ES2061797T3 - Mini-proinsulina, su preparacion y empleo. - Google Patents

Mini-proinsulina, su preparacion y empleo.

Info

Publication number
ES2061797T3
ES2061797T3 ES89111027T ES89111027T ES2061797T3 ES 2061797 T3 ES2061797 T3 ES 2061797T3 ES 89111027 T ES89111027 T ES 89111027T ES 89111027 T ES89111027 T ES 89111027T ES 2061797 T3 ES2061797 T3 ES 2061797T3
Authority
ES
Spain
Prior art keywords
insulin
proinsulin
mini
employment
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89111027T
Other languages
English (en)
Inventor
Michael Dr Dorschug
Paul Dr Habermann
Gerhard Dr Seipke
Eugen Dr Uhlmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2061797T3 publication Critical patent/ES2061797T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/695—Corticotropin [ACTH]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

UNA MINI - PROINSULINA EN LA QUE EN LUGAR DE LA CADENA C EL AMINOACIDO ARG PUENTEA LAS CADENAS A Y B, MUESTRA ACTIVIDAD INSULINA Y ES APROPIADA PARA LA PRODUCCION DE MEDICAMENTOS PARA ELTRATAMIENTO DE LA DIABETES MELLITUS. SE PUEDE TRANSPONER ADEMAS, SIMPLEMENTE CON TRIPSINA EN UN DERIVADO DE INSULINA CUYA CADENA B SE ALARGA EN ARG. ESTE SE PUEDE TRANSFORMAR EN INSULINA CON CARBOXIPEPTIDASA B. TAMBIEN SE PUEDE TRANSFORMAR LA MINIPROINSULINA DE FORMA VENTAJOSDA DIRECTAMENTE EN INSULINA POR UN PROCESO DE COCCION.
ES89111027T 1988-06-23 1989-06-17 Mini-proinsulina, su preparacion y empleo. Expired - Lifetime ES2061797T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3821159 1988-06-23

Publications (1)

Publication Number Publication Date
ES2061797T3 true ES2061797T3 (es) 1994-12-16

Family

ID=6357053

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89111027T Expired - Lifetime ES2061797T3 (es) 1988-06-23 1989-06-17 Mini-proinsulina, su preparacion y empleo.

Country Status (18)

Country Link
EP (1) EP0347781B1 (es)
JP (1) JP3043764B2 (es)
KR (1) KR0139629B1 (es)
AT (1) ATE101620T1 (es)
AU (1) AU611303B2 (es)
CA (1) CA1341211C (es)
DE (1) DE58906966D1 (es)
DK (1) DK175182B1 (es)
ES (1) ES2061797T3 (es)
FI (1) FI102076B (es)
HK (1) HK1006023A1 (es)
HU (3) HUT52548A (es)
IE (1) IE62511B1 (es)
IL (1) IL90694A (es)
NO (1) NO302376B1 (es)
NZ (1) NZ229645A (es)
PT (1) PT90939B (es)
ZA (1) ZA894742B (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4885163A (en) * 1987-02-24 1989-12-05 Eli Lilly And Company Topical use of IGF-II for wound healing
US5358857A (en) * 1989-08-29 1994-10-25 The General Hospital Corp. Method of preparing fusion proteins
US5227293A (en) * 1989-08-29 1993-07-13 The General Hospital Corporation Fusion proteins, their preparation and use
CZ283234B6 (cs) * 1990-09-05 1998-02-18 Hoechst Aktiengesellschaft Enymatický způsob konverse preproinsulinů na insuliny
TW224471B (es) * 1991-11-26 1994-06-01 Lilly Co Eli
FR2686899B1 (fr) 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
SG46612A1 (en) 1992-12-02 1998-02-20 Hoechst Ag Process for obtaining proinsulin in processing correctly linked cystine bridges
DK0622376T3 (da) * 1993-04-27 2001-11-12 Hoechst Ag Amorfe monosfæriske former af insulinderivater
WO1995016708A1 (en) * 1993-12-17 1995-06-22 Novo Nordisk A/S Proinsulin-like compounds
US6001604A (en) * 1993-12-29 1999-12-14 Bio-Technology General Corp. Refolding of proinsulins without addition of reducing agents
DE4405179A1 (de) * 1994-02-18 1995-08-24 Hoechst Ag Verfahren zur Gewinnung von Insulin mit korrekt verbundenen Cystinbrücken
WO1997005166A1 (en) 1995-07-25 1997-02-13 Novartis Ag Transforming growth factor beta crystals
DE19544233A1 (de) 1995-11-28 1997-06-05 Hoechst Ag Verfahren zur Nutzung des Hefe-ADH II-Promotorsystems zur biotechnologischen Produktion heterologer Proteine in hohen Ausbeuten
DE59711533D1 (de) 1996-07-26 2004-05-27 Aventis Pharma Gmbh Insulinderivate mit erhöhter Zinkbindung
DE19825447A1 (de) 1998-06-06 1999-12-09 Hoechst Marion Roussel De Gmbh Neue Insulinanaloga mit erhöhter Zinkbildung
DE19915938A1 (de) * 1999-04-09 2000-10-19 Aventis Pharma Gmbh Herstellung von pankreatischer Procarboxypeptidase B, Isoformen und Muteinen davon und ihre Verwendung
EP1274720A4 (en) 2000-04-12 2004-08-18 Human Genome Sciences Inc FUSION PROTEINS CONTAINING ALBUMIN
DE10108100A1 (de) * 2001-02-20 2002-08-29 Aventis Pharma Gmbh Verwendung supersekretierbarer Peptide in Verfahren zu deren Herstellung und paralleler Verbesserung der Exportate eines oder mehrerer anderer Polypeptide von Interesse
US7638618B2 (en) 2001-02-20 2009-12-29 Sanofi-Aventis Deutschland Gmbh Nucleic acids encoding a hirudin and pro-insulin as superscretable peptides and for parallel improvement of the exported forms of one or more polypeptides of interest
US7202059B2 (en) 2001-02-20 2007-04-10 Sanofi-Aventis Deutschland Gmbh Fusion proteins capable of being secreted into a fermentation medium
US7312192B2 (en) * 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
PT1463751E (pt) 2001-12-21 2013-08-26 Human Genome Sciences Inc Proteínas de fusão de albumina
CA2513213C (en) 2003-01-22 2013-07-30 Human Genome Sciences, Inc. Albumin fusion proteins
ES2306981T3 (es) * 2003-01-31 2008-11-16 N.V. Organon Metodo para aislamiento de proteinas en condiciones anoxicas.
KR20110059602A (ko) 2008-08-07 2011-06-02 바이오콘 리미티드 인슐린 화합물의 제조방법
RU2447149C1 (ru) * 2011-03-24 2012-04-10 Винсорт Менеджемент Инк РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pMSIN4, КОДИРУЮЩАЯ ГИБРИДНЫЙ ПОЛИПЕПТИД - ПРЕДШЕСТВЕННИК ИНСУЛИНА ЧЕЛОВЕКА, ШТАММ BL21(DE3)/pMSIN4-ПРОДУЦЕНТ РЕКОМБИНАНТНОГО ИНСУЛИНА ЧЕЛОВЕКА, СПОСОБ ПОЛУЧЕНИЯ РЕКОМБИНАНТНОГО ИНСУЛИНА ЧЕЛОВЕКА
PL2739646T3 (pl) 2011-05-10 2018-05-30 Stefan Hermann Kompleksowy układ buforowy do renaturacji ludzkiej proinsuliny lub pochodnych proinsuliny
CN102849910A (zh) * 2012-10-10 2013-01-02 清华大学深圳研究生院 一种从污泥中回收腐殖酸并改善污泥厌氧消化的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3326473A1 (de) * 1983-07-22 1985-01-31 Hoechst Ag, 6230 Frankfurt Pharmazeutisches mittel zur behandlung des diabetes mellitus
DK58285D0 (da) * 1984-05-30 1985-02-08 Novo Industri As Peptider samt fremstilling og anvendelse deraf
DK129385A (da) * 1985-03-22 1986-09-23 Novo Industri As Peptider og fremstilling deraf
DK437786D0 (da) * 1986-09-12 1986-09-12 Nordisk Gentofte Insulinprecursorer
US4764592A (en) * 1987-04-23 1988-08-16 Eli Lilly And Company Crystalline human proinsulin and process for its production
US4992418A (en) * 1987-07-17 1991-02-12 Mount Sinai School Of Medicine Superactive human insulin analogue-[10-Aspartic Acid-B]Human Insulin

Also Published As

Publication number Publication date
DK309989A (da) 1989-12-24
HU214704B (hu) 2000-03-28
DE58906966D1 (de) 1994-03-24
IE892032L (en) 1989-12-23
DK309989D0 (da) 1989-06-22
CA1341211C (en) 2001-03-27
AU3671889A (en) 1990-01-04
NO892597D0 (no) 1989-06-22
PT90939A (pt) 1989-12-29
EP0347781B1 (de) 1994-02-16
AU611303B2 (en) 1991-06-06
DK175182B1 (da) 2004-06-28
FI893046L (fi) 1989-12-24
NZ229645A (en) 1991-02-26
PT90939B (pt) 1994-11-30
IL90694A (en) 1995-07-31
NO892597L (no) 1989-12-27
HK1006023A1 (en) 1999-02-05
IE62511B1 (en) 1995-02-08
KR0139629B1 (ko) 1998-07-01
NO302376B1 (no) 1998-02-23
FI893046A0 (fi) 1989-06-21
ZA894742B (en) 1990-03-28
FI102076B1 (fi) 1998-10-15
ATE101620T1 (de) 1994-03-15
EP0347781A2 (de) 1989-12-27
KR910000796A (ko) 1991-01-30
HUT52548A (en) 1990-07-28
HU211552A9 (en) 1995-12-28
EP0347781A3 (en) 1990-05-09
JPH0285298A (ja) 1990-03-26
IL90694A0 (en) 1990-01-18
FI102076B (fi) 1998-10-15
JP3043764B2 (ja) 2000-05-22

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