ES2130247T3 - Derivados amidino y su uso como inhibidores de la oxido nitrico sintasa. - Google Patents

Derivados amidino y su uso como inhibidores de la oxido nitrico sintasa.

Info

Publication number
ES2130247T3
ES2130247T3 ES93900357T ES93900357T ES2130247T3 ES 2130247 T3 ES2130247 T3 ES 2130247T3 ES 93900357 T ES93900357 T ES 93900357T ES 93900357 T ES93900357 T ES 93900357T ES 2130247 T3 ES2130247 T3 ES 2130247T3
Authority
ES
Spain
Prior art keywords
group
6alkyl
pct
formula
sec
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93900357T
Other languages
English (en)
Inventor
Richard Mansfield Beams
Harold Francis Hodson
Richard Michael John La Palmer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Application granted granted Critical
Publication of ES2130247T3 publication Critical patent/ES2130247T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/14—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyrrole Compounds (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

DERIVADOS AMIDINO DE LA FORMULA (Y) Y LAS SALES, Y LOS ESTERES ACEPTABLES FARMACEUTICAMENTE Y LAS AMIDAS DE ELLO, EN EL QUE: R1 ES UN GRUPO ALQUIL DE CADENA SIMPLE O RAMIFICADA DERIVADA O RECTA C1-6, UN GRUPO C2-6 ALQUENIL, UN GRUPO C2-6 ALQUINIL, UN GRUPO C3-6 CICLOALQUIL O UN GRUPO C3-6 CICLOALQUIL C1-6 ALQUIL; Q ES UN GRUPO ALQUILENO, ALQUENILENO O ALQUINILENO QUE TIENEN DE 3 A 6 ATOMOS DE CARBONO Y QUE PUEDEN SER OPCIONALMENTE SUSTITUIDOS POR UNO O MAS GRUPOS C1-3ALQUIL; UN GRUPO DE LA FORMULA -(CH2)PX(CH2)QO)X DONDE X ES 0, 1 O 2, O O NR2 DONDE R2 ES H O C1-6 ALQUIL; O UN GRUPO DE LA FORMULA _(CH2)RA(CH2)SS ES 0, 1 O 2 Y A ES UN ANILLO CARBOCICLICO O HETEROCICLICO DE 3 A 6 MIEMBROS QUE PUEDE OPCIONALMENTE SER SUSTITUIDO POR UNO O MAS SUSTITUYENTES APROPIADOS TALES COMO C1-6 ALQUIL, C1-6 ALCOXI, HIDROXI, HALO, NITRO, CIANO, TRIFLUORO C1-6 ALQUIL, AMINO, C1-6 ALQUILAMINO O DIC1-6 ALQUILAMINO; Y LAS FORMULAS FARMACEUTICAS QUE LOS CONTIENEN SON DESCRITOS PARA USO EN MEDICINA, TAMBIEN SON DESCRITOS NUEVOS COMPONENTES DE LA FORMULA (I) Y LA PREPARACION DE TALES NUEVOS COMPONENTES.
ES93900357T 1991-12-24 1992-12-23 Derivados amidino y su uso como inhibidores de la oxido nitrico sintasa. Expired - Lifetime ES2130247T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919127376A GB9127376D0 (en) 1991-12-24 1991-12-24 Amidino derivatives

Publications (1)

Publication Number Publication Date
ES2130247T3 true ES2130247T3 (es) 1999-07-01

Family

ID=10706815

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93900357T Expired - Lifetime ES2130247T3 (es) 1991-12-24 1992-12-23 Derivados amidino y su uso como inhibidores de la oxido nitrico sintasa.

Country Status (20)

Country Link
US (1) US5863931A (es)
EP (1) EP0618898B1 (es)
JP (1) JP3171850B2 (es)
AT (1) ATE178588T1 (es)
AU (1) AU669345B2 (es)
CA (1) CA2126327C (es)
CY (1) CY2197B1 (es)
DE (1) DE69228879T2 (es)
DK (1) DK0618898T3 (es)
ES (1) ES2130247T3 (es)
GB (1) GB9127376D0 (es)
GR (1) GR3030492T3 (es)
HU (1) HU217618B (es)
IL (1) IL104212A (es)
MY (1) MY109421A (es)
NZ (1) NZ246202A (es)
RU (1) RU2130014C1 (es)
TW (1) TW255881B (es)
WO (1) WO1993013055A1 (es)
ZA (1) ZA9210018B (es)

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CA2126327A1 (en) 1993-07-08
DK0618898T3 (da) 1999-10-18
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DE69228879T2 (de) 1999-08-26
MY109421A (en) 1997-01-31
RU94031155A (ru) 1996-04-20
EP0618898A1 (en) 1994-10-12
HU217618B (hu) 2000-03-28
GR3030492T3 (en) 1999-10-29
EP0618898B1 (en) 1999-04-07
US5863931A (en) 1999-01-26
WO1993013055A1 (en) 1993-07-08
AU669345B2 (en) 1996-06-06
NZ246202A (en) 1996-05-28
CY2197B1 (en) 2002-11-08
RU2130014C1 (ru) 1999-05-10
DE69228879D1 (de) 1999-05-12
GB9127376D0 (en) 1992-02-19
TW255881B (es) 1995-09-01
HU9401848D0 (en) 1994-09-28
ATE178588T1 (de) 1999-04-15
AU3169293A (en) 1993-07-28
IL104212A0 (en) 1993-05-13
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ZA9210018B (en) 1994-06-23
CA2126327C (en) 2005-05-17

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