ES2115207T3 - Metodo para la produccion de e-1-(4'-(2-dimetilaminoetoxi)-fenil)-1-(3'-hidroxifenil)-2-fenil-1-buteno. - Google Patents

Metodo para la produccion de e-1-(4'-(2-dimetilaminoetoxi)-fenil)-1-(3'-hidroxifenil)-2-fenil-1-buteno.

Info

Publication number
ES2115207T3
ES2115207T3 ES94903888T ES94903888T ES2115207T3 ES 2115207 T3 ES2115207 T3 ES 2115207T3 ES 94903888 T ES94903888 T ES 94903888T ES 94903888 T ES94903888 T ES 94903888T ES 2115207 T3 ES2115207 T3 ES 2115207T3
Authority
ES
Spain
Prior art keywords
fenil
formula
compound
dimetilaminoetoxi
hidroxifenil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94903888T
Other languages
English (en)
Inventor
Helmut Grill
Axel Woschina
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Deutschland GmbH
Original Assignee
Klinge Pharma GmbH and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Klinge Pharma GmbH and Co filed Critical Klinge Pharma GmbH and Co
Application granted granted Critical
Publication of ES2115207T3 publication Critical patent/ES2115207T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C07C217/20—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by halogen atoms, by trihalomethyl, nitro or nitroso groups, or by singly-bound oxygen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A METODOS PARA LA PRODUCCION DE E-1-[4`-(2-DIMETILAMINOETOXI)-FENIL]-1-(3`-HIDROXIFENIL)-2FENIL-1-BUTENO DE FORMULA (I) EL CUAL COMPRENDE EL CALENTAMIENTO DEL COMPUESTO DE FORMULA (II) (DONDE R ES UN GRUPO PROTECTOR FACILMENTE HIDROLIZABLE) EN PRESENCIA DE UN SOLVENTE ORGANICO Y GAS HCL Y EL ENFRIAMIENTO DE LA REACCION PARA OBTENER EL COMPUESTO DE FORMULA (IIIA), Y DESPUES CALENTAR EL COMPUESTO AISLADO DE FORMULA (IIIA) EN PRESENCIA DE ACIDO SULFURICO O ACIDO CLORHIDRICO PARA OBTENER EL COMPUESTO DE ACUERDO CON LA FORMULA (I).
ES94903888T 1994-01-03 1994-01-03 Metodo para la produccion de e-1-(4'-(2-dimetilaminoetoxi)-fenil)-1-(3'-hidroxifenil)-2-fenil-1-buteno. Expired - Lifetime ES2115207T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN94194961A CN1142815A (zh) 1994-01-03 1994-01-03 E-1-[4'-(2-二甲氨基乙氧基)-苯基]-1-(3'羟苯基)-2-苯基-1-丁烯的制备方法
PCT/EP1994/000001 WO1995018786A1 (en) 1994-01-03 1994-01-03 Method for the production of e-1-[4'-(2-dimethylaminoethoxy)-phenyl]-1-(3'-hydroxyphenyl)-2-phenyl-1-butene

Publications (1)

Publication Number Publication Date
ES2115207T3 true ES2115207T3 (es) 1998-06-16

Family

ID=37708199

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94903888T Expired - Lifetime ES2115207T3 (es) 1994-01-03 1994-01-03 Metodo para la produccion de e-1-(4'-(2-dimetilaminoetoxi)-fenil)-1-(3'-hidroxifenil)-2-fenil-1-buteno.

Country Status (15)

Country Link
US (1) US5693863A (es)
EP (1) EP0738256B1 (es)
JP (1) JPH09507240A (es)
CN (1) CN1142815A (es)
AU (1) AU691113B2 (es)
CZ (1) CZ330994A3 (es)
DE (1) DE69409835T2 (es)
EE (1) EE03191B1 (es)
ES (1) ES2115207T3 (es)
FI (1) FI950011A7 (es)
IL (1) IL112166A0 (es)
NO (1) NO301003B1 (es)
PL (1) PL177916B1 (es)
RU (1) RU2124499C1 (es)
WO (1) WO1995018786A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9601167D0 (en) * 1996-01-20 1996-03-20 Univ Bradford Tamoxifen and analogues thereof
HUP9900951A3 (en) 1996-01-20 2000-02-28 Bradford University Bradford Process for producing tamoxifen and analogues thereof
GB9715479D0 (en) * 1997-07-23 1997-10-01 Univ Bradford Tamoxifen and analogues thereof
JP4572407B2 (ja) * 2005-03-04 2010-11-04 学校法人東京理科大学 ドロロキシフェンの製造方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3046719C2 (de) * 1980-12-11 1983-02-17 Klinge Pharma GmbH, 8000 München 1,1,2-Triphenyl-but-1-en-Derivate, Verfahren zu ihrer Herstellung und Arzneimittel
GB2196003A (en) * 1986-09-11 1988-04-20 Nat Res Dev Iodo-and bromo-tamoxifen derivatives
DE3736682A1 (de) * 1987-10-29 1989-05-11 Klinge Co Chem Pharm Fab Verfahren zur herstellung von trans-1,1,2-triphenyl-but-1-en-derivaten

Also Published As

Publication number Publication date
EP0738256A1 (en) 1996-10-23
IL112166A0 (en) 1995-03-15
NO945077D0 (no) 1994-12-29
PL306666A1 (en) 1995-07-10
RU2124499C1 (ru) 1999-01-10
FI950011A0 (fi) 1995-01-02
NO945077L (no) 1995-07-04
AU691113B2 (en) 1998-05-07
PL177916B1 (pl) 2000-01-31
CN1142815A (zh) 1997-02-12
EP0738256B1 (en) 1998-04-22
JPH09507240A (ja) 1997-07-22
WO1995018786A1 (en) 1995-07-13
AU5815894A (en) 1995-08-01
FI950011L (fi) 1995-07-04
US5693863A (en) 1997-12-02
NO301003B1 (no) 1997-09-01
DE69409835T2 (de) 1998-10-01
DE69409835D1 (de) 1998-05-28
CZ330994A3 (en) 1995-07-12
EE03191B1 (et) 1999-06-15
FI950011A7 (fi) 1995-07-04

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