ATE530531T1 - Verfahren zur herstellung von bosentan - Google Patents
Verfahren zur herstellung von bosentanInfo
- Publication number
- ATE530531T1 ATE530531T1 AT08170830T AT08170830T ATE530531T1 AT E530531 T1 ATE530531 T1 AT E530531T1 AT 08170830 T AT08170830 T AT 08170830T AT 08170830 T AT08170830 T AT 08170830T AT E530531 T1 ATE530531 T1 AT E530531T1
- Authority
- AT
- Austria
- Prior art keywords
- compound
- formula
- hydroxy
- salt
- bosentan
- Prior art date
Links
- GJPICJJJRGTNOD-UHFFFAOYSA-N bosentan Chemical compound COC1=CC=CC=C1OC(C(=NC(=N1)C=2N=CC=CN=2)OCCO)=C1NS(=O)(=O)C1=CC=C(C(C)(C)C)C=C1 GJPICJJJRGTNOD-UHFFFAOYSA-N 0.000 title abstract 3
- 229960003065 bosentan Drugs 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI20072360 ITMI20072360A1 (it) | 2007-12-18 | 2007-12-18 | Procedimento per la preparazione di bosentan |
| ITMI20080992 ITMI20080992A1 (it) | 2008-05-28 | 2008-05-28 | Procedimento per la preparazione di composti benzensolfonammidici |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE530531T1 true ATE530531T1 (de) | 2011-11-15 |
Family
ID=40404499
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08170830T ATE530531T1 (de) | 2007-12-18 | 2008-12-05 | Verfahren zur herstellung von bosentan |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20090156811A1 (de) |
| EP (1) | EP2072503B1 (de) |
| AT (1) | ATE530531T1 (de) |
| CA (1) | CA2646795A1 (de) |
| ES (1) | ES2376375T3 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8664390B2 (en) | 2007-06-29 | 2014-03-04 | Generics (Uk) Limited | Process for the introduction of hydroxyethoxy side chain in bosentan |
| NZ585438A (en) | 2007-10-24 | 2012-09-28 | Generics Uk Ltd | Novel crystalline forms of 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-pyrimidin-4-yI]-benzenesulfonamide |
| CA2712860C (en) * | 2008-02-08 | 2014-11-18 | Abhay Gaitonde | Process for preparing bosentan |
| EP2268634A2 (de) * | 2008-03-13 | 2011-01-05 | Actavis Group PTC EHF | Verfahren zur herstellung von bosentan und verwandte verbindungen unter verwendung neuer zwischenprodukte |
| CA2741928A1 (en) | 2008-11-03 | 2010-06-03 | Generics [Uk] Limited | Hplc method for the analysis of bosentan and related substances and use of these substances as reference standards and markers |
| WO2011024056A2 (en) * | 2009-08-27 | 2011-03-03 | Aurobindo Pharma Limited | An improved process for the preparation of bosentan |
| CA2781541A1 (en) * | 2009-11-12 | 2011-05-19 | Ranbaxy Laboratories Limited | Crystalline forms of bosentan salt and processes for their preparation |
| JP6129739B2 (ja) * | 2010-10-01 | 2017-05-17 | ザック システム エス．ピー．エー．ＺａＣｈ Ｓｙｓｔｅｍ Ｓ．ｐ．Ａ． | ボセンタン一水和物及びその中間体の製造方法 |
| WO2012056468A1 (en) * | 2010-10-13 | 2012-05-03 | Matrix Laboratories Ltd | A process for the preparation of bosentan |
| ITMI20120701A1 (it) | 2012-04-27 | 2013-10-28 | Dipharma Francis Srl | Procedimento per la purificazione di un composto benzensolfonammidico |
| KR102004422B1 (ko) * | 2012-12-20 | 2019-07-26 | 제일약품주식회사 | 보센탄 일수화물의 제조방법, 이에 사용되는 신규 중간체 및 이의 제조방법 |
| CN113173888A (zh) * | 2021-04-28 | 2021-07-27 | 山东鲁抗医药股份有限公司 | 替格瑞洛杂质a及其制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US529740A (en) * | 1894-11-27 | lytten | ||
| RU2086544C1 (ru) | 1991-06-13 | 1997-08-10 | Хоффманн-Ля Рош АГ | Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина |
| IL111959A (en) * | 1993-12-17 | 2000-07-16 | Tanabe Seiyaku Co | N-(polysubstituted pyrimidin-4-yl) benzenesulfonamide derivatives their preparation and pharmaceutical compositions containing them |
| US5739333A (en) * | 1995-05-16 | 1998-04-14 | Tanabe Seiyaku Co., Ltd. | Sulfonamide derivative and process for preparing the same |
| WO1997017018A1 (en) | 1995-11-09 | 1997-05-15 | Brigham & Women's Hospital | Aperiodic ultrasound phased array |
| US5883254A (en) * | 1996-11-08 | 1999-03-16 | Hoffmann-La Roche Inc. | Process for making pyrimidine derivatives |
| US6136971A (en) | 1998-07-17 | 2000-10-24 | Roche Colorado Corporation | Preparation of sulfonamides |
-
2008
- 2008-12-05 AT AT08170830T patent/ATE530531T1/de not_active IP Right Cessation
- 2008-12-05 ES ES08170830T patent/ES2376375T3/es active Active
- 2008-12-05 EP EP08170830A patent/EP2072503B1/de not_active Not-in-force
- 2008-12-11 US US12/332,491 patent/US20090156811A1/en not_active Abandoned
- 2008-12-16 CA CA002646795A patent/CA2646795A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2072503A2 (de) | 2009-06-24 |
| ES2376375T3 (es) | 2012-03-13 |
| EP2072503A3 (de) | 2009-07-15 |
| EP2072503B1 (de) | 2011-10-26 |
| CA2646795A1 (en) | 2009-06-18 |
| US20090156811A1 (en) | 2009-06-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |