ES2117035T3 - Derivados antiproliferativos del 4-h-nafto(1,2-b)pirano. - Google Patents

Derivados antiproliferativos del 4-h-nafto(1,2-b)pirano.

Info

Publication number
ES2117035T3
ES2117035T3 ES92309169T ES92309169T ES2117035T3 ES 2117035 T3 ES2117035 T3 ES 2117035T3 ES 92309169 T ES92309169 T ES 92309169T ES 92309169 T ES92309169 T ES 92309169T ES 2117035 T3 ES2117035 T3 ES 2117035T3
Authority
ES
Spain
Prior art keywords
alkyl
carboxide
hydrogen
phenyl
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92309169T
Other languages
English (en)
Inventor
Colin Peter Dell
Colin William Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co Ltd
Eli Lilly and Co
Original Assignee
Eli Lilly and Co Ltd
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB919121358A external-priority patent/GB9121358D0/en
Priority claimed from GB929213058A external-priority patent/GB9213058D0/en
Application filed by Eli Lilly and Co Ltd, Eli Lilly and Co filed Critical Eli Lilly and Co Ltd
Application granted granted Critical
Publication of ES2117035T3 publication Critical patent/ES2117035T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Transplantation (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE PRESENTA UN COMPUESTO FARMACEUTICO DE LA FORMULA (I) EN LA CUAL N ES 0,1 O 2 Y R1 ESTA SUJETA A CUALQUIERA DE LAS POSICIONES 5, 6, 7, 8, 9 O 10, Y CADA R1 ES HALO, TRIFLUOROMETIL, ALCOXIDO C1-C4, HIDROXIDO, NITRO, ALQUIL C1-C4, ALQUILTIO C1-C4, HIDROXIALQUIL C1-C4, HIDROXIALCOXIDO C1-C4, TRIFLUOROMETIL, CARBOXIDO, -COOR5 EN DONDE R5 ES UN GRUPO ESTER, -CONR6R7 O NR6R7 DONDE R6V Y R7 SON CADA HIDROGENO O ALQUIL C1-C4; E2 ES FENIL, NAFTIL O HETEROARIL SELECCIONADO ENTRE TIENIL, PIRIDIL, BENZOTIENIL, QUINOLINIL, BENZOFURANGIL O BENZIMIDAZOLIL, DICHOS GRUPOS DE FENIL, NAFTIL Y HETEROARIL ESTAN OPCIONALMENTE SUBSTITUIDOS, O R2 ES FURANIL OPCIONALMENTE SUBSTITUIDO CON ALQUIL C1-C4; R3 ES NITRILO, CARBOXIDO, -COOR8 DONDE R8 ES UN GRUPO ESTER, -CONR9R10 DONDE R9 Y R10 SON CADA UNA HIDROGENO O ALQUIL C1-C4, O R11SO2TE SUBSTITUIDO; Y R4 ES -NR12R13, -NHCOR12, -N(COR12)2 O -N=CHOCH2R12 DONDE R12 Y R13 SON CADA UNA HIDROGENO O ALQUIL C1-C4 OPCIONALMENTE SUBSTITUIDO CON CARBOXIDO, O LA SIGUIENTE FORMULA EN DONDE X ES ALQUILENO C2-C4 O -NHSO2R14 DONDE R14 ES ALQUIL C1C4 O FENIL OPCIONALMENTE SUBSTITUIDO; CON LA CONDICION DE QUE CUANDO N ES 0, R3 ES NITRILO Y R4 ES -NH, R2 NO ES FENIL O FENIL SUBSTITUIDO EN LA POSICION PARA CON UN SUBSTITUYENTE SIMPLE DE CLORO, HIDROXIDO O METOXIDO. ASIMISMO SE PRESENTAN LAS SALES DE LOS COMPUESTOS.
ES92309169T 1991-10-09 1992-10-08 Derivados antiproliferativos del 4-h-nafto(1,2-b)pirano. Expired - Lifetime ES2117035T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919121358A GB9121358D0 (en) 1991-10-09 1991-10-09 Pharmaceutical compounds
GB929213058A GB9213058D0 (en) 1992-06-19 1992-06-19 Pharmaceutical compounds

Publications (1)

Publication Number Publication Date
ES2117035T3 true ES2117035T3 (es) 1998-08-01

Family

ID=26299655

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92309169T Expired - Lifetime ES2117035T3 (es) 1991-10-09 1992-10-08 Derivados antiproliferativos del 4-h-nafto(1,2-b)pirano.

Country Status (22)

Country Link
US (1) US5284868A (es)
EP (1) EP0537949B1 (es)
JP (1) JPH05194477A (es)
KR (1) KR100228841B1 (es)
CN (1) CN1034938C (es)
AT (1) ATE167859T1 (es)
AU (1) AU658003B2 (es)
CA (1) CA2079428A1 (es)
CZ (1) CZ281688B6 (es)
DE (1) DE69226060T2 (es)
DK (1) DK0537949T3 (es)
ES (1) ES2117035T3 (es)
FI (1) FI924551A7 (es)
HU (1) HU218916B (es)
IL (1) IL103356A (es)
MX (1) MX9205714A (es)
MY (1) MY111368A (es)
NO (1) NO301587B1 (es)
NZ (1) NZ244627A (es)
PH (1) PH30659A (es)
RU (1) RU2071472C1 (es)
TW (1) TW221292B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9203497D0 (en) * 1992-02-19 1992-04-08 Lilly Industries Ltd Pharmaceutical compounds
EP1004584A3 (en) * 1992-11-18 2000-07-05 Eli Lilly And Company Limited Pyranoquinoline derivatives as inhibitors of cell proliferation
GB9306062D0 (en) * 1993-03-24 1993-05-12 Lilly Industries Ltd Pharmaceutical compounds
EP0619314A1 (en) * 1993-04-09 1994-10-12 Eli Lilly And Company 4-Phenyl-4H- naphtho(2,1-b)pyran derivatives and their pharmaceutical use
WO1995008289A2 (en) * 1993-09-16 1995-03-30 Scimed Life Systems, Inc. Percutaneous repair of cardiovascular anomalies and repair compositions
US5407955A (en) * 1994-02-18 1995-04-18 Eli Lilly And Company Methods for lowering serum cholesterol and inhibiting smooth muscle cell proliferation, restenosis, endometriosis, and uterine fibroid disease
US5665591A (en) * 1994-12-06 1997-09-09 Trustees Of Boston University Regulation of smooth muscle cell proliferation
KR20000015944A (ko) 1996-05-24 2000-03-15 팜 윌리암 엔. 신체 통로의 질병을 치료 또는 예방하기 위한조성물 및 방법
IL119069A0 (en) 1996-08-14 1996-11-14 Mor Research Applic Ltd Pharmaceutical composition comprising tyrphostins
US7053117B2 (en) * 2001-05-16 2006-05-30 Cytovia, Inc. Substituted 4H-chromenes and analogs as activators of caspases and inducers of apoptosis and the use thereof
TR200401209T4 (tr) * 1999-11-05 2004-07-21 Cytovia, Inc. Kaspazların aktivatörleri ve apoptoz endüserleri olarak yer değiştiren 4H-kromen ve analogları ile bunların kullanımı
US6858607B1 (en) 2001-05-16 2005-02-22 Cytovia, Inc. 7,8-fused 4H-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof
WO2002092076A1 (en) * 2001-05-16 2002-11-21 Cytovia, Inc. Substituted coumarins and quinolines as caspases activators
AU2003230411A1 (en) * 2002-05-16 2003-12-02 Cytovia, Inc. Substituted 4-aryl-4h-pyrrolo(2,3-h)chromenes and analogs as activators of caspases and inducers of apoptosis and the use thereof
US7476741B2 (en) * 2002-05-16 2009-01-13 Cytovia, Inc. Substituted 4H-chromens, 2H-chromenes, chromans and analogs as activators of caspases and inducers of apoptosis and the use thereof
US20040127519A1 (en) * 2002-12-12 2004-07-01 Pharmacia Corporation Method of using aminocyanopyridine compounds as mitogen activated protein kinase-activated protein kinase-2 inhibitors
US20040127511A1 (en) * 2002-12-12 2004-07-01 Pharmacia Corporation Tricyclic aminocyanopyridine inhibitors of mitogen activated protein kinase-activated protein kinase-2
NZ553688A (en) * 2004-09-09 2011-05-27 Florey Howard Inst Enzyme inhibitors for the inhibition of insulin-regulated aminopeptidase
AU2006214892B2 (en) * 2005-02-16 2013-06-27 Kt & G Co., Ltd Pharmaceutical composition for the treatment or prevention of diseases involving obesity, diabetes, metabolic syndrome, neuro-degenerative diseases and mitochondria dysfunction diseases
US20080183282A1 (en) * 2006-03-09 2008-07-31 Saul Yedgar Use of lipid conjugates for the coating of stents and catheters
WO2009065169A1 (en) * 2007-11-19 2009-05-28 Howard Florey Institute Insulin-regulated aminopeptidase (irap) inhibitors and uses thereof
EA015364B1 (ru) * 2009-03-18 2011-06-30 Учреждение Российской Академии Наук Институт Элементоорганических Соединений Им. А.Н. Несмеянова Ран (Инэос Ран) 6,6'-диизопропил-8,8'-диметил-2,2'-динитро-3,3'-бис(трифторметил)- 3н,3'н-[9,9']ди[бензо(f)хроменил]-5,10,5',10'-тетраол, обладающий противоопухолевой и противогрибковой активностью, и способ его получения
US20130296344A1 (en) 2010-11-12 2013-11-07 Ruprecht-Karls-Universitat Heidelberg Chromene derivatives and their analoga as wnt pathway antagonists
CN104185631A (zh) * 2011-11-10 2014-12-03 纪念斯隆-凯特琳癌症中心 用2-氨基-4H-萘并[1,2-b]吡喃-3-甲腈治疗卵巢癌

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU724509A1 (ru) * 1978-09-21 1980-03-30 Пермский государственный фармацевтический институт Способ получени 2-ароил-3н- нафто 2,1-в пиранонов-3
EP0412160A4 (en) * 1988-04-14 1991-09-11 Yamanouchi Pharmaceutical Co. Ltd. Substance q-2819 and process for its preparation

Also Published As

Publication number Publication date
ATE167859T1 (de) 1998-07-15
FI924551A0 (fi) 1992-10-08
HU9203183D0 (en) 1992-12-28
NO301587B1 (no) 1997-11-17
KR100228841B1 (ko) 1999-11-01
IL103356A (en) 1998-02-22
DE69226060T2 (de) 1998-11-19
HU218916B (hu) 2000-12-28
RU2071472C1 (ru) 1997-01-10
JPH05194477A (ja) 1993-08-03
PH30659A (en) 1997-09-16
NO923910L (no) 1993-04-13
MX9205714A (es) 1993-04-01
EP0537949B1 (en) 1998-07-01
NO923910D0 (no) 1992-10-08
AU2621692A (en) 1993-04-22
NZ244627A (en) 1994-12-22
CZ281688B6 (cs) 1996-12-11
TW221292B (es) 1994-02-21
MY111368A (en) 1999-12-31
DE69226060D1 (de) 1998-08-06
EP0537949A1 (en) 1993-04-21
HUT62281A (en) 1993-04-28
AU658003B2 (en) 1995-03-30
CA2079428A1 (en) 1993-04-10
CN1034938C (zh) 1997-05-21
IL103356A0 (en) 1993-03-15
DK0537949T3 (da) 1999-02-15
FI924551A7 (fi) 1993-04-10
US5284868A (en) 1994-02-08
CN1073437A (zh) 1993-06-23
KR930007931A (ko) 1993-05-20
CZ303592A3 (en) 1993-12-15

Similar Documents

Publication Publication Date Title
ES2117035T3 (es) Derivados antiproliferativos del 4-h-nafto(1,2-b)pirano.
ECSP941102A (es) Pirazolopirimidinonas para el tratamiento de la impotencia
PA8450401A1 (es) Pirazolopirimidonas para la disfuncion sexual
CO5640136A2 (es) Derivados de hexahidropiridoisoquinolinas inhibidores de dpp-iv y composiciones farmaceuticas que los contienen
ES2188584T3 (es) Derivados heterociclicos de amina.
ES2182535T3 (es) Derivados de benzo(b)tiepina-1,-dioxido, procedimiento para su preparacion, medicamentos que contienen estos compuestos y su utilizacion.
ES2101223T3 (es) Composicion de aciete de refrigerador para refrigerante de fluoroalcano.
ES2079719T3 (es) Derivados de amidinofenilalanina, procedimiento para su preparacion, su utilizacion y agentes que los contienen en calidad de anticoagulantes.
ES2081302T3 (es) Aril- y heteroaril-piperazinil carboxamidas que tienen actividad sobre el sistema nervioso central.
MX9205817A (es) Derivados de benzodiazepina, procedimiento para supreparacion y medicamentos que los contienen
AR006793A1 (es) Compuestos pirazol o sus sales y herbicidas conteniendo los mismos
ES2059804T3 (es) Procedimiento de preparacion de eteres de oxima de propenona.
ES2133544T3 (es) Derivados de indazol.
ES2065755T3 (es) Derivados de 3-aminopiridacinas activos sobre el sistema nervioso central.
ZA936658B (en) Benzopyran compounds process for their preparation and the pharmaceutical compositions which contain them
ES2004985A6 (es) Procedimiento de preparacion de 1-4aminofenil-4-metil-7,8-metilendioxi-3,4-dihidro-5h-2,3-benzodiazepina y sus sales de adicion acidas
ES2117097T3 (es) Derivados de 4h-nafto(1,2-b)piranos como agentes antiproliferativos.
ES2056073T3 (es) Aril-aralquil-eteres, procedimientos para su preparacion y composicion farmaceutica que los comprende.
MX9203360A (es) Derivados de hexahidroazepinas y composiciones farmaceuticas que los contienen.
ES2063117T3 (es) Derivados del tieno(2,3-d)acepina, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
ES2125963T3 (es) Nuevos derivados espiranicos del 3-amino-cromano, sus procedimientos de preparacion y las composiciones farmaceuticas que los contienen.
ES2055717T3 (es) Derivados de benzo- y tieno-3,4-dihidro-piridina, procedimientos para su preparacion y medicamentos que contienen estos compuestos.
ES2136614T3 (es) Derivados de 1,4-dihidropiridina, su procedimiento de preparacion y composicion terapeutica que los contiene.
ES2061530T3 (es) 9-amino-1,4-etano-1,2,3,4-tetrahidroacridina y compuestos afines, intermediarios y un procedimiento para la preparacion de los mismos y su uso como medicamentos.
ES2054729T3 (es) Derivados de pirrolidina.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 537949

Country of ref document: ES