ES2111289T3 - Metodos y kits de diagnostico que emplean promotores de estres en mamiferos para determinar la toxicidad de un compuesto. - Google Patents

Metodos y kits de diagnostico que emplean promotores de estres en mamiferos para determinar la toxicidad de un compuesto.

Info

Publication number
ES2111289T3
ES2111289T3 ES94907826T ES94907826T ES2111289T3 ES 2111289 T3 ES2111289 T3 ES 2111289T3 ES 94907826 T ES94907826 T ES 94907826T ES 94907826 T ES94907826 T ES 94907826T ES 2111289 T3 ES2111289 T3 ES 2111289T3
Authority
ES
Spain
Prior art keywords
stress
tools
diagnostic methods
toxic
mammals
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94907826T
Other languages
English (en)
Other versions
ES2111289T5 (es
Inventor
Spencer B Farr
Marque D Todd
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xenometrix Inc
Harvard University
Original Assignee
Xenometrix Inc
Harvard University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21734317&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2111289(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Xenometrix Inc, Harvard University filed Critical Xenometrix Inc
Application granted granted Critical
Publication of ES2111289T3 publication Critical patent/ES2111289T3/es
Publication of ES2111289T5 publication Critical patent/ES2111289T5/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/87—Mycoplasma

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

EL INVENTO PROPORCIONA METODOS Y HERRAMIENTAS DE DIAGNOSTICO PARA IDENTIFICAR Y CARACTERIZAR COMPUESTOS TOXIXOS. ESTOS METODOS Y HERRAMIENTAS DE DIAGNOSTICO MIDEN NIVELES DE TRANSCRIPCION O TRASLACION DE GENES UNIDOS A PROMOTORES DE STRESS EUCAROTICOS INNATOS, ESPECIALMENTE LOS DE LOS MAMIFEROS. LAS HERRAMIENTAS Y METODOS DE ESTE INVENTO UTILIZAN AL MENOS UN PROMOTOR DE STRESS DE CADA UNO DE LOS SIGUIENTES GRUPOS: STRESS REDOX, STRESS DNA, STRESS PROTEINA, Y STRESS ENERGICO/IONICO. EL INVENTO TAMBIEN PROPORCIONA METODOS Y HERRAMIENTAS DE DIAGNOSTICO PARA IDENTIFICAR Y CARACTERIZAR COMPUESTOS QUE SON TOXICOS PARA ORGANOS ESPECIFICOS, TALES COMO LA PIEL O LOS OJOS, ASI COMO PARA CADA UNO DE LOS STRESSES INDIVIDUALES INDICADOS ANTES. LOS METODOS Y HERRAMIENTAS DE DIAGNOSTICO DE ESTE INVENTO PRODUCEN INFORMACION REFERENTE A LA ACCION DE UN COMPUESTO SOBRE UN NIVEL SUBCELULAR. ESTA INFORMACION PUEDE SER UTILIZADA PARA DISEÑAR ANTITOXINAS PARA COMPUESTOS HALLADOS PARA SER TOXICOS Y UN DISEÑO DE DROGA ACTIVA.
ES94907826T 1993-01-21 1994-01-21 Metodos y kits de diagnostico que emplean promotores de estres en mamiferos para determinar la toxicidad de un compuesto. Expired - Lifetime ES2111289T5 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US889693A 1993-01-21 1993-01-21
US8896 2001-12-07

Publications (2)

Publication Number Publication Date
ES2111289T3 true ES2111289T3 (es) 1998-03-01
ES2111289T5 ES2111289T5 (es) 2005-07-16

Family

ID=21734317

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94907826T Expired - Lifetime ES2111289T5 (es) 1993-01-21 1994-01-21 Metodos y kits de diagnostico que emplean promotores de estres en mamiferos para determinar la toxicidad de un compuesto.

Country Status (12)

Country Link
US (3) US5811231A (es)
EP (1) EP0680517B2 (es)
JP (1) JP3509100B2 (es)
AT (1) ATE160178T1 (es)
AU (1) AU692434B2 (es)
CA (1) CA2154265C (es)
DE (1) DE69406772T3 (es)
DK (1) DK0680517T4 (es)
ES (1) ES2111289T5 (es)
GR (1) GR3026129T3 (es)
HK (1) HK1004920A1 (es)
WO (1) WO1994017208A1 (es)

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Also Published As

Publication number Publication date
US5811231A (en) 1998-09-22
GR3026129T3 (en) 1998-05-29
AU6124394A (en) 1994-08-15
US20030027127A1 (en) 2003-02-06
ES2111289T5 (es) 2005-07-16
JPH09503121A (ja) 1997-03-31
EP0680517B1 (en) 1997-11-12
DE69406772T2 (de) 1998-03-12
HK1004920A1 (en) 1998-12-11
JP3509100B2 (ja) 2004-03-22
ATE160178T1 (de) 1997-11-15
DK0680517T3 (da) 1998-07-27
AU692434B2 (en) 1998-06-11
DE69406772T3 (de) 2005-11-17
EP0680517A1 (en) 1995-11-08
CA2154265C (en) 2011-01-04
WO1994017208A1 (en) 1994-08-04
CA2154265A1 (en) 1994-08-04
DE69406772D1 (de) 1997-12-18
DK0680517T4 (da) 2005-05-02
EP0680517B2 (en) 2005-01-19
US20030219714A1 (en) 2003-11-27

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