ES2114220T3 - Peptido inhibidor de la fosfolipasa c. - Google Patents

Peptido inhibidor de la fosfolipasa c.

Info

Publication number
ES2114220T3
ES2114220T3 ES94926371T ES94926371T ES2114220T3 ES 2114220 T3 ES2114220 T3 ES 2114220T3 ES 94926371 T ES94926371 T ES 94926371T ES 94926371 T ES94926371 T ES 94926371T ES 2114220 T3 ES2114220 T3 ES 2114220T3
Authority
ES
Spain
Prior art keywords
leu
val
single bond
phospholipase
tyr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94926371T
Other languages
English (en)
Inventor
Motoo Yamasaki
Genkichi Ishikawa
Yoshimi Honma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Application granted granted Critical
Publication of ES2114220T3 publication Critical patent/ES2114220T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Detergent Compositions (AREA)

Abstract

UNA FOSFOLIPASA C INHIBIDORA DE PEPTIDO REPRESENTADA POR LA FORMULA GENERAL (I), EN DONDE J1 Y J2 CADA UNO REPRESENTA HIDROGENO O SE COMBINAN JUNTOS PARA REPRESENTAR UN ENLACE SIMPLE; W REPRESENTA HIDROGENO, ALKANOILO (NO)SUSTITUIDO, AROILO (NO SUSTITUIDO) O COUMARILO; X REPRESENTA UN ENLACE SIMPLE, -LEUO SER-LEU-VAL-GLU-LEU-VAL-SER-TYR-TYR-GLU-LYS-HIS-ALA-LEU- (EN DONDE AL MENOS UN RESIDUO DE AMINOACIDO ENTRE EL PRIMER Y DECIMOCUARTO RESIDUOS DE AMINOACIDOS EN EL LADO N-TERMINAL PUEDEN SER SUPRIMIDOS); Y REPRESENTA UN ENLACE SIMPLE O -PRO-VAL-; Y Z REPRESENTA HIDROXI O AMINO.
ES94926371T 1993-09-10 1994-09-08 Peptido inhibidor de la fosfolipasa c. Expired - Lifetime ES2114220T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP22539793 1993-09-10
PCT/JP1994/001486 WO1995007293A1 (en) 1993-09-10 1994-09-08 Phospholipase c inhibiting peptide

Publications (1)

Publication Number Publication Date
ES2114220T3 true ES2114220T3 (es) 1998-05-16

Family

ID=16828725

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94926371T Expired - Lifetime ES2114220T3 (es) 1993-09-10 1994-09-08 Peptido inhibidor de la fosfolipasa c.

Country Status (7)

Country Link
US (1) US5847074A (es)
EP (1) EP0672679B1 (es)
AT (1) ATE162850T1 (es)
CA (1) CA2149038C (es)
DE (1) DE69408299T2 (es)
ES (1) ES2114220T3 (es)
WO (1) WO1995007293A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2189674A1 (en) * 1995-03-10 1996-09-11 Motoo Yamasaki Peptides inhibiting phospholipase c
US5677420A (en) * 1995-03-10 1997-10-14 Kyowa Hakko Kogyo Co., Ltd. Phospholipase c-inhibiting peptides
ATE425177T1 (de) * 2000-07-17 2009-03-15 Astellas Pharma Inc Reduziertes fk228 und seine verwendung
US20020107193A1 (en) * 2000-11-09 2002-08-08 Glazner Gordon W. Therapeutic uses for IP3 receptor-mediated calcium channel modulators
US6527912B2 (en) 2001-03-30 2003-03-04 Lam Research Corporation Stacked RF excitation coil for inductive plasma processor

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5580956A (en) * 1992-03-11 1996-12-03 Kyowa Hakko Kogyo Co., Ltd. Phospholipase C-inhibiting peptides

Also Published As

Publication number Publication date
ATE162850T1 (de) 1998-02-15
CA2149038A1 (en) 1995-03-16
EP0672679B1 (en) 1998-01-28
EP0672679A4 (en) 1995-12-06
WO1995007293A1 (en) 1995-03-16
US5847074A (en) 1998-12-08
CA2149038C (en) 2000-06-13
DE69408299T2 (de) 1998-08-20
EP0672679A1 (en) 1995-09-20
DE69408299D1 (de) 1998-03-05

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