ES2114952T3 - Agentes antianginales derivados de quinazolinona. - Google Patents

Agentes antianginales derivados de quinazolinona.

Info

Publication number
ES2114952T3
ES2114952T3 ES92923814T ES92923814T ES2114952T3 ES 2114952 T3 ES2114952 T3 ES 2114952T3 ES 92923814 T ES92923814 T ES 92923814T ES 92923814 T ES92923814 T ES 92923814T ES 2114952 T3 ES2114952 T3 ES 2114952T3
Authority
ES
Spain
Prior art keywords
alkyl
optionally replaced
quinazolinone
alcoxide
conr5r6
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92923814T
Other languages
English (en)
Inventor
Nicholas Kenneth Terrett
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PFIZER
Pfizer Inc
Original Assignee
PFIZER
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PFIZER, Pfizer Inc filed Critical PFIZER
Application granted granted Critical
Publication of ES2114952T3 publication Critical patent/ES2114952T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Paper (AREA)
  • Ropes Or Cables (AREA)

Abstract

SE PRESENTAN COMPUESTOS DE LA FORMULA (I) Y LAS SALES FARMACOLOGICAMENTE ACEPTABLES DE LOS MISMOS EN LA QUE R1 ES H, ALQUILO C1-C4, ALCOXIDO C1-C4 O CONR5R6; R2 ES H O ALQUILO C1-C4; R3 ES ALQUILO C2-C4; R4 ES H, ALCANOILO C2-C4 OPCIONALMENTE SUSTITUIDO CON NR7R8, (HIDROXI)ALQUILO C2-C4 OPCIONALMENTE SUSTITUIDO CON NR7R8, CH = CHCO2R9, CH = CHCONR7R8, CH2CH2CO2R9, CH2CH2CONR7R8, SO2NR7R8, SO2NH(CH2)NNR7R8 O IMIDAZOLILO; R5 Y R6 SON CADA UNA INDEPENDIENTEMENTE H O ALQUILO C1-C4; R7 Y R8 SON CADA UNA INDEPENDIENTEMENTE H O ALQUILO C1-C4; O JUNTO CON EL ATOMO DE NITROGENO AL CUAL ESTAN UNIDAS FORMAN UN GRUPO DE PIRROLIDINO, PIPERIDINO, MORFOLINO O 4-(NR10)-1-PIPERAZINILO EN DONDE CUALQUIERA DE DICHOS GRUPOS ESTA OPCIONALMENTE SUSTITUIDO CON CONR5R6; R9 ES H O ALQUILO C1-C4; R10 ES H ALQUILO C1-C3 O (HIDROXI)ALQUILO C2-C3; Y N VALE 2, 3 O 4; CON LA CONDICION DE QUE R4 NO SE H CUANDO R1 ES H, ALQUILO C1-C4 O ALCOXIDO C1-C4; LOS COMPUESTOS SON INHIBIDORES SELECTIVOS DEL CGMP PDE Y UTILES EN EL TRATAMIENTO DE ENFERMEDADES CARDIOVASCULARES TALES COMO LA ANGINA, LA HIPERTENSION, EL FALLO CARDIACO Y LA ARTERIOSCLEROSIS.
ES92923814T 1991-12-11 1992-11-27 Agentes antianginales derivados de quinazolinona. Expired - Lifetime ES2114952T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919126260A GB9126260D0 (en) 1991-12-11 1991-12-11 Therapeutic agents

Publications (1)

Publication Number Publication Date
ES2114952T3 true ES2114952T3 (es) 1998-06-16

Family

ID=10706040

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92923814T Expired - Lifetime ES2114952T3 (es) 1991-12-11 1992-11-27 Agentes antianginales derivados de quinazolinona.

Country Status (11)

Country Link
US (1) US5482941A (es)
EP (1) EP0628032B1 (es)
JP (1) JP2525126B2 (es)
AT (1) ATE166052T1 (es)
CA (1) CA2122360C (es)
DE (1) DE69225500T2 (es)
DK (1) DK0628032T3 (es)
ES (1) ES2114952T3 (es)
FI (1) FI114023B (es)
GB (1) GB9126260D0 (es)
WO (1) WO1993012095A1 (es)

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JPH07502029A (ja) 1995-03-02
JP2525126B2 (ja) 1996-08-14
CA2122360A1 (en) 1993-06-24
EP0628032B1 (en) 1998-05-13
DE69225500T2 (de) 1998-09-10
CA2122360C (en) 1997-11-18
EP0628032A1 (en) 1994-12-14
DE69225500D1 (de) 1998-06-18
DK0628032T3 (da) 1998-10-07
WO1993012095A1 (en) 1993-06-24
FI942769A7 (fi) 1994-06-10
FI114023B (fi) 2004-07-30
FI942769A0 (fi) 1994-06-10
ATE166052T1 (de) 1998-05-15
US5482941A (en) 1996-01-09

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