ES2115816T3 - Derivados macrolidas de 16-eslabones y su procedimiento de preparacion. - Google Patents

Derivados macrolidas de 16-eslabones y su procedimiento de preparacion.

Info

Publication number
ES2115816T3
ES2115816T3 ES94110679T ES94110679T ES2115816T3 ES 2115816 T3 ES2115816 T3 ES 2115816T3 ES 94110679 T ES94110679 T ES 94110679T ES 94110679 T ES94110679 T ES 94110679T ES 2115816 T3 ES2115816 T3 ES 2115816T3
Authority
ES
Spain
Prior art keywords
hydrogen atom
macrolid
derivatives
link
preparation procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94110679T
Other languages
English (en)
Inventor
Keiichi Ajito
Osamu Hara
Ken-Ichi Kurihara
Nobue Kikuchi
Minako Araake
Akira Shimizu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meiji Seika Kaisha Ltd
Original Assignee
Meiji Seika Kaisha Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP16941893A external-priority patent/JP3023041B2/ja
Priority claimed from JP5300686A external-priority patent/JPH07149788A/ja
Priority claimed from JP6105096A external-priority patent/JPH07309889A/ja
Priority claimed from JP6126654A external-priority patent/JPH07330791A/ja
Priority claimed from JP6145125A external-priority patent/JPH0812696A/ja
Application filed by Meiji Seika Kaisha Ltd filed Critical Meiji Seika Kaisha Ltd
Application granted granted Critical
Publication of ES2115816T3 publication Critical patent/ES2115816T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE PRESENTAN DERIVADOS MACROLIDOS DE 16 MIEMBROS REPRESENTADOS POR LA FORMULA (I) EN LA QUE R1 REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO SUSTITUYENTE QUE PROTEGE UN GRUPO DE HIDROXIL; R2 REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO SUSTITUYENTE QUE PROTEGE UN GRUPO DE HIDROXIL; R3 REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO DE AZILO ALIFATICO DE CADENA RECTA QUE TIENE ENTRE 2 Y 4 ATOMOS DE CARBONO; Y R4 REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO DE AZILO ALIFATICO O AROMATICO DE CADENA RECTA QUE TIENE ENTRE 1 Y 10 ATOMOS DE CARBONO; O UNA SAL FARMACOLOGICAMENTE ACEPTABLE DE LOS MISMOS. TAMBIEN SE PRESENTA UN NUEVO PROCESO PARA PRODUCIR ESTOS DERIVADOS MACROLIDOS DE 16 MIEMBROS.
ES94110679T 1993-07-08 1994-07-08 Derivados macrolidas de 16-eslabones y su procedimiento de preparacion. Expired - Lifetime ES2115816T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP16941893A JP3023041B2 (ja) 1993-07-08 1993-07-08 新規１６員環マクロリド誘導体
JP5300686A JPH07149788A (ja) 1993-11-30 1993-11-30 新規１６員環マクロリド誘導体及びそれらの効率的製造法
JP6105096A JPH07309889A (ja) 1994-05-19 1994-05-19 新規１６員環マクロリド誘導体及びそれらの新規製造法
JP6126654A JPH07330791A (ja) 1994-06-08 1994-06-08 新規１６員環マクロリド誘導体及びそれらの新規包括的製造法
JP6145125A JPH0812696A (ja) 1994-06-27 1994-06-27 新規１６員環マクロリド誘導体及びそれらの効率的製造法

Publications (1)

Publication Number Publication Date
ES2115816T3 true ES2115816T3 (es) 1998-07-01

Family

ID=27526205

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94110679T Expired - Lifetime ES2115816T3 (es) 1993-07-08 1994-07-08 Derivados macrolidas de 16-eslabones y su procedimiento de preparacion.

Country Status (8)

Country Link
US (1) US5602106A (es)
EP (1) EP0633266B1 (es)
KR (1) KR100360568B1 (es)
CN (2) CN1046534C (es)
AT (1) ATE165604T1 (es)
CA (1) CA2127578A1 (es)
DE (1) DE69409874T2 (es)
ES (1) ES2115816T3 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000073317A1 (fr) * 1999-06-01 2000-12-07 Meiji Seika Kaisha, Ltd. Derives de leucomycine modifiee en position 3
DE602007006663D1 (de) 2006-06-12 2010-07-01 Univ Ramot Verfahren zur behandlung von krebs
CN102344946B (zh) * 2010-08-02 2014-06-25 中牧实业股份有限公司 一种生物转化合成普拉特霉素a1的方法
KR20140004187A (ko) * 2011-01-31 2014-01-10 메이지 세이카 파루마 가부시키가이샤 신규 마크로라이드 유도체
CA2894992A1 (en) 2012-12-24 2014-07-03 Ramot At Tel-Aviv University Ltd. Agents for treating genetic diseases resulting from nonsense mutations, and methods for identifying the same
RU2746047C1 (ru) * 2017-04-06 2021-04-06 Шенянг Фуянг Фармасьютекал Технолоджи Ко., Лтд. Применение карримицина и его фармацевтически приемлемой соли для производства медикаментов для лечения и/или профилактики опухоли
RU2766176C2 (ru) * 2017-07-04 2022-02-08 Шенянг Фуянг Фармасьютекал Технолоджи Ко., Лтд. Применение изовалерил-спирамицина i, ii и/или iii при изготовлении препарата для лечения и/или профилактики опухоли и получения лекарственного препарата

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2638458A1 (fr) * 1988-10-27 1990-05-04 Adir Nouveaux derives de la tylosine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
JP3063943B2 (ja) * 1992-02-26 2000-07-12 明治製菓株式会社 血漿中において抗菌活性の持続する新規１６員環マクロリド誘導体及びその合成中間体とそれらの製造法
EP0595303B1 (en) * 1992-10-29 1999-04-14 Meiji Seika Kaisha Ltd. 16-Membered macrolide derivatives and process for producing the same

Also Published As

Publication number Publication date
ATE165604T1 (de) 1998-05-15
DE69409874D1 (de) 1998-06-04
DE69409874T2 (de) 1999-01-21
CN1219539A (zh) 1999-06-16
EP0633266B1 (en) 1998-04-29
US5602106A (en) 1997-02-11
CN1106818A (zh) 1995-08-16
KR100360568B1 (en) 2003-03-12
CA2127578A1 (en) 1995-01-09
CN1046534C (zh) 1999-11-17
EP0633266A1 (en) 1995-01-11
CN1093134C (zh) 2002-10-23

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