DK224587A - Ekstracellulaer superoxiddismutase (ec-sod), dna-fragment, der indkoder ec-sod, fremgangsmaade til fremstilling af ec-sod samt anvendelse af ec-sod - Google Patents

Ekstracellulaer superoxiddismutase (ec-sod), dna-fragment, der indkoder ec-sod, fremgangsmaade til fremstilling af ec-sod samt anvendelse af ec-sod

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Publication number
DK224587A
DK224587A DK224587A DK224587A DK224587A DK 224587 A DK224587 A DK 224587A DK 224587 A DK224587 A DK 224587A DK 224587 A DK224587 A DK 224587A DK 224587 A DK224587 A DK 224587A
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Prior art keywords
sod
extracellular
preparing
procedure
dna fragment
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DK224587A
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English (en)
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DK224587D0 (da
Inventor
Stefan Marklund
Thomas Edlund
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Syn Tek Ab
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Application filed by Syn Tek Ab filed Critical Syn Tek Ab
Priority to DK224587A priority Critical patent/DK224587D0/da
Publication of DK224587A publication Critical patent/DK224587A/da
Publication of DK224587D0 publication Critical patent/DK224587D0/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0089—Oxidoreductases (1.) acting on superoxide as acceptor (1.15)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0065—Oxidoreductases (1.) acting on hydrogen peroxide as acceptor (1.11)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A61K38/446—Superoxide dismutase (1.15)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Physics & Mathematics (AREA)
  • Pulmonology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
DK224587A 1985-09-03 1987-05-01 Ekstracellulaer superoxiddismutase (ec-sod), dna-fragment, der indkoder ec-sod, fremgangsmaade til fremstilling af ec-sod samt anvendelse af ec-sod DK224587D0 (da)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK224587A DK224587D0 (da) 1985-09-03 1987-05-01 Ekstracellulaer superoxiddismutase (ec-sod), dna-fragment, der indkoder ec-sod, fremgangsmaade til fremstilling af ec-sod samt anvendelse af ec-sod

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK402785A DK402785D0 (da) 1985-09-03 1985-09-03 Fremgangsmaade til fremstilling af et enzym
PCT/DK1986/000098 WO1987001387A1 (en) 1985-09-03 1986-09-02 A superoxide dismutase
DK224587A DK224587D0 (da) 1985-09-03 1987-05-01 Ekstracellulaer superoxiddismutase (ec-sod), dna-fragment, der indkoder ec-sod, fremgangsmaade til fremstilling af ec-sod samt anvendelse af ec-sod

Publications (2)

Publication Number Publication Date
DK224587A true DK224587A (da) 1987-05-01
DK224587D0 DK224587D0 (da) 1987-05-01

Family

ID=8129425

Family Applications (2)

Application Number Title Priority Date Filing Date
DK402785A DK402785D0 (da) 1985-09-03 1985-09-03 Fremgangsmaade til fremstilling af et enzym
DK224587A DK224587D0 (da) 1985-09-03 1987-05-01 Ekstracellulaer superoxiddismutase (ec-sod), dna-fragment, der indkoder ec-sod, fremgangsmaade til fremstilling af ec-sod samt anvendelse af ec-sod

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK402785A DK402785D0 (da) 1985-09-03 1985-09-03 Fremgangsmaade til fremstilling af et enzym

Country Status (18)

Country Link
US (1) US5130245A (da)
EP (1) EP0236385B1 (da)
JP (2) JP2643934B2 (da)
KR (1) KR920008738B1 (da)
CN (1) CN1030718C (da)
AT (1) ATE69466T1 (da)
AU (1) AU598756B2 (da)
CA (1) CA1340329C (da)
DE (1) DE3682505D1 (da)
DK (2) DK402785D0 (da)
FI (1) FI100252B (da)
HU (1) HU215937B (da)
IE (1) IE59078B1 (da)
IL (1) IL79926A (da)
NO (1) NO301132B1 (da)
SU (1) SU1779263A3 (da)
WO (1) WO1987001387A1 (da)
ZA (1) ZA871267B (da)

Families Citing this family (43)

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EP0213628A3 (en) * 1985-09-03 1988-09-21 Yeda Research And Development Company, Ltd. Expression of superoxide dismutase in eukaryotic cells
US6610520B1 (en) 1985-11-22 2003-08-26 Bio-Technology General Corp. Gene encoding human manganese superoxide dismutase and recombinant polypeptide encoded thereby
JPS63132820A (ja) * 1986-11-22 1988-06-04 Minoru Nakano 口腔用組成物
US5260204A (en) * 1987-03-14 1993-11-09 Boehringer Ingelheim International Gmbh Human manganese superoxide dismutase (hMn-SOD)
EP0282899B1 (de) * 1987-03-14 1996-01-10 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Humane Mangan-Superoxiddismutase (hMn-SOD)
EP0691401A1 (en) * 1987-03-27 1996-01-10 Bio-Technology General Corporation Human manganese superoxide dismutase analogs, pharmaceutical compositions containing them, and use thereof
DK310788A (da) * 1987-06-09 1988-12-10 Int Cardiovascular Med Inc Praeparat indeholdende superoxid-dismutase, dets fremstilling og anvendelse til behandling af global iskaemi
JPH01238537A (ja) * 1988-03-18 1989-09-22 Toyo Jozo Co Ltd 肝障害治療剤
JPH01246225A (ja) * 1988-03-28 1989-10-02 Toyo Jozo Co Ltd 膵炎治療剤
JPH0262829A (ja) * 1988-05-18 1990-03-02 Nippon Kayaku Co Ltd 虚血に基づく傷害の予防及び治療剤
DK455789D0 (da) * 1989-09-15 1989-09-15 Symbicom Ab Polypeptid
DE4038563A1 (de) * 1990-12-04 1992-06-11 Gruenenthal Gmbh Verwendung von superoxiddismutasen zur prophylaxe und/oder behandlung von organversagen bei risikopatienten mit polytrauma
DE4239877C1 (de) * 1992-11-27 1994-03-17 Boehringer Ingelheim Int Stabilisierte Superoxid-Dismutase (SOD)-Zusammensetzung
EP0627486A1 (en) * 1993-06-04 1994-12-07 N.V. Innogenetics S.A. New extracellular superoxide dismutase, a process for preparing the same and compositions containing the same
DK75393D0 (da) * 1993-06-24 1993-06-24 Symbicom Ab Production of protein
US5747026A (en) * 1993-10-15 1998-05-05 University Of Alabama At Birmingham Research Foundation Antioxidants
US6127356A (en) 1993-10-15 2000-10-03 Duke University Oxidant scavengers
US5994339A (en) * 1993-10-15 1999-11-30 University Of Alabama At Birmingham Research Foundation Oxidant scavengers
DE4336641C2 (de) * 1993-10-22 1995-09-07 Deutsches Rheuma Forschungszen Verwendung von Superoxid-Dismutase (SOD) zur Behandlung retroviraler Erkrankungen
WO1996009053A1 (en) * 1994-09-20 1996-03-28 Duke University Oxidoreductase activity of manganic porphyrins
EP0789584B1 (de) * 1994-11-04 2001-09-19 Polymun Scientific Immunbiologische Forschung GmbH Applikation von sod in liposomen
MY128323A (en) * 1996-09-30 2007-01-31 Otsuka Pharma Co Ltd Thiazole derivatives for inhibition of cytokine production and of cell adhesion
WO1999006059A2 (en) * 1997-07-30 1999-02-11 Board Of Regents, The University Of Texas System Methods and compositions relating to no-mediated cytotoxicity
US6171856B1 (en) 1997-07-30 2001-01-09 Board Of Regents, The University Of Texas System Methods and compositions relating to no-mediated cytotoxicity
DE69813898T2 (de) 1997-11-03 2004-03-11 Duke University Substituierte porphyrinen
DK1071474T3 (da) 1998-04-24 2006-04-10 Univ Duke Substituerede porphyriner
ATE312103T1 (de) * 1999-01-25 2005-12-15 Nat Jewish Med & Res Center Substituierte porphyrine und deren therapeutische verwendungen
DK1392328T3 (da) * 2001-01-19 2009-11-09 Nat Jewish Health Medikament til beskyttelse i radioterapi
FI20010898A0 (fi) * 2001-04-30 2001-04-30 Ylae Herttuala Seppo Ekstrasellulaarinen superoksididismutaasi (EC-SOD) geeniterapia restenoosoin ehkäisemiseksi
EP1439842A4 (en) * 2001-06-01 2009-09-02 Nat Jewish Med & Res Center OXIDANT CAPTAIN FOR THE TREATMENT OF DIABETES OR FOR THE USE IN THE TRANSPLANTATION OR INDUCTION OF IMMUNOTOLERANE
CN1649620A (zh) * 2002-04-30 2005-08-03 非特生物技术有限责任公司 医疗装置
WO2003103680A1 (en) * 2002-06-07 2003-12-18 Duke University Substituted porphyrins
WO2005042583A1 (en) * 2003-10-31 2005-05-12 Bio Clue & Solution Co., Ltd. Ec sod and cell transducing ec sod and use thereof
CN100345973C (zh) * 2004-11-18 2007-10-31 中国农业大学 超氧化物歧化酶基因的表达方法及其专用载体
DK2300003T3 (da) 2008-05-23 2014-05-26 Nat Jewish Health Forbindelser til anvendelse i behandling af skade forbundet med eksponering for en alkylerende art
US20100098768A1 (en) * 2008-10-16 2010-04-22 Clarkson University Method of neuroprotection from oxidant injury using metal oxide nanoparticles
CN102660580A (zh) * 2012-05-18 2012-09-12 深圳市北科生物科技有限公司 Sod基因修饰间充质干细胞的构建方法及其应用
EP2968676B1 (en) * 2013-03-15 2017-05-03 Baxter International Inc Immobilization of active agent on a substrate
JP6513643B2 (ja) 2013-06-07 2019-05-15 バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ トリヒドロキシフェニル基を含む化合物を使用する基体上の活性剤の固定化
CN104342409B (zh) * 2014-06-17 2018-05-25 吉林金梓源生物科技股份有限公司 重组人参超氧化物歧化酶的制备方法
CN104342408B (zh) * 2014-06-18 2018-05-25 吉林金梓源生物科技股份有限公司 重组蛹虫草超氧化物歧化酶的制备方法
JP7792252B2 (ja) * 2019-02-19 2025-12-25 メディツィニシェ ウニベルジテート ウィーン 新規組換えジアミンオキシダーゼおよび過剰ヒスタミンによって特徴づけられる疾患の治療のためのその使用
CN115786287A (zh) * 2022-08-24 2023-03-14 江苏恰瑞生物科技有限公司 一种重组sod蛋白及其培育方法

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DK145950C (da) * 1979-05-17 1983-09-26 Forenede Bryggerier As Fremgangsmaade til isolering af cu,zn-superoxid-dismutase fra vandige oploesninger indeholdende dette enzym sammen med ledsagende proteiner
US4530901A (en) * 1980-01-08 1985-07-23 Biogen N.V. Recombinant DNA molecules and their use in producing human interferon-like polypeptides
JPS56102787A (en) * 1980-01-18 1981-08-17 Mamoru Sugiura Preparation of human placenta superoxide dismutase
JPS5729285A (en) * 1980-07-30 1982-02-17 Takeda Chem Ind Ltd Superoxide dismutase and its preparation
JPS57155991A (en) * 1981-03-23 1982-09-27 Green Cross Corp:The Preparation of superoxide dismutase derived from human placenta
EP0091539B2 (en) * 1982-03-31 1996-11-27 Ajinomoto Co., Inc. Gene coding for interleukin-2 polypeptide, recombinant DNA carrying said gene, cell lines possessing the recombinant DNA,and method for producing interleukin-2 using said cells
IT1150598B (it) * 1982-12-14 1986-12-17 Ines Bianchi Procedimento per la purificazione della superossidodismutasi mediante cromatografia di affinita'
DE3486452T2 (de) * 1983-10-03 1997-11-06 Chiron Corp., Emeryville, Calif. Superoxiddismutase und deren Expression in Mikroorganismen
JPS61111690A (ja) * 1984-11-06 1986-05-29 Ube Ind Ltd 組換えｄｎａおよびその用途
JPS61139390A (ja) * 1984-12-13 1986-06-26 Nippon Kayaku Co Ltd ひとｓｏｄをコ−ドする新規ｄｎａおよびそれを有する微生物

Also Published As

Publication number Publication date
NO871816D0 (no) 1987-04-30
KR920008738B1 (ko) 1992-10-08
CA1340329C (en) 1999-01-26
IE59078B1 (en) 1994-01-12
ZA871267B (en) 1987-10-28
NO871816L (no) 1987-07-02
EP0236385A1 (en) 1987-09-16
ATE69466T1 (de) 1991-11-15
EP0236385B1 (en) 1991-11-13
HU215937B (hu) 1999-03-29
IE862342L (en) 1987-03-03
JP2643934B2 (ja) 1997-08-25
CN1030718C (zh) 1996-01-17
AU598756B2 (en) 1990-07-05
DK402785D0 (da) 1985-09-03
CN86106774A (zh) 1987-07-15
FI100252B (fi) 1997-10-31
JPS63501473A (ja) 1988-06-09
NO301132B1 (no) 1997-09-15
FI871853L (fi) 1987-04-28
DK224587D0 (da) 1987-05-01
FI871853A0 (fi) 1987-04-28
JP2688190B2 (ja) 1997-12-08
DE3682505D1 (de) 1991-12-19
HUT46059A (en) 1988-09-28
WO1987001387A1 (en) 1987-03-12
IL79926A (en) 1994-10-07
IL79926A0 (en) 1986-12-31
AU6370886A (en) 1987-03-24
SU1779263A3 (ru) 1992-11-30
JPH08317793A (ja) 1996-12-03
US5130245A (en) 1992-07-14
KR880700066A (ko) 1988-02-15

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