ES2129486T3 - Procedimiento para la preparacion de acido (6s)-5,6,7,8-tetrahidrofolico. - Google Patents

Procedimiento para la preparacion de acido (6s)-5,6,7,8-tetrahidrofolico.

Info

Publication number
ES2129486T3
ES2129486T3 ES93119354T ES93119354T ES2129486T3 ES 2129486 T3 ES2129486 T3 ES 2129486T3 ES 93119354 T ES93119354 T ES 93119354T ES 93119354 T ES93119354 T ES 93119354T ES 2129486 T3 ES2129486 T3 ES 2129486T3
Authority
ES
Spain
Prior art keywords
acid
tetrahidrofolico
procedure
preparation
value
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93119354T
Other languages
English (en)
Inventor
Pascal Jequier
Fabrizio Marazza
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cerbios Pharma SA
Original Assignee
Cerbios Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cerbios Pharma SA filed Critical Cerbios Pharma SA
Application granted granted Critical
Publication of ES2129486T3 publication Critical patent/ES2129486T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE OBTIENE EL (6S)-THF, EN UN PROCESO EN EL CUAL SE SEPARA A PARTIR DE UNA SOLUCION ACUOSA DE UNA MEZCLA DE (6RS)-DIASTEREOISOMEROS DE UNA SAL DE METAL ALCALINO DEL 5,6,7,8 ETRAHIDROFOL A UNA TEMPERATURA DESDE 5 NES DE UNA CRISTALIZACION SELECTIVA AÑADIENDO ACIDO DE FORMA PROPORCIONADA SUFICIENTEMENTE LARGA, HASTA QUE EL VALOR DE PH SE ESTABILIZA SOBRE UN VALOR EN LA ZONA DESDE 4,8 HASTA 5,3, Y SE SEPARA A CONTINUACION EL CUERPO SOLIDO FORMADO, ES DECIR (6S) DO COMO MATERIAL DE PARTIDA PARA LA ELABORACION DEL (6S) 5) N (10)
ES93119354T 1992-12-01 1993-12-01 Procedimiento para la preparacion de acido (6s)-5,6,7,8-tetrahidrofolico. Expired - Lifetime ES2129486T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH03674/92A CH686672A5 (de) 1992-12-01 1992-12-01 Verfahren zur Herstellung von (6S)-5,6,7,8-Tetrahydrofolsaeure.

Publications (1)

Publication Number Publication Date
ES2129486T3 true ES2129486T3 (es) 1999-06-16

Family

ID=4261076

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93119354T Expired - Lifetime ES2129486T3 (es) 1992-12-01 1993-12-01 Procedimiento para la preparacion de acido (6s)-5,6,7,8-tetrahidrofolico.

Country Status (6)

Country Link
US (1) US5489684A (es)
EP (1) EP0600460B1 (es)
JP (1) JP2588363B2 (es)
CH (1) CH686672A5 (es)
DE (1) DE59309380D1 (es)
ES (1) ES2129486T3 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH686369A5 (de) * 1994-05-09 1996-03-15 Eprova Ag Stabile kristalline (6S)- und (6R)-Tetrahydrofolseure.
US5710271A (en) * 1994-06-08 1998-01-20 Dibra S.P.A. Process for the preparation and separation of diastereomeric salts of folinic acid
CH689831A5 (de) * 1995-11-07 1999-12-15 Eprova Ag Stabile kristalline Tetrahydrofolsaeure-Salze.
CH693905A5 (de) * 1999-04-15 2004-04-15 Eprova Ag Stabile kristalline Salze von 5-Methyltetrahydrofolsäure.
CH695217A5 (de) * 1999-07-14 2006-01-31 Merck Eprova Ag Verfahren zur Trennung optischer Isomeren von Tetrahydrofolsäureestersalzen und Tetrahydrofolsäure.
CH694251A5 (de) * 1999-07-14 2004-10-15 Eprova Ag Herstellung von Tetrahydropterin und Derivaten.
ITMI20020132A1 (it) * 2002-01-25 2003-07-25 Gmt Fine Chemicals Sa Processo per l'ottenimento dell'acido (6s)-5,6,7,8-tetraidrofolico
CH698729B1 (de) 2007-05-30 2009-10-15 Cerbios Pharma Sa Stabile, kristalline (6S)-N(5)-Methyl-5, 6,7,8-tetrahydrofolsäure.

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5838285A (ja) * 1981-08-25 1983-03-05 Kanegafuchi Chem Ind Co Ltd ５−メチル−（６ｒｓ）−５，６，７，８−テトラヒドロ−ｌ−葉酸のマグネシウム塩またはその遊離酸の製法
CH673459A5 (es) * 1987-05-15 1990-03-15 Eprova Ag
DE3821875C1 (es) * 1988-06-29 1990-02-15 Eprova Ag, Forschungsinstitut, Schaffhausen, Ch
JPH0265787A (ja) * 1988-08-30 1990-03-06 Kyowa Hakko Kogyo Co Ltd Ｌ（‐）‐テトラヒドロ葉酸の製造法
CH676981A5 (es) * 1988-11-11 1991-03-28 Eprova Ag
FR2659330B1 (fr) * 1990-03-09 1994-02-11 Sapec Sa Composes diastereoisomeres derivant de l'acide tetrahydrofolique, procede de preparation et utilisation dans la synthese de diastereomeres 6s et 6r de folates reduits.
CH680731A5 (es) * 1990-04-12 1992-10-30 Sapec Fine Chemicals
CH681303A5 (es) * 1991-01-16 1993-02-26 Eprova Ag
CH682665A5 (de) * 1991-10-29 1993-10-29 Sapec Fine Chemicals Verfahren zur Reinigung von rohen Erdalkalimetallsalzen von N(5)-Methyl-5,6,7,8-tetrahydrofolsäure.
CH683262A5 (it) * 1992-01-22 1994-02-15 Applied Pharma Res Procedimento per la separazione dei diastereomeri del sale di calcio dell'acido (6(R,S)-N-formiltetraidrofolico).

Also Published As

Publication number Publication date
EP0600460B1 (de) 1999-02-17
JPH06211857A (ja) 1994-08-02
JP2588363B2 (ja) 1997-03-05
US5489684A (en) 1996-02-06
CH686672A5 (de) 1996-05-31
DE59309380D1 (de) 1999-03-25
EP0600460A1 (de) 1994-06-08

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