ES2128567T3 - Metanoantracenos sustituidos con piperidinilo como antagonistas d1/d2 y antagonistas 5ht2 de la serotonina. - Google Patents
Metanoantracenos sustituidos con piperidinilo como antagonistas d1/d2 y antagonistas 5ht2 de la serotonina.Info
- Publication number
- ES2128567T3 ES2128567T3 ES94919752T ES94919752T ES2128567T3 ES 2128567 T3 ES2128567 T3 ES 2128567T3 ES 94919752 T ES94919752 T ES 94919752T ES 94919752 T ES94919752 T ES 94919752T ES 2128567 T3 ES2128567 T3 ES 2128567T3
- Authority
- ES
- Spain
- Prior art keywords
- sup
- sub
- chosen
- alkyl
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
NUEVOS COMPUESTOS DE PIPERIDINILO DE FORMULA (I) EN LA QUE X E Y SON INDEPENDIENTEMENTE ELEGIDOS ENTRE HIDROGENO, HALOGENO Y ALCOXI C1-6, R1 ES ELEGIDO ENTRE ANILLO HETEROARILO DE SEIS ELEMENTOS QUE CONTIENE DE 1 A 3 HETEROATOMOS ELEGIDOS ENTRE NITROGENO, OXIGENO Y AZUFRE Y SUS DERIVADOS BENZ, QUE PUEDE LLEVAR 1-2 SUSTITUYENTES ELEGIDOS ENTRE ALQUIL C1-6, HIDROXI, ALCOXI C1-6 QUE PUEDE LLEVAR UN GRUPO TRIFLUORMETILO, ALCOXICARBONILO C1-6, HIDROXIALQUIL C-6, BENCILOXI, HALO, ALQUILAMINOCARBONILO C-3, ARILO C1-3, AMINOCARBONILO QUE TIENE LA FORMULA : CONR{SUP,C}R{SUP,D} DONDE R{SUP,C} Y R{SUP,D} SON ELEGIDOS INDEPENDIENTEMENTE DE HIDROGENO, 2-PIRROLIDINILO, Y C16ALQUIL O DONDE R{SUP,C} Y R{SUP,D} JUNTO CON EL ATOMO DE NITROGENO AL QUE ESTAN ASOCIADO FORMAN UN NUCLEO HETEROCICLICO DE 6 ELEMENTOS EN EL QUE DICHO NITROGENO ES EL UNICO HETEROATOMO, R{SUP,E}S(O){SUB,N} R{SUP,F}HH Y R{SUP,G}S DONDE R{SUP,E} Y R{SUP,F} SON INDEPENDIENTEMENTE ELEGIDO ENTRE HIDROGENO Y ALQUILO C1-6 Y N ES O, Q E Y R{SUP,G} ES ELEGIDO ENTRE ALQUILCARBONILAMINOFENILO C{SUB,1-3} Y DI{(C{SUB,13})ALQUILAMINO{(C{SUB,1-6})ALQUILO, DONDE AL MENOS UNO DE LOS SUSTITUYENTES SOBRE EL NUCLEO HETEROARILO DE CINCO O SEIS ELEMENTOS ES UN SULFOXIDO QUIRAL DE LA FORMULA C{SUB,14}ALQUILSO, Y SUS SALES FARMACEUTICAMENTE ACEPTABLES, SON UTILES COMO ANTAGONISTAS DE DOPAMINA Y SON PARTICULARMENTE UTILES COMO AGENTES ANTISICOTICAS EN HUMANOS. LOS COMPUESTOS PUEDEN TAMBIEN SER UTILES EN OTROS TRASTORNOS NEUROLOGICOS Y PSIQUIATRICOS QUE INCLUIDO LA ESQUIZOFRENIA. TAMBIEN SE DESCRIBEN PROCESOS PARA PREPARAR LOS COMPUESTOS PIPERIDINILO ASI COMO SU USO EN MEDICINA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939314250A GB9314250D0 (en) | 1993-07-09 | 1993-07-09 | Piperidinyl compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2128567T3 true ES2128567T3 (es) | 1999-05-16 |
Family
ID=10738563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES94919752T Expired - Lifetime ES2128567T3 (es) | 1993-07-09 | 1994-07-04 | Metanoantracenos sustituidos con piperidinilo como antagonistas d1/d2 y antagonistas 5ht2 de la serotonina. |
Country Status (26)
| Country | Link |
|---|---|
| EP (1) | EP0707579B1 (es) |
| JP (1) | JP3031634B2 (es) |
| AP (1) | AP521A (es) |
| AT (1) | ATE175963T1 (es) |
| AU (1) | AU687414B2 (es) |
| CA (1) | CA2163994A1 (es) |
| CZ (1) | CZ4496A3 (es) |
| DE (1) | DE69416131T2 (es) |
| DK (1) | DK0707579T3 (es) |
| DZ (1) | DZ1796A1 (es) |
| ES (1) | ES2128567T3 (es) |
| FI (1) | FI960084A0 (es) |
| GB (2) | GB9314250D0 (es) |
| HR (1) | HRP940394A2 (es) |
| HU (1) | HU219239B (es) |
| IL (1) | IL110222A (es) |
| MY (1) | MY111604A (es) |
| NO (1) | NO960080L (es) |
| NZ (1) | NZ268048A (es) |
| PL (1) | PL312498A1 (es) |
| RU (1) | RU2128178C1 (es) |
| SG (1) | SG45425A1 (es) |
| SI (1) | SI9400281A (es) |
| SK (1) | SK2996A3 (es) |
| WO (1) | WO1995001974A1 (es) |
| ZA (1) | ZA944930B (es) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9117639D0 (en) * | 1991-08-15 | 1991-10-02 | Ici Plc | Therapeutic compounds |
-
1993
- 1993-07-09 GB GB939314250A patent/GB9314250D0/en active Pending
-
1994
- 1994-06-30 AP APAP/P/1994/000652A patent/AP521A/en active
- 1994-07-01 GB GB9413235A patent/GB9413235D0/en active Pending
- 1994-07-04 JP JP7503893A patent/JP3031634B2/ja not_active Expired - Fee Related
- 1994-07-04 NZ NZ268048A patent/NZ268048A/en unknown
- 1994-07-04 CA CA002163994A patent/CA2163994A1/en not_active Abandoned
- 1994-07-04 HU HU9503554A patent/HU219239B/hu not_active IP Right Cessation
- 1994-07-04 WO PCT/GB1994/001439 patent/WO1995001974A1/en not_active Ceased
- 1994-07-04 CZ CZ9644A patent/CZ4496A3/cs unknown
- 1994-07-04 RU RU96102585A patent/RU2128178C1/ru active
- 1994-07-04 AT AT94919752T patent/ATE175963T1/de not_active IP Right Cessation
- 1994-07-04 AU AU70779/94A patent/AU687414B2/en not_active Ceased
- 1994-07-04 SK SK29-96A patent/SK2996A3/sk unknown
- 1994-07-04 EP EP94919752A patent/EP0707579B1/en not_active Expired - Lifetime
- 1994-07-04 SG SG1996007272A patent/SG45425A1/en unknown
- 1994-07-04 PL PL94312498A patent/PL312498A1/xx unknown
- 1994-07-04 ES ES94919752T patent/ES2128567T3/es not_active Expired - Lifetime
- 1994-07-04 DE DE69416131T patent/DE69416131T2/de not_active Expired - Lifetime
- 1994-07-04 DK DK94919752T patent/DK0707579T3/da active
- 1994-07-05 IL IL11022294A patent/IL110222A/xx not_active IP Right Cessation
- 1994-07-06 HR HR9314250.3A patent/HRP940394A2/xx not_active Application Discontinuation
- 1994-07-07 ZA ZA944930A patent/ZA944930B/xx unknown
- 1994-07-08 SI SI9400281A patent/SI9400281A/sl unknown
- 1994-07-09 MY MYPI94001799A patent/MY111604A/en unknown
- 1994-07-09 DZ DZ940075A patent/DZ1796A1/fr active
-
1996
- 1996-01-08 NO NO960080A patent/NO960080L/no not_active Application Discontinuation
- 1996-01-08 FI FI960084A patent/FI960084A0/fi unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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