004066121A2 (en) * | 2003-01-15 | 2004-08-05 | Nxstage Medical Inc. | Waste balancing for extracorporeal blood treatment systems |
| US8235931B2 (en) | 2003-01-15 | 2012-08-07 | Nxstage Medical, Inc. | Waste balancing for extracorporeal blood treatment systems |
| KR101098125B1 (ko) * | 2005-07-01 | 2011-12-26 | 감브로 룬디아 아베 | 필터 테스트 장치 및 방법 |
| US7534349B2 (en) * | 2005-09-02 | 2009-05-19 | Nephros, Inc. | Dual stage ultrafilter devices in the form of portable filter devices, shower devices, and hydration packs |
| US7775375B2 (en) | 2005-11-03 | 2010-08-17 | Medica S.R.L. | Redundant ultrafiltration device |
| DE102006012198A1 (de) * | 2006-03-16 | 2007-09-27 | Seccua Gmbh | Steuerungen eines Filtrationssystems |
| US20070240578A1 (en) * | 2006-04-12 | 2007-10-18 | Dileo Anthony | Filter with memory, communication and temperature sensor |
| US20070243113A1 (en) | 2006-04-12 | 2007-10-18 | Dileo Anthony | Filter with memory, communication and concentration sensor |
| US8007568B2 (en) * | 2006-04-12 | 2011-08-30 | Millipore Corporation | Filter with memory, communication and pressure sensor |
| US20110094310A1 (en) * | 2006-04-12 | 2011-04-28 | Millipore Corporation | Filter with memory, communication and pressure sensor |
| CN201464214U (zh) * | 2009-07-30 | 2010-05-12 | 上海吉鸿生物科技有限公司 | 改进型多功能标本盒 |
| DE102009054395A1 (de) | 2009-11-24 | 2011-06-01 | Fresenius Medical Care Deutschland Gmbh | Verfahren zum Anpassen von Grenzwertfenstern, Steuervorrichtung, medizinische Behandlungsvorrichtung und medizinische Überwachungsvorrichtung |
| JP5399218B2 (ja) * | 2009-11-24 | 2014-01-29 | 日機装株式会社 | 血液浄化装置 |
| SE0951009A1 (sv) * | 2009-12-22 | 2011-06-23 | Anordning och förfarande för rening och anrikning av biologiskt prov | |
| US10980431B2 (en) * | 2009-12-28 | 2021-04-20 | Gambro Lundia Ab | Apparatus and method for prediction of rapid symptomatic blood pressure decrease |
| DE102010048771A1 (de) * | 2010-10-14 | 2012-05-16 | B. Braun Avitum Ag | Verfahren und Vorrichtung zur Messung und Behebung von Systemänderungen in einer Vorrichtung zur Behandlung von Blut |
| EP2452705B1 (en) * | 2010-11-10 | 2015-08-12 | Gambro Lundia AB | Device for the treatment of blood with selective extraction of solutes |
| EP2962710A1 (de) * | 2014-07-03 | 2016-01-06 | Berlin Heart GmbH | Verfahren und Herzunterstützungssystem zur Bestimmung eines Auslassdrucks |
| JP6388118B2 (ja) | 2014-09-19 | 2018-09-12 | 澁谷工業株式会社 | 人工透析装置 |
| CN108495610B (zh) | 2016-01-22 | 2021-03-12 | 巴克斯特国际公司 | 无菌溶液产品袋 |
| EP3405400B1 (en) | 2016-01-22 | 2020-02-19 | Baxter International Inc. | Method and machine for producing sterile solution product bags |
| JP6946318B2 (ja) * | 2016-03-08 | 2021-10-06 | フレセニウス メディカル ケア ホールディングス インコーポレーテッド | 透析システムの血液回路中の閉塞を検出するための方法およびシステム |
| WO2019219502A1 (en) * | 2018-05-15 | 2019-11-21 | Baxter International Inc. | A method and an apparatus for evaluating a condition of a water purification system |
| CN111088156B (zh) * | 2020-01-06 | 2021-03-30 | 山东省海洋资源与环境研究院 | 一种用于海洋环境监测的大肠菌群测试片及与其配合使用的附属装置 |
| EP4319831A1 (en) * | 2021-04-09 | 2024-02-14 | Gambro Lundia AB | Determining a water permeability status of a forward osmosis membrane using transmembrane pressure |
| JP2023049603A (ja) * | 2021-09-29 | 2023-04-10 | 旭化成メディカル株式会社 | 濾過器の試験方法及び製造方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2860784A (en) * | 1955-03-15 | 1958-11-18 | Du Pont | Filtration method |
| US4191182A (en) * | 1977-09-23 | 1980-03-04 | Hemotherapy Inc. | Method and apparatus for continuous plasmaphersis |
| US4107037A (en) * | 1977-09-28 | 1978-08-15 | Continental Oil Company | Method and apparatus for automatic control of filtrate quality |
| DE3110022C2 (de) * | 1981-03-16 | 1986-06-05 | Fresenius AG, 6380 Bad Homburg | Vorrichtung zur Erzeugung steriler Flüssigkeiten |
| EP0121085B1 (de) * | 1983-03-01 | 1986-09-10 | Sartorius GmbH. | Gerät zur Aufbereitung medizinischer Infusionslösungen |
| DE3444671A1 (de) * | 1984-12-07 | 1986-06-12 | Fresenius AG, 6380 Bad Homburg | Haemodiafiltrationsgeraet |
| DE3529973A1 (de) * | 1985-08-22 | 1987-03-05 | Braun Melsungen Ag | Vorrichtung zur haemodiafiltration |
| DE3641843A1 (de) * | 1986-12-08 | 1988-06-16 | Fresenius Ag | Haemodialysevorrichtung mit sterilisiereinrichtung |
| JPS63205104A (ja) * | 1987-02-20 | 1988-08-24 | Nitto Electric Ind Co Ltd | 膜モジユ−ルの運転方法 |
| JPS6430603A (en) * | 1987-07-24 | 1989-02-01 | Jun Kayaba | Water filter |
| SE465404B (sv) * | 1988-03-03 | 1991-09-09 | Gambro Ab | Dialyssystem |
| WO1990012635A1 (de) * | 1989-04-24 | 1990-11-01 | Henkel Kommanditgesellschaft Auf Aktien | Zusatzeinrichtung für separator |
| EP0426786A1 (en) * | 1989-04-25 | 1991-05-15 | Charles Doucet | A process for filtering a fluid and a filter for implementing it |
| DE3927633C1 (es) * | 1989-08-22 | 1990-10-04 | Fresenius Ag, 6380 Bad Homburg, De | |
| GB8923376D0 (en) * | 1989-10-17 | 1989-12-06 | Bio Flo Ltd | Transmembrane pressure controlled filtration system |
| US5069792A (en) * | 1990-07-10 | 1991-12-03 | Baxter International Inc. | Adaptive filter flow control system and method |
| FR2691364B1 (fr) * | 1992-05-19 | 1999-08-20 | Hospal Ind | Rein artificiel avec dispositif de filtration du liquide de dialyse. |
-
1993
- 1993-04-27 FR FR9305198A patent/FR2704432B1/fr not_active Expired - Fee Related
-
1994
- 1994-04-26 US US08/233,790 patent/US5476592A/en not_active Expired - Lifetime
- 1994-04-26 CA CA002122207A patent/CA2122207C/fr not_active Expired - Fee Related
- 1994-04-27 EP EP94420131A patent/EP0622087B1/fr not_active Expired - Lifetime
- 1994-04-27 CN CN94190228A patent/CN1117588C/zh not_active Expired - Fee Related
- 1994-04-27 ES ES94420131T patent/ES2107776T3/es not_active Expired - Lifetime
- 1994-04-27 JP JP08930294A patent/JP3553637B2/ja not_active Expired - Fee Related
- 1994-04-27 WO PCT/FR1994/000477 patent/WO1994025085A1/fr not_active Ceased
- 1994-04-27 DE DE69405038T patent/DE69405038T2/de not_active Expired - Lifetime
- 1994-04-27 AT AT94420131T patent/ATE157015T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2122207C (fr) | 2007-04-03 |
| EP0622087B1 (fr) | 1997-08-20 |
| WO1994025085A1 (fr) | 1994-11-10 |
| ATE157015T1 (de) | 1997-09-15 |
| FR2704432B1 (fr) | 1995-06-23 |
| FR2704432A1 (fr) | 1994-11-04 |
| CN1108028A (zh) | 1995-09-06 |
| CN1117588C (zh) | 2003-08-13 |
| CA2122207A1 (fr) | 1994-10-28 |
| DE69405038D1 (de) | 1997-09-25 |
| JP3553637B2 (ja) | 2004-08-11 |
| JPH078553A (ja) | 1995-01-13 |
| US5476592A (en) | 1995-12-19 |
| DE69405038T2 (de) | 1998-02-26 |
| EP0622087A1 (fr) | 1994-11-02 |
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