ES2129388T3 - Fluoroquinolonil-cefems antimicrobianos. - Google Patents

Fluoroquinolonil-cefems antimicrobianos.

Info

Publication number
ES2129388T3
ES2129388T3 ES89870151T ES89870151T ES2129388T3 ES 2129388 T3 ES2129388 T3 ES 2129388T3 ES 89870151 T ES89870151 T ES 89870151T ES 89870151 T ES89870151 T ES 89870151T ES 2129388 T3 ES2129388 T3 ES 2129388T3
Authority
ES
Spain
Prior art keywords
fluoroquinolonil
cefems
antimicrobials
halogen
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89870151T
Other languages
English (en)
Inventor
Thomas Prosser Demuth Jr
Ronald Eugene White
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Chilcott Pharmaceuticals Inc
Original Assignee
Procter and Gamble Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter and Gamble Pharmaceuticals Inc filed Critical Procter and Gamble Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2129388T3 publication Critical patent/ES2129388T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

CEFEMAS FLUOROQUINOLONIL ANTIMICROBIAL DE LA FORMULA: EN DONDE (1) R1 Y R2 SON GRUPOS ENTRE ESOS CONOCIDOS EN EL ARTE PARA LA SUSTITUCION EN LA POSICION 7 DE UN CEFEMA ACTIVO ANTIMICROBIALMENTE; (2) R3 ES UNA PARTE HETEROCICLICA, QUE CONTIENE NITROGENO, SUSTITUIDO O INSUSTITUIDO; Y (3) R4 ES HIDROGENO, HALOGENO, ALCOXI REBAJADO O ALCOXI CICLICO, AMINO, NITRO O CIANO. PREFERIBLEMENTE, R3 ES PIPERAZINE SUSTITUIDO O INSUSTITUIDO, AMINOPIRROLIDINE-3, O AMINOMETILPIRROLIDINE-3. R4 ES PREFERIBLEMENTE HIDROGENO O HALOGENO.
ES89870151T 1988-10-24 1989-10-20 Fluoroquinolonil-cefems antimicrobianos. Expired - Lifetime ES2129388T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26194988A 1988-10-24 1988-10-24
US41802589A 1989-10-12 1989-10-12

Publications (1)

Publication Number Publication Date
ES2129388T3 true ES2129388T3 (es) 1999-06-16

Family

ID=26948930

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89870151T Expired - Lifetime ES2129388T3 (es) 1988-10-24 1989-10-20 Fluoroquinolonil-cefems antimicrobianos.

Country Status (14)

Country Link
EP (1) EP0366640B1 (es)
JP (1) JPH03503421A (es)
KR (1) KR0139638B1 (es)
AT (1) ATE176473T1 (es)
AU (1) AU620651B2 (es)
CA (1) CA2001204A1 (es)
DE (1) DE68928925T2 (es)
DK (1) DK527389A (es)
ES (1) ES2129388T3 (es)
GR (1) GR3030052T3 (es)
NZ (1) NZ231113A (es)
PH (1) PH26519A (es)
SG (1) SG54293A1 (es)
WO (1) WO1990004595A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5147871A (en) * 1986-07-03 1992-09-15 Hoffmann La-Roche, Inc. Anti-bacterial cephalosporin compounds
CS273349B2 (en) * 1988-03-31 1991-03-12 Hoffmann La Roche Method of cephalosporin's new derivatives production
US5336768A (en) * 1988-05-24 1994-08-09 Hoffmann-La Roche Inc. Antibacterial cephalosporin compounds
EP0366189A3 (en) * 1988-10-24 1992-01-02 Norwich Eaton Pharmaceuticals, Inc. Novel antimicrobial lactam-quinolones
US5328908A (en) * 1988-10-24 1994-07-12 Procter & Gamble Pharmaceuticals, Inc. Antimicrobial quinolone thioureas
US5180719A (en) * 1988-10-24 1993-01-19 Norwich Eaton Pharmaceuticals, Inc. Antimicrobial quinolonyl lactam esters
US5491139A (en) * 1988-10-24 1996-02-13 The Procter & Gamble Company Antimicrobial quinolonyl lactams
US5273973A (en) * 1988-10-24 1993-12-28 Norwich Eaton Pharmaceuticals, Inc. Antimicrobial quinolonyl esters
CA2001203C (en) * 1988-10-24 2001-02-13 Thomas P. Demuth, Jr. Novel antimicrobial dithiocarbamoyl quinolones
US5162523A (en) * 1989-07-21 1992-11-10 Hoffmann-La Roche Inc. Cephalosporin antibacterial compounds
US5159077A (en) * 1989-07-21 1992-10-27 Hoffmann-La Roche Inc. Penam antibacterial compounds
KR100204987B1 (ko) * 1990-04-18 1999-06-15 제이코버스 코넬리스 레이서 항미생물성 퀴놀로닐 락탐
US5066800A (en) * 1990-04-27 1991-11-19 Hoffmann-La Roche Inc. Qunoline intermediates useful therein for synthesizing antibacterial compounds
ES2101119T3 (es) * 1991-10-01 1997-07-01 Procter & Gamble Pharma Procedimiento para preparar quinolonil-lactamas antimicrobianas.
DE4234330A1 (de) * 1992-10-12 1994-04-14 Bayer Ag Chinoloncarbonsäuren
FR2873695A1 (fr) * 2004-07-30 2006-02-03 Palumed Sa Molecules hybrides qa ou q est une aminoquinoleine et a est un antibiotique ou un inhibiteur de resistance), leur synthese et leurs utilisations en tant qu'agent antibacterien
GB201818410D0 (en) * 2018-11-12 2018-12-26 Imperial Innovations Ltd Compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS565484A (en) * 1979-06-27 1981-01-20 Dainippon Pharmaceut Co Ltd Cephalosporin derivative and its salt
JPS565485A (en) * 1979-06-27 1981-01-20 Dainippon Pharmaceut Co Ltd Cephalosporin derivative and its salt
ZA874696B (en) * 1986-07-03 1988-01-04 F. Hoffmann-La Roche & Co. Aktiengesellschaft Acyl derivatives
JP2676082B2 (ja) * 1987-12-25 1997-11-12 住友化学工業株式会社 ゴキブリ防除用マイクロカプセル剤
NZ227470A (en) * 1987-12-28 1991-06-25 Hoffmann La Roche Acyl derivatives of substituted cephem compounds; pharmaceutical compositions and methods for preparation and treatment
EP0366193A3 (en) * 1988-10-24 1992-01-08 Norwich Eaton Pharmaceuticals, Inc. Novel antimicrobial quinolonyl lactams
CA2001203C (en) * 1988-10-24 2001-02-13 Thomas P. Demuth, Jr. Novel antimicrobial dithiocarbamoyl quinolones
EP0366189A3 (en) * 1988-10-24 1992-01-02 Norwich Eaton Pharmaceuticals, Inc. Novel antimicrobial lactam-quinolones

Also Published As

Publication number Publication date
GR3030052T3 (en) 1999-07-30
DK527389D0 (da) 1989-10-24
DK527389A (da) 1990-04-25
AU4369789A (en) 1990-04-26
EP0366640A3 (en) 1992-01-02
DE68928925T2 (de) 1999-08-26
EP0366640A2 (en) 1990-05-02
CA2001204A1 (en) 1990-04-24
NZ231113A (en) 1992-06-25
ATE176473T1 (de) 1999-02-15
JPH03503421A (ja) 1991-08-01
KR0139638B1 (ko) 1998-06-01
AU620651B2 (en) 1992-02-20
SG54293A1 (en) 1998-11-16
WO1990004595A1 (en) 1990-05-03
PH26519A (en) 1992-08-07
DE68928925D1 (de) 1999-03-18
KR900006347A (ko) 1990-05-08
EP0366640B1 (en) 1999-02-03

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