ES2055037T3 - Derivados de 4-amino-3-acil-quinolina y su uso como inhibidores de la secrecion de acido gastrico. - Google Patents

Derivados de 4-amino-3-acil-quinolina y su uso como inhibidores de la secrecion de acido gastrico.

Info

Publication number
ES2055037T3
ES2055037T3 ES89301804T ES89301804T ES2055037T3 ES 2055037 T3 ES2055037 T3 ES 2055037T3 ES 89301804 T ES89301804 T ES 89301804T ES 89301804 T ES89301804 T ES 89301804T ES 2055037 T3 ES2055037 T3 ES 2055037T3
Authority
ES
Spain
Prior art keywords
alcoxi
alkyl
amino
gastric acid
acid secretion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89301804T
Other languages
English (en)
Inventor
Robert John Ife
Thomas Henry Brown
Colin Andrew Leach
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Intercredit BV
Original Assignee
SmithKline Beecham Intercredit BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Intercredit BV filed Critical SmithKline Beecham Intercredit BV
Application granted granted Critical
Publication of ES2055037T3 publication Critical patent/ES2055037T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

COMPUESTOS DE LA FORMULA(I) N LA QYE R ES H, ALQUILO C1 - 6, ALCOXI C1 - 6, ALCOXI - C1 - 6 - ALQUILO, CICLOALQUILO C3 - 6, CICLOALQUIL C3 - 6 ALQUILO C1 - 6, FENILO, FENILO C1 - 6 ALQUILO, LOS GRUPOS FENILO ESTAN OPCIONALMENTE SUSTITUIDOS; R2 ES H, ALQUILO C1 - 6, ALCOXI C1 6, AMINO, ALQUILTIO C1 - 6, HALOGENO, CIANO, HIDROXI, CARBAMOILO, CARBOXI, ALCANOILO C1 - 6, TRIFLUOROMETILO; M ES 1,2 O 3; P ES DE 0 A 4; R3 ES HIDROXI C1 - 6 ALQUILO, POLIHIDROXI C1 - 6 ALQUILO, ALCOXI C1 - 6 ALQUILO C1 - 6, HIDROXI C1 - 6 ALCOXI, POLIHIDROXI C1 - 6 ALCOXI, ALCOXI C1 - 6 ALCOXI C1 - 6, O HIDROXI C1 - 6 ALCOXI C1 - 6 ALCOXI; Y R4 ES H, ALQUILO C1 - 6, O ALCOXI C1 - 6, PROCESOS PARA SU PREPARACION, INTERMEDIARIOS UTILES EN SU PREPARACION, COMPUESTOS FARMACEUTICOS QUE LOS CONTIENEN Y SU USO EN TERAPIA COMO INHIBIDORES D SECRECION DE ACIDO GASTRICO.
ES89301804T 1988-02-25 1989-02-23 Derivados de 4-amino-3-acil-quinolina y su uso como inhibidores de la secrecion de acido gastrico. Expired - Lifetime ES2055037T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888804444A GB8804444D0 (en) 1988-02-25 1988-02-25 Compounds

Publications (1)

Publication Number Publication Date
ES2055037T3 true ES2055037T3 (es) 1994-08-16

Family

ID=10632376

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89301804T Expired - Lifetime ES2055037T3 (es) 1988-02-25 1989-02-23 Derivados de 4-amino-3-acil-quinolina y su uso como inhibidores de la secrecion de acido gastrico.

Country Status (22)

Country Link
US (1) US5089504A (es)
EP (1) EP0330485B1 (es)
JP (1) JPH0774204B2 (es)
KR (1) KR0159083B1 (es)
CN (2) CN1027368C (es)
AU (1) AU606508B2 (es)
CA (1) CA1332839C (es)
CZ (1) CZ398391A3 (es)
DE (1) DE68906687T2 (es)
DK (1) DK166623B1 (es)
ES (1) ES2055037T3 (es)
FI (1) FI93952C (es)
GB (1) GB8804444D0 (es)
HU (1) HU208814B (es)
IE (1) IE63239B1 (es)
IL (1) IL89346A (es)
MY (1) MY105158A (es)
NZ (1) NZ228098A (es)
PT (1) PT89789B (es)
WO (1) WO1989008104A1 (es)
ZA (1) ZA891402B (es)
ZW (1) ZW1989A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8918265D0 (en) * 1989-08-10 1989-09-20 Smithkline Beckman Intercredit Compounds
KR920701162A (ko) * 1990-03-28 1992-08-11 오츠카 아끼히코 퀴놀린 유도체, 당해 유도체를 함유하는 항궤양제 및 당해 유도체의 제조방법
WO1992012969A1 (en) * 1991-01-29 1992-08-06 Smithkline Beecham Intercredit B.V. Salts of a 4-amino-3-acyl quinoline derivative and their use as inhibitors of gastric acid secretion
GB9126438D0 (en) * 1991-12-12 1992-02-12 Smithkline Beecham Intercredit New quinoline derivatives
US5362743A (en) * 1993-03-09 1994-11-08 Pfizer Inc. Aminoquinoline derivatives
SE9302005D0 (sv) 1993-06-11 1993-06-11 Ab Astra New active compounds
IS4164A (is) * 1993-06-11 1994-12-12 Ab Astra Efnasambönd sem hindra flæði magasýru
US5556863A (en) * 1993-06-11 1996-09-17 Astra Aktiebolag Compound for gastric acid secretion inhibition
US6479514B1 (en) 1998-05-23 2002-11-12 Altana Pharma Ag Quinoline-aminomethyl-pyridyl derivatives with anti-helicobacter activity
US6852739B1 (en) 1999-02-26 2005-02-08 Nitromed Inc. Methods using proton pump inhibitors and nitric oxide donors
HN2000000203A (es) 1999-11-30 2001-06-13 Pfizer Prod Inc Procedimiento para la obtencion de 1,2,3,4-tetrahidroquinolinas 4-carboxiamino-2- sustituidas.
UA80393C2 (uk) 2000-12-07 2007-09-25 Алтана Фарма Аг Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці
EP1453493A2 (en) * 2001-11-19 2004-09-08 ALTANA Pharma AG Reversible proton pump inhibitors for the treatment of airway disorders
MY140561A (en) 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
WO2004012659A2 (en) 2002-08-01 2004-02-12 Nitromed, Inc. Nitrosated proton pump inhibitors, compositions and methods of use
PT1606261E (pt) 2003-03-10 2010-01-11 Nycomed Gmbh Novo processo para a preparação de roflumilast
EP1682133A1 (en) 2003-11-03 2006-07-26 AstraZeneca AB Imidazo 1,2-a pyridine derivatives for the treatment of silent gastro-esophageal reflux
US8663694B2 (en) * 2005-03-16 2014-03-04 Takeda Gmbh Taste masked dosage form containing roflumilast
CN106496119A (zh) * 2016-10-17 2017-03-15 江南大学 一种n‑苯基‑8‑氨基喹啉的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2652398A (en) * 1949-11-17 1953-09-15 Endo Products Inc N-substituted-2-amino (methyl) quinolines
US3470186A (en) * 1967-06-02 1969-09-30 American Cyanamid Co Substituted 4-anilino-3-quinolinecarboxylic acids and esters
CA942748A (en) * 1970-09-18 1974-02-26 Venkatachala L. Narayanan 1-aziridinylcarbonyl substituted-3-quinolinecarboxylic acid compounds
ZA801526B (en) * 1979-03-26 1981-08-26 Robins Co Inc A H 4-amino-3-quinolinecarboxylic acids and esters-antisecretory, anti-ulcer compounds
US4343804A (en) * 1979-03-26 1982-08-10 A. H. Robins Company, Inc. 4-Amino-3-quinolinecarboxylic acids and esters-antisecretory anti-ulcer compounds
GB8621425D0 (en) * 1986-09-05 1986-10-15 Smith Kline French Lab Compounds
GB8804443D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
GB8804446D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
GB8804445D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds

Also Published As

Publication number Publication date
DE68906687T2 (de) 1993-12-02
HU208814B (en) 1994-01-28
ZA891402B (en) 1990-09-26
DE68906687D1 (de) 1993-07-01
DK528889A (da) 1989-10-24
FI93952B (fi) 1995-03-15
NZ228098A (en) 1990-10-26
AU606508B2 (en) 1991-02-07
EP0330485A1 (en) 1989-08-30
MY105158A (en) 1994-08-30
CZ398391A3 (en) 1994-05-18
ZW1989A1 (en) 1989-09-13
JPH0774204B2 (ja) 1995-08-09
EP0330485B1 (en) 1993-05-26
IE890568L (en) 1989-08-25
WO1989008104A1 (en) 1989-09-08
CN1100414A (zh) 1995-03-22
PT89789A (pt) 1989-10-04
CA1332839C (en) 1994-11-01
JPH02503318A (ja) 1990-10-11
DK528889D0 (da) 1989-10-24
HU891463D0 (en) 1990-01-28
US5089504A (en) 1992-02-18
FI895048A0 (fi) 1989-10-24
IL89346A (en) 1994-01-25
IE63239B1 (en) 1995-04-05
FI93952C (fi) 1995-06-26
KR900700457A (ko) 1990-08-13
DK166623B1 (da) 1993-06-21
CN1027368C (zh) 1995-01-11
GB8804444D0 (en) 1988-03-23
CN1035501A (zh) 1989-09-13
KR0159083B1 (ko) 1998-12-01
AU3181989A (en) 1989-09-22
HUT53086A (en) 1990-09-28
PT89789B (pt) 1994-05-31

Similar Documents

Publication Publication Date Title
ES2055037T3 (es) Derivados de 4-amino-3-acil-quinolina y su uso como inhibidores de la secrecion de acido gastrico.
MX9203550A (es) Derivados de 4-aminoquinolina y su uso como medicamentos.
ES2058527T3 (es) Derivados de pirimidina condensados procedimiento y compuestos intermedios para su preparacion y composiciones farmaceuticas que los contienen.
ATE108763T1 (de) Neue benzocyclohepten-derivate, deren herstellung und verwendung für pharmazeutika.
ES8306373A1 (es) "procedimiento para la preparacion de 9-(2-(3-indolil)-etil)-1-oxa-4,9-diazaspiro (5.5) undecan-3-onas".
PT76450A (de) Spiro/4.(3+n)-2-aza-3-carbonsaeure-derivate verfahren zu ihrer herstellung diese enthaltende mittel und ihre verwendung
ES2124257T3 (es) Composicion, metodo y equipo para la estimulacion de la actividad antitumoral y para el tratamiento de tumores.
ES8801277A1 (es) Procedimiento para preparar (1,2,4) triazolo (1,5-c) quinazolinas
NO160516C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive, nye diazabicyclo-(3,3,1)-nonaner.
FI895046A0 (fi) 4-amino-3-acylkinolinderivat samt deras anvaendning saosom inhibitorer av sekretion av matsmaeltningsvaetskor.
PT83535B (pt) Processo para a preparacao de composicoes farmaceuticas contendo derivados de aminoacidos
ATE6778T1 (de) Chinazolinderivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen.
AU6216886A (en) Substituted 2-cyano-2-phenyl ethyl-amine
ES2111871T3 (es) Nuevos derivados de aminoacidos, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.
ES2016464A6 (es) Procedimiento para preparar derivados de 2', 5' -oligoadenilato.
NO840526L (no) Derivater av n-iminopyridiniumbetainer, fremgangsmaate til deres fremstilling og deres anvendelse i medikamenter
ES2061532T3 (es) Derivados sustituidos de acido piridina-2,4-dicarboxilico, procedimientos para su preparacion, utilizacion de los mismos, asi como medicamentos a base de estos compuestos.
NO167286C (no) Fremgangsmaate for fremstilling av terapeutisk aktive benzotiazepin-derivater.
FI864970A0 (fi) Nya kristallina salter av aryloxi-propanolaminer, foerfarande foer deras framstaellning och deras anvaendning.
ES8500924A1 (es) Procedimiento para la preparacion de derivados de acido fenilacetico
MX9303392A (es) Derivados de imidazo benzoxazin-1-ona substituidos y proceso para su preparacion.
ES8605247A1 (es) Procedimiento para la obtencion de arisulfonilguanidinas sustituidas
ES8505357A1 (es) Un procedimiento para la preparacion de derivados de carboxi-tiazolo (3,2-a) pirimidina nuevos
ES2003758A6 (es) Procedimiento para preparar nuevos derivados de acidos fenilaceticos
ES2031552T3 (es) 2-selenometil-1,4-dihidropiridinas, un procedimiento para su preparacion y composiciones farmaceuticas que los contienen.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 330485

Country of ref document: ES