ES2111237T3 - Derivados de la bencenosulfonamida y procedimiento de preparacion. - Google Patents

Derivados de la bencenosulfonamida y procedimiento de preparacion.

Info

Publication number
ES2111237T3
ES2111237T3 ES94119833T ES94119833T ES2111237T3 ES 2111237 T3 ES2111237 T3 ES 2111237T3 ES 94119833 T ES94119833 T ES 94119833T ES 94119833 T ES94119833 T ES 94119833T ES 2111237 T3 ES2111237 T3 ES 2111237T3
Authority
ES
Spain
Prior art keywords
group
substituted
alquinilo
formula
substitute
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94119833T
Other languages
English (en)
Inventor
Koichiro Yamada
Kosuke Yasuda
Kohei Kikkawa
Rikako Kohno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Pharma Corp
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Application granted granted Critical
Publication of ES2111237T3 publication Critical patent/ES2111237T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/69—Benzenesulfonamido-pyrimidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

UN DERIVADO DE BENCENOSULFONAMIDA DE LA FORMULA [I]: EN EL QUE LOS ANILLOS A Y B SON IGUALES O DIFERENTES, Y CADA UNO UN ANILLO DE BENCENO SUSTITUIDO O NO SUSTITUIDO, Q ES UN ENLACE SIMPLE O UN GRUPO DE LA FORMULA: - O -, - S - - SO -, - SO2 -, O - CH2 -, Y ES UN GRUPO DE LA FORMULA: - O -, - S - O - NH -, ALK ES UN GRUPO ALQUILENO INFERIOR O GRUPO ALQUENILENO INFERIOR, Z ES UN ENLACE UNICO O UN GRUPO DE LA FORMULA: - O - O - NH -, R ES UN GRUPO ARILO O HETEROCICLICO AROMATICO, SUSTITUIDO O NO SUSTITUIDO, R1 ES UN ATOMO DE HIDROGENO, GRUPO TRIFLUOROMETILO, GRUPO ALQUILO INFERIOR SUSTITUIDO O NO SUSTITUIDO, GRUPO ALQUENILO INFERIOR SUSTITUIDO O NO SUSTITUIDO, GRUPO ALQUILAMINO MONO- O DI- INFERIOR, GRUPO ALQUILTIO INFERIOR SUSTITUIDO O NO SUSTITUIDO, GRUPO ALCOXI INFERIOR SUSTITUIDO O NO SUSTITUIDO, GRUPO ALQUINILO INFERIOR SUSTITUIDO O NO SUSTITUIDO, GRUPO HETEROCICLICO AROMATICO, GRUPO HETEROCICLICO ALIFATICO SUSTITUIDO O NO SUSTITUIDO, O GRUPO ARILO, SIEMPRE QUE, CUANDO Z SEA UN ENLACE UNICO, R SEA UN GRUPO HETEROCICLICO AROMATICO SUSTITUIDO O NO SUSTITUIDO, O UNA SAL DEL MISMO FARMACEUTICAMENTE ACEPTABLE, Y PROCESOS PARA PREPARAR LOS MISMOS, TENIENDO ESTOS COMPUESTOS ACTIVIDAD ANTAGONISTA DEL ENDOTELIO, Y SIENDO UTILES EN LA PROFILAXIS O TRATAMIENTO DE VARIAS ENFERMEDADES ORIGINADAS POR EL ENDOTELIO.
ES94119833T 1993-12-17 1994-12-15 Derivados de la bencenosulfonamida y procedimiento de preparacion. Expired - Lifetime ES2111237T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP31877993 1993-12-17
JP14062894 1994-06-23
JP18355394 1994-08-04

Publications (1)

Publication Number Publication Date
ES2111237T3 true ES2111237T3 (es) 1998-03-01

Family

ID=27318092

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94119833T Expired - Lifetime ES2111237T3 (es) 1993-12-17 1994-12-15 Derivados de la bencenosulfonamida y procedimiento de preparacion.

Country Status (16)

Country Link
US (2) US5589478A (es)
EP (1) EP0658548B1 (es)
KR (1) KR100250176B1 (es)
CN (1) CN1051544C (es)
AT (1) ATE160341T1 (es)
AU (1) AU676620B2 (es)
CA (1) CA2137953C (es)
DE (1) DE69406900T2 (es)
DK (1) DK0658548T3 (es)
ES (1) ES2111237T3 (es)
FI (1) FI115137B (es)
GR (1) GR3025855T3 (es)
IL (1) IL111959A (es)
MY (1) MY130908A (es)
SG (1) SG52234A1 (es)
TW (1) TW430661B (es)

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US6376523B1 (en) 1994-05-20 2002-04-23 Texas Biotechnology Corporation Benzenesulfonamides and the use thereof to modulate the activity of endothelin
US6541498B2 (en) 1993-05-20 2003-04-01 Texas Biotechnology Benzenesulfonamides and the use thereof to modulate the activity of endothelin
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RU2151767C1 (ru) * 1994-12-20 2000-06-27 Ф.Хоффманн-Ля Рош Аг Сульфонамиды и фармацевтическая композиция
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CZ260596A3 (en) * 1995-10-12 1997-12-17 Hoffmann La Roche Sulfonamide derivative, process of its preparation and pharmaceutical composition containing thereof
JP3087968B2 (ja) * 1995-12-20 2000-09-18 山之内製薬株式会社 アリールエテンスルホンアミド誘導体及びその医薬組成物
US5977117A (en) * 1996-01-05 1999-11-02 Texas Biotechnology Corporation Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin
US5958905A (en) * 1996-03-26 1999-09-28 Texas Biotechnology Corporation Phosphoramidates, phosphinic amides and related compounds and the use thereof to modulate the activity of endothelin
US5804585A (en) 1996-04-15 1998-09-08 Texas Biotechnology Corporation Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin
CN1067821C (zh) * 1997-03-13 2001-06-27 倚天资讯股份有限公司 一种互联网实时广播装置及其方法
US5783705A (en) * 1997-04-28 1998-07-21 Texas Biotechnology Corporation Process of preparing alkali metal salys of hydrophobic sulfonamides
TR200202738T2 (tr) 1997-04-28 2003-03-21 Texas Biotechnology Corporation Endotelin ile ilgili hastalıkların tedavisinde kullanılan sülfanoamidler
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Also Published As

Publication number Publication date
CN1111242A (zh) 1995-11-08
EP0658548B1 (en) 1997-11-19
FI945900A7 (fi) 1995-06-18
IL111959A0 (en) 1995-06-29
DK0658548T3 (da) 1998-03-16
KR100250176B1 (ko) 2000-09-01
HK1004333A1 (en) 1998-11-20
US5589478A (en) 1996-12-31
IL111959A (en) 2000-07-16
ATE160341T1 (de) 1997-12-15
AU8046194A (en) 1995-06-22
DE69406900T2 (de) 1998-04-09
FI945900A0 (fi) 1994-12-15
CA2137953A1 (en) 1995-06-18
DE69406900D1 (de) 1998-01-02
FI115137B (fi) 2005-03-15
MY130908A (en) 2007-07-31
CN1051544C (zh) 2000-04-19
AU676620B2 (en) 1997-03-13
US5728706A (en) 1998-03-17
SG52234A1 (en) 1998-09-28
EP0658548A1 (en) 1995-06-21
GR3025855T3 (en) 1998-04-30
CA2137953C (en) 2002-03-26
KR950017972A (ko) 1995-07-22
TW430661B (en) 2001-04-21

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