ES2124257T3 - Composicion, metodo y equipo para la estimulacion de la actividad antitumoral y para el tratamiento de tumores. - Google Patents

Composicion, metodo y equipo para la estimulacion de la actividad antitumoral y para el tratamiento de tumores.

Info

Publication number
ES2124257T3
ES2124257T3 ES92910345T ES92910345T ES2124257T3 ES 2124257 T3 ES2124257 T3 ES 2124257T3 ES 92910345 T ES92910345 T ES 92910345T ES 92910345 T ES92910345 T ES 92910345T ES 2124257 T3 ES2124257 T3 ES 2124257T3
Authority
ES
Spain
Prior art keywords
composition
equipment
tumor activity
tumors
stimulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92910345T
Other languages
English (en)
Other versions
ES2124257T4 (es
Inventor
Tetsuhiko Shirasaka
Masakazu Fukushima
Hideyuki Ohshimo
Yuji Shimamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taiho Pharmaceutical Co Ltd
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Publication of ES2124257T3 publication Critical patent/ES2124257T3/es
Application granted granted Critical
Publication of ES2124257T4 publication Critical patent/ES2124257T4/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

SE PRESENTA UNA COMPOSICION PARA POTENCIAR LA ACTIVIDAD ANTITUMORAL DEL TEGAFUR Y REDUCIR LOS SUS EFECTOS ADVERSOS, LA COMPOSICION COMPRENDE UN COMPUESTO REPRESENTADO POR LA FORMULA GENERAL (I) EN LA QUE X REPRESENTA HALOGENO O CIANO Y ACIDO OXONICO O UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO, ASI COMO UN METODO Y UN EQUIPO PARA EL USO DEL COMPUESTO, ASIMISMO SE PRESENTA UNA COMPOSICION PARA CURAR TUMORES QUE COMPRENDE TEGAFUR, UN COMPUESTO REPRESENTADO POR LA FORMULA (I) Y UN ACIDO OXONICO O UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO; ASI COMO UN METODO Y UN EQUIPO PARA LOS MISMOS.
ES92910345T 1991-05-27 1992-05-22 Composición, método y equipo para la estimulación de la actividad antitumoral y para el tratamiento de tumores. Expired - Lifetime ES2124257T4 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP12124791 1991-05-27
JP121247/91 1991-05-27
PCT/JP1992/000656 WO1992021345A1 (en) 1991-05-27 1992-05-22 Composition, method and kit for potentiating antitumor activity and for curing tumor

Publications (2)

Publication Number Publication Date
ES2124257T3 true ES2124257T3 (es) 1999-02-01
ES2124257T4 ES2124257T4 (es) 2012-03-23

Family

ID=14806544

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92910345T Expired - Lifetime ES2124257T4 (es) 1991-05-27 1992-05-22 Composición, método y equipo para la estimulación de la actividad antitumoral y para el tratamiento de tumores.

Country Status (14)

Country Link
US (1) US5525603A (es)
EP (1) EP0543015B1 (es)
JP (1) JP2614164B2 (es)
KR (1) KR0148589B1 (es)
AT (1) ATE173165T1 (es)
AU (1) AU654555B2 (es)
CA (1) CA2087540C (es)
DE (2) DE69227571T2 (es)
DK (1) DK0543015T3 (es)
ES (1) ES2124257T4 (es)
HU (1) HU211987A9 (es)
LU (1) LU91852I2 (es)
TW (1) TW209833B (es)
WO (1) WO1992021345A1 (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5719132A (en) * 1996-06-27 1998-02-17 Bristol-Myers Squibb Company Compositions and methods of treating HIV with d4T, 5-fluorouracil/tegafur, and uracil
NZ330360A (en) * 1997-06-02 1999-03-29 Hoffmann La Roche 5'-deoxy-cytidine derivatives, their manufacture and use as antitumoral agents
JPH11116564A (ja) * 1997-10-09 1999-04-27 Otsuka Chem Co Ltd クロモン誘導体
US6005098A (en) * 1998-02-06 1999-12-21 Hoffmann-La Roche Inc. 5'deoxycytidine derivatives
US6538001B1 (en) * 1998-10-12 2003-03-25 Nikolai Borisovich Leonidov Crystalline modification of 5-fluoro-1-(tetrahydro-2-furyl) uracil and complex compounds based thereon, producing antineoplastic effect
JP2002255828A (ja) * 2001-02-28 2002-09-11 Ajinomoto Co Inc 抗腫瘍剤
MXPA04006822A (es) 2002-01-14 2004-12-08 Novartis Ag Combinaciones que comprenden epotilonas y anti-metabolitos.
CN1761665A (zh) * 2003-03-14 2006-04-19 大鹏药品工业株式会社 抗肿瘤效果增强剂和抗肿瘤剂
ATE540679T1 (de) * 2004-04-29 2012-01-15 Taiho Pharmaceutical Co Ltd Verfahren zur verringerung der gastrointestinalen toxizität durch verabreichung von tegafur
KR100844477B1 (ko) 2004-06-09 2008-07-07 다이호야쿠힌고교 가부시키가이샤 항종양 효과 증강제, 항종양제 및 암 치료 방법
CN101155600B (zh) * 2005-04-01 2011-05-04 大鹏药品工业株式会社 放射线治疗增强剂
JP4994618B2 (ja) * 2005-08-11 2012-08-08 学校法人北里研究所 Ｔｓ−１／カンプトテシン類による化学放射線療法
US8198264B2 (en) * 2006-04-28 2012-06-12 National Cancer Center Method for treating head and neck cancer
CN101921227B (zh) * 2007-04-03 2012-09-05 南京工业大学 5-氯-4-羟基-2(1h)-吡啶酮晶型及其制备方法和应用
TWI468188B (zh) 2008-01-30 2015-01-11 Univ Tokushima Anti-cancer effect enhancers consisting of oxaliplatin liposomal preparations and anticancer agents comprising the formulation
WO2009139085A1 (ja) 2008-05-12 2009-11-19 静岡県 抗腫瘍剤、キット及び癌治療方法
US8598188B2 (en) 2009-03-12 2013-12-03 Kinki University Method for predicting therapeutic efficacy of chemotherapy on non-small-cell lung cancer
PT2415870T (pt) 2009-03-31 2016-10-25 Delta-Fly Pharma Inc Molécula de arni para timidilato sintase e utilização da mesma
TW201043237A (en) 2009-04-22 2010-12-16 Taiho Pharmaceutical Co Ltd Method for predicting a therapeutic effect of the chemotherapy for renal cell cancer
CA2761243A1 (en) 2009-05-12 2010-11-18 Taiho Pharmaceutical Co., Ltd. Anti-tumor agent containing tegafur-gimeracil-oteracil potassium combination drug and oxaliplatin
DK2495243T3 (en) 2009-10-27 2017-03-27 Delta-Fly Pharma Inc NEW 5-FLUOROURACIL DERIVATE
CN102309491B (zh) * 2010-07-02 2015-06-10 天津金耀集团有限公司 一种替加氟、吉美斯特复方注射液
EP2671590A4 (en) 2011-01-31 2014-09-03 Taiho Pharmaceutical Co Ltd TEGA-SAFE COMPOSITION FOR UNIQUE OR MULTIPLE DAILY DOSAGE
WO2012157647A1 (ja) 2011-05-16 2012-11-22 大鵬薬品工業株式会社 胃癌患者に対するテガフール・ギメラシル・オテラシルカリウム配合剤及びｅｇｆｒ阻害剤からなる化学療法の選択方法
MX353289B (es) 2011-05-25 2018-01-05 Taiho Pharmaceutical Co Ltd Tableta revestida en seco que contiene tegafur, gimeracil y oteracil potasico.
CN103159673B (zh) * 2011-12-12 2015-02-04 山东新时代药业有限公司 一种制备吉美嘧啶的精制方法
JPWO2013137433A1 (ja) 2012-03-16 2015-08-03 大鵬薬品工業株式会社 ３剤を組み合わせた新規な抗腫瘍剤
WO2013180274A1 (ja) * 2012-06-01 2013-12-05 大鵬薬品工業株式会社 胃癌患者に対する化学療法の選択方法
CN114436822B (zh) * 2022-01-12 2024-04-16 厦门稀土材料研究所 一枝蒿酮酸和生物碱复盐及其制备方法和用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55111420A (en) * 1979-02-20 1980-08-28 Ono Pharmaceut Co Ltd Antitumorigenic agent
JPS562913A (en) * 1979-06-21 1981-01-13 Ono Pharmaceut Co Ltd Antitumor agent
JPS5646867A (en) * 1979-09-25 1981-04-28 Ono Pharmaceut Co Ltd Pyridone derivative, its preparation and antineoplasmic agent
DK175432B1 (da) * 1984-10-30 2004-10-18 Otsuka Pharma Co Ltd Middel til forögelse af anticancervirkningen af anticancerforbindelser
JPS62155215A (ja) * 1984-11-30 1987-07-10 Otsuka Pharmaceut Co Ltd 抗腫瘍活性増強剤
NL194430C (nl) * 1989-01-05 2002-04-04 Otsuka Pharma Co Ltd Niet-injecteerbaar farmaceutisch preparaat met anti-kankerwerking.
JPH0578249A (ja) * 1991-09-20 1993-03-30 Taiho Yakuhin Kogyo Kk ５−フルオロウラシル類により起こる嘔気・嘔吐の防止及び治療剤

Also Published As

Publication number Publication date
EP0543015A1 (en) 1993-05-26
EP0543015A4 (en) 1994-06-01
DK0543015T3 (da) 1999-07-26
DE122011100040I2 (de) 2012-08-09
US5525603A (en) 1996-06-11
AU1791292A (en) 1993-01-08
ES2124257T4 (es) 2012-03-23
CA2087540A1 (en) 1992-11-28
DE69227571D1 (de) 1998-12-17
CA2087540C (en) 1999-01-19
WO1992021345A1 (en) 1992-12-10
EP0543015B1 (en) 1998-11-11
ATE173165T1 (de) 1998-11-15
DE69227571T2 (de) 1999-04-29
DE122011100040I1 (de) 2011-11-24
JP2614164B2 (ja) 1997-05-28
HU211987A9 (en) 1996-01-29
KR0148589B1 (ko) 1998-11-02
LU91852I2 (fr) 2011-10-03
TW209833B (es) 1993-07-21
AU654555B2 (en) 1994-11-10

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