ES2118151T3 - Derivados de pirazolo(3,4-a)acridina como analgesicos. - Google Patents
Derivados de pirazolo(3,4-a)acridina como analgesicos.Info
- Publication number
- ES2118151T3 ES2118151T3 ES93103604T ES93103604T ES2118151T3 ES 2118151 T3 ES2118151 T3 ES 2118151T3 ES 93103604 T ES93103604 T ES 93103604T ES 93103604 T ES93103604 T ES 93103604T ES 2118151 T3 ES2118151 T3 ES 2118151T3
- Authority
- ES
- Spain
- Prior art keywords
- hydrogen
- loweralkyl
- aryl
- arylloweralkyl
- integer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- DZBUGLKDJFMEHC-UHFFFAOYSA-N acridine Chemical compound C1=CC=CC2=CC3=CC=CC=C3N=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-N 0.000 title 2
- 229940035676 analgesics Drugs 0.000 title 1
- 239000000730 antalgic agent Substances 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 7
- 239000001257 hydrogen Substances 0.000 abstract 7
- 150000002431 hydrogen Chemical group 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000003226 pyrazolyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A COMPUESTOS QUE TIENEN LA FORMULA I DONDE, X ES HIDROGENO, ALQUILO INFERIOR, ALCOXI INFERIOR, HALOGENO O TRIFLUOROMETILO; R1 ES HIDROGENO O -NR4R5, DONDE CADA R4 Y R5 SON, INDEPENDIENTEMENTE, HIDROGENO, ALQUILO INFERIOR O ARILALQUILO INFERIOR; R2, QUE ES UN SUSTITUYENTE EN UNO DE LOS DOS ATOMOS DE NITROGENO DEL ANILLO DE PIRAZOL, ES HIDROGENO, ALQUILO INFERIOR, ALQUENILO INFERIOR, ARILO, ARILALQUILO INFERIOR, CIANOALQUILO INFERIOR, CMH2MCOOR6, -NR7R8, -CNH2NNR7R8 O -N=CH-ARILO, R6 ES HIDROGENO O ALQUILO INFERIOR, M ES UN ENTERO DE 1 A 3, CADA R7 Y R8 ES, INDEPENDIENTEMENTE, HIDROGENO O ALQUILO INFERIOR Y N ES UN ENTERO DE 2 A 4; Y R3 ES HIDROGENO O -CHOH-ARILO; O A LAS SALES DE ADICION ACIDAS FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS Y A UN PROCESO PARA SU PREPARACION. LOS COMPUESTOS MUESTRAN ACTIVIDAD ANALGESICA Y, POR TANTO, SE PUEDEN UTILIZAR COMO MEDICAMENTOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/848,558 US5179100A (en) | 1992-03-09 | 1992-03-09 | 4,5-dihydropyrazolo[3,4-a]acridines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2118151T3 true ES2118151T3 (es) | 1998-09-16 |
Family
ID=25303626
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES93103604T Expired - Lifetime ES2118151T3 (es) | 1992-03-09 | 1993-03-05 | Derivados de pirazolo(3,4-a)acridina como analgesicos. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5179100A (es) |
| EP (1) | EP0560231B1 (es) |
| JP (1) | JP2656201B2 (es) |
| AT (1) | ATE166874T1 (es) |
| DE (1) | DE69318869T2 (es) |
| DK (1) | DK0560231T3 (es) |
| ES (1) | ES2118151T3 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5179100A (en) * | 1992-03-09 | 1993-01-12 | Hoechst-Roussel Pharmaceuticals Inc. | 4,5-dihydropyrazolo[3,4-a]acridines |
| US5428040A (en) * | 1993-08-31 | 1995-06-27 | The Du Pont Merck Pharmaceutical Company | Carbocyclic fused-ring quinolinecarboxylic acids useful as immunosuppressive agents |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4999430A (en) * | 1989-07-31 | 1991-03-12 | Warner-Lambert Company | Derivatives of 1,2,3,4-tetrahydro-9-acrisinamine |
| US5179100A (en) * | 1992-03-09 | 1993-01-12 | Hoechst-Roussel Pharmaceuticals Inc. | 4,5-dihydropyrazolo[3,4-a]acridines |
-
1992
- 1992-03-09 US US07/848,558 patent/US5179100A/en not_active Expired - Lifetime
-
1993
- 1993-03-05 EP EP93103604A patent/EP0560231B1/en not_active Expired - Lifetime
- 1993-03-05 AT AT93103604T patent/ATE166874T1/de not_active IP Right Cessation
- 1993-03-05 ES ES93103604T patent/ES2118151T3/es not_active Expired - Lifetime
- 1993-03-05 DK DK93103604T patent/DK0560231T3/da active
- 1993-03-05 DE DE69318869T patent/DE69318869T2/de not_active Expired - Fee Related
- 1993-03-08 JP JP5046183A patent/JP2656201B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69318869D1 (de) | 1998-07-09 |
| EP0560231B1 (en) | 1998-06-03 |
| JPH0649067A (ja) | 1994-02-22 |
| DK0560231T3 (da) | 1999-03-22 |
| DE69318869T2 (de) | 1998-11-12 |
| US5179100A (en) | 1993-01-12 |
| EP0560231A1 (en) | 1993-09-15 |
| JP2656201B2 (ja) | 1997-09-24 |
| ATE166874T1 (de) | 1998-06-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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