ES2128309T3 - Utilizacion de taurina para la fabricacion de un medicamento para estimular actividad de mieloperoxidasa. - Google Patents
Utilizacion de taurina para la fabricacion de un medicamento para estimular actividad de mieloperoxidasa.Info
- Publication number
- ES2128309T3 ES2128309T3 ES91306903T ES91306903T ES2128309T3 ES 2128309 T3 ES2128309 T3 ES 2128309T3 ES 91306903 T ES91306903 T ES 91306903T ES 91306903 T ES91306903 T ES 91306903T ES 2128309 T3 ES2128309 T3 ES 2128309T3
- Authority
- ES
- Spain
- Prior art keywords
- acid
- aminoethanesulphonic
- ethanesulphonic
- propanesulphonic
- taurine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 title abstract 5
- 102000003896 Myeloperoxidases Human genes 0.000 title abstract 2
- 108090000235 Myeloperoxidases Proteins 0.000 title abstract 2
- 230000000694 effects Effects 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 229960003080 taurine Drugs 0.000 title abstract 2
- 229940126601 medicinal product Drugs 0.000 title 1
- QZTKDVCDBIDYMD-UHFFFAOYSA-N 2,2'-[(2-amino-2-oxoethyl)imino]diacetic acid Chemical compound NC(=O)CN(CC(O)=O)CC(O)=O QZTKDVCDBIDYMD-UHFFFAOYSA-N 0.000 abstract 2
- IHPYMWDTONKSCO-UHFFFAOYSA-N 2,2'-piperazine-1,4-diylbisethanesulfonic acid Chemical compound OS(=O)(=O)CCN1CCN(CCS(O)(=O)=O)CC1 IHPYMWDTONKSCO-UHFFFAOYSA-N 0.000 abstract 2
- AJTVSSFTXWNIRG-UHFFFAOYSA-N 2-[bis(2-hydroxyethyl)amino]ethanesulfonic acid Chemical compound OCC[NH+](CCO)CCS([O-])(=O)=O AJTVSSFTXWNIRG-UHFFFAOYSA-N 0.000 abstract 2
- DBXNUXBLKRLWFA-UHFFFAOYSA-N N-(2-acetamido)-2-aminoethanesulfonic acid Chemical compound NC(=O)CNCCS(O)(=O)=O DBXNUXBLKRLWFA-UHFFFAOYSA-N 0.000 abstract 2
- MKWKNSIESPFAQN-UHFFFAOYSA-N N-cyclohexyl-2-aminoethanesulfonic acid Chemical compound OS(=O)(=O)CCNC1CCCCC1 MKWKNSIESPFAQN-UHFFFAOYSA-N 0.000 abstract 2
- CCIVGXIOQKPBKL-UHFFFAOYSA-N ethanesulfonic acid Chemical compound CCS(O)(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-N 0.000 abstract 2
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 abstract 1
- 239000007991 ACES buffer Substances 0.000 abstract 1
- 239000008000 CHES buffer Substances 0.000 abstract 1
- PJWWRFATQTVXHA-UHFFFAOYSA-N Cyclohexylaminopropanesulfonic acid Chemical compound OS(=O)(=O)CCCNC1CCCCC1 PJWWRFATQTVXHA-UHFFFAOYSA-N 0.000 abstract 1
- 239000007995 HEPES buffer Substances 0.000 abstract 1
- OWXMKDGYPWMGEB-UHFFFAOYSA-N HEPPS Chemical compound OCCN1CCN(CCCS(O)(=O)=O)CC1 OWXMKDGYPWMGEB-UHFFFAOYSA-N 0.000 abstract 1
- 239000007993 MOPS buffer Substances 0.000 abstract 1
- 239000007983 Tris buffer Substances 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- QWPPOHNGKGFGJK-UHFFFAOYSA-N hypochlorous acid Chemical compound ClO QWPPOHNGKGFGJK-UHFFFAOYSA-N 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000002779 inactivation Effects 0.000 abstract 1
- 150000002617 leukotrienes Chemical class 0.000 abstract 1
- KCXFHTAICRTXLI-UHFFFAOYSA-N propane-1-sulfonic acid Chemical compound CCCS(O)(=O)=O KCXFHTAICRTXLI-UHFFFAOYSA-N 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cephalosporin Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
COMPUESTOS DE ION HIBRIDO SELECCIONADOS DE: TAURINA (ACIDO 2-AMINOETANOSULFONICO), 2(N-MORFOLINO) ACIDO ETANOSULFONICO (MES), N-(2 ACETAMINO) ACIDO IMINODIACETICO (ADA), PIPERACINA-N, N'' BIS (ACIDO 2-ETANOSULFONICO (PIPES), ACIDO N-(2-ACETAMIDO)-2-AMINOETANOSULFONICO (ACES), ACIDO N, N-BIS (2-HIDROXIETILO)-2-AMINOETANOSULFONICO (BES), 3-(N-MORFOLINO) PROPANOSULFONICO (MOPS), ACIDO N-N[TRIS (HIDROXIMETILO)-METILO]-2-AMINOETANOSULFONICO (TES), ACIDO N-2-HIDROXIETILPIPERAZINA-N''-2-ETANOSULFONICO (HEPES), ACIDO N-2-HIDROXIETILPIPERAZINA-N''3-PROPANOSULFONICO (H)EPPS), ACIDO 2-(CICLOEXILAMINO) ETANOSULFONICO (CHES) O ACIDO 3-(CICLOEXILAMINO) PROPANOSULFONICO (CAPS), Y SUS DERIVADOS N-HALO PUEDEN USARSE SEPARADAMENTE O EN COMBINACION EN EL TRATAMIENTO DE CONDICIONES CLINICAS RELACIONADAS MEDIANTE LA ESTIMULACION DE ACTIVIDAD MIELOPEROXIDASA, QUE A SU VEZ ESTIMULA LA PRODUCCION DE ACIDO HIPOCLOROSO "IN VIVO", QUE LLEVA "INTER ALIA" A LA INACTIVACION REALZADA LEUKOTRIENA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IE274190 | 1990-07-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2128309T3 true ES2128309T3 (es) | 1999-05-16 |
Family
ID=11036287
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES91306903T Expired - Lifetime ES2128309T3 (es) | 1990-07-30 | 1991-07-29 | Utilizacion de taurina para la fabricacion de un medicamento para estimular actividad de mieloperoxidasa. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5248680A (es) |
| EP (1) | EP0469813B1 (es) |
| JP (1) | JPH0597666A (es) |
| AT (1) | ATE175112T1 (es) |
| AU (1) | AU641529B2 (es) |
| CA (1) | CA2048068A1 (es) |
| DE (1) | DE69130692T2 (es) |
| ES (1) | ES2128309T3 (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7404967B2 (en) | 1994-12-21 | 2008-07-29 | Cosmederm, Inc. | Topical product formulations containing strontium for reducing skin irritation |
| JPH10513452A (ja) * | 1995-02-03 | 1998-12-22 | コスメダーム・テクノロジーズ | 皮膚刺激を軽減するための製剤及び方法 |
| US5716959A (en) * | 1996-02-13 | 1998-02-10 | T. Ronald Theodore | Method of treating disease with piperazine zwitterion compounds |
| SE9601395D0 (sv) * | 1996-04-12 | 1996-04-12 | Dieter Haeussinger | New therapeutic treatment 1 |
| US6111085A (en) * | 1996-09-13 | 2000-08-29 | Isis Pharmaceuticals, Inc. | Carbamate-derivatized nucleosides and oligonucleosides |
| US20050124608A1 (en) * | 2001-04-03 | 2005-06-09 | Redmond H. P. | Treatment of cancers |
| US20030027818A1 (en) * | 2001-04-03 | 2003-02-06 | Redmond H. Paul | Treatment of cancers |
| US6114337A (en) * | 1998-11-27 | 2000-09-05 | Pugliese; Peter T. | Zwitteronic-fatty acid compounds having anti-inflammatory properties |
| CA2311796A1 (en) | 1997-11-28 | 1999-06-10 | Peter M. Pugliese | Zwitterionic fatty acid compounds for anti-inflammation |
| US6448251B1 (en) * | 1997-11-28 | 2002-09-10 | Peter T. Pugliese | Zwitterionic-fatty acid compounds having anti-inflammatory properties |
| RU2156129C1 (ru) * | 2000-03-14 | 2000-09-20 | Закрытое акционерное общество "Корпорация ОЛИФЕН" | Биологически активное средство тонизирующего действия |
| CA2386985A1 (en) * | 2000-08-11 | 2002-02-21 | The Lawson Health Research Institute | Compositions and methods for inhibiting islet dysfunction and autoimmune disorders |
| US20040116521A1 (en) * | 2000-09-14 | 2004-06-17 | Waldemar Gottardi | Fungicidal agent containing n-chlorotaurine and use thereof |
| FR2816837A1 (fr) * | 2000-11-17 | 2002-05-24 | Oreal | Utilisation d'au moins un derive amino sulfonique dans une composition destinee a favoriser la desquamation de la peau |
| GB0109428D0 (en) * | 2001-04-17 | 2001-06-06 | Process & Ind Design Consultan | Therapeutic compositions |
| DE10133197A1 (de) * | 2001-07-07 | 2003-01-23 | Beiersdorf Ag | Aminosäuren enthaltende kosmetische und dermatologische Zubereitungen zur Behandlung und aktiven Prävention trockener Haut und anderer negativer Veränderungen der physiologischen Homöostase der gesunden Haut |
| US20060127342A1 (en) * | 2004-12-09 | 2006-06-15 | Georgia Levis | Taurine-based compositions, therapeutic methods, and assays |
| EP2120555A1 (en) * | 2007-01-31 | 2009-11-25 | Adam Heller | Methods and compositions for the treatment of pain |
| MX2012003212A (es) | 2009-09-17 | 2012-09-07 | North Texas Medical Ass | Papel del acido n-2-hidroxi-etil-piperazina-n´-2-etano sulfonico (hepes) en el control del dolor y reversion de lesiones por desmielinizacion. |
| US20140377814A1 (en) * | 2012-02-07 | 2014-12-25 | Industry-Academic Cooperation Foundation, Yonsei University | Method For The Fixation Or Conversion Of High-Pressure Carbon Dioxide Using Barophilic Sulfur-Oxidizing Chemolithoautotrophs |
| JP2014040393A (ja) * | 2012-08-23 | 2014-03-06 | Taisho Pharmaceutical Co Ltd | 遺伝子発現調節剤 |
| TW201619605A (zh) * | 2014-10-24 | 2016-06-01 | Shiseido Co Ltd | 用以改善起因於角質層剝離之抑制或促進之肌膚狀態的美容方法及評價方法 |
| RU2614691C2 (ru) * | 2015-07-14 | 2017-03-28 | Федеральное государственное бюджетное научное учреждение "Институт экспериментальной медицины" (ФГБНУ "ИЭМ") | Гепатопротекторное средство |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE52977B1 (en) * | 1981-11-24 | 1988-04-27 | Pascale Ltd | Protective composition for users of cyanoacrylate adhesives |
| JPS592686A (ja) * | 1982-06-25 | 1984-01-09 | Green Cross Corp:The | ミエロペルオキシダ−ゼの粉末製剤 |
| EP0100827B1 (en) * | 1982-08-17 | 1986-09-03 | Rosical Limited | Pharmaceutical composition containing an aliphatic aminosulphonic acid |
| IE853206L (en) * | 1985-12-18 | 1987-06-18 | Sullivan Donncha O | Use of aminosulfonic acids in treatment of inflammatory¹conditions |
| GB8713091D0 (en) * | 1987-06-04 | 1987-07-08 | Millrine W P | Pharmaceutical compositions |
| WO1990003185A1 (en) * | 1988-09-28 | 1990-04-05 | Ideon Corporation | Combination enzyme immunotherapeutics |
-
1991
- 1991-07-25 AU AU81332/91A patent/AU641529B2/en not_active Ceased
- 1991-07-26 US US07/736,247 patent/US5248680A/en not_active Expired - Fee Related
- 1991-07-29 AT AT91306903T patent/ATE175112T1/de not_active IP Right Cessation
- 1991-07-29 DE DE69130692T patent/DE69130692T2/de not_active Expired - Fee Related
- 1991-07-29 JP JP3188644A patent/JPH0597666A/ja active Pending
- 1991-07-29 EP EP91306903A patent/EP0469813B1/en not_active Expired - Lifetime
- 1991-07-29 CA CA002048068A patent/CA2048068A1/en not_active Abandoned
- 1991-07-29 ES ES91306903T patent/ES2128309T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0469813A3 (en) | 1992-11-19 |
| AU641529B2 (en) | 1993-09-23 |
| US5248680A (en) | 1993-09-28 |
| EP0469813A2 (en) | 1992-02-05 |
| JPH0597666A (ja) | 1993-04-20 |
| DE69130692T2 (de) | 1999-09-09 |
| EP0469813B1 (en) | 1998-12-30 |
| CA2048068A1 (en) | 1992-01-31 |
| DE69130692D1 (de) | 1999-02-11 |
| AU8133291A (en) | 1992-02-13 |
| ATE175112T1 (de) | 1999-01-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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