ES2111537T3 - Inhibidor de la ribonucleasa de placenta humana recombinante y metodo de produccion. - Google Patents

Inhibidor de la ribonucleasa de placenta humana recombinante y metodo de produccion.

Info

Publication number
ES2111537T3
ES2111537T3 ES90908084T ES90908084T ES2111537T3 ES 2111537 T3 ES2111537 T3 ES 2111537T3 ES 90908084 T ES90908084 T ES 90908084T ES 90908084 T ES90908084 T ES 90908084T ES 2111537 T3 ES2111537 T3 ES 2111537T3
Authority
ES
Spain
Prior art keywords
ribonuclease inhibitor
human placental
production method
recombinant human
human placenta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90908084T
Other languages
English (en)
Inventor
Martin Kendall Lewis
John William Shultz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Promega Corp
Original Assignee
Promega Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Promega Corp filed Critical Promega Corp
Application granted granted Critical
Publication of ES2111537T3 publication Critical patent/ES2111537T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA CLONACION IN VITRO DE UN GEN PARA EL INHIBIDOR RIBONUCLEASA PLACENTAL, HUMANO DEBE SER OBTENIDO POR LA TECNOLOGIA DNA RECOMBINANTE. EL METODO DESCRITO OBTIENE EL GEN QUE CODIFICA EL INHIBIDOR, LA EXPRESION DE ESE PRODUCTO EN UNA CELULA HUESPED, Y EL REPLIEGE Y LA PURIFICACION DEL PRODUCTO. UN VECTOR QUE INCLUYE UNA SECUENCIA DE GEN DNA CODIFICADA, CODIFICADORA PARA EL INHIBIDOR ES TAMBIEN DESCRITA; COMO TAMBIEN UN HUESPED QUE ES COMPATIBLE CON, Y CONTIENE EL VECTOR. TAMBIEN ES PRESENTADA LA SECUENCIA DE GEN DEL INHIBIDOR.
ES90908084T 1989-04-24 1990-04-18 Inhibidor de la ribonucleasa de placenta humana recombinante y metodo de produccion. Expired - Lifetime ES2111537T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US34236289A 1989-04-24 1989-04-24

Publications (1)

Publication Number Publication Date
ES2111537T3 true ES2111537T3 (es) 1998-03-16

Family

ID=23341508

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90908084T Expired - Lifetime ES2111537T3 (es) 1989-04-24 1990-04-18 Inhibidor de la ribonucleasa de placenta humana recombinante y metodo de produccion.

Country Status (8)

Country Link
EP (1) EP0422217B1 (es)
JP (2) JP3009458B2 (es)
AT (1) ATE162853T1 (es)
AU (1) AU646803B2 (es)
DE (1) DE69031996T2 (es)
DK (1) DK0422217T3 (es)
ES (1) ES2111537T3 (es)
WO (1) WO1990012881A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0291686B1 (en) * 1987-04-14 1993-10-13 The President And Fellows Of Harvard College Inhibitors of angiogenin
US7560248B1 (en) 1999-01-20 2009-07-14 Wisconsin Alumni Research Foundation Oxidation-resistant ribonuclease inhibitor
AU5927900A (en) * 1999-07-13 2001-01-30 Zymogenetics Inc. Alpha protein - 27
DE102005015005A1 (de) 2005-04-01 2006-10-05 Qiagen Gmbh Verfahren zur Behandlung einer Biomoleküle enthaltenden Probe
GB201101794D0 (en) * 2011-02-02 2011-03-16 Fermentas Uab Protein production
PL436077A1 (pl) * 2020-11-25 2022-05-30 Blirt Spółka Akcyjna Liofilizowany i gotowy do liofilizacji rekombinowany ludzki inhibitor RNaz

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0291686B1 (en) * 1987-04-14 1993-10-13 The President And Fellows Of Harvard College Inhibitors of angiogenin

Also Published As

Publication number Publication date
EP0422217A1 (en) 1991-04-17
JP2000078992A (ja) 2000-03-21
ATE162853T1 (de) 1998-02-15
EP0422217B1 (en) 1998-01-28
AU646803B2 (en) 1994-03-10
JP3009458B2 (ja) 2000-02-14
AU5537790A (en) 1990-11-16
DE69031996T2 (de) 1998-06-10
WO1990012881A1 (en) 1990-11-01
DK0422217T3 (da) 1998-03-02
JPH03505677A (ja) 1991-12-12
EP0422217A4 (en) 1992-08-19
DE69031996D1 (de) 1998-03-05
JP3366596B2 (ja) 2003-01-14

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