KR900000077A - 일정 수분을 함유하는 서방형 제제 - Google Patents

일정 수분을 함유하는 서방형 제제 Download PDF

Info

Publication number
KR900000077A
KR900000077A KR1019890007506A KR890007506A KR900000077A KR 900000077 A KR900000077 A KR 900000077A KR 1019890007506 A KR1019890007506 A KR 1019890007506A KR 890007506 A KR890007506 A KR 890007506A KR 900000077 A KR900000077 A KR 900000077A
Authority
KR
South Korea
Prior art keywords
weight
formulation
alcohol
formulation according
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
KR1019890007506A
Other languages
English (en)
Other versions
KR0136279B1 (ko
Inventor
하필드 쟌느
토마스 레스러 스튜워트
떼레즈 안뜨와네트 말코와스카 산드라
존 닐 필립
Original Assignee
에프.샤레
유로셀티크 소시에떼 아노님
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 에프.샤레, 유로셀티크 소시에떼 아노님 filed Critical 에프.샤레
Publication of KR900000077A publication Critical patent/KR900000077A/ko
Application granted granted Critical
Publication of KR0136279B1 publication Critical patent/KR0136279B1/ko
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

내용 없음

Description

일정수분을 함유하는 서방형 제제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (11)

  1. 3알킬크산틴, 적어도 하나의 친수성 또는 소수성 중합체, 융점이 25~90℃인 적어도 하나의 왁스와 2-10중량%, 바람직하게는 4-9중량%의 물을 포함함을 특징으로 하는 서방형 경구용 고형제제.
  2. 제1항에 있어서, 수분의 함량은 제제의 중량에 대하여 4-8%, 바람직하게는 5-7%임을 특징으로 하는 제제.
  3. 제1항 또는 제2항의 어느한항에 있어서, 3-알킬크산틴은 1,3-디메틸크산틴, 바람직하게는 테오필린임을 특징으로 하는 제제.
  4. 제3항에 있어서, 테오필린은 제제중에 40-85중량%, 바람직하게는 50-80중량%포함함을 특징으로 하는 제제.
  5. 제1항 내지 제4항의 어느한항에 있어서, 적어도 하나의 친수성 또는 소수성 중합체를 1-20중량%, 바람직하게는 2-12중량%포함함을 특징으로 하는 제제.
  6. 제1항 내지 제5항의 어느한항에 있어서, 적어도 하나의 친수성 또는 소수성 중합체는 셀룰로오즈에테르, 바람직하게는 하이드록시 알킬셀룰로오즈에테르 또는 카르복시알킬셀룰로오즈임을 특징으로 하는 제제.
  7. 제6항에 있어서, 셀룰로오즈에테르는 하이드록시 프로필 셀룰로오즈, 하이드록시 메틸셀룰로오즈 또는 하이드록시 에틸 셀룰로오즈, 바람직하게는 하이드록시 에틸 셀룰로오즈임을 특징으로 하는 제제.
  8. 제1항 내지 제7항의 어느한항에 있어서, 제제중 적어도 하나의 왁스는 4-40중량%, 바람직하게는 8-36중량%포함함을 특징으로 하는 제제.
  9. 제1항 내지 제8항의 어느한항에 있어서, 적어도 하나의 왁수는 폴릴알킬글리콜, 지방산, 지방산 에스테르 또는 지방족 알코올로 바람직하게는 C12-C36지방족 알코올임을 특징으로 하는 제제.
  10. 제9항에 있어서, 지방족 알코올은 C14-C22지방족 알코올, 바람직하게는 미리스틸알코올, 스테아릴알코올, 세틸알코올 또는 세토스테아릴 알코올, 특히 바람직하게는 세틸알코올이나 세토스테아릴 알코올임을 특징으로 하는 방법.
  11. 제1항 내지 제10항중 어느한항에 있어서, 제형에 정제임을 특징으로 하는 제제.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890007506A 1988-06-02 1989-06-01 일정수분을 함유하는 서방형 제제 Expired - Lifetime KR0136279B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8813064 1988-06-02
GB888813064A GB8813064D0 (en) 1988-06-02 1988-06-02 Controlled release dosage forms having defined water content

Publications (2)

Publication Number Publication Date
KR900000077A true KR900000077A (ko) 1990-01-30
KR0136279B1 KR0136279B1 (ko) 1998-04-25

Family

ID=10637952

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890007506A Expired - Lifetime KR0136279B1 (ko) 1988-06-02 1989-06-01 일정수분을 함유하는 서방형 제제

Country Status (19)

Country Link
US (1) US5091189A (ko)
EP (1) EP0344960B1 (ko)
JP (1) JPH0816060B2 (ko)
KR (1) KR0136279B1 (ko)
AT (1) ATE83925T1 (ko)
AU (1) AU610401B2 (ko)
CA (1) CA1323834C (ko)
DE (1) DE68904119T2 (ko)
DK (1) DK175130B1 (ko)
ES (1) ES2053989T3 (ko)
FI (1) FI93695C (ko)
GB (2) GB8813064D0 (ko)
GR (1) GR3007088T3 (ko)
IE (1) IE61998B1 (ko)
IL (1) IL90462A (ko)
NO (1) NO176232C (ko)
NZ (1) NZ229372A (ko)
PT (1) PT90722B (ko)
ZA (1) ZA894201B (ko)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5912268A (en) * 1995-05-22 1999-06-15 Alza Corporation Dosage form and method for treating incontinence
US6262115B1 (en) * 1995-05-22 2001-07-17 Alza Coporation Method for the management of incontinence
TR200001942T2 (tr) 1997-12-22 2000-11-21 Euro-Celtique, S.A. Opioid agonist/antagonist kombinasyonlar
CN1204890C (zh) * 1997-12-22 2005-06-08 欧罗赛铁克股份有限公司 防止阿片样物质滥用的方法
WO2000030446A1 (en) 1998-11-23 2000-06-02 Bonnie Davis Dosage formulations for acetylcholinesterase inhibitors
SI2283842T1 (sl) * 2000-02-08 2015-07-31 Euro-Celtique S.A. Oralne formulacije opioidnih agonistov, varne pred zlorabo
EP1387673B1 (en) 2001-05-11 2010-12-29 Endo Pharmaceuticals Inc. Abuse-resistant controlled-release opioid dosage form
US7052706B2 (en) * 2001-06-08 2006-05-30 Nostrum Pharmaceuticals, Inc. Control release formulation containing a hydrophobic material as the sustained release agent
DK1416842T3 (da) * 2001-07-18 2009-03-16 Euro Celtique Sa Farmaceutiske kombinationer af oxycodon og naloxon
US20030157168A1 (en) * 2001-08-06 2003-08-21 Christopher Breder Sequestered antagonist formulations
ES2326794T3 (es) 2001-08-06 2009-10-20 Euro-Celtique S.A. Formulaciones de agonistas opioides con antagonista liberable y secuestrado.
US20030044458A1 (en) * 2001-08-06 2003-03-06 Curtis Wright Oral dosage form comprising a therapeutic agent and an adverse-effect agent
IN192180B (ko) * 2001-09-28 2004-03-06 Ranbaxy Lab
PT1485078E (pt) * 2002-03-15 2013-01-14 Cypress Bioscience Inc Milnacipran para o tratamento do síndrome do intestino irritável
LT2425821T (lt) 2002-04-05 2017-07-25 Euro-Celtique S.A. Farmacinis preparatas, turintis oksikodono ir naloksono
SI1551372T1 (en) 2002-09-20 2018-08-31 Alpharma Pharmaceuticals Llc SUBVENCATION DATA AND RELATED CONSTRUCTIONS AND PROCEDURES
US20060003004A1 (en) * 2002-10-25 2006-01-05 Collegium Pharmaceutical, Inc. Pulsatile release compositions of milnacipran
US20040132826A1 (en) * 2002-10-25 2004-07-08 Collegium Pharmaceutical, Inc. Modified release compositions of milnacipran
AU2004207578B2 (en) * 2003-01-28 2007-06-28 Collegium Pharmaceutical, Inc. Multiparticulate compositions of milnacipran for oral administration
US20040202717A1 (en) * 2003-04-08 2004-10-14 Mehta Atul M. Abuse-resistant oral dosage forms and method of use thereof
TWI347201B (en) 2003-04-21 2011-08-21 Euro Celtique Sa Pharmaceutical products,uses thereof and methods for preparing the same
EP1604666A1 (en) * 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD)
EP2039349A1 (en) * 2004-10-19 2009-03-25 KRKA, tovarna zdravil, d.d., Novo mesto Solid pharmaceutical composition comprising donepezil hydrochloride
EP1702558A1 (en) * 2005-02-28 2006-09-20 Euro-Celtique S.A. Method and device for the assessment of bowel function
ZA200802602B (en) * 2005-08-24 2009-10-28 Rubicon Res Pvt Ltd Controlled release formulation
SI2484346T1 (sl) 2006-06-19 2017-05-31 Alpharma Pharmaceuticals Llc Farmacevtski sestavki
BRPI0717149B1 (pt) * 2006-09-29 2016-02-16 Procter & Gamble composição oral contendo redes de gel e processo para o preparo da mesma.
US8623418B2 (en) * 2007-12-17 2014-01-07 Alpharma Pharmaceuticals Llc Pharmaceutical composition
US20100151014A1 (en) * 2008-12-16 2010-06-17 Alpharma Pharmaceuticals, Llc Pharmaceutical composition
US20100266645A1 (en) * 2007-12-17 2010-10-21 Alfred Liang Pharmaceutical compositions
SI2317991T1 (sl) * 2008-07-07 2017-09-29 Euro-Celtique S.A. Uporaba opioidnih antagonistov za zdravljenje retencije urina
PL2405915T3 (pl) 2009-03-10 2019-05-31 Euro Celtique Sa Kompozycje farmaceutyczne o natychmiastowym uwalnianiu zawierające oksykodon i nalokson
KR20160034352A (ko) 2013-07-23 2016-03-29 유로-셀티큐 에스.에이. 장내 세균총이상을 초래하고/하거나 장내 박테리아 전위에 대한 위험을 증가시키는 질환과 통증으로 인해 고통받고 있는 환자에서 통증을 치료하는데 사용하기 위한 옥시코돈과 날록손의 조합물
CN114053235B (zh) * 2020-08-07 2023-07-18 广州白云山光华制药股份有限公司 茶碱缓释片及其制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3965256A (en) * 1972-05-16 1976-06-22 Synergistics Slow release pharmaceutical compositions
US4443428A (en) * 1982-06-21 1984-04-17 Euroceltique, S.A. Extended action controlled release compositions
FR2535202B1 (fr) * 1982-11-03 1985-08-09 Fabre Sa Pierre Comprimes de theophylline a liberation controlee et leur procede de fabrication
US4743247A (en) * 1984-08-13 1988-05-10 Alza Corporation Process for manufacturing dosage form
US4753800A (en) * 1985-10-04 1988-06-28 Warner-Lambert Company Medicament adsorbates and their preparation
US4892742A (en) * 1985-11-18 1990-01-09 Hoffmann-La Roche Inc. Controlled release compositions with zero order release
GB8613688D0 (en) * 1986-06-05 1986-07-09 Euro Celtique Sa Pharmaceutical composition
ES2058111T3 (es) * 1986-06-10 1994-11-01 Euro Celtique Sa Composicion de liberacion controlada de dihidrocodeina.
GB8626098D0 (en) * 1986-10-31 1986-12-03 Euro Celtique Sa Controlled release hydromorphone composition
GB8628728D0 (en) * 1986-12-02 1987-01-07 Euro Celtique Sa Spheroids

Also Published As

Publication number Publication date
IE61998B1 (en) 1994-12-14
NO176232B (no) 1994-11-21
DK266889A (da) 1989-12-03
GB8911629D0 (en) 1989-07-05
EP0344960A3 (en) 1990-03-07
FI93695C (fi) 1995-05-26
IE891744L (en) 1989-12-02
IL90462A0 (en) 1990-01-18
DE68904119D1 (de) 1993-02-11
EP0344960A2 (en) 1989-12-06
AU610401B2 (en) 1991-05-16
NO176232C (no) 1995-03-01
ES2053989T3 (es) 1994-08-01
KR0136279B1 (ko) 1998-04-25
ZA894201B (en) 1990-03-28
NZ229372A (en) 1991-07-26
IL90462A (en) 1993-01-31
FI892664A0 (fi) 1989-06-01
ATE83925T1 (de) 1993-01-15
PT90722B (pt) 1994-11-30
DE68904119T2 (de) 1993-06-09
GB2219207B (en) 1992-01-02
GB2219207A (en) 1989-12-06
FI892664L (fi) 1989-12-03
NO892229D0 (no) 1989-06-01
NO892229L (no) 1989-12-04
DK266889D0 (da) 1989-06-01
US5091189A (en) 1992-02-25
CA1323834C (en) 1993-11-02
GB8813064D0 (en) 1988-07-06
FI93695B (fi) 1995-02-15
DK175130B1 (da) 2004-06-14
JPH0816060B2 (ja) 1996-02-21
AU3512789A (en) 1989-12-07
JPH0225420A (ja) 1990-01-26
PT90722A (pt) 1989-12-29
GR3007088T3 (ko) 1993-07-30
EP0344960B1 (en) 1992-12-30

Similar Documents

Publication Publication Date Title
YU47258B (sh) Postupak za dobijanje čvrstog preparata sa produženim oslobadjanjem aktivnog jedinjenja
KR880000089A (ko) 서방형 약제 조성물
ATE307569T1 (de) Gelierbare pharmazeutische zusammensetzungen
PT786986E (pt) Formulacoes farmaceuticas
SE8504580L (sv) Bladliknande preparat
DK456985D0 (da) Forbedret vehikel for afgivelse af aktive farmaceutiske ingredienser til human hud
KR890017292A (ko) 광개시제 분산액
ES2038643T3 (es) Procedimiento para la obtencion de una composicion farmaceutica topica.
KR950010875A (ko) 피부외용제
ES462418A1 (es) Un procedimiento para la preparacion de composiciones biolo-gicamente activas.
DE69022314D1 (de) Stabile emulgierte Tretinoin-Cremeformulierungen.
FI935051A0 (fi) Lanolinderivat som penetrationfraemjande aemnen och anvaendning av dessa i preparat innehaollande laekemedel eller andra biologiskt aktiva substanser
ES8400028A1 (es) Metodo de preparacion de una composicion tixotropica anhidra.
KR870007699A (ko) 약용과 화장용으로 대표적으로 사용되는 제제형의 즉석제조용 조성물
JPS57126414A (en) Ointment
EP0211555A3 (en) Transparent silicone compositions
FR2449686B1 (fr) Nouvel ester de l'acide 1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetique et sa preparation, ainsi que medicament le comprenant et sa preparation
JPS5750914A (en) Betamethasone external pharmaceutical
ES2102013T3 (es) Procedimiento para la obtencion de alquil- y/o alquenil-oligoglucosidos.
NO912890L (no) Preparat inneholdende salicylsyre for behandling av hudsykdommer med avskalling.
KR890006209A (ko) 분말형 메이크업화장의 분사식 고정제 조성물
JPS5679626A (en) Semi-solid medicine
KR920007620A (ko) 실리마린 및 약학 또는 화장품조성물의 용해방법
KR930700158A (ko) 피부 자극 완화 조성물 및 이것을 함유하는 경피외용제
SE8401748D0 (sv) Antimykotiskt medel i form av krem med hoggradig frigoring av verksam substans

Legal Events

Date Code Title Description
PA0109 Patent application

Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19890601

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 19940523

Comment text: Request for Examination of Application

Patent event code: PA02011R01I

Patent event date: 19890601

Comment text: Patent Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 19970818

Patent event code: PE09021S01D

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 19971030

GRNT Written decision to grant
PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 19980121

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 19980121

End annual number: 3

Start annual number: 1

PG1601 Publication of registration
PR1001 Payment of annual fee

Payment date: 20001229

Start annual number: 4

End annual number: 4

PR1001 Payment of annual fee

Payment date: 20011222

Start annual number: 5

End annual number: 5

PR1001 Payment of annual fee

Payment date: 20021218

Start annual number: 6

End annual number: 6

PR1001 Payment of annual fee

Payment date: 20031219

Start annual number: 7

End annual number: 7

PR1001 Payment of annual fee

Payment date: 20041221

Start annual number: 8

End annual number: 8

PR1001 Payment of annual fee

Payment date: 20051226

Start annual number: 9

End annual number: 9

PR1001 Payment of annual fee

Payment date: 20061219

Start annual number: 10

End annual number: 10

PR1001 Payment of annual fee

Payment date: 20080103

Start annual number: 11

End annual number: 11

PR1001 Payment of annual fee

Payment date: 20090105

Start annual number: 12

End annual number: 12

PR1001 Payment of annual fee

Payment date: 20100112

Start annual number: 13

End annual number: 13

PR1001 Payment of annual fee

Payment date: 20110118

Start annual number: 14

End annual number: 14

FPAY Annual fee payment

Payment date: 20120117

Year of fee payment: 15

PR1001 Payment of annual fee

Payment date: 20120117

Start annual number: 15

End annual number: 15

EXPY Expiration of term
PC1801 Expiration of term

Termination date: 20131009

Termination category: Expiration of duration