ES2109697T3 - Benzotriazoles que absorben radiacion uv que tienen un grupo estireno. - Google Patents
Benzotriazoles que absorben radiacion uv que tienen un grupo estireno.Info
- Publication number
- ES2109697T3 ES2109697T3 ES94915393T ES94915393T ES2109697T3 ES 2109697 T3 ES2109697 T3 ES 2109697T3 ES 94915393 T ES94915393 T ES 94915393T ES 94915393 T ES94915393 T ES 94915393T ES 2109697 T3 ES2109697 T3 ES 2109697T3
- Authority
- ES
- Spain
- Prior art keywords
- benzotriazoles
- absorb
- radiation
- styrene group
- ch2ch
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical group C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 title 1
- 150000001565 benzotriazoles Chemical class 0.000 title 1
- 230000005855 radiation Effects 0.000 title 1
- 229920000642 polymer Polymers 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 239000000178 monomer Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D249/18—Benzotriazoles
- C07D249/20—Benzotriazoles with aryl radicals directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F12/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an aromatic carbocyclic ring
- C08F12/02—Monomers containing only one unsaturated aliphatic radical
- C08F12/32—Monomers containing only one unsaturated aliphatic radical containing two or more rings
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F212/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an aromatic carbocyclic ring
- C08F212/02—Monomers containing only one unsaturated aliphatic radical
- C08F212/32—Monomers containing only one unsaturated aliphatic radical containing two or more rings
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/16—Nitrogen-containing compounds
- C08K5/34—Heterocyclic compounds having nitrogen in the ring
- C08K5/3467—Heterocyclic compounds having nitrogen in the ring having more than two nitrogen atoms in the ring
- C08K5/3472—Five-membered rings
- C08K5/3475—Five-membered rings condensed with carbocyclic rings
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
- G02B1/04—Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
- G02B1/041—Lenses
- G02B1/043—Contact lenses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
- A61F2/16—Intraocular lenses
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Materials For Medical Uses (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Polyethers (AREA)
- Graft Or Block Polymers (AREA)
- Polyurethanes Or Polyureas (AREA)
- Eyeglasses (AREA)
- Prostheses (AREA)
- Polyamides (AREA)
- Silicon Polymers (AREA)
Abstract
UN MONOMERO REACTIVO PARA LA PREPARACION DE POLIMEROS ABSORBEDORES DE ULTRAVIOLETAS QUE TIENE LA FORMULA (I) EN LA QUE R{SUP,1} ES HALOGENO O UN GRUPO ALCOXI DE CADENA LINEAL O RAMIFICADA C{SUB,1}-C{SUB,6}; Y R{SUP,2} ES UN GRUPO (CH{SUB,2}){SUB,3}O-, -CH(CH{SUB,3}CH{SUB,2}O-, CH{SUB,2}CH(CH{SUB,3})O-, -(CH{SUB,2}){SUB,3}OCH{SUB,2}-, (CH{SUB,2}){SUB,2}OCH{SUB,2}-, -CH(CH{SUB,3})CH{SUB,2}OCH{SUB,2}O -CH{SUB,2}CH(CH{SUB,3})OCH{SUB,2}-. EL COMPUESTO SE PUEDE UTILIZAR PARA LA PRODUCCION DE POLIMEROS ABSORBEDORES DE ULTRAVIOLETAS, TALES COMO LOS UTILIZADOS EN DISPOSITIVOS OCULARES INCLUIDAS LAS LENTES DE CONTACTO Y LAS INTRAOCULARES.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5202093A | 1993-04-22 | 1993-04-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2109697T3 true ES2109697T3 (es) | 1998-01-16 |
Family
ID=21974898
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES94915393T Expired - Lifetime ES2109697T3 (es) | 1993-04-22 | 1994-04-22 | Benzotriazoles que absorben radiacion uv que tienen un grupo estireno. |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US5637726A (es) |
| EP (1) | EP0695298B1 (es) |
| JP (1) | JP2858953B2 (es) |
| KR (1) | KR100340651B1 (es) |
| AT (1) | ATE160343T1 (es) |
| AU (1) | AU681658B2 (es) |
| BR (1) | BR9406280A (es) |
| CA (1) | CA2160677C (es) |
| DE (1) | DE69406914T2 (es) |
| ES (1) | ES2109697T3 (es) |
| SG (1) | SG52670A1 (es) |
| WO (1) | WO1994024112A1 (es) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5455152A (en) * | 1994-09-27 | 1995-10-03 | Eastman Kodak Company | Benzotriazole based UV absorbing monomers and photographic elements containing polymers formed from them |
| EP0750224A3 (en) * | 1995-06-19 | 1997-01-08 | Eastman Kodak Company | 2'-Hydroxyphenyl benzotriazole based UV absorbing polymers with particular substituents and photographic elements containing them |
| DE69725405T2 (de) | 1996-05-09 | 2004-06-17 | Takiron Co. Ltd. | Funktionelles blockcopolymer und verfahren zu dessen herstellung |
| US6244707B1 (en) * | 1998-07-21 | 2001-06-12 | Wesley Jessen Corporation | UV blocking lenses and material containing benzotriazoles and benzophenones |
| US6183083B1 (en) | 1998-09-08 | 2001-02-06 | Wesley-Jessen Corporation | Contact lens comprising a violet tint |
| US6284895B1 (en) * | 2000-12-27 | 2001-09-04 | Council Of Scientific And Industrial Research | Bromo-functionalized benzotriazole UV absorbers |
| EP1476503A1 (en) * | 2002-02-19 | 2004-11-17 | Ciba SC Holding AG | Containers or films comprising hydroxyphenylbenzotriazole uv absorbers for protecting contents against the effects of uv radiation |
| US20040186241A1 (en) * | 2003-03-20 | 2004-09-23 | Gemert Barry Van | Photochromic ocular devices |
| WO2005066694A2 (en) | 2003-12-29 | 2005-07-21 | Advanced Medical Optics, Inc. | Intraocular lenses having a visible light-selective-transmissive-region |
| EP1740999A1 (en) * | 2004-04-30 | 2007-01-10 | Advanced Medical Optics, Inc. | Ophthalmic devices having a highly selective violet light transmissive filter and related methods |
| US20060115516A1 (en) * | 2004-11-22 | 2006-06-01 | Pearson Jason C | Copolymerizable methine and anthraquinone compounds and articles containing them |
| DE602005026554D1 (de) * | 2004-11-22 | 2011-04-07 | Abbott Medical Optics Inc | Copolymerisierbare azoverbindungen und artikel damit |
| WO2006108114A2 (en) | 2005-04-01 | 2006-10-12 | The Regents Of The University Of Colorado | A graft fixation device and method |
| US20060252850A1 (en) * | 2005-05-04 | 2006-11-09 | Bausch & Lomb Incorporated | Radiation-absorbing polymeric materials and ophthalmic devices comprising same |
| ES2611129T3 (es) * | 2005-09-08 | 2017-05-05 | Calhoun Vision Inc. | Nuevos elementos ópticos ajustables con protección aumentada frente a la luz ultravioleta |
| US20070092830A1 (en) * | 2005-10-24 | 2007-04-26 | Bausch & Lomb Incorporated | Polymeric radiation-absorbing materials and ophthalmic devices comprising same |
| US20070092831A1 (en) * | 2005-10-24 | 2007-04-26 | Bausch & Lomb Incorporated | Radiation-absorbing polymeric materials and ophthalmic devices comprising same |
| JP5448166B2 (ja) * | 2006-10-13 | 2014-03-19 | アルコン,インコーポレイテッド | 特有の青−紫カットオフおよび青色光透過特徴を備えた眼内レンズ |
| TW200916531A (en) * | 2007-08-09 | 2009-04-16 | Alcon Inc | Ophthalmic lens materials containing chromophores that absorb both UV and short wavelength visible light |
| TWI435915B (zh) * | 2007-08-09 | 2014-05-01 | Alcon Inc | 含有吸收紫外光(uv)及短波長可見光二者的發色團之眼科鏡體材料(一) |
| US7803359B1 (en) | 2008-05-06 | 2010-09-28 | Alcon, Inc. | UV-absorbers for ophthalmic lens materials |
| US8043607B2 (en) | 2008-07-15 | 2011-10-25 | Novartis Ag | UV-absorbers for ophthalmic lens materials |
| US8236053B1 (en) | 2008-10-08 | 2012-08-07 | Novartis Ag | 2-amino benzophenone UV-absorbers for ophthalmic lens materials |
| TWI453199B (zh) | 2008-11-04 | 2014-09-21 | Alcon Inc | 用於眼用鏡片材料之紫外光/可見光吸收劑 |
| MY158359A (en) * | 2009-09-15 | 2016-09-30 | Novartis Ag | Prepolymers suitable for making ultra-violet absorbing contact lenses |
| RU2566305C2 (ru) | 2010-04-29 | 2015-10-20 | Новартис Аг | Искусственные хрусталики с сочетанием уф абсорбентов и хромофоров синего света |
| NZ621745A (en) | 2010-07-30 | 2015-01-30 | Novartis Ag | Amphiphilic polysiloxane prepolymers and uses thereof |
| RU2569365C2 (ru) | 2010-07-30 | 2015-11-27 | Новартис Аг | Способ изготовления поглощающих уф-излучение офтальмологических линз |
| EP2625217B1 (en) | 2010-10-06 | 2018-07-04 | Novartis AG | Chain-extended polysiloxane crosslinkers with dangling hydrophilic polymer chains |
| HUE044765T2 (hu) | 2010-10-06 | 2019-11-28 | Novartis Ag | Polimerizálható hosszabbított láncú polisziloxánok hidrofil oldalcsoportokkal |
| NZ606787A (en) | 2010-10-06 | 2014-11-28 | Novartis Ag | Water-processable silicone-containing prepolymers and uses thereof |
| US9427493B2 (en) | 2011-03-07 | 2016-08-30 | The Regents Of The University Of Colorado | Shape memory polymer intraocular lenses |
| MY164605A (en) | 2011-10-12 | 2018-01-30 | Novartis Ag | Method for making uv-absorbing ophthalmic lenses |
| US9594188B2 (en) | 2011-12-06 | 2017-03-14 | University Of Florida Research Foundation, Inc. | UV blocker loaded contact lenses |
| US8585938B1 (en) | 2012-03-30 | 2013-11-19 | Novartis Ag | UV-absorbers for ophthalmic lens materials |
| CN104871036B (zh) | 2012-12-17 | 2019-12-10 | 诺华股份有限公司 | 制备改进的uv吸收性眼用透镜的方法 |
| JP6441367B2 (ja) * | 2013-09-13 | 2018-12-19 | ジョンソン・アンド・ジョンソン・サージカル・ビジョン・インコーポレイテッド | 形状記憶ポリマー眼内レンズ |
| TWI622677B (zh) * | 2015-10-28 | 2018-05-01 | High light transmission heat insulation fabric and manufacturing method thereof | |
| CA3010570C (en) | 2016-02-22 | 2020-11-03 | Novartis Ag | Uv/visible-absorbing vinylic monomers and uses thereof |
| CA3010331C (en) | 2016-02-22 | 2021-06-22 | Novartis Ag | Uv-absorbing vinylic monomers and uses thereof |
| KR20250159067A (ko) * | 2017-01-31 | 2025-11-07 | 다이니폰 인사츠 가부시키가이샤 | 광학 필름, 편광판, 및 화상 표시 장치 |
| WO2018208709A1 (en) * | 2017-05-09 | 2018-11-15 | Warner Babcock Institute For Green Chemistry, Llc | Stilbene derivatives for the treatment of cns and other disorders |
| US11993037B1 (en) | 2018-03-02 | 2024-05-28 | Johnson & Johnson Vision Care, Inc. | Contact lens displaying improved vision attributes |
| US11543683B2 (en) | 2019-08-30 | 2023-01-03 | Johnson & Johnson Vision Care, Inc. | Multifocal contact lens displaying improved vision attributes |
| US12486348B2 (en) | 2019-08-30 | 2025-12-02 | Johnson & Johnson Vision Care, Inc. | Contact lens displaying improved vision attributes |
| US10935695B2 (en) | 2018-03-02 | 2021-03-02 | Johnson & Johnson Vision Care, Inc. | Polymerizable absorbers of UV and high energy visible light |
| US12534623B2 (en) | 2018-03-02 | 2026-01-27 | Johnson & Johnson Vision Care, Inc. | Contact lens with improved tear film optical quality |
| US12486403B2 (en) | 2018-03-02 | 2025-12-02 | Johnson & Johnson Vision Care, Inc. | Polymerizable absorbers of UV and high energy visible light |
| AU2019399661A1 (en) | 2018-12-10 | 2021-05-20 | Seed Co., Ltd. | UV absorbing ocular lens |
| US12509428B2 (en) | 2019-06-28 | 2025-12-30 | Johnson & Johnson Vision Care, Inc. | Polymerizable fused tricyclic compounds as absorbers of UV and visible light |
| US11958824B2 (en) | 2019-06-28 | 2024-04-16 | Johnson & Johnson Vision Care, Inc. | Photostable mimics of macular pigment |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3072585A (en) * | 1960-01-13 | 1963-01-08 | American Cyanamid Co | Vinylbenzyloxy phenylbenzotriazoles |
| NL279774A (es) * | 1961-06-16 | |||
| US3529055A (en) * | 1966-03-18 | 1970-09-15 | Nat Starch Chem Corp | Suntan composition and method containing alkali soluble polymeric sun screening agents |
| GB1346764A (en) * | 1970-06-09 | 1974-02-13 | Agfa Gevaert | Ultraviolet absorbing filter layers |
| US3813255A (en) * | 1970-06-09 | 1974-05-28 | Agfa Gevaert Nv | Ultraviolet-absorbing polymers compositions and filter |
| USRE33477E (en) * | 1973-06-20 | 1990-12-04 | Wesley-Jessen, Inc. | Ultraviolet absorbing hydrophilic corneal contact lenses |
| US4508882A (en) * | 1981-08-24 | 1985-04-02 | Asahi Glass Company Ltd. | Benzotriazole compound and homopolymer or copolymers thereof |
| US4380643A (en) * | 1981-08-24 | 1983-04-19 | Asahi Glass Company, Ltd. | Benzotriazole compound and homopolymer or copolymers thereof |
| DE8132839U1 (de) * | 1981-11-10 | 1982-03-11 | B. Braun Melsungen Ag, 3508 Melsungen | Versteifungskern fuer einen katheterschlauch |
| US4504628A (en) * | 1982-02-01 | 1985-03-12 | The Dow Chemical Company | Polymerizable UV light stabilizers from isocyanatoalkyl esters of unsaturated carboxylic acids |
| US4528311A (en) * | 1983-07-11 | 1985-07-09 | Iolab Corporation | Ultraviolet absorbing polymers comprising 2-hydroxy-5-acrylyloxyphenyl-2H-benzotriazoles |
| DE3475617D1 (en) * | 1983-07-26 | 1989-01-19 | Ciba Geigy Ag | Compounds which can be copolymerised |
| DE3333502A1 (de) * | 1983-09-16 | 1985-04-18 | Röhm GmbH, 6100 Darmstadt | Uv-absorber enthaltende thermoplastische kunststoff-formmassen |
| US4812575A (en) * | 1983-09-29 | 1989-03-14 | The United States Of America As Represented By The United States Department Of Energy | Process for the preparation of benozotriazoles and their polymers, and 2(2-hydroxy-5-isopropenylphenyl)2H-benzotriazole produced thereby |
| DE3439483A1 (de) * | 1984-10-27 | 1986-05-07 | Röhm GmbH, 6100 Darmstadt | Radikalisch polymerisierbarer uv-absorber, verfahren zu seiner herstellung und seine polymere |
| US4853478A (en) * | 1985-12-16 | 1989-08-01 | The Goodyear Tire & Rubber Company | Functionalized monomers from 1-(1-isocyanato-1-methlethyl)-3 or 4-(1-methylethenyl) benzene |
| US4719248A (en) * | 1985-08-08 | 1988-01-12 | Bausch & Lomb Incorporated | Ultraviolet blocking agents for contact lenses |
| JPS6199961A (ja) * | 1985-08-30 | 1986-05-19 | Clarion Co Ltd | ピンチロ−ラ駆動機構 |
| US4686268A (en) * | 1986-06-11 | 1987-08-11 | Morisawa & Co., Ltd. | Copolymers of benzotriazol monomers with maleic or fumaric acid derivatives and polymeric material compositions |
| US4716234A (en) * | 1986-12-01 | 1987-12-29 | Iolab Corporation | Ultraviolet absorbing polymers comprising 2-(2'-hydroxy-5'-acryloyloxyalkoxyphenyl)-2H-benzotriazole |
| US4868251A (en) * | 1986-12-24 | 1989-09-19 | Allergan, Inc. | Ultraviolet light absorbing silicone compositions |
| US4803254A (en) * | 1987-03-11 | 1989-02-07 | Iolab Corporation | Vinylsilylalkoxy arylbenzotriazole compounds and UV absorbing compositions made therefrom |
| US4845180A (en) * | 1988-03-21 | 1989-07-04 | Allergan, Inc. | Ultraviolet light absorbing compounds, compositions and methods for making same |
| IL90362A0 (en) * | 1988-05-26 | 1989-12-15 | Alcon Lab Inc | Ultraviolet absorbing hydrogels and lenses containing the same |
| US5039459A (en) * | 1988-11-25 | 1991-08-13 | Johnson & Johnson Vision Products, Inc. | Method of forming shaped hydrogel articles including contact lenses |
| JPH04119179A (ja) * | 1990-09-03 | 1992-04-20 | Nippon Paint Co Ltd | 繊維の染色方法 |
| JP2685980B2 (ja) * | 1990-11-26 | 1997-12-08 | 株式会社メニコン | 紫外線吸収性眼内レンズ |
| JP3251676B2 (ja) * | 1992-12-28 | 2002-01-28 | 興和株式会社 | 親水性紫外線吸収剤 |
-
1994
- 1994-04-22 SG SG1996007622A patent/SG52670A1/en unknown
- 1994-04-22 KR KR1019950704606A patent/KR100340651B1/ko not_active Expired - Fee Related
- 1994-04-22 AT AT94915393T patent/ATE160343T1/de not_active IP Right Cessation
- 1994-04-22 ES ES94915393T patent/ES2109697T3/es not_active Expired - Lifetime
- 1994-04-22 CA CA002160677A patent/CA2160677C/en not_active Expired - Lifetime
- 1994-04-22 BR BR9406280A patent/BR9406280A/pt not_active IP Right Cessation
- 1994-04-22 WO PCT/US1994/004296 patent/WO1994024112A1/en not_active Ceased
- 1994-04-22 JP JP6523545A patent/JP2858953B2/ja not_active Expired - Lifetime
- 1994-04-22 DE DE69406914T patent/DE69406914T2/de not_active Expired - Lifetime
- 1994-04-22 EP EP94915393A patent/EP0695298B1/en not_active Expired - Lifetime
- 1994-04-22 US US08/535,086 patent/US5637726A/en not_active Expired - Lifetime
- 1994-04-22 AU AU66667/94A patent/AU681658B2/en not_active Ceased
-
1996
- 1996-11-27 US US08/757,807 patent/US5729322A/en not_active Expired - Lifetime
-
1998
- 1998-02-04 US US09/018,833 patent/US5866635A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| KR100340651B1 (ko) | 2002-11-18 |
| US5729322A (en) | 1998-03-17 |
| JPH08509227A (ja) | 1996-10-01 |
| CA2160677C (en) | 1999-01-19 |
| JP2858953B2 (ja) | 1999-02-17 |
| US5637726A (en) | 1997-06-10 |
| AU681658B2 (en) | 1997-09-04 |
| CA2160677A1 (en) | 1994-10-27 |
| WO1994024112A1 (en) | 1994-10-27 |
| US5866635A (en) | 1999-02-02 |
| DE69406914T2 (de) | 1998-05-28 |
| SG52670A1 (en) | 1998-09-28 |
| ATE160343T1 (de) | 1997-12-15 |
| BR9406280A (pt) | 1996-02-06 |
| DE69406914D1 (de) | 1998-01-02 |
| EP0695298A1 (en) | 1996-02-07 |
| EP0695298B1 (en) | 1997-11-19 |
| AU6666794A (en) | 1994-11-08 |
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