ES2112421T3 - Nuevos farmacos a base de fosfolipidos acilados. - Google Patents

Nuevos farmacos a base de fosfolipidos acilados.

Info

Publication number
ES2112421T3
ES2112421T3 ES93912305T ES93912305T ES2112421T3 ES 2112421 T3 ES2112421 T3 ES 2112421T3 ES 93912305 T ES93912305 T ES 93912305T ES 93912305 T ES93912305 T ES 93912305T ES 2112421 T3 ES2112421 T3 ES 2112421T3
Authority
ES
Spain
Prior art keywords
carbon atoms
hydrogen
hydrocarbyl
chain
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93912305T
Other languages
English (en)
Inventor
Charles Pidgeon
Robert J Markovich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Corp Technologies Inc
Original Assignee
Research Corp Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Corp Technologies Inc filed Critical Research Corp Technologies Inc
Application granted granted Critical
Publication of ES2112421T3 publication Critical patent/ES2112421T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/117—Esters of phosphoric acids with cycloaliphatic alcohols

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

LA INVENCION DESCRIBE UN COMPONENTE QUE TIENE LA FORMULA (A) O SALES DE ELLO ACEPTABLES FARMACEUTICAMENTE, EN DONDE UNO DE R1 Y R2 ES UN GRUPO ACILO DE ACIDO GRASO HETEROATOMO QUE TIENE 13-14 ATOMOS DE CARBONO EN LA CADENA PRINCIPAL Y HASTA UN TOTAL DE 18 ATOMOS DE CARBONOS, MIENTRAS EL OTRO ES HIDROGENO, UN HETEROATOMO DE GRUPO ACILO DE ACIDO GRASO QUE CONTIENE DE 13-14 ATOMOS DE CARBONO EN LA CADENA PRINCIPAL Y HASTA UN TOTAL DE 18 ATOMOS DE CARBONO O UN GRUPO ACIL DE UN ACIDO GRASO QUE CONTIENE 4-26 ATOMOS DE CARBONO EN LA CADENA PRINCIPAL Y HASTA UN TOTAL DE 30 ATOMOS DE CARBONO Y R ES UN CARACTERISTICO GRUPO POLAR QUE SE ORIGINA NATURALMENTE DE UN GLICEROLFOSFOLIPIDO AISLADO DE ORIGEN ENDOGENO. ESTA INVENCION TAMBIEN DESCRIBE LA APLICACION DE LOS COMPONENTES DE LA PRESENTE INVENCION PARA EVITAR LAS INFECCIONES DE RETROVIRUS Y PARA EL TRATAMIENTO DE AIDS O ENFERMEDADES RELACIONADAS A AIDS.
ES93912305T 1992-04-16 1993-04-16 Nuevos farmacos a base de fosfolipidos acilados. Expired - Lifetime ES2112421T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/869,697 US6602861B1 (en) 1992-04-16 1992-04-16 Acylated phospholipid drugs

Publications (1)

Publication Number Publication Date
ES2112421T3 true ES2112421T3 (es) 1998-04-01

Family

ID=25354097

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93912305T Expired - Lifetime ES2112421T3 (es) 1992-04-16 1993-04-16 Nuevos farmacos a base de fosfolipidos acilados.

Country Status (7)

Country Link
US (2) US6602861B1 (es)
EP (1) EP0636134B1 (es)
AT (1) ATE161261T1 (es)
CA (1) CA2133444A1 (es)
DE (1) DE69315827T2 (es)
ES (1) ES2112421T3 (es)
WO (1) WO1993021191A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5599947A (en) * 1993-01-14 1997-02-04 G. D. Searle & Co. Fatty acid analogs and prodrugs
US5859052A (en) * 1993-01-14 1999-01-12 G. D. Searle & Co. Fatty acid analogs and prodrugs
US7135584B2 (en) 1995-08-07 2006-11-14 Wake Forest University Lipid analogs for treating viral infections
AU3216695A (en) 1994-08-29 1996-03-22 University Of North Carolina At Chapel Hill, The Lipid analogs for treating viral infections
US6350472B1 (en) * 1998-12-14 2002-02-26 Steinbach, Pylant, And Hermann, L.L.C. Method of treating HIV infection with transdermal gel containing mammalian liver extract
PT1144420E (pt) * 1999-01-15 2004-04-30 Univ Illinois Fosfatidilinositois sulfatados a sua preparacao e a sua utilizacao
US7026469B2 (en) 2000-10-19 2006-04-11 Wake Forest University School Of Medicine Compositions and methods of double-targeting virus infections and cancer cells
NO328803B1 (no) 2000-03-03 2010-05-18 Thia Medica Nye fettsyreanaloger
US7309696B2 (en) 2000-10-19 2007-12-18 Wake Forest University Compositions and methods for targeting cancer cells
MXPA04001917A (es) 2001-08-31 2004-06-15 Thomson Licensing Sa Contador de secuencia para una corriente audio-visual.
EP1585960A2 (en) * 2002-01-14 2005-10-19 Vertex Pharmaceuticals Incorporated Mucin immobilized chromatography
AU2003278602C1 (en) 2002-06-20 2010-08-12 Pronova Biopharma Norge As Sulfur-containing phospholipid derivatives
EP1592415A2 (en) * 2003-01-22 2005-11-09 Encore Pharmaceuticals, Inc Therapeutically active compounds
EP2242495A2 (en) * 2008-01-16 2010-10-27 Technion Research and Development Foundation, Ltd. Use of antimicrobial polymers for re-sensitization of microorganisms upon emergence of resistance to anti-microbial agents
WO2011016043A2 (en) 2009-08-06 2011-02-10 Technion Research & Development Foundation Ltd. Antibiotic drug delivery and potentiation
AU2017290724A1 (en) 2016-06-29 2019-01-17 Machavert Pharmaceuticals Llc Phospholipid compositions
JP6664638B1 (ja) * 2018-04-27 2020-03-13 株式会社 レオロジー機能食品研究所 新規プラズマローゲン誘導体

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4471113A (en) 1982-02-03 1984-09-11 The United States Of America As Represented By The Department Of Energy Prodrugs based on phospholipid-nucleoside conjugates
US5059591B1 (en) 1983-05-26 2000-04-25 Liposome Co Inc Drug preparations of reduced toxicity
JPS608948A (ja) * 1983-06-29 1985-01-17 Fujitsu Ltd 動作モ−ド検査方式
US4594193A (en) * 1984-09-26 1986-06-10 Research Corporation Thiol based lipids and membranes made therefrom
US4569794A (en) 1984-12-05 1986-02-11 Eli Lilly And Company Process for purifying proteins and compounds useful in such process
US4772475A (en) * 1985-03-08 1988-09-20 Yamanouchi Pharmaceutical Co., Ltd. Controlled-release multiple units pharmaceutical formulation
JPH068302B2 (ja) 1986-03-04 1994-02-02 財団法人生産開発科学研究所 重合性リン脂質化合物
DE3638687A1 (de) * 1986-11-13 1988-05-19 Lentia Gmbh Einstufiges verfahren zur herstellung von gemischt substituierten 1,2-di-acyl-sn-glycero-3-phosphocholinen
IL84387A0 (en) 1987-11-06 1990-02-09 Rapaport Erich Pharmaceutical compositions containing a substituted phosphatide
US5151445A (en) 1988-02-03 1992-09-29 Washington University Method of inhibiting parasitic activity
US4927879A (en) 1988-02-25 1990-05-22 Purdue Research Foundation Method for solid phase membrane mimetics
US4931498A (en) 1988-02-25 1990-06-05 Purdue Research Foundation Immobilized artificial membranes
US5073571A (en) 1988-06-16 1991-12-17 Washington University Method of inhibiting virus
US5082967A (en) 1988-06-16 1992-01-21 Washington University Novel fatty acid analog enzyme substrates
DE3929217A1 (de) 1989-09-02 1991-03-07 Boehringer Mannheim Gmbh Verwendung von phospholipid-derivaten als antivirale arzneimittel und neue phospholipide
SE463789B (sv) 1990-03-27 1991-01-21 Henrik Gerhard Renvall Saett att registrera, oeverfoera och lagra information med hjaelp av streckkoder
US5149527A (en) * 1990-09-18 1992-09-22 Oncotech, Inc. Immunopotentiating protocol for chemotherapy-responsive tumors

Also Published As

Publication number Publication date
DE69315827D1 (de) 1998-01-29
CA2133444A1 (en) 1993-10-28
ATE161261T1 (de) 1998-01-15
US6602861B1 (en) 2003-08-05
EP0636134B1 (en) 1997-12-17
DE69315827T2 (de) 1998-07-16
WO1993021191A1 (en) 1993-10-28
US5846955A (en) 1998-12-08
EP0636134A1 (en) 1995-02-01

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