ES2126232T3 - Derivados del acido 8-oxo-5,8-dihidro-6h-dibenzo(a,g)quinolicina-13-propanoico como ligantes de los receptores benzodiacepinicos asociados a los receptores gabaa. - Google Patents

Derivados del acido 8-oxo-5,8-dihidro-6h-dibenzo(a,g)quinolicina-13-propanoico como ligantes de los receptores benzodiacepinicos asociados a los receptores gabaa.

Info

Publication number
ES2126232T3
ES2126232T3 ES95402841T ES95402841T ES2126232T3 ES 2126232 T3 ES2126232 T3 ES 2126232T3 ES 95402841 T ES95402841 T ES 95402841T ES 95402841 T ES95402841 T ES 95402841T ES 2126232 T3 ES2126232 T3 ES 2126232T3
Authority
ES
Spain
Prior art keywords
sub
receptors
group
quinolicina
propanoico
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95402841T
Other languages
English (en)
Inventor
Beno T Marabout
Mireille Sevrin
Jacques Froissant
Emmanuelle Dachary
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Application granted granted Critical
Publication of ES2126232T3 publication Critical patent/ES2126232T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Addiction (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

COMPUESTOS DE FORMULA GENERAL (I) EN LA QUE X REPRESENTA UN ATOMO DE HIDROGENO O DE HALOGENO O UN GRUPO ALQUILO, ALCOXI O TRIFLUORMETILO, Y REPRESENTA UN ATOMO DE HIDROGENO O DE HALOGENO O UN GRUPO ALQUILO O ALCOXI, R REPRESENTA UN GRUPO HIDROXI O METOXI O UN GRUPO DE FORMULA GENERAL NR{SUB,2}R{SUB,3} EN LA QUE R{SUB,2} Y R{SUB,3} REPRESENTAN CADA UNO UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO, 2-METOXIETILO, 2-AMINOETILO, 3-AMINOPROPILO, 2-(DIMETILAMINO)ETILO, 3-(DIMETILAMINO)PROPILO O 2-PIPERIDIN-1ILETILO, O TAMBIEN R{SUB,2} Y R{SUB,3} FORMAN JUNTOS UN CICLO MORFOLINILO, PIRRODINILO O PIPERAZINILO EVENTUALMENTE SUSTITUIDOS EN 4. LOS COMPUESTOS DE LA INVENCION PUEDEN TAMBIEN SER UTILIZADOS EN EL TRATAMIENTO DE LAS AFECCIONES UNIDAS A LOS TRASTORNOS DE LA TRANSMISION GABAERGICA DE LOS RECEPTORES GABA{SUB,A}.
ES95402841T 1994-12-29 1995-12-18 Derivados del acido 8-oxo-5,8-dihidro-6h-dibenzo(a,g)quinolicina-13-propanoico como ligantes de los receptores benzodiacepinicos asociados a los receptores gabaa. Expired - Lifetime ES2126232T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9415836A FR2728902B1 (fr) 1994-12-29 1994-12-29 Derives d'acide 8-oxo-5,8-dihydro-6h-dibenzo(a,g)quinolizine-13-propanoique, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
ES2126232T3 true ES2126232T3 (es) 1999-03-16

Family

ID=9470389

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95402841T Expired - Lifetime ES2126232T3 (es) 1994-12-29 1995-12-18 Derivados del acido 8-oxo-5,8-dihidro-6h-dibenzo(a,g)quinolicina-13-propanoico como ligantes de los receptores benzodiacepinicos asociados a los receptores gabaa.

Country Status (26)

Country Link
US (1) US5614517A (es)
EP (1) EP0719776B1 (es)
JP (1) JPH08239383A (es)
KR (1) KR960022518A (es)
CN (1) CN1058009C (es)
AR (1) AR002015A1 (es)
AT (1) ATE172973T1 (es)
AU (1) AU697988B2 (es)
BR (1) BR9506105A (es)
CA (1) CA2166233A1 (es)
CO (1) CO4700297A1 (es)
CZ (1) CZ348895A3 (es)
DE (1) DE69505781T2 (es)
DK (1) DK0719776T3 (es)
ES (1) ES2126232T3 (es)
FI (1) FI956299A7 (es)
FR (1) FR2728902B1 (es)
HU (1) HU215393B (es)
IL (1) IL116596A (es)
NO (1) NO305084B1 (es)
NZ (1) NZ280766A (es)
PL (1) PL181811B1 (es)
RU (1) RU2155764C2 (es)
SK (1) SK280546B6 (es)
TW (1) TW385311B (es)
ZA (1) ZA9511035B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2806723B1 (fr) * 2000-03-23 2002-05-10 Sanofi Synthelabo DERIVES D'ACIDE 8-OXO-5,8-DIHYDRO-6H-DIBENZO [a,g] QUINOLIZINE-13-PROPANOIQUE , LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
US6686352B2 (en) * 2001-05-18 2004-02-03 Hoffmann-La Roche Inc. Substituted imidazo [1,5-a] pyrimido [5,4-d] [1] benzazepine derivatives
CN104127414B (zh) * 2013-05-03 2018-04-13 中国科学院上海药物研究所 一种六氢二苯并[a,g]喹嗪类化合物的药物用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4013616A (en) * 1971-11-22 1977-03-22 Wallace Richard A Mixed polymeric structural material and method
FR2537583B1 (fr) * 1982-12-14 1985-08-09 Urpha Enantiomeres levogyres des derives de la tetrahydro-5, 6, 13, 13a 8h-dibenzo (a,g-) quinolizine, procedes d'obtention, compositions pharmaceutiques les contenant et application
GB8429710D0 (en) * 1984-11-23 1985-01-03 Fujisawa Pharmaceutical Co Pharmaceutical composition
JPS61130289A (ja) * 1984-11-29 1986-06-18 Ss Pharmaceut Co Ltd １３−プロピルベルベリンの塩
HU195505B (en) * 1985-05-24 1988-05-30 Chinoin Gyogyszer Es Vegyeszet Process for producing 7,8-methylendioxy-14-hydroxy-berban derivatives and pharmaceuticals comprising the same

Also Published As

Publication number Publication date
AU697988B2 (en) 1998-10-22
EP0719776A1 (fr) 1996-07-03
JPH08239383A (ja) 1996-09-17
EP0719776B1 (fr) 1998-11-04
TW385311B (en) 2000-03-21
FI956299L (fi) 1996-06-30
DE69505781D1 (de) 1998-12-10
HU9503846D0 (en) 1996-02-28
DK0719776T3 (da) 1999-07-19
RU2155764C2 (ru) 2000-09-10
CZ348895A3 (en) 1996-07-17
FI956299A7 (fi) 1996-06-30
FI956299A0 (fi) 1995-12-28
IL116596A0 (en) 1996-03-31
DE69505781T2 (de) 1999-06-17
FR2728902B1 (fr) 1997-01-31
PL312080A1 (en) 1996-07-08
SK280546B6 (sk) 2000-03-13
US5614517A (en) 1997-03-25
HU215393B (hu) 1998-12-28
NO955325D0 (no) 1995-12-28
NO305084B1 (no) 1999-03-29
HUT74186A (en) 1996-11-28
CO4700297A1 (es) 1998-12-29
NO955325L (no) 1996-07-01
KR960022518A (ko) 1996-07-18
FR2728902A1 (fr) 1996-07-05
NZ280766A (en) 1996-09-25
AR002015A1 (es) 1998-01-07
IL116596A (en) 1998-10-30
BR9506105A (pt) 1997-12-23
AU4070895A (en) 1996-07-04
SK165895A3 (en) 1996-07-03
CA2166233A1 (en) 1996-06-30
ZA9511035B (en) 1996-07-01
CN1058009C (zh) 2000-11-01
CN1131154A (zh) 1996-09-18
ATE172973T1 (de) 1998-11-15
PL181811B1 (pl) 2001-09-28

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