ES2111047T3 - Metodos para la deteccion de metastasis de carcinomas mediante la amplificacion de los acidos nucleicos. - Google Patents
Metodos para la deteccion de metastasis de carcinomas mediante la amplificacion de los acidos nucleicos.Info
- Publication number
- ES2111047T3 ES2111047T3 ES92305862T ES92305862T ES2111047T3 ES 2111047 T3 ES2111047 T3 ES 2111047T3 ES 92305862 T ES92305862 T ES 92305862T ES 92305862 T ES92305862 T ES 92305862T ES 2111047 T3 ES2111047 T3 ES 2111047T3
- Authority
- ES
- Spain
- Prior art keywords
- methods
- metastasis
- carcinomas
- amplification
- detection
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
SE SUMINISTRA METODOS PARA DETECTAR LAS METASTASIS DE UN CARCINOMA DE UN TEJIDO DEL CUERPO SELECCIONADO O EN UN FLUIDO. ESTOS METODOS OFRECEN UNA SENSIBILIDAD MEJORADA COMPARADOS CON LOS METODOS DE DIAGNOSTICOS ANTERIORES. EN UNA CONFORMACION DE LA INVENCION, LAS SECUENCIAS DEL ACIDO NUCLEICOS ASOCIADAS CON EL CARCINOMA OBJETO SON IDENTIFICADAS PARA DETECTAR CUALQUIER MORBILIDAD RESIDUAL MINIMA EN CARCINOMAS DE PULMON. EL METODO UTILIZA TECNICAS DE AMPLIFICACION DEL ACIDO NUCLEICO, PREFERIBLEMENTE, LA REACCION DE LA CADENA DE POLIMERASA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72006191A | 1991-06-26 | 1991-06-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2111047T3 true ES2111047T3 (es) | 1998-03-01 |
Family
ID=24892478
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES92305862T Expired - Lifetime ES2111047T3 (es) | 1991-06-26 | 1992-06-25 | Metodos para la deteccion de metastasis de carcinomas mediante la amplificacion de los acidos nucleicos. |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US5543296A (es) |
| EP (1) | EP0520794B1 (es) |
| JP (1) | JP3898233B2 (es) |
| AU (1) | AU662906B2 (es) |
| CA (1) | CA2072314C (es) |
| DE (1) | DE69223284T2 (es) |
| DK (1) | DK0520794T3 (es) |
| ES (1) | ES2111047T3 (es) |
| GR (1) | GR3026153T3 (es) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU662906B2 (en) * | 1991-06-26 | 1995-09-21 | F. Hoffmann-La Roche Ag | Methods for detection of carcinoma metastases by nucleic acid amplification |
| CA2148350A1 (en) * | 1992-10-29 | 1994-05-11 | Carlo Croce | Methods of detecting micrometastasis of prostate cancer |
| US5674682A (en) * | 1992-10-29 | 1997-10-07 | Thomas Jefferson University | Nucleic acid primers for detecting micrometastasis of prostate cancer |
| US5641672A (en) * | 1993-06-09 | 1997-06-24 | The Trustees Of Columbia University In The City Of New York | Cloning and uses of the genetic locus bcl-6 |
| US5601990A (en) * | 1994-09-13 | 1997-02-11 | Thomas Jefferson University | Methods of diagnosing colorectal tumors and metastasis thereof |
| US5561041A (en) * | 1993-11-12 | 1996-10-01 | The Johns Hopkins University School Of Medicine | Nucleic acid mutation detection by analysis of sputum |
| US6235470B1 (en) | 1993-11-12 | 2001-05-22 | The Johns Hopkins University School Of Medicine | Detection of neoplasia by analysis of saliva |
| US6025127A (en) * | 1994-01-14 | 2000-02-15 | The Johns Hopkins University School Of Medicine | Nucleic acid mutation detection in histologic tissue |
| CA2187775A1 (en) * | 1994-04-15 | 1995-10-26 | Aaron E. Katz | Method for molecular staging of prostate cancer |
| WO1996021042A2 (en) * | 1995-01-04 | 1996-07-11 | Trustees Of Boston University | Primers for the pcr amplification of metastatic sequences |
| EP0871768B1 (en) * | 1995-03-17 | 2004-07-07 | John Wayne Cancer Institute | Detection of melanoma metastases with a multiple marker assay |
| EP0904397A4 (en) * | 1996-04-16 | 2003-01-29 | Smithkline Beecham Corp | METHOD FOR DETECTION OF THE PROSTATE SPECIFIC ANTIGEN USED FOR MONITORING AND DIAGNOSING PROSTATE CANCER |
| EP2264045B1 (en) * | 1996-08-14 | 2015-10-21 | Life Technologies Corporation | Stable compositions for nucleic acid amplification and sequencing |
| US6287822B1 (en) | 1997-08-05 | 2001-09-11 | Transgenomic, Inc. | Mutation detection method |
| WO1998024935A1 (en) * | 1996-12-06 | 1998-06-11 | Urocor, Inc. | Diagnosis of disease state using mrna profiles |
| US7332270B1 (en) | 1997-03-24 | 2008-02-19 | Urocor, Inc. | Diagnosis of disease state using mRNA profiles in peripheral leukocytes |
| US6190857B1 (en) * | 1997-03-24 | 2001-02-20 | Urocor, Inc. | Diagnosis of disease state using MRNA profiles in peripheral leukocytes |
| DE69840669D1 (de) * | 1997-04-10 | 2009-04-30 | Stichting Katholieke Univ | Pca3, pca3-gene und verfahren zu ihrer verwendung |
| US6300088B1 (en) | 1997-11-24 | 2001-10-09 | Duke University | Method of detecting prostate specific antigen |
| DE19813788A1 (de) * | 1998-03-27 | 1999-10-07 | Deutsches Krebsforsch | Nachweisverfahren für Tumorzellen |
| AU3762699A (en) * | 1998-04-27 | 1999-11-16 | Pacific Northwest Cancer Foundation | (nr-cam) gene, nucleic acids and nucleic acid products for therapeutic and diagnostic uses for tumors |
| EP1084276A1 (de) * | 1998-06-10 | 2001-03-21 | Memorec Medical Molecular Research Cologne Stoffel GmbH | Träger für die parallele identifizierung und erstellung von transkriptionsprofilen von polynucleinsäuren |
| US7226731B1 (en) | 1998-07-24 | 2007-06-05 | The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | PB 39, a gene dysregulated in prostate cancer, and uses thereof |
| EP1100903A1 (en) * | 1998-07-24 | 2001-05-23 | THE UNITED STATES OF AMERICA, as represented by the Secretary of the Department of Health and Human Services | Pb 39, a gene dysregulated in prostate cancer, and uses thereof |
| US6455692B1 (en) | 1998-08-04 | 2002-09-24 | Transgenomic, Inc. | Method of concentrating polynucleotides using MIPC |
| WO2000008212A1 (en) * | 1998-08-07 | 2000-02-17 | Cellay, Llc | Gel microdrops in genetic analysis |
| EP1151142A2 (en) * | 1999-01-28 | 2001-11-07 | Gen-Probe Incorporated | Nucleic acid sequences for detecting genetic markers for cancer in a biological sample |
| EP1222266B1 (en) | 1999-09-29 | 2006-03-29 | Diagnocure Inc. | Pca3 messenger rna in benign and malignant prostate tissues |
| US6203992B1 (en) | 1999-10-15 | 2001-03-20 | Abbott Laboratories | Nucleic acid primers and probes for detecting tumor cells |
| US6902890B1 (en) * | 1999-11-04 | 2005-06-07 | Diadexus, Inc. | Method of diagnosing monitoring, staging, imaging and treating cancer |
| WO2001034837A1 (en) * | 1999-11-12 | 2001-05-17 | Limeart Limited | Diagnosis and prognosis of cancer through detection of the tumor antigen 17-1a by rt-pcr |
| CA2404431C (en) * | 2000-03-27 | 2011-06-07 | Thomas Jefferson University | Guanylyl cyclase c in the detection of stomach and esophageal cancers |
| AU2001253852A1 (en) * | 2000-03-31 | 2001-10-15 | Institut Gustave Roussy | Preprocalcitonin as tumor rejection antigen precursor and uses thereof |
| US7829276B2 (en) * | 2000-09-18 | 2010-11-09 | Thomas Jefferson University | Methods of using CRCA-1 as a stomach and esophageal cancer marker |
| US6897024B2 (en) | 2001-05-31 | 2005-05-24 | Stichting Katholieke Universiteit More Particularly The University Medical Centre Nijmegen | Nucleic acid molecules comprising the promoter for PCA3, and uses thereof |
| CA2466896A1 (en) | 2001-09-06 | 2003-03-20 | Adnagen Ag | Method and diagnosis kit for selecting and or qualitative and/or quantitative detection of cells |
| WO2003044224A1 (de) * | 2001-11-22 | 2003-05-30 | Adnagen Ag | Diagnose-kit, dns-chip sowie verfahren zur diagnostik oder behandlungskontrolle bei hodenkrebs |
| US8980568B2 (en) | 2001-10-11 | 2015-03-17 | Aviva Biosciences Corporation | Methods and compositions for detecting non-hematopoietic cells from a blood sample |
| US8986944B2 (en) | 2001-10-11 | 2015-03-24 | Aviva Biosciences Corporation | Methods and compositions for separating rare cells from fluid samples |
| US7026120B2 (en) * | 2002-04-15 | 2006-04-11 | Abbott Laboratories | Probes for detecting tumor cells |
| GR1004303B (el) * | 2002-11-05 | 2003-07-30 | Ελευθεριος Γεωργακοπουλος | ΝΕΑ ΜΕΘΟΔΟΣ ΑΝΙΧΝΕΥΣΗΣ ΤΟΥ ΚΑΡΚΙΝΙΚΟΥ ΜΕΜΒΡΑΝΙΚΟΥ ΑΝΤΙΓΟΝΟΥ Ep-Cam ΚΑΙ ΠΡΟΣΔΙΟΡΙΣΜΟΣ ΚΥΚΛΟΦΟΡΟΥΝΤΩΝ ΜΙΚΡΟΜΕΤΑΣΤΑΤΙΚΩΝ ΚΑΡΚΙΝΙΚΩΝ ΚΥΤΤΑΡΩΝ ΣΤΟ ΠΕΡΙΦΕΡΙΚΟ ΑΙΜΑ ΑΣΘΕΝΩΝ (ΚΑΙ ΣΕ ΙΣΤΟΥΣ) ΜΕ ΚΑΡΚΙΝΟ ΕΠΙΘΗΛΙΑΚΗΣ ΠΡΟΕΛΕΥΣΗΣ |
| EP1572105B1 (en) * | 2002-11-14 | 2011-08-31 | John Wayne Cancer Institute | Detection of micro metastasis of melanoma and breast cancer in paraffin-embedded tumor draining lymph nodes by multimaker quantitative rt-pcr |
| US8039218B2 (en) | 2002-11-14 | 2011-10-18 | John Wayne Cancer Institute | Detection of cancer cells in body fluids |
| EP1592809B1 (en) | 2003-02-07 | 2013-04-10 | Diagnocure Inc. | Method to detect prostate cancer in a sample |
| WO2004094986A2 (en) | 2003-04-16 | 2004-11-04 | Handylab, Inc. | System and method for electrochemical detection of biological compounds |
| EP2290073A3 (en) | 2004-05-28 | 2011-08-31 | Asuragen, Inc. | Methods and compositions involving microRNA |
| ES2301268B1 (es) * | 2004-10-25 | 2009-05-01 | Centro De Investigacion Biomolecular Aplicada Salamanca, S.L. | Empleo del gen slug, o de sus productos de replicacion, transcripcion o expresion, en la identificacion, diagnostico, prevencion o tratamiento de la diseminacion del cancer y/o desarrollo de metastasis. |
| EP2302055B1 (en) | 2004-11-12 | 2014-08-27 | Asuragen, Inc. | Methods and compositions involving miRNA and miRNA inhibitor molecules |
| CA2491067A1 (en) | 2004-12-24 | 2006-06-24 | Stichting Katholieke Universiteit | Mrna rations in urinary sediments and/or urine as a prognostic marker for prostate cancer |
| US20060161076A1 (en) * | 2005-01-06 | 2006-07-20 | Diamics, Inc. | Systems and methods for collection of cell clusters |
| US20060189893A1 (en) * | 2005-01-06 | 2006-08-24 | Diamics, Inc. | Systems and methods for detecting abnormal cells |
| US20070292882A1 (en) * | 2006-06-16 | 2007-12-20 | Sysmex Corporation | Method and apparatus for detecting cancer cell |
| EP2041299A4 (en) | 2006-07-14 | 2010-01-13 | Aviva Biosciences Corp | METHOD AND COMPOSITIONS FOR DETECTION OF RARE CELLS FROM A BIOLOGICAL SAMPLE |
| US20080131878A1 (en) * | 2006-12-05 | 2008-06-05 | Asuragen, Inc. | Compositions and Methods for the Detection of Small RNA |
| WO2008073915A2 (en) * | 2006-12-08 | 2008-06-19 | Asuragen, Inc. | Micrornas differentially expressed in leukemia and uses thereof |
| EP2104734A2 (en) * | 2006-12-08 | 2009-09-30 | Asuragen, INC. | Mir-20 regulated genes and pathways as targets for therapeutic intervention |
| CA2671270A1 (en) * | 2006-12-29 | 2008-07-17 | Asuragen, Inc. | Mir-16 regulated genes and pathways as targets for therapeutic intervention |
| US20090232893A1 (en) * | 2007-05-22 | 2009-09-17 | Bader Andreas G | miR-143 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION |
| AU2008261951A1 (en) * | 2007-06-08 | 2008-12-18 | Asuragen, Inc. | miR-34 regulated genes and pathways as targets for therapeutic intervention |
| WO2009036332A1 (en) | 2007-09-14 | 2009-03-19 | Asuragen, Inc. | Micrornas differentially expressed in cervical cancer and uses thereof |
| WO2009052386A1 (en) * | 2007-10-18 | 2009-04-23 | Asuragen, Inc. | Micrornas differentially expressed in lung diseases and uses thereof |
| WO2009070805A2 (en) | 2007-12-01 | 2009-06-04 | Asuragen, Inc. | Mir-124 regulated genes and pathways as targets for therapeutic intervention |
| WO2009126726A1 (en) * | 2008-04-08 | 2009-10-15 | Asuragen, Inc | Methods and compositions for diagnosing and modulating human papillomavirus (hpv) |
| WO2009137807A2 (en) | 2008-05-08 | 2009-11-12 | Asuragen, Inc. | Compositions and methods related to mirna modulation of neovascularization or angiogenesis |
| JP5585811B2 (ja) * | 2009-01-23 | 2014-09-10 | 国立大学法人金沢大学 | 肺癌、肺癌合併lems及びlemsの検査方法 |
| WO2013040251A2 (en) | 2011-09-13 | 2013-03-21 | Asurgen, Inc. | Methods and compositions involving mir-135b for distinguishing pancreatic cancer from benign pancreatic disease |
| KR101762340B1 (ko) | 2015-12-09 | 2017-07-27 | 주식회사 포스코 | 수지 조성물 및 이를 이용한 흑색 수지 강판, 및 그 제조방법 |
| GB201802312D0 (en) * | 2018-02-13 | 2018-03-28 | Vib Vzw | Melanoma disease stratification |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4965188A (en) * | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| US4683195A (en) * | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| WO1991009944A2 (en) * | 1989-12-22 | 1991-07-11 | F.Hoffmann-La Roche Ag | High temperature reverse transcriptases |
| US5085983A (en) * | 1988-08-19 | 1992-02-04 | City Of Hope | Detection of human tumor progression and drug resistance |
| US5024934A (en) * | 1988-03-14 | 1991-06-18 | The Board Of Regents, The University Of Texas System | Detection of minimal numbers of neoplastic cells carrying DNA translocations by DNA sequence amplification |
| US5057410A (en) * | 1988-08-05 | 1991-10-15 | Cetus Corporation | Chimeric messenger RNA detection methods |
| AU662906B2 (en) * | 1991-06-26 | 1995-09-21 | F. Hoffmann-La Roche Ag | Methods for detection of carcinoma metastases by nucleic acid amplification |
-
1992
- 1992-06-22 AU AU18465/92A patent/AU662906B2/en not_active Expired
- 1992-06-25 ES ES92305862T patent/ES2111047T3/es not_active Expired - Lifetime
- 1992-06-25 EP EP92305862A patent/EP0520794B1/en not_active Revoked
- 1992-06-25 DK DK92305862.2T patent/DK0520794T3/da active
- 1992-06-25 DE DE69223284T patent/DE69223284T2/de not_active Revoked
- 1992-06-25 CA CA002072314A patent/CA2072314C/en not_active Expired - Lifetime
- 1992-06-26 JP JP20940392A patent/JP3898233B2/ja not_active Expired - Lifetime
-
1994
- 1994-12-16 US US08/357,565 patent/US5543296A/en not_active Expired - Lifetime
-
1995
- 1995-05-31 US US08/454,720 patent/US5766888A/en not_active Expired - Lifetime
-
1998
- 1998-02-17 GR GR980400328T patent/GR3026153T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GR3026153T3 (en) | 1998-05-29 |
| EP0520794A1 (en) | 1992-12-30 |
| CA2072314A1 (en) | 1992-12-27 |
| DE69223284T2 (de) | 1998-06-25 |
| AU662906B2 (en) | 1995-09-21 |
| US5766888A (en) | 1998-06-16 |
| DK0520794T3 (da) | 1998-04-27 |
| EP0520794B1 (en) | 1997-11-26 |
| JPH05269000A (ja) | 1993-10-19 |
| JP3898233B2 (ja) | 2007-03-28 |
| CA2072314C (en) | 2007-07-31 |
| US5543296A (en) | 1996-08-06 |
| DE69223284D1 (de) | 1998-01-08 |
| AU1846592A (en) | 1993-01-07 |
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Legal Events
| Date | Code | Title | Description |
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| FG2A | Definitive protection |
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