ES2130138T3 - Derivado de xantina. - Google Patents

Derivado de xantina.

Info

Publication number
ES2130138T3
ES2130138T3 ES91917824T ES91917824T ES2130138T3 ES 2130138 T3 ES2130138 T3 ES 2130138T3 ES 91917824 T ES91917824 T ES 91917824T ES 91917824 T ES91917824 T ES 91917824T ES 2130138 T3 ES2130138 T3 ES 2130138T3
Authority
ES
Spain
Prior art keywords
represents hydrogen
different
xantina
derivative
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91917824T
Other languages
English (en)
Inventor
Fumio Suzuki
Junichi Shimada
Akio Ishii
Hiromi Nonaka
Nobuo Kosaka
Shunji Hita Ichikawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Application granted granted Critical
Publication of ES2130138T3 publication Critical patent/ES2130138T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Led Devices (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

UN NUEVO DERIVADO DE LA XANTINA REPRESENTADO POR LA FORMULA GENERAL (I), QUE ANTAGONIZA SELECTIVAMENTE AL RECEPTOR DE ADENOSINA Y UNA SAL FARMACOLOGICAMENTE ACEPTABLE DEL MISMO. EN LA FORMULA (I) R1 Y R2 PUEDEN SER IGUALES O DIFERENTES Y CADA UNO REPRESENTA HIDROGENO, PROPILO, BUTILO O ALILO; R3 REPRESENTA HIDROGENO O ALQUILO INFERIOR; Y1 Y Y2 PUEDEN SER IGUALES O DIFERENTES Y CADA UNO REPRESENTA HIDROGENO O METILO; Y Z REPRESENTA FENILO (IN)SUSTITUIDO, PIRIDILO, IMIDAZOLILO, FURILO O TIENILO.
ES91917824T 1990-10-18 1991-10-17 Derivado de xantina. Expired - Lifetime ES2130138T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP28017190 1990-10-18

Publications (1)

Publication Number Publication Date
ES2130138T3 true ES2130138T3 (es) 1999-07-01

Family

ID=17621294

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91917824T Expired - Lifetime ES2130138T3 (es) 1990-10-18 1991-10-17 Derivado de xantina.

Country Status (6)

Country Link
EP (1) EP0559893B1 (es)
AT (1) ATE176470T1 (es)
CA (1) CA2094270C (es)
DE (1) DE69130869T2 (es)
ES (1) ES2130138T3 (es)
WO (1) WO1992006976A1 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5484920A (en) * 1992-04-08 1996-01-16 Kyowa Hakko Kogyo Co., Ltd. Therapeutic agent for Parkinson's disease
CA2093403C (en) * 1992-04-08 1999-08-10 Fumio Suzuki Therapeutic agent for parkinson's disease
PT628311E (pt) * 1992-07-08 2002-09-30 Kyowa Hakko Kogyo Kk Derivado de xantina com actividade antidepressiva
TW252044B (es) * 1992-08-10 1995-07-21 Boehringer Ingelheim Kg
JP2613355B2 (ja) * 1992-09-28 1997-05-28 協和醗酵工業株式会社 パーキンソン氏病治療剤
CA2112031A1 (en) * 1992-12-24 1994-06-25 Fumio Suzuki Xanthine derivatives
WO1994025462A1 (en) * 1993-05-03 1994-11-10 The United States Of America, Represented By The 8-substituted 1,3,7-trialkyl-xanthine derivatives as a2-selective adenosine receptor antagonists
ES2070087B1 (es) * 1993-08-13 1996-02-16 Pfizer Derivados de indol
CA2161011A1 (en) * 1994-02-23 1995-08-31 Fumio Suzuki Xanthine derivatives
ATE325610T1 (de) 1997-09-05 2006-06-15 Kyowa Hakko Kogyo Kk Xanthinderivative zur behandlung von hirnischämie
AU1688599A (en) * 1998-01-05 1999-07-26 Eisai Co. Ltd. Purine derivatives and adenosine a2 receptor antagonists serving as preventives/remedies for diabetes
EP1234576B1 (en) * 1999-10-29 2006-03-08 Kyowa Hakko Kogyo Co., Ltd. Pharmaceutical composition for eating disorders
FR2804958B1 (fr) * 2000-02-15 2005-07-08 Hoechst Marion Roussel Inc Derives de xanthine, leur procede de preparation et les intermediaires de ce procede, leur application comme medicament et les compositions pharmaceutiques les renfermant
CN101543497A (zh) 2002-01-28 2009-09-30 协和发酵工业株式会社 治疗运动疾病患者的方法
JPWO2005000313A1 (ja) * 2003-06-27 2006-08-03 協和醗酵工業株式会社 抗てんかん剤
EP1709967A4 (en) * 2004-01-28 2010-09-15 Kyowa Hakko Kirin Co Ltd MEDICINE AGAINST MIGRAINE
ES2273599B1 (es) 2005-10-14 2008-06-01 Universidad De Barcelona Compuestos para el tratamiento de la fibrilacion auricular.
EP2121705A2 (en) * 2006-12-01 2009-11-25 Cv Therapeutics, Inc. A2a adenosine receptor antagonists
JP2010513353A (ja) * 2006-12-22 2010-04-30 シュバルツ ファルマ アクチェンゲゼルシャフト 選択的ａ２ａ受容体アンタゴニストとしての８−エチニルキサンチン誘導体
RU2477726C1 (ru) * 2011-10-18 2013-03-20 Общество С Ограниченной Ответственностью "Ньювак" (Ооо "Ньювак") Замещенные феноксиуксусные кислоты, их эфиры и амиды, включающие 2,6-диоксо-2,3,6,7-тетрагидро-1н-пурин-8-иловый фрагмент, - антагонисты аденозинового a2a рецептора и их применение
WO2020125779A1 (en) * 2018-12-21 2020-06-25 Sunshine Lake Pharma Co., Ltd. 8-substituted styryl xanthine derivatives and uses thereof
CN111018856B (zh) * 2019-12-12 2021-10-01 广东东阳光药业有限公司 8-取代的苯乙烯基黄嘌呤衍生物及其用途
CN111072663B (zh) * 2019-12-12 2021-10-01 广东东阳光药业有限公司 8-取代的苯乙烯基黄嘌呤衍生物及其用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2152207T3 (es) * 1989-10-20 2001-02-01 Kyowa Hakko Kogyo Kk Derivados condensados de la purina.

Also Published As

Publication number Publication date
WO1992006976A1 (en) 1992-04-30
EP0559893B1 (en) 1999-02-03
DE69130869D1 (en) 1999-03-18
EP0559893A1 (en) 1993-09-15
ATE176470T1 (de) 1999-02-15
DE69130869T2 (de) 1999-06-10
CA2094270A1 (en) 1992-04-19
EP0559893A4 (en) 1994-07-06
CA2094270C (en) 1997-01-21

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