ES2128471T3 - Agente administrable oralmente que disminuye el colesterol. - Google Patents
Agente administrable oralmente que disminuye el colesterol.Info
- Publication number
- ES2128471T3 ES2128471T3 ES94111996T ES94111996T ES2128471T3 ES 2128471 T3 ES2128471 T3 ES 2128471T3 ES 94111996 T ES94111996 T ES 94111996T ES 94111996 T ES94111996 T ES 94111996T ES 2128471 T3 ES2128471 T3 ES 2128471T3
- Authority
- ES
- Spain
- Prior art keywords
- orally administrable
- weight
- lowering agent
- cholesterol lowering
- hydroxypropylmethylcellulose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 title 2
- 235000012000 cholesterol Nutrition 0.000 title 1
- 239000003529 anticholesteremic agent Substances 0.000 abstract 3
- 229940127226 anticholesterol agent Drugs 0.000 abstract 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 2
- 239000003957 anion exchange resin Substances 0.000 abstract 2
- 239000011248 coating agent Substances 0.000 abstract 2
- 238000000576 coating method Methods 0.000 abstract 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 abstract 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 abstract 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 abstract 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 235000012239 silicon dioxide Nutrition 0.000 abstract 1
- 239000000377 silicon dioxide Substances 0.000 abstract 1
- 230000009747 swallowing Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
- A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE PROPORCIONA CON UN AGENTE REDUCTOR DEL COLESTEROL, ADMINISTRABLE POR VIA ORAL, QUE SE OBTIENE MEDIANTE REVESTIMIENTO CON TABLETAS PLANAS DE HIDROXIPROPILMETILCELULOSA, CONTENIENDO UNA RESINA DE INTERCAMBIO DE ANIONES COMO UN COMPONENTE ACTIVO, Y CONTENIENDO DEL 14 AL 20% POR PESO DE AGUA, Y NO MAS DEL 2% POR PESO DE DIOXIDO DE SILICIO, BASADO EN EL PESO DE LA RESINA DE INTERCAMBIO DE ANIONES. EL AGENTE REDUCTOR DEL COLESTEROL, ADMINISTRABLE POR VIA ORAL, SE OBTIENE REVISTIENDO LAS TABLETAS MENCIONADAS ANTERIORMENTE CON UNA SOLUCION ACUOSA DE 10-30 CST DE HIDROXIPROPILMETILCELULOSA. ADEMAS DE CARACTERIZARSE POR LA FACILIDAD DE SU DEGLUCION, EL AGENTE REDUCTOR DEL COLESTEROL, ADMINISTRABLE POR VIA ORAL, DE LA PRESENTE INVENCION ES SUPERIOR EN LA CONFIGURABILIDAD DE COMPRESION, ESTABILIDAD EN MEDIO HUMECTADOR Y FLUIDEZ.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP19239293 | 1993-08-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2128471T3 true ES2128471T3 (es) | 1999-05-16 |
Family
ID=16290545
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES94111996T Expired - Lifetime ES2128471T3 (es) | 1993-08-03 | 1994-08-01 | Agente administrable oralmente que disminuye el colesterol. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5447726A (es) |
| EP (1) | EP0637447B1 (es) |
| KR (1) | KR100322340B1 (es) |
| CN (1) | CN1069518C (es) |
| AT (1) | ATE175111T1 (es) |
| CA (1) | CA2129079C (es) |
| DE (1) | DE69415601T2 (es) |
| ES (1) | ES2128471T3 (es) |
| TW (1) | TW349866B (es) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0793960B1 (en) * | 1996-03-05 | 2001-08-01 | Mitsubishi Chemical Corporation | Use of anion exchange resins for the manufacture of a medicament for the treatment of hyperphosphatemia |
| US6066336A (en) * | 1997-09-29 | 2000-05-23 | Bristol-Myers Squibb Company | Cholesterol-lowering tablets |
| JP2001115022A (ja) * | 1999-10-18 | 2001-04-24 | Shin Etsu Chem Co Ltd | 室温硬化性オルガノポリシロキサン組成物 |
| US6733780B1 (en) * | 1999-10-19 | 2004-05-11 | Genzyme Corporation | Direct compression polymer tablet core |
| US20020054903A1 (en) * | 1999-10-19 | 2002-05-09 | Joseph Tyler | Direct compression polymer tablet core |
| US7964218B2 (en) * | 2000-09-06 | 2011-06-21 | Mitsubishi Tanabe Pharma Corporation | Granular preparations for oral administration |
| EP1348442A4 (en) * | 2000-11-28 | 2005-02-02 | Mitsubishi Pharma Corp | ANTI-OBESITY AGENTS AND DIET FOOD |
| US20030070584A1 (en) | 2001-05-15 | 2003-04-17 | Cynthia Gulian | Dip coating compositions containing cellulose ethers |
| US7879869B2 (en) * | 2001-07-30 | 2011-02-01 | Mitsubishi Tanabe Pharma Corporation | Drugs for ameliorating postcibal hyperglycemia |
| US8309118B2 (en) | 2001-09-28 | 2012-11-13 | Mcneil-Ppc, Inc. | Film forming compositions containing sucralose |
| US7429619B2 (en) | 2002-08-02 | 2008-09-30 | Mcneil Consumer Healthcare | Polyacrylic film forming compositions |
| US7335795B2 (en) | 2004-03-22 | 2008-02-26 | Ilypsa, Inc. | Crosslinked amine polymers |
| US7608674B2 (en) * | 2003-11-03 | 2009-10-27 | Ilypsa, Inc. | Pharmaceutical compositions comprising cross-linked small molecule amine polymers |
| US7449605B2 (en) * | 2003-11-03 | 2008-11-11 | Ilypsa, Inc. | Crosslinked amine polymers |
| US7767768B2 (en) * | 2003-11-03 | 2010-08-03 | Ilypsa, Inc. | Crosslinked amine polymers |
| US7459502B2 (en) * | 2003-11-03 | 2008-12-02 | Ilypsa, Inc. | Pharmaceutical compositions comprising crosslinked polyamine polymers |
| US7385012B2 (en) | 2003-11-03 | 2008-06-10 | Ilypsa, Inc. | Polyamine polymers |
| CA2551528A1 (en) * | 2003-12-31 | 2005-07-21 | Genzyme Corporation | Enteric coated aliphatic amine polymer bile acid sequestrants |
| US20060177415A1 (en) * | 2004-11-01 | 2006-08-10 | Burke Steven K | Once a day formulation for phosphate binders |
| US7985418B2 (en) | 2004-11-01 | 2011-07-26 | Genzyme Corporation | Aliphatic amine polymer salts for tableting |
| JP2009507019A (ja) | 2005-09-02 | 2009-02-19 | ジェンザイム・コーポレーション | リン酸塩を除去する方法およびそれに使用される重合体 |
| CN103027896B (zh) | 2005-09-15 | 2016-01-20 | 基酶有限公司 | 胺聚合物的小袋制剂 |
| JP5301273B2 (ja) * | 2006-08-09 | 2013-09-25 | 田辺三菱製薬株式会社 | 錠剤 |
| BRPI0717545A2 (pt) | 2006-09-29 | 2013-10-22 | Gezyme Corp | Composição farmacêutica, método para tratar uma doença, polímero de amida, rede de polímero, e, método para preparar um polímero de amida |
| JP2010513271A (ja) | 2006-12-14 | 2010-04-30 | ゲンズイメ コーポレーション | アミド−アミンポリマー組成物 |
| KR102997081B1 (ko) | 2024-09-20 | 2026-07-30 | 동서대학교 산학협력단 | 골프 퍼팅 연습장치 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS607652B2 (ja) * | 1976-06-12 | 1985-02-26 | 三菱油化株式会社 | 陰イオン交換体の製造法 |
| GB1573487A (en) * | 1977-05-23 | 1980-08-28 | Bristol Myers Co | Bile acid binding composition |
| EP0098884B1 (en) * | 1982-01-18 | 1986-07-23 | Mitsubishi Petrochemical Co., Ltd. | Cholesterol lowering drug |
| JPS60209523A (ja) * | 1984-04-03 | 1985-10-22 | Mitsubishi Petrochem Co Ltd | コレステロ−ル低下剤 |
| US4956182A (en) * | 1989-03-16 | 1990-09-11 | Bristol-Myers Company | Direct compression cholestyramine tablet and solvent-free coating therefor |
| JPH02286621A (ja) * | 1989-04-26 | 1990-11-26 | Mitsubishi Kasei Corp | 経口コレステロール低下剤 |
| EP0497985B1 (en) * | 1990-08-24 | 1998-07-22 | Shin-Etsu Chemical Co., Ltd. | Coating base for pharmaceutical film and production thereof |
| ATE173931T1 (de) * | 1991-07-03 | 1998-12-15 | Upjohn Co | Tabletten mit hohem gehalt an colestipolhydrochlorid |
| JPH06157325A (ja) * | 1992-11-30 | 1994-06-03 | Mitsubishi Kasei Corp | 経口コレステロール低下剤 |
-
1994
- 1994-07-28 CA CA002129079A patent/CA2129079C/en not_active Expired - Lifetime
- 1994-07-29 US US08/282,553 patent/US5447726A/en not_active Expired - Lifetime
- 1994-08-01 EP EP94111996A patent/EP0637447B1/en not_active Expired - Lifetime
- 1994-08-01 AT AT94111996T patent/ATE175111T1/de not_active IP Right Cessation
- 1994-08-01 DE DE69415601T patent/DE69415601T2/de not_active Expired - Lifetime
- 1994-08-01 ES ES94111996T patent/ES2128471T3/es not_active Expired - Lifetime
- 1994-08-02 TW TW083107074A patent/TW349866B/zh not_active IP Right Cessation
- 1994-08-03 CN CN94108633A patent/CN1069518C/zh not_active Expired - Lifetime
- 1994-08-03 KR KR1019940019207A patent/KR100322340B1/ko not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CN1069518C (zh) | 2001-08-15 |
| ATE175111T1 (de) | 1999-01-15 |
| DE69415601T2 (de) | 1999-07-22 |
| CN1107334A (zh) | 1995-08-30 |
| CA2129079C (en) | 2006-01-17 |
| US5447726A (en) | 1995-09-05 |
| KR950005316A (ko) | 1995-03-20 |
| EP0637447B1 (en) | 1998-12-30 |
| EP0637447A3 (en) | 1995-05-24 |
| DE69415601D1 (de) | 1999-02-11 |
| CA2129079A1 (en) | 1995-02-04 |
| EP0637447A2 (en) | 1995-02-08 |
| KR100322340B1 (ko) | 2002-06-20 |
| TW349866B (en) | 1999-01-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0637447A3 (en) | Oral cholesterol-lowering agent. | |
| CA2201749A1 (en) | Stable aqueous alfa interferon solution formulations | |
| NO994621D0 (no) | Ernaeringsformuleringer inneholdende oligosakkarider | |
| KR920014465A (ko) | 입욕제 | |
| BG106681A (en) | Solutions containing epinastine | |
| CA2105088A1 (en) | Liquid soap personal cleanser with critical heat cycle stabilizing system | |
| BRPI0417585A (pt) | composição pregabalina | |
| ES2052065T3 (es) | Formulacion dispersable. | |
| EP0418892A3 (en) | Bathing preparation | |
| KR910002426A (ko) | 함수성 외용제 | |
| MX9203360A (es) | Derivados de hexahidroazepinas y composiciones farmaceuticas que los contienen. | |
| CA2057734A1 (en) | Oxidized-type glutathione alkyl ester | |
| FI812804L (fi) | 2-(1,4-bensodioxan-2-ylalkyl)-imidazoler anvaendbara som antidepressiva laekemedel | |
| ATE396743T1 (de) | Stabile elektrolytlösungen enthaltend taurolidin | |
| NO911119L (no) | Fremgangsmaate for fremstilling av farmasoeytisk jodpreparat | |
| CA2047802A1 (en) | Pharmaceutical compositions | |
| ES2112299T3 (es) | Composiciones detergentes granulares de alta densidad aparente. | |
| ES2154659T3 (es) | Soluciones acuosas de isotiazolin-3-onas estables al almacenamiento. | |
| SE9301112D0 (sv) | A new composition | |
| DK0548635T3 (da) | Farmaceutisk præparat af Roxindol eller Carmoxirol med foropkvældet stivelse | |
| CA2376121A1 (en) | Stable xylometazoline and oxymetazoline solution | |
| EP0462948A3 (en) | Pharmaceutical compositions comprising 3-amino-epsilon-caprolactames for enhancing learning and memory | |
| GR3023941T3 (en) | Cyclic derivatives of angiopeptin, their preparation and their pharmaceutical compositions. | |
| NO960271D0 (no) | Tiokarbamoylforbindelser anvendt som mikrobiocider | |
| ES2049696T3 (es) | Utilizacion de una amida como agente espesante y composicion que la contiene. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
Ref document number: 637447 Country of ref document: ES |