ES2117551B1 - Quinolinas naftalenicas con accion antagonista de los leucotrienos, procedimiento para su preparacion y utilizacion de las mismas. - Google Patents

Quinolinas naftalenicas con accion antagonista de los leucotrienos, procedimiento para su preparacion y utilizacion de las mismas.

Info

Publication number
ES2117551B1
ES2117551B1 ES9502547A ES9502547A ES2117551B1 ES 2117551 B1 ES2117551 B1 ES 2117551B1 ES 9502547 A ES9502547 A ES 9502547A ES 9502547 A ES9502547 A ES 9502547A ES 2117551 B1 ES2117551 B1 ES 2117551B1
Authority
ES
Spain
Prior art keywords
hydrogen
leukotrenees
quinolins
alkyl
naphthalenic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES9502547A
Other languages
English (en)
Other versions
ES2117551A1 (es
Inventor
Casellas David Mauleon
Avellana Jaime Pascual
Perez M Luisa Garcia
Benet Albert Palomer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Menarini SA
Original Assignee
Laboratorios Menarini SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Menarini SA filed Critical Laboratorios Menarini SA
Priority to ES9502547A priority Critical patent/ES2117551B1/es
Priority to PCT/EP1996/005811 priority patent/WO1997024331A1/en
Priority to AU13783/97A priority patent/AU1378397A/en
Priority to EP96944059A priority patent/EP0874826A1/en
Publication of ES2117551A1 publication Critical patent/ES2117551A1/es
Application granted granted Critical
Publication of ES2117551B1 publication Critical patent/ES2117551B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/10—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms
    • C07C17/14—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms in the side-chain of aromatic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/54—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

QUINOLINAS NAFTALENICAS CON ACCION ANTAGONISTA DE LOS LEUCOTRIENOS, PROCEDIMIENTO PARA SU PREPARACION Y UTILIZACION DE LAS MISMAS. NUEVAS QUINOLINAS I EL SUSTITUYENTE QUE CONTIENE A ESTA UNIDO A LA POSICION 6 O 7 DEL SISTEMA 2-NAFTOLICO; R1, R2, R6 SON HIDROGENO, FLUOR, CLORO, BROMO, -OCH3 O (C1-C4)-ALQUILO; R3 ES HIDROGENO O METILO; R4, R5 SON HIDROGENO, -OH, -NH2 (C1-C4)-ALQUILCARBONILAMINO (C1-C4)-ALCOXICARBONILALQUILO, CARBAMOILO, CARBAMOILALQUILO, N,N-DIALQUILCARBAMOILALQUILO; -A- ES UN BIRRADICAL -O-, -S-, SO2-, -SO-, -SO2NR7- O -NR7SO2-, R7 ES HIDROGENO O UN (C1-C4)-ALQUILO; B ES OXIGENO O AZUFRE O -SO2- O UN ENLACE SENCILLO; D ES UN GRUPO 5-TETRAZOLILO O -COOR8-, DONDE R8 ES HIDROGENO, UN (C1-C4)-ALQUILO O UN GRUPO FENILALQUILO DE MENOS DE 10 ATOMOS DE CARBONO; M ES UN ENTERO 0-4; N Y P SON 0-6, SIENDO N+P MENOR O IGUAL A 6. PRESENTAN ACCION ANTAGONISTA DE LOS LEUCOTRIENOS.
ES9502547A 1995-12-29 1995-12-29 Quinolinas naftalenicas con accion antagonista de los leucotrienos, procedimiento para su preparacion y utilizacion de las mismas. Expired - Fee Related ES2117551B1 (es)

Priority Applications (4)

Application Number Priority Date Filing Date Title
ES9502547A ES2117551B1 (es) 1995-12-29 1995-12-29 Quinolinas naftalenicas con accion antagonista de los leucotrienos, procedimiento para su preparacion y utilizacion de las mismas.
PCT/EP1996/005811 WO1997024331A1 (en) 1995-12-29 1996-12-23 Naphthalene quinolines having leukotriene-antagonistic action
AU13783/97A AU1378397A (en) 1995-12-29 1996-12-23 Naphthalene quinolines having leukotriene-antagonistic action
EP96944059A EP0874826A1 (en) 1995-12-29 1996-12-23 Naphthalene quinolines having leukotriene-antagonistic action

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9502547A ES2117551B1 (es) 1995-12-29 1995-12-29 Quinolinas naftalenicas con accion antagonista de los leucotrienos, procedimiento para su preparacion y utilizacion de las mismas.

Publications (2)

Publication Number Publication Date
ES2117551A1 ES2117551A1 (es) 1998-08-01
ES2117551B1 true ES2117551B1 (es) 1999-04-01

Family

ID=8292586

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9502547A Expired - Fee Related ES2117551B1 (es) 1995-12-29 1995-12-29 Quinolinas naftalenicas con accion antagonista de los leucotrienos, procedimiento para su preparacion y utilizacion de las mismas.

Country Status (4)

Country Link
EP (1) EP0874826A1 (es)
AU (1) AU1378397A (es)
ES (1) ES2117551B1 (es)
WO (1) WO1997024331A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1177176E (pt) 1999-04-28 2006-08-31 Aventis Pharma Gmbh Derivados de acidos triarilicos como ligandos de receptores ppar.

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5084575A (en) * 1987-07-31 1992-01-28 American Home Products Corporation Quinoline substituted naphthalenepropionic acid derivatives as anti-inflammatory/antiallergic agents
US4920130A (en) * 1987-11-02 1990-04-24 Rorer Pharamceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
US4920132A (en) * 1987-11-03 1990-04-24 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
US4920131A (en) * 1987-11-03 1990-04-24 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
GB8728051D0 (en) * 1987-12-01 1988-01-06 Leo Pharm Prod Ltd Chemical compounds
ES2103181B1 (es) * 1994-08-01 1998-04-01 Menarini Lab Amidas naftalenicas con accion antagonista de los leucotrienos.
ES2103180B1 (es) * 1994-08-01 1998-04-01 Menarini Lab Fenilacetamidas con accion antagonista de los leucotrienos.

Also Published As

Publication number Publication date
ES2117551A1 (es) 1998-08-01
WO1997024331A1 (en) 1997-07-10
AU1378397A (en) 1997-07-28
EP0874826A1 (en) 1998-11-04

Similar Documents

Publication Publication Date Title
ES2065175T3 (es) Derivados de 1-azabiciclo(3.2.2)nonan-3-amina.
ES2101223T3 (es) Composicion de aciete de refrigerador para refrigerante de fluoroalcano.
CO4520187A1 (es) Tienil- y furanil-oxazolidinonas piridocondensadas
PE20001551A1 (es) Derivados de eter biarilico como inhibidores de la recaptacion de monoaminas para el tratamiento de trastornos del snc
YU74792A (sh) Herbicidi
ES2036551T3 (es) Compuestos heterociclicos.
ES2185636T3 (es) Derivados de isoxazol y su utilizacion como herbicidas.
ES2014034B3 (es) 11-beta-(4-isopropenilfenil)-estra-4,9-dienos, su obtencion y preparaciones farmaceuticas que los contienen.
ES2031513T3 (es) Quinazolindionas y piridopirimidinadionas.
AU540766B2 (en) Nonapeptide and decapeptide analogs of lhrh
YU6992A (sh) Novi herbicidi
ES2184858T3 (es) Cetoenoles alquil-dihalogenofenil substituidos como pesticidas y herbicidas.
ES2183905T3 (es) Inhibidores de metaloproteasa de matriz.
ES2136209T3 (es) Nuevos nitronilfenoles estericamente impedidos utiles como captadores de radicales libres.
ES2099528T3 (es) Utilizacion de polisiloxanos con modificacion organofuncional, para desespumar carburante diesel.
EA199900756A1 (ru) Замещенные изохинолины в качестве нервно-мышечных блокаторов ультракраткосрочного действия
ES2139933T3 (es) 2,3-dihidro-1-(2,2,2-trifluoroetil)-2-oxo-5-fenil-1h-1,4-benzodiacepinas.
ES2087477T3 (es) Derivados de pirimidina-4-carboxamida, su preparacion y su aplicacion en terapeutica.
AR005672A1 (es) Derivados de la distamicina, proceso para prepararlos, y su utilizacion como agentes antitumorales y antivirales.
AR245713A1 (es) Derivados de acido 1-heterociclil-1h-imidazol-5-carboxilico, procedimiento para su produccion y composiciones herbicidas que los comprenden.
ES2110086T3 (es) Indoles sustituidos como antagonistas de la angiotensina ii.
ES2066057T3 (es) Compuestos de organosilano.
CO4370018A1 (es) Derivados de naftaleno, metodo de preparacion y uso
ES2140181T3 (es) Androstenonas.
FI820199L (fi) Imidazodiazepiner

Legal Events

Date Code Title Description
EC2A Search report published

Date of ref document: 19980801

Kind code of ref document: A1

Effective date: 19980801

FD1A Patent lapsed

Effective date: 20051230