ES2129620T3 - Mezclas polimericas con grupos zwiterionicos. - Google Patents

Mezclas polimericas con grupos zwiterionicos.

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Publication number
ES2129620T3
ES2129620T3 ES94902958T ES94902958T ES2129620T3 ES 2129620 T3 ES2129620 T3 ES 2129620T3 ES 94902958 T ES94902958 T ES 94902958T ES 94902958 T ES94902958 T ES 94902958T ES 2129620 T3 ES2129620 T3 ES 2129620T3
Authority
ES
Spain
Prior art keywords
polymer
polymers
zwitterionic group
blending
zwiterionic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94902958T
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English (en)
Inventor
Stephen Alister Jones
Peter William Biocom Stratford
Steven Rimmer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Vascular Devices Ltd
Original Assignee
Biocompatibles Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocompatibles Ltd filed Critical Biocompatibles Ltd
Application granted granted Critical
Publication of ES2129620T3 publication Critical patent/ES2129620T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L23/00Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
    • C08L23/02Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers not modified by chemical after-treatment
    • C08L23/10Homopolymers or copolymers of propene
    • C08L23/12Polypropene
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/26Mixtures of macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06Use of macromolecular materials
    • A61L33/062Mixtures of macromolecular compounds
    • CCHEMISTRY; METALLURGY
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    • C08L101/00Compositions of unspecified macromolecular compounds
    • C08L101/02Compositions of unspecified macromolecular compounds characterised by the presence of specified groups, e.g. terminal or pendant functional groups
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    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L23/00Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
    • C08L23/02Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers not modified by chemical after-treatment
    • C08L23/04Homopolymers or copolymers of ethene
    • C08L23/06Polyethylene
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    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L23/00Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
    • C08L23/26Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers modified by chemical after-treatment
    • C08L23/32Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers modified by chemical after-treatment by reaction with compounds containing phosphorus or sulfur
    • C08L23/34Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers modified by chemical after-treatment by reaction with compounds containing phosphorus or sulfur by chlorosulfonation
    • CCHEMISTRY; METALLURGY
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    • C08L25/00Compositions of, homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an aromatic carbocyclic ring; Compositions of derivatives of such polymers
    • C08L25/02Homopolymers or copolymers of hydrocarbons
    • C08L25/04Homopolymers or copolymers of styrene
    • CCHEMISTRY; METALLURGY
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    • C08L25/00Compositions of, homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an aromatic carbocyclic ring; Compositions of derivatives of such polymers
    • C08L25/02Homopolymers or copolymers of hydrocarbons
    • C08L25/04Homopolymers or copolymers of styrene
    • C08L25/08Copolymers of styrene
    • C08L25/12Copolymers of styrene with unsaturated nitriles
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    • C08L33/00Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
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    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L33/00Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • C08L33/04Homopolymers or copolymers of esters
    • C08L33/06Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, which oxygen atoms are present only as part of the carboxyl radical
    • C08L33/10Homopolymers or copolymers of methacrylic acid esters
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    • C08L33/00Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
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    • C08L43/00Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing boron, silicon, phosphorus, selenium, tellurium or a metal; Compositions of derivatives of such polymers
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    • C08L75/00Compositions of polyureas or polyurethanes; Compositions of derivatives of such polymers
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    • C08L81/00Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing sulfur with or without nitrogen, oxygen or carbon only; Compositions of polysulfones; Compositions of derivatives of such polymers
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    • C08L21/00Compositions of unspecified rubbers
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    • C08L27/00Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Compositions of derivatives of such polymers
    • C08L27/02Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Compositions of derivatives of such polymers not modified by chemical after-treatment
    • C08L27/04Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Compositions of derivatives of such polymers not modified by chemical after-treatment containing chlorine atoms
    • C08L27/06Homopolymers or copolymers of vinyl chloride
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    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L33/00Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • C08L33/04Homopolymers or copolymers of esters
    • C08L33/06Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, which oxygen atoms are present only as part of the carboxyl radical
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    • C08L7/00Compositions of natural rubber
    • C08L7/02Latex
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    • C08L79/00Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing nitrogen with or without oxygen or carbon only, not provided for in groups C08L61/00 - C08L77/00
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S524/00Synthetic resins or natural rubbers -- part of the class 520 series
    • Y10S524/916Hydrogel compositions

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Materials Engineering (AREA)
  • Materials For Medical Uses (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Dental Preparations (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA BIOCOMPATIBILIDAD DE VARIOS POLIMEROS SE MEJORA A BASE DE MEZCLARLOS CON UN POLIMERO QUE INCLUYA GRUPOS ZWITTERIONICOS. EL GRUPO ZWITTERIONICO ES NORMALMENTE UN GRUPO ZWITTERIONICO DE ESTER DE FOSFATO AMONICO Y EL POLIMERO QUE LO CONTENGA SE PUEDE PRODUCIR MEDIANTE LA POLIMERIZACION DE RADICAL LIBRE DE MONOMEROS NO SATURADOS ETILENICALMENTE INCLUIDO UN MONOMERO QUE TIENE EL GRUPO ZWITTERIONICO. LA MEZCLA DE LOS DOS POLIMEROS A BASE DE MEZCLAR EN SECO POLIMEROS EN PARTICULAS O DE MEZCLAR POLIMEROS EN UNA SOLUCION O DISPERSION LIQUIDA SEGUIDO DE LA SEPARACION DEL MEDIO LIQUIDO. LA ABSORCION DE FIBRINOGENOS Y/O LA ACTIVACION DE LAS PLAQUETAS DE LOS POLIMEROS SE PUEDE REDUCIR A UN VALOR INFERIOR A UN 80% O INCLUSO INFERIOR A UN 60% DEL POLIMERO BASE A BASE DE INTRODUCIR CANTIDADES SUPERIORES A UN 10% O SUPERIORES A UN 30% DEL POLIMERO QUE CONTIENE EL GRUPO ZWITTERIONICO. LAS MEZCLAS PREFERENTES SON LAS DE COPOLIMEROS DE SAL INTERIOR DE FOSFATO DE 2-(METACRILOXIETIL)-2''(TRIMETILAMONIO)ETILO CON ALQUIL(MET)ACRILATO SUPERIOR, MEZCLADOS CON POLIMEROS OLEFINICOS Y/O CON LATEXES DE CAUCHO. LOS PRODUCTOS SE PUEDEN UTILIZAR PARA DISPOSITIVOS MEDICOS QUE ENTRAN EN CONTACTO CON FLUIDOS CORPORALES, ESPECIALMENTE SANGRE, PLASMA, SUERO Y/O LAGRIMAS.
ES94902958T 1992-12-23 1993-12-23 Mezclas polimericas con grupos zwiterionicos. Expired - Lifetime ES2129620T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929226791A GB9226791D0 (en) 1992-12-23 1992-12-23 New materials

Publications (1)

Publication Number Publication Date
ES2129620T3 true ES2129620T3 (es) 1999-06-16

Family

ID=10727088

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94902958T Expired - Lifetime ES2129620T3 (es) 1992-12-23 1993-12-23 Mezclas polimericas con grupos zwiterionicos.

Country Status (12)

Country Link
US (3) US5712326A (es)
EP (1) EP0626983B1 (es)
JP (1) JP3957741B2 (es)
AT (1) ATE178927T1 (es)
AU (1) AU674724B2 (es)
CA (1) CA2129905C (es)
DE (1) DE69324480T2 (es)
DK (1) DK0626983T3 (es)
ES (1) ES2129620T3 (es)
GB (1) GB9226791D0 (es)
RU (1) RU94045273A (es)
WO (1) WO1994014897A1 (es)

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AU674724B2 (en) 1997-01-09
AU5711094A (en) 1994-07-19
US6395800B1 (en) 2002-05-28
US5712326A (en) 1998-01-27
EP0626983B1 (en) 1999-04-14
JPH07504459A (ja) 1995-05-18
CA2129905C (en) 2006-02-21
JP3957741B2 (ja) 2007-08-15
US6150432A (en) 2000-11-21
ATE178927T1 (de) 1999-04-15
WO1994014897A1 (en) 1994-07-07
RU94045273A (ru) 1996-07-10
DK0626983T3 (da) 1999-10-25
EP0626983A1 (en) 1994-12-07
DE69324480D1 (de) 1999-05-20
DE69324480T2 (de) 1999-08-12
GB9226791D0 (en) 1993-02-17
CA2129905A1 (en) 1994-07-07

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