ES2125320T3 - Cis-oxalato(trans-l-1,2-ciclohexandiamina)pt(ii) opticamente puro y procedimiento para resolver isomeros opticos de un compuesto de complejo de platino. - Google Patents

Cis-oxalato(trans-l-1,2-ciclohexandiamina)pt(ii) opticamente puro y procedimiento para resolver isomeros opticos de un compuesto de complejo de platino.

Info

Publication number
ES2125320T3
ES2125320T3 ES93830160T ES93830160T ES2125320T3 ES 2125320 T3 ES2125320 T3 ES 2125320T3 ES 93830160 T ES93830160 T ES 93830160T ES 93830160 T ES93830160 T ES 93830160T ES 2125320 T3 ES2125320 T3 ES 2125320T3
Authority
ES
Spain
Prior art keywords
cyclohexandiamine
oxalate
cis
trans
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93830160T
Other languages
English (en)
Inventor
Takeshi Tozawa
Yasunobu Komoda
Junji Ohnishi
Yukie Masuda
Junichi Taniuchi
Chihiro Nakanishi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanaka Kikinzoku Kogyo KK
Original Assignee
Tanaka Kikinzoku Kogyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26356339&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2125320(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from JP5019508A external-priority patent/JP2673331B2/ja
Application filed by Tanaka Kikinzoku Kogyo KK filed Critical Tanaka Kikinzoku Kogyo KK
Application granted granted Critical
Publication of ES2125320T3 publication Critical patent/ES2125320T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)

Abstract

UN PROCESO PARA SEPARAR UN COMPUESTO OPTICAMENTE COMPLEJO DE PLATINO ACTIVO OPTICAMENTE, QUE CONSISTE EN UNA MEZCLA DE UN D QUIDA DE ALTO RENDIMIENTO UTILIZANDO UNA COLUMNA CON UN RELLENO DE KIRAL. EL RELLENO DE KIRAL PUEDE SER, POR EJEMPLO, UN DERIVADO DE ESTER DE CELULOSA, UN DERIVADO DE CARBAMATO DE CELULOSA, UN DERIVADO DE CARBAMATO DE AMILOSA, UN ESTER DE ACIDO POLIMETACRILICO Y CICLODEXTRINA BETA Y GAMMA. UN CIX ANS SEPARADO DE UN D CONTRADO QUE ES MARCADAMENTE EFECTIVO COMO MATERIA PRIMA PARA PREPARAR UN AGENTE CARCINOESTATICO. LA TOTAL PUREZA OPTICA DEL COMPUESTO SE REFLEJA EN QUE SU PUNTO DE FUSION ES MAS BAJO, EN COMPARACION CON EL DE UNA SUBSTANCIA IMPURA.
ES93830160T 1992-04-22 1993-04-09 Cis-oxalato(trans-l-1,2-ciclohexandiamina)pt(ii) opticamente puro y procedimiento para resolver isomeros opticos de un compuesto de complejo de platino. Expired - Lifetime ES2125320T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP4129668A JPH06287021A (ja) 1992-04-22 1992-04-22 光学活性な白金錯化合物の光学的分割方法
JP5019508A JP2673331B2 (ja) 1993-01-12 1993-01-12 光学的に高純度なシス―オキザラート（トランス―１―１，２―シクロヘキサンジアミン）白金（▲ｉｉ▼）

Publications (1)

Publication Number Publication Date
ES2125320T3 true ES2125320T3 (es) 1999-03-01

Family

ID=26356339

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93830160T Expired - Lifetime ES2125320T3 (es) 1992-04-22 1993-04-09 Cis-oxalato(trans-l-1,2-ciclohexandiamina)pt(ii) opticamente puro y procedimiento para resolver isomeros opticos de un compuesto de complejo de platino.

Country Status (5)

Country Link
US (1) US5298642A (es)
EP (1) EP0567438B1 (es)
JP (1) JPH06287021A (es)
DE (1) DE69322992C5 (es)
ES (1) ES2125320T3 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2183714A1 (es) * 2001-05-25 2003-03-16 Desynth S A Un procedimiento para la fabricacion de oxalato de (1r,2r-ciclohexanodiamina)-platino (ii).

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3025602B2 (ja) * 1993-05-21 2000-03-27 デビオファーム エス．アー． 光学的に高純度なシス−オキザラート（トランス−ｌ−１，２−シクロヘキサンジアミン）白金（ＩＩ）錯体の製造方法
JPH09278785A (ja) * 1996-04-10 1997-10-28 Tanaka Kikinzoku Kogyo Kk 白金化合物の製造方法
JP3154399B2 (ja) * 1996-07-04 2001-04-09 デビオファーム エス．アー． 白金化合物の製造方法
DK0801070T3 (da) * 1996-04-10 2003-05-19 Debiopharm Sa Fremgangsmåde til fremstilling af platinforbindelse
GB9804013D0 (en) * 1998-02-25 1998-04-22 Sanofi Sa Formulations
AUPR330201A0 (en) 2001-02-23 2001-03-22 University Of Sydney, The Metal complexes and therapeutic uses thereof
US20040186172A1 (en) * 2001-07-02 2004-09-23 Houssam Ibrahim Oxaliplatin active substance with a very low content of oxalic acid
US6476068B1 (en) 2001-12-06 2002-11-05 Pharmacia Italia, S.P.A. Platinum derivative pharmaceutical formulations
EP2330110A1 (en) 2003-11-25 2011-06-08 Platco Technologies (Proprietary) Limited Platinum(II) complexes, preparation and use
DE102004005906B3 (de) * 2004-02-05 2005-09-29 W.C. Heraeus Gmbh Verfahren zur Herstellung von 1,2-Diaminocylohexan-Platin(II)-Komplexen
EP1749015B1 (en) 2004-02-05 2014-04-02 Fresenius Kabi Oncology Ltd. A process for the preparation of an anti-tumor platinum(ii)-complex
EP1658300A1 (en) * 2004-07-12 2006-05-24 Sicor Inc. Cis-diiodo- (trans-l-1,2-cyclohexanediamine) platinum (ii) complex and processes for preparing high purity oxaliplatin
JP2006248978A (ja) * 2005-03-10 2006-09-21 Mebiopharm Co Ltd 新規なリポソーム製剤
US7956208B2 (en) 2006-01-30 2011-06-07 Platco Technologies (Proprietary) Limited Preparation of platinum (II) complexes
WO2009093133A1 (en) * 2008-01-25 2009-07-30 Medichem, S.A. Method for determining the enantiomeric purity of indane derivatives

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6041077B2 (ja) * 1976-09-06 1985-09-13 喜徳 喜谷 １，２‐ジアミノシクロヘキサン異性体のシス白金（２）錯体
JPS6034958B2 (ja) * 1978-09-02 1985-08-12 喜徳 喜谷 新規白金錯体
AU538863B2 (en) * 1980-05-27 1984-08-30 Bristol-Myers Company Platinum complex salts have anti-tumor property
JPS595198A (ja) * 1982-06-30 1984-01-12 Seiwa Kasei Kk 光学分割剤、その合成法およびそれを使用した光学分割方法
IL74449A (en) * 1984-03-01 1988-07-31 Us Commerce Tetrahalo-1,2-cyclohexane-diamino platinum complexes and anti-neoplastic compositions comprising them
US4550187A (en) * 1984-04-12 1985-10-29 The Research Foundation Of State University Of New York Synthesis of platinum (IV) antineoplastic agents
JPS61122283A (ja) * 1984-11-20 1986-06-10 Daicel Chem Ind Ltd グリセリン誘導体の光学分割方法
US4737589A (en) * 1985-08-27 1988-04-12 Nippon Kayaku Kabushiki Kaisha Platinum Complexes
JPS62277147A (ja) * 1986-05-23 1987-12-02 Matsushita Electric Works Ltd 薄膜の製法
CS269719B1 (en) * 1986-12-29 1990-05-14 Kiss Frantisek Platinum cytostatic
JPS63203692A (ja) * 1987-02-19 1988-08-23 Nippon Kayaku Co Ltd 新規白金錯体
JP2896589B2 (ja) * 1990-03-12 1999-05-31 チッソ株式会社 光学異性体分離剤

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2183714A1 (es) * 2001-05-25 2003-03-16 Desynth S A Un procedimiento para la fabricacion de oxalato de (1r,2r-ciclohexanodiamina)-platino (ii).

Also Published As

Publication number Publication date
DE69322992D1 (de) 1999-02-25
US5298642A (en) 1994-03-29
DE69322992T2 (de) 1999-05-27
JPH06287021A (ja) 1994-10-11
EP0567438A1 (en) 1993-10-27
DE69322992C5 (de) 2009-08-13
EP0567438B1 (en) 1999-01-13

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