ES2113547T3 - Matrices quimioluminiscentes fotoactivables. - Google Patents

Matrices quimioluminiscentes fotoactivables.

Info

Publication number
ES2113547T3
ES2113547T3 ES93918420T ES93918420T ES2113547T3 ES 2113547 T3 ES2113547 T3 ES 2113547T3 ES 93918420 T ES93918420 T ES 93918420T ES 93918420 T ES93918420 T ES 93918420T ES 2113547 T3 ES2113547 T3 ES 2113547T3
Authority
ES
Spain
Prior art keywords
analyte
photosensitizer
matrix
methods
chemiluminescent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93918420T
Other languages
English (en)
Inventor
John S Pease
Hrair Kirakossian
Daniel B Wagner
Edwin F Ullman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics GmbH Germany
Original Assignee
Behringwerke AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behringwerke AG filed Critical Behringwerke AG
Application granted granted Critical
Publication of ES2113547T3 publication Critical patent/ES2113547T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/829—Liposomes, e.g. encapsulation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/905—Photochemical activation of reactions
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Polymerisation Methods In General (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

SE PRESENTAN METODOS PARA ETIQUETAR UN MATERIAL. LOS METODOS CONSISTEN EN COMBINAR EL MATERIAL CON (A) UN FOTOSENSIBILIZADOR CAPAZ DE GENERAR TRAS UNA IRRADIACION OXIGENO SINGULETE Y (B) UN COMPUESTO QUIMIOLUMINISCENTE CAPAZ DE SER ACTIVADO POR EL OXIGENO SINGLETE EN DONDE EL FOTOSENSIBILIZADOR Y EL COMPUESTO QUIMIOLUMINISCENTE SE INCORPORAN EN UNA MATRIZ EN PARTICULAS O EN UNA MATRIZ SOLIDA QUE NO SE PRESENTA EN PARTICULAS. LA MATRIZ EN PARTICULAS PUEDE SER SOLIDA O FLUIDA. CON LOS METODOS SE PUEDE GENERAR UNA LUMINISCENCIA RETARDADA QUE SE PUEDE CONSEGUIR TRAS LA IRRADIACION DE LA MATRIZ. LOS METODOS SE PUEDEN LLEVAR A CABO PARA DETERMINAR UNA SUSTANCIA DE ANALISIS EN UN MEDIO QUE SE SOSPECHE CONTENGA LA SUSTANCIA DE ANALISIS. UN METODO CONSISTE EN COMETER UN MEDIO QUE SE SOSPECHA CONTIENE UNA SUSTANCIA DE ANALISIS A UNAS CONDICIONES BAJOS LAS QUE SE FORME UN COMPLEJO DE MIEMBROS DE PARES AGLUTINANTES ESPECIFICOS (SBP) EN RELACION A LA PRESENCIA DE LA SUSTANCIA DE ANALISIS Y DETERMINAR SIEL COMPLEJO DE MIEMBROS DE SBP SE HA FORMADO UTILIZANDO COMO ETIQUETA UNA SOLA COMPOSICION CON PROPIEDADES QUIMIOLUMINISCENTES Y FOTOSENSIBILIZADORAS. TRAS LA ACTIVACION DE LA PROPIEDAD FOTOSENSIBILIZADORA SE GENERA OXIGENO SINGLETE Y ACTIVA LA PROPIEDAD QUIMIOLUMINISCENTE. TAMBIEN SE PRESENTAN COMPOSICIONES Y KITS.
ES93918420T 1992-07-31 1993-07-30 Matrices quimioluminiscentes fotoactivables. Expired - Lifetime ES2113547T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US92306992A 1992-07-31 1992-07-31

Publications (1)

Publication Number Publication Date
ES2113547T3 true ES2113547T3 (es) 1998-05-01

Family

ID=25448070

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93918420T Expired - Lifetime ES2113547T3 (es) 1992-07-31 1993-07-30 Matrices quimioluminiscentes fotoactivables.

Country Status (9)

Country Link
US (2) US5618732A (es)
EP (1) EP0653066B1 (es)
JP (1) JP3464798B2 (es)
AT (1) ATE162892T1 (es)
CA (1) CA2141451C (es)
DE (1) DE69316757T2 (es)
DK (1) DK0653066T3 (es)
ES (1) ES2113547T3 (es)
WO (1) WO1994003812A1 (es)

Families Citing this family (145)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5856522A (en) * 1995-05-04 1999-01-05 Tropix, Inc. Method of using synthesis of 1,2-dioxetanes and kits therefore
US6251581B1 (en) 1991-05-22 2001-06-26 Dade Behring Marburg Gmbh Assay method utilizing induced luminescence
US5578498A (en) 1991-05-22 1996-11-26 Behringwerke Ag Metal chelate containing compositions for use in chemiluminescent assays
WO1995006877A1 (en) * 1993-09-03 1995-03-09 Behringwerke Ag Fluorescent oxygen channeling immunoassays
US5830526A (en) * 1994-12-28 1998-11-03 Fibermark, Inc. Light-activated antimicrobial and antiviral materials
US5811253A (en) * 1995-09-01 1998-09-22 Johnson & Johnson Clinical Diagnostics, Inc. Use of vanadium bromoperoxidase as a signal-generating enzyme for chemiluminescent systems: test kits and analytical methods
WO1997023646A1 (en) * 1995-12-22 1997-07-03 Behringwerke Aktiengesellschaft Detection of differences in nucleic acids
US6143287A (en) * 1996-02-27 2000-11-07 New York Blood Center, Inc. Method and composition for hair removal
EP0852012B1 (en) * 1996-05-01 2006-07-26 Dade Behring Marburg GmbH Chemiluminescent compositions and their use in the detection of hydrogen peroxide
US20030027126A1 (en) 1997-03-14 2003-02-06 Walt David R. Methods for detecting target analytes and enzymatic reactions
US7622294B2 (en) 1997-03-14 2009-11-24 Trustees Of Tufts College Methods for detecting target analytes and enzymatic reactions
US6544797B1 (en) * 1997-04-09 2003-04-08 Biosite Diagnostics, Inc. Compositions and methods for inhibiting light-induced inactivation of biological reagents
US6432662B1 (en) * 1997-04-15 2002-08-13 Pierce Chemical Company Assay of peroxidase activity
WO1999006821A1 (de) * 1997-08-01 1999-02-11 Presens Precision Sensing Gmbh Verfahren und vorrichtung zur referenzierung von fluoreszenzintensitätssignalen
AT409306B (de) * 1997-10-03 2002-07-25 Hoffmann La Roche Optisch chemischer sensor
DE19756782A1 (de) * 1997-12-19 1999-06-24 Dade Behring Marburg Gmbh Nachweis und Bestimmung festphasenassoziierter Faktoren
US6365346B1 (en) * 1998-02-18 2002-04-02 Dade Behring Inc. Quantitative determination of nucleic acid amplification products
JP2002504689A (ja) 1998-02-18 2002-02-12 デイド・ベーリング・インコーポレイテッド 複数の検体の検出において使用するための化学ルミネセンス組成物
WO1999049823A1 (en) * 1998-03-30 1999-10-07 Fibermark, Inc. Light-activated antimicrobial polymeric materials
US8198096B2 (en) * 1998-05-05 2012-06-12 Massachusetts Institute Of Technology Emissive polymers and devices incorporating these polymers
US20050147534A1 (en) * 1998-05-05 2005-07-07 Massachusetts Institute Of Technology Emissive sensors and devices incorporating these sensors
EP1080162B1 (en) * 1998-05-05 2004-03-10 Massachusetts Institute Of Technology Emissive polymers and devices incorporating these polymers
DE19835457A1 (de) * 1998-08-05 2000-02-17 Fraunhofer Ges Forschung Vorrichtung zur photoaktivierten Produktion von Singulett-Sauerstoff und Verfahren zur Herstellung der Vorrichtung
EP1153296A4 (en) * 1999-02-16 2002-07-17 Princeton Separations ACTIVATION FILM FOR CHEMILUMINESCENT ANALYSIS AND METHODS OF USE
US6322980B1 (en) 1999-04-30 2001-11-27 Aclara Biosciences, Inc. Single nucleotide detection using degradation of a fluorescent sequence
US6627400B1 (en) 1999-04-30 2003-09-30 Aclara Biosciences, Inc. Multiplexed measurement of membrane protein populations
US6838292B1 (en) 1999-04-19 2005-01-04 Alion Science And Technology Corporation Detection of biological warfare agents
US7001725B2 (en) 1999-04-30 2006-02-21 Aclara Biosciences, Inc. Kits employing generalized target-binding e-tag probes
US6649351B2 (en) 1999-04-30 2003-11-18 Aclara Biosciences, Inc. Methods for detecting a plurality of analytes by mass spectrometry
US6673550B2 (en) 1999-04-30 2004-01-06 Aclara Biosciences, Inc. Electrophoretic tag reagents comprising fluorescent compounds
US20030235832A1 (en) * 2000-06-21 2003-12-25 Ahmed Chenna Multiplexed analysis by chromatographic separation of molecular tags
WO2001009605A1 (en) * 1999-07-30 2001-02-08 Lakowicz Joseph R Background suppression in fluorometry
US6232104B1 (en) 1999-08-17 2001-05-15 Dade Behring Inc. Detection of differences in nucleic acids by inhibition of spontaneous DNA branch migration
US6703248B1 (en) * 1999-12-15 2004-03-09 Dade Behring Marburg Gmbh Particles for diagnostic and therapeutic use
CA2395567A1 (en) 2000-01-12 2001-07-19 Light Sciences Corporation Novel treatment for eye disease
US7537938B2 (en) * 2000-04-28 2009-05-26 Monogram Biosciences, Inc. Biomarker detection in circulating cells
US7771929B2 (en) * 2000-04-28 2010-08-10 Monogram Biosciences, Inc. Tag library compounds, compositions, kits and methods of use
US7160735B2 (en) * 2000-04-28 2007-01-09 Monogram Biosciences, Inc. Tagged microparticle compositions and methods
US20030207300A1 (en) * 2000-04-28 2003-11-06 Matray Tracy J. Multiplex analytical platform using molecular tags
EP1305632B1 (en) * 2000-05-04 2011-07-27 Siemens Healthcare Diagnostics Products GmbH Methods for detection of multiple analytes
DE10025145A1 (de) * 2000-05-20 2001-11-22 Presens Prec Sensing Gmbh Phosphoreszierende Polyelektrolytaggregate
US7846733B2 (en) * 2000-06-26 2010-12-07 Nugen Technologies, Inc. Methods and compositions for transcription-based nucleic acid amplification
JP2004506791A (ja) * 2000-08-21 2004-03-04 マサチューセッツ・インスティチュート・オブ・テクノロジー 高い内部自由体積を有するポリマー
AU2002213096B2 (en) 2000-10-06 2007-03-29 Nugen Technologies, Inc. Methods and probes for detection and/or quantification of nucleic acid sequences
US7635571B2 (en) * 2000-12-07 2009-12-22 Siemens Healthcare Diagnostics Products Gmbh Amplified signal in binding assays
EP1427847B1 (en) 2000-12-13 2010-07-28 Nugen Technologies, Inc. Methods and compositions for generation of multiple copies of nucleic acid sequences and methods of detection thereof
DE10101576B4 (de) * 2001-01-15 2016-02-18 Presens Precision Sensing Gmbh Optischer Sensor und Sensorfeld
MXPA02012739A (es) * 2001-03-09 2004-04-20 Nugen Technologies Inc Metodos y composiciones para amplificacion de secuencias de arn.
EP1565747B1 (en) * 2001-03-29 2013-11-27 Cellect Technologies Corp. Method and system for separating and sorting particles
US7041459B2 (en) 2001-05-21 2006-05-09 Monogram Biosciences, Inc. Analyzing phosphorylated proteins
CZ20033143A3 (en) * 2001-05-21 2004-04-14 Aclara Biosciences, Inc. Methods and compositions for analyzing proteins
AU2002344221A1 (en) * 2001-05-26 2002-12-09 Aclara Biosciences, Inc. Catalytic amplification of multiplexed assay signals
JP4576752B2 (ja) * 2001-05-29 2010-11-10 富士レビオ株式会社 化学発光増強剤
EP1409998A4 (en) * 2001-06-09 2007-07-11 Glsynthesis Inc LIPID STRUCTURES AND ITS USES
US20030087309A1 (en) * 2001-08-27 2003-05-08 Shiping Chen Desktop drug screening system
US6648506B2 (en) 2001-09-07 2003-11-18 Board Of Trustees Of Michigan State University Fluorescence emission ratio imaging thermography for use in heat transfer analysis
US7045311B2 (en) * 2001-10-25 2006-05-16 Monogram Biosciences, Inc. Whole cell assay systems for cell surface proteases
US6780602B2 (en) * 2001-11-01 2004-08-24 Microbiosystems, Limited Partnership Taxonomic identification of pathogenic microorganisms and their toxic proteins
WO2003042697A1 (en) * 2001-11-14 2003-05-22 Genospectra, Inc. Biochemical analysis system with combinatorial chemistry applications
US7462325B2 (en) * 2001-11-30 2008-12-09 Nomadics, Inc. Luminescent polymer particles
US20030119203A1 (en) * 2001-12-24 2003-06-26 Kimberly-Clark Worldwide, Inc. Lateral flow assay devices and methods for conducting assays
EP1478765A4 (en) * 2002-03-05 2006-12-06 Aclara Biosciences Inc MULTIPLEX ANALYSIS USING MEMBRANE-FIXED SENSITIZERS
US20040229294A1 (en) * 2002-05-21 2004-11-18 Po-Ying Chan-Hui ErbB surface receptor complexes as biomarkers
US20040229380A1 (en) * 2002-05-21 2004-11-18 Po-Ying Chan-Hui ErbB heterodimers as biomarkers
US7402397B2 (en) * 2002-05-21 2008-07-22 Monogram Biosciences, Inc. Detecting and profiling molecular complexes
US20040229299A1 (en) * 2002-05-21 2004-11-18 Badal M. Youssouf Intracellular complexes as biomarkers
US20040229293A1 (en) * 2002-05-21 2004-11-18 Po-Ying Chan-Hui Surface receptor complexes as biomarkers
US20040175765A1 (en) * 2002-07-05 2004-09-09 Sharat Singh Cell-screening assay and composition
WO2004007634A2 (en) * 2002-07-15 2004-01-22 Massachusetts Institute Of Technology Emissive, high charge transport polymers
US6764819B2 (en) * 2002-07-16 2004-07-20 Emp Biotech Gmbh Method for chemiluminescent detection
ATE442589T1 (de) * 2002-07-25 2009-09-15 Aclara Biosciences Inc Nachweis der rezeptoroligomerisierung
US7432105B2 (en) * 2002-08-27 2008-10-07 Kimberly-Clark Worldwide, Inc. Self-calibration system for a magnetic binding assay
US20050098766A1 (en) * 2002-09-19 2005-05-12 Watson David L.Jr. Chemiluminescent processes and systems
US20040091850A1 (en) * 2002-11-08 2004-05-13 Travis Boone Single cell analysis of membrane molecules
US7781172B2 (en) * 2003-11-21 2010-08-24 Kimberly-Clark Worldwide, Inc. Method for extending the dynamic detection range of assay devices
US20040121337A1 (en) * 2002-12-19 2004-06-24 Nomadics, Inc. Luminescent polymers and methods of use thereof
US20040121334A1 (en) * 2002-12-19 2004-06-24 Kimberly-Clark Worldwide, Inc. Self-calibrated flow-through assay devices
BRPI0408928A (pt) 2003-04-01 2006-09-12 Monogram Biosciences Inc métodos para determinar uma situação de doença em um paciente, uma situação apoptótica de células em uma amostra, e uma situação de um cáncer em um paciente
US7851209B2 (en) * 2003-04-03 2010-12-14 Kimberly-Clark Worldwide, Inc. Reduction of the hook effect in assay devices
CA2521920A1 (en) * 2003-04-10 2004-10-28 Mallinckrodt Inc. Olivetol-cyclodextrin complexes and regio-selective process for preparing delta 9-tetrahydrocannabinol
JP2006523465A (ja) * 2003-04-14 2006-10-19 ニューゲン テクノロジーズ， インコーポレイテッド ランダムにプライミングされる複合プライマーを用いる大規模増幅
US7402398B2 (en) * 2003-07-17 2008-07-22 Monogram Biosciences, Inc. Measuring receptor homodimerization
US7381370B2 (en) * 2003-07-18 2008-06-03 Dade Behring Inc. Automated multi-detector analyzer
EP1673399B1 (en) * 2003-08-11 2017-04-05 Monogram BioSciences, Inc. Detecting and profiling molecular complexes
CA2543830A1 (en) * 2003-10-27 2005-05-19 Monogram Biosciences, Inc. Detecting human anti-therapeutic antibodies
US20060257929A1 (en) * 2003-11-12 2006-11-16 Microbiosystems, Limited Partnership Method for the rapid taxonomic identification of pathogenic microorganisms and their toxic proteins
US7713748B2 (en) * 2003-11-21 2010-05-11 Kimberly-Clark Worldwide, Inc. Method of reducing the sensitivity of assay devices
US7943395B2 (en) * 2003-11-21 2011-05-17 Kimberly-Clark Worldwide, Inc. Extension of the dynamic detection range of assay devices
US7815854B2 (en) 2004-04-30 2010-10-19 Kimberly-Clark Worldwide, Inc. Electroluminescent illumination source for optical detection systems
US20050244953A1 (en) * 2004-04-30 2005-11-03 Kimberly-Clark Worldwide, Inc. Techniques for controlling the optical properties of assay devices
US20060019265A1 (en) * 2004-04-30 2006-01-26 Kimberly-Clark Worldwide, Inc. Transmission-based luminescent detection systems
US7796266B2 (en) * 2004-04-30 2010-09-14 Kimberly-Clark Worldwide, Inc. Optical detection system using electromagnetic radiation to detect presence or quantity of analyte
WO2006034081A2 (en) * 2004-09-17 2006-03-30 Massachusetts Institute Of Technology Polymers for analyte detection
US7939267B2 (en) * 2004-11-04 2011-05-10 Laboratory Corporation Of America Holdings Detection of activation of endothelial cells as surrogate marker for angiogenesis
WO2006052548A1 (en) * 2004-11-05 2006-05-18 University Of Maryland Biotechnology Institute Metal-enhanced fluorescence from plastic substrates
US20070121113A1 (en) * 2004-12-22 2007-05-31 Cohen David S Transmission-based optical detection systems
US20060166376A1 (en) * 2005-01-21 2006-07-27 Craig Alan R Compositions for use as a signal generation component and methods of using same
US20070037174A1 (en) * 2005-08-12 2007-02-15 Rampal Jang B Chemiluminescent generated fluorescent labeling
EP1929046B1 (en) * 2005-09-07 2012-07-11 Nugen Technologies, Inc. Improved nucleic acid amplification procedure
JP4993749B2 (ja) * 2005-11-25 2012-08-08 独立行政法人科学技術振興機構 分析方法及び分析装置
WO2008019086A2 (en) * 2006-08-04 2008-02-14 Massachusetts Institute Of Technology Detection of explosives, toxins and other compositions
US8283423B2 (en) 2006-09-29 2012-10-09 Massachusetts Institute Of Technology Polymer synthetic technique
US8802447B2 (en) * 2006-10-05 2014-08-12 Massachusetts Institute Of Technology Emissive compositions with internal standard and related techniques
US20100055725A1 (en) * 2006-10-17 2010-03-04 Zymera, Inc. System for assays of aminotransferase
US20090215189A1 (en) * 2006-10-27 2009-08-27 Massachusetts Institute Of Technology Sensor of species including toxins and chemical warfare agents
CA2669398C (en) * 2006-11-13 2016-01-05 Perkinelmer Las, Inc. Detecting molecular interactions comprising a target-selective binding agent and a target molecule with fluorescence resonance energy transfer (fret)
WO2008098100A2 (en) * 2007-02-07 2008-08-14 Perscitus Biosciences, Llc Detection of molecule proximity
WO2009086197A1 (en) * 2007-12-20 2009-07-09 Monogram Biosciences, Inc. Her-2 diagnostic methods
US8034568B2 (en) * 2008-02-12 2011-10-11 Nugen Technologies, Inc. Isothermal nucleic acid amplification methods and compositions
US7846666B2 (en) 2008-03-21 2010-12-07 Nugen Technologies, Inc. Methods of RNA amplification in the presence of DNA
US8583204B2 (en) 2008-03-28 2013-11-12 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US8682408B2 (en) 2008-03-28 2014-03-25 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US11730407B2 (en) 2008-03-28 2023-08-22 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US20090258435A1 (en) * 2008-04-15 2009-10-15 Siemens Healthcare Diagnostics Inc., A Corporation Of California Biotin-receptor reagents for sensitivity modulation in assays
US20120295259A1 (en) 2011-05-19 2012-11-22 Laboratory Corporation Of America Holdings Methods for Determining the Likelihood of Survival and for Predicting Likelihood of Metastasis in Cancer Patients
EP2438442B1 (en) 2008-12-01 2017-08-09 Laboratory Corporation of America Holdings Methods and assays for measuring p95 and/or p95 complexes in a sample and antibodies specific for p95
BRPI1007321A2 (en) 2009-01-15 2018-07-10 Laboratory Corporation Of America Holdings methods for measuring and / or quantifying the presence and / or amount of her-3 or her-3 in a complex in a patient sample, and to determine if an individual with cancer is likely to respond to treatment with a targeted therapy. and antibody.
WO2010095033A1 (en) 2009-02-20 2010-08-26 Perkinelmer Biosignal, Inc. Multiplex assay methods and compositions
US9347947B2 (en) 2009-03-12 2016-05-24 Siemens Healthcare Diagnostics Inc. Immunoassays employing non-particulate chemiluminescent reagent
US8153442B2 (en) * 2009-10-21 2012-04-10 Siemens Healthcare Diagnostics Inc. Stabilization of signal generation in particles used in assays
WO2013163129A1 (en) 2012-04-23 2013-10-31 Siemens Healthcare Diagnostics Inc. Biological assay sample analyzer
DK2856254T3 (da) 2012-05-29 2020-02-17 Siemens Healthcare Diagnostics Inc Blænderindretning til et luminescensbaseret prøveanalyseringsapparat
US9244083B2 (en) 2012-11-30 2016-01-26 Siemens Healthcare Diagnostics Inc. Compositions and methods for detecting vitamin D
WO2014152845A1 (en) 2013-03-20 2014-09-25 Siemens Healthcare Diagnostics Inc. Light and shutter for a sample analyzer
CA2908515A1 (en) 2013-04-05 2014-10-09 Laboratory Corporation Of America Holdings Systems and methods for facilitating diagnosis, prognosis and treatment of cancer based on detection of her3 activation
US20140308751A1 (en) 2013-04-12 2014-10-16 Siemens Healthcare Diagnostics Inc. Assays for Analyte Homologs
KR102309377B1 (ko) 2014-06-27 2021-10-05 지멘스 헬쓰케어 다이아그노스틱스 인크. 비타민 d 에피머에 특이적인 결합 파트너
KR20180021934A (ko) 2014-06-27 2018-03-05 지멘스 헬쓰케어 다이아그노스틱스 인크. 비타민 d 검정에서 비타민 d 에피머에 특이적인 결합 파트너
US9597918B2 (en) 2014-09-30 2017-03-21 Michael Joseph Jersa, III Smart clip
US10451614B2 (en) 2016-03-15 2019-10-22 Laboratory Corporation Of America Holdings Methods of assessing protein interactions between cells
US20190227082A1 (en) 2016-07-06 2019-07-25 Prothena Biosciences Limited Assay for detecting total and s129 phosphorylated alpha-synuclein
WO2018017472A1 (en) 2016-07-18 2018-01-25 Siemens Healthcare Diagnostics Inc. Sample analyzer system with a sample vessel having opaque and translucent portions
CN108445238A (zh) * 2018-02-11 2018-08-24 北京科美生物技术有限公司 检测促黄体生成素的均相免疫检测试剂套装及其制备方法和应用
CN108445239B (zh) * 2018-02-11 2021-11-02 科美诊断技术股份有限公司 检测β人绒毛膜促性腺激素的均相免疫检测试剂套装及其制备方法和应用
CN108169497A (zh) * 2018-02-11 2018-06-15 北京科美生物技术有限公司 人泌乳素检测试剂盒及其制备方法与应用
EP4398021A3 (en) 2018-05-04 2024-09-11 Siemens Healthcare Diagnostics, Inc. Illumination unit with multiple light sources for generating a uniform illumination spot
WO2019223691A1 (zh) 2018-05-21 2019-11-28 博阳生物科技（上海）有限公司 一种化学发光分析测定方法及使用该方法的系统、试剂盒
CN110514651A (zh) 2018-05-21 2019-11-29 博阳生物科技（上海）有限公司 一种化学发光免疫分析测定方法及使用该方法的系统、试剂盒
CN119395003A (zh) 2018-07-30 2025-02-07 美国西门子医学诊断股份有限公司 用于进行生物素测定的试剂盒、微流体装置和方法
CN116626021A (zh) 2018-08-13 2023-08-22 上海索昕生物科技有限公司 一种用于化学发光分析的微球组合物及其应用
CN121678646A (zh) * 2019-12-31 2026-03-17 科美博阳诊断技术(上海)有限公司 一种受体试剂及其应用
JP7486978B2 (ja) * 2020-02-28 2024-05-20 キヤノン株式会社 検査薬、検査キットおよび検査方法
CN115397464A (zh) * 2020-04-24 2022-11-25 美国西门子医学诊断股份有限公司 用于使用抗人免疫球蛋白抗体的抗微生物血清学测定的组合物、试剂盒和方法
CN113087703B (zh) * 2021-03-03 2022-04-15 四川大学华西医院 一种能特异性标记脂滴的光敏剂及其制备方法
US20240168022A1 (en) * 2021-04-21 2024-05-23 Siemens Healthcare Diagnostics Inc. Compositions, kits, and methods for anti-microbial serology assays using anti-human immunoglobulin antibody

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3850578A (en) * 1973-03-12 1974-11-26 H Mcconnell Process for assaying for biologically active molecules
US4315998A (en) * 1974-06-12 1982-02-16 Research Corporation Polymer-bound photosensitizing catalysts
US4199559A (en) * 1974-08-12 1980-04-22 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US3996345A (en) * 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4383031A (en) * 1975-04-28 1983-05-10 Miles Laboratories, Inc. Homogeneous chemiluminescent specific binding assay
US4174384A (en) * 1975-06-30 1979-11-13 Syva Company Fluorescence quenching with immunological pairs in immunoassays
GB1575343A (en) * 1977-05-10 1980-09-17 Ici Ltd Method for preparing liposome compositions containing biologically active compounds
US4529561A (en) * 1978-03-24 1985-07-16 The Regents Of The University Of California Method for producing liposomes in selected size range
US4277437A (en) * 1978-04-05 1981-07-07 Syva Company Kit for carrying out chemically induced fluorescence immunoassay
US4233402A (en) * 1978-04-05 1980-11-11 Syva Company Reagents and method employing channeling
US4220450A (en) * 1978-04-05 1980-09-02 Syva Company Chemically induced fluorescence immunoassay
US4380580A (en) * 1978-04-10 1983-04-19 Miles Laboratories, Inc. Heterogenous chemiluminescent specific binding assay
US4193983A (en) * 1978-05-16 1980-03-18 Syva Company Labeled liposome particle compositions and immunoassays therewith
US4226993A (en) * 1978-07-24 1980-10-07 Miles Laboratories, Inc. Amino-functionalized phthalhydrazides
US4318707A (en) * 1978-11-24 1982-03-09 Syva Company Macromolecular fluorescent quencher particle in specific receptor assays
US4576912A (en) * 1978-11-30 1986-03-18 Technicon Instruments Corporation Fluoroimmunoassaying
US4261968A (en) * 1979-05-10 1981-04-14 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4299916A (en) * 1979-12-26 1981-11-10 Syva Company Preferential signal production on a surface in immunoassays
US4483921A (en) * 1981-01-12 1984-11-20 Collaborative Research, Inc. Immunoassay with antigen or antibody labeled liposomes sequestering enzyme
US4650770A (en) * 1981-04-27 1987-03-17 Syntex (U.S.A.) Inc. Energy absorbing particle quenching in light emitting competitive protein binding assays
CA1180647A (en) * 1981-07-17 1985-01-08 Cavit Akin Light-emitting polynucleotide hybridization diagnostic method
CA1190838A (en) * 1981-07-17 1985-07-23 Cavit Akin Homogeneous nucleic acid hybridization diagnostics by non-radiative energy transfer
US4522803A (en) * 1983-02-04 1985-06-11 The Liposome Company, Inc. Stable plurilamellar vesicles, their preparation and use
US4654300A (en) * 1982-04-02 1987-03-31 Syntex (U.S.A.) Inc. Fluorescent microbead quenching assay
US4483929A (en) * 1982-05-03 1984-11-20 Liposome Technology Incorporated Liposomes with glycolipid-linked antibodies
US4485054A (en) * 1982-10-04 1984-11-27 Lipoderm Pharmaceuticals Limited Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV)
US4588578A (en) * 1983-08-08 1986-05-13 The Liposome Company, Inc. Lipid vesicles prepared in a monophase
US4652533A (en) * 1983-04-28 1987-03-24 Pandex Laboratories, Inc. Method of solid phase immunoassay incorporating a luminescent label
EP0144914A3 (en) * 1983-12-12 1986-08-13 Miles Inc. Hybridization assay employing labeled pairs of hybrid binding reagents
US4950588A (en) * 1985-07-10 1990-08-21 Molecular Diagnostics, Inc. Prolonged enhanced chemiluminescence
CA1273552A (en) * 1985-12-23 1990-09-04 Michael J. Heller Fluorescent stokes shift probes for polynucleotide hybridization assays
ATE88761T1 (de) * 1986-01-10 1993-05-15 Amoco Corp Kompetitiver homogener test.
US4857652A (en) * 1986-07-17 1989-08-15 Board Of Governors Of Wayne State University Chemiluminescent 1,2-dioxetane compounds
US4959182A (en) * 1986-07-17 1990-09-25 Board Of Governors Of Wayne State University Method and compositions providing enhanced chemiluminescence from 1,2-dioxetanes
US4962192A (en) * 1986-07-17 1990-10-09 Board Of Governors Of Wayne State University Chemiluminescent 1,2-dioxetane compounds
US5616729A (en) * 1986-07-17 1997-04-01 Board Of Governors Of Wayne State University Enhanced chemiluminescence from 1,2-dioxetanes through energy transfer to tethered fluorescers
US5004565A (en) * 1986-07-17 1991-04-02 The Board Of Governors Of Wayne State University Method and compositions providing enhanced chemiluminescence from 1,2-dioxetanes
US4931223A (en) * 1986-07-24 1990-06-05 Tropix, Inc. Methods of using chemiluminescent 1,2-dioxetanes
US4956477A (en) * 1987-12-31 1990-09-11 Tropix, Inc. Synthesis of 1,2-dioxetanes
BR8707399A (pt) * 1986-07-24 1988-09-13 Quest Systems Inc Metodo de detectar uma substancia usando decomposicao enzimaticamente induzida de dioxetanos
US4978614A (en) * 1988-10-26 1990-12-18 Tropix, Inc. Method of detecting a substance using enzymatically-induced decomposition of dioxetanes
US4891324A (en) * 1987-01-07 1990-01-02 Syntex (U.S.A.) Inc. Particle with luminescer for assays
US4806485A (en) * 1987-02-27 1989-02-21 Cooperative Institute For Research In Environmental Sciences Univers. Of Colorado Method of improving the detection limits of UV-VIS absorbing compounds in HPLC by the use of a singlet oxygen trap
US5017473A (en) * 1987-05-26 1991-05-21 Becton, Dickinson And Company Homogeneous chemiluminescence immunoassay using a light absorbing material
US4943525A (en) * 1987-11-02 1990-07-24 Bioventures, Inc. Simultaneous immunoassay for the determination of antigens and antibodies
NL8703075A (nl) * 1987-12-18 1989-07-17 Nederlanden Staat Acridiniumverbindingen als chemiluminescentie-merkstof.
JPH0731201B2 (ja) * 1987-12-31 1995-04-10 トロピックス・インコーポレーテッド 化学発光による測定法
NZ227506A (en) * 1987-12-31 1992-06-25 London Diagnostics Inc Specific binding assays using chemiluminescent compounds
JP2681061B2 (ja) * 1988-06-08 1997-11-19 ロンドン・ダイアグノスティック・インコーポレーテッド 検出可能なシグナルのセンシタイザー誘導発生を利用したアッセイ
US4952707A (en) * 1988-06-30 1990-08-28 Tropix, Inc. Enzymatically-cleavable chemiluminescent fused polycyclic ring-containing 1,2-dioxetanes
US4931569A (en) * 1988-09-14 1990-06-05 Tropix, Inc. Purification of stable water-soluble dioxetanes
US5132204A (en) * 1989-05-31 1992-07-21 Chiron Corporation Chemiluminescent double-triggered 1, 2-dioxetanes
WO1991005063A1 (en) * 1989-10-05 1991-04-18 Exoxemis, Inc. Haloperoxidase acid optimum chemiluminescence assay system
US5094958A (en) * 1990-08-30 1992-03-10 Fiberchem Inc. Method of self-compensating a fiber optic chemical sensor
ATE208039T1 (de) * 1991-05-22 2001-11-15 Dade Behring Marburg Gmbh Bestimmungsmethoden unter verwendung von induzierter lumineszenz
US5272090A (en) * 1992-03-31 1993-12-21 Moshe Gavish Sensor element for determining the amount of oxygen dissolved in a sample

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ATE162892T1 (de) 1998-02-15
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US5709994A (en) 1998-01-20
DE69316757D1 (de) 1998-03-05
CA2141451A1 (en) 1994-02-17

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