ATE172973T1 - 8-oxo-5,8-dihydro-6h-dibenzo(a,g>chinolizin-13- propansäure-derivate als liganden der mit gabaa rezeptoren verbundenen benzodiazepine rezeptoren - Google Patents

8-oxo-5,8-dihydro-6h-dibenzo(a,g>chinolizin-13- propansäure-derivate als liganden der mit gabaa rezeptoren verbundenen benzodiazepine rezeptoren

Info

Publication number
ATE172973T1
ATE172973T1 AT95402841T AT95402841T ATE172973T1 AT E172973 T1 ATE172973 T1 AT E172973T1 AT 95402841 T AT95402841 T AT 95402841T AT 95402841 T AT95402841 T AT 95402841T AT E172973 T1 ATE172973 T1 AT E172973T1
Authority
AT
Austria
Prior art keywords
receptors
quinolicin
dibenzo
dihydro
ligands
Prior art date
Application number
AT95402841T
Other languages
English (en)
Inventor
Benoit Marabout
Mireille Sevrin
Jacques Froissant
Emmanuelle Dachary
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo filed Critical Synthelabo
Application granted granted Critical
Publication of ATE172973T1 publication Critical patent/ATE172973T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Addiction (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT95402841T 1994-12-29 1995-12-18 8-oxo-5,8-dihydro-6h-dibenzo(a,g>chinolizin-13- propansäure-derivate als liganden der mit gabaa rezeptoren verbundenen benzodiazepine rezeptoren ATE172973T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9415836A FR2728902B1 (fr) 1994-12-29 1994-12-29 Derives d'acide 8-oxo-5,8-dihydro-6h-dibenzo(a,g)quinolizine-13-propanoique, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
ATE172973T1 true ATE172973T1 (de) 1998-11-15

Family

ID=9470389

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95402841T ATE172973T1 (de) 1994-12-29 1995-12-18 8-oxo-5,8-dihydro-6h-dibenzo(a,g>chinolizin-13- propansäure-derivate als liganden der mit gabaa rezeptoren verbundenen benzodiazepine rezeptoren

Country Status (26)

Country Link
US (1) US5614517A (de)
EP (1) EP0719776B1 (de)
JP (1) JPH08239383A (de)
KR (1) KR960022518A (de)
CN (1) CN1058009C (de)
AR (1) AR002015A1 (de)
AT (1) ATE172973T1 (de)
AU (1) AU697988B2 (de)
BR (1) BR9506105A (de)
CA (1) CA2166233A1 (de)
CO (1) CO4700297A1 (de)
CZ (1) CZ348895A3 (de)
DE (1) DE69505781T2 (de)
DK (1) DK0719776T3 (de)
ES (1) ES2126232T3 (de)
FI (1) FI956299A7 (de)
FR (1) FR2728902B1 (de)
HU (1) HU215393B (de)
IL (1) IL116596A (de)
NO (1) NO305084B1 (de)
NZ (1) NZ280766A (de)
PL (1) PL181811B1 (de)
RU (1) RU2155764C2 (de)
SK (1) SK280546B6 (de)
TW (1) TW385311B (de)
ZA (1) ZA9511035B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2806723B1 (fr) * 2000-03-23 2002-05-10 Sanofi Synthelabo DERIVES D'ACIDE 8-OXO-5,8-DIHYDRO-6H-DIBENZO [a,g] QUINOLIZINE-13-PROPANOIQUE , LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
US6686352B2 (en) * 2001-05-18 2004-02-03 Hoffmann-La Roche Inc. Substituted imidazo [1,5-a] pyrimido [5,4-d] [1] benzazepine derivatives
CN104127414B (zh) * 2013-05-03 2018-04-13 中国科学院上海药物研究所 一种六氢二苯并[a,g]喹嗪类化合物的药物用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4013616A (en) * 1971-11-22 1977-03-22 Wallace Richard A Mixed polymeric structural material and method
FR2537583B1 (fr) * 1982-12-14 1985-08-09 Urpha Enantiomeres levogyres des derives de la tetrahydro-5, 6, 13, 13a 8h-dibenzo (a,g-) quinolizine, procedes d'obtention, compositions pharmaceutiques les contenant et application
GB8429710D0 (en) * 1984-11-23 1985-01-03 Fujisawa Pharmaceutical Co Pharmaceutical composition
JPS61130289A (ja) * 1984-11-29 1986-06-18 Ss Pharmaceut Co Ltd １３−プロピルベルベリンの塩
HU195505B (en) * 1985-05-24 1988-05-30 Chinoin Gyogyszer Es Vegyeszet Process for producing 7,8-methylendioxy-14-hydroxy-berban derivatives and pharmaceuticals comprising the same

Also Published As

Publication number Publication date
AU697988B2 (en) 1998-10-22
EP0719776A1 (de) 1996-07-03
JPH08239383A (ja) 1996-09-17
EP0719776B1 (de) 1998-11-04
TW385311B (en) 2000-03-21
FI956299L (fi) 1996-06-30
DE69505781D1 (de) 1998-12-10
HU9503846D0 (en) 1996-02-28
ES2126232T3 (es) 1999-03-16
DK0719776T3 (da) 1999-07-19
RU2155764C2 (ru) 2000-09-10
CZ348895A3 (en) 1996-07-17
FI956299A7 (fi) 1996-06-30
FI956299A0 (fi) 1995-12-28
IL116596A0 (en) 1996-03-31
DE69505781T2 (de) 1999-06-17
FR2728902B1 (fr) 1997-01-31
PL312080A1 (en) 1996-07-08
SK280546B6 (sk) 2000-03-13
US5614517A (en) 1997-03-25
HU215393B (hu) 1998-12-28
NO955325D0 (no) 1995-12-28
NO305084B1 (no) 1999-03-29
HUT74186A (en) 1996-11-28
CO4700297A1 (es) 1998-12-29
NO955325L (no) 1996-07-01
KR960022518A (ko) 1996-07-18
FR2728902A1 (fr) 1996-07-05
NZ280766A (en) 1996-09-25
AR002015A1 (es) 1998-01-07
IL116596A (en) 1998-10-30
BR9506105A (pt) 1997-12-23
AU4070895A (en) 1996-07-04
SK165895A3 (en) 1996-07-03
CA2166233A1 (en) 1996-06-30
ZA9511035B (en) 1996-07-01
CN1058009C (zh) 2000-11-01
CN1131154A (zh) 1996-09-18
PL181811B1 (pl) 2001-09-28

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