ES2131503T3 - Procedimiento para la preparacion de acidos 2-aril-propionicos. - Google Patents

Procedimiento para la preparacion de acidos 2-aril-propionicos.

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Publication number
ES2131503T3
ES2131503T3 ES91200184T ES91200184T ES2131503T3 ES 2131503 T3 ES2131503 T3 ES 2131503T3 ES 91200184 T ES91200184 T ES 91200184T ES 91200184 T ES91200184 T ES 91200184T ES 2131503 T3 ES2131503 T3 ES 2131503T3
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ES
Spain
Prior art keywords
compound
ester
ring system
sub
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91200184T
Other languages
English (en)
Inventor
Mauro Atillio Bertola
Arthur Friedrich Marx
Hein Simon Koger
Wilhelmus Johannes Quax
Der Laken Cornelis Jacobus Van
Gareth Thomas Phillips
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SHELL INT RESEARCH
Gist Brocades NV
Shell Internationale Research Maatschappij BV
Original Assignee
SHELL INT RESEARCH
Gist Brocades NV
Shell Internationale Research Maatschappij BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SHELL INT RESEARCH, Gist Brocades NV, Shell Internationale Research Maatschappij BV filed Critical SHELL INT RESEARCH
Application granted granted Critical
Publication of ES2131503T3 publication Critical patent/ES2131503T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/83—Arthrobacter
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/832—Bacillus
    • Y10S435/836—Bacillus licheniformis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/832—Bacillus
    • Y10S435/839—Bacillus subtilis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/848—Escherichia
    • Y10S435/849—Escherichia coli
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/874—Pseudomonas
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Neurology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

UN PROCESO PARA LA PREPARACION DE UN COMPUESTO ACTIVO FARMACEUTICAMENTE CON FORMA ESTEREOESPECIFICA QUE TENGA LA FORMULA: O UNA SAL ACEPTABLE FARMACEUTICAMENTE O UN ESTER DEL MISMO, COMO UNA SAL DE METAL ALCALINO O UNA SAL DE METAL DE TIERRA ALCALINA O UN ESTER PIVABILO, EN DONDE R SUB 1 REPRESENTA A UN GRUPO ARILO OPCIONALMENTE SUSTITUIDO COMO POR EJEMPLO UN GRUPO FENILO O NAFTILO OPCIONALMENTE INCLUIDO EN UN SISTEMA DE ANILLO HETEROCICLICO, QUE ES OPCIONALMENTE SUSTITUIDO, O REPRESENTA A UN SISTEMA DE ANILLO HETEROAROMATICO QUE ADEMAS DE LOS ATOMOS DE CARBONO CONTIENE UNO O MAS ATOMOS SELECCIONADOS DEL NITROGENO, SULFURO Y OXIGENO, SIENDO ESTE SISTEMA DE ANILLO OPCIONALMENTE SUSTITUIDO, QUE CONSISTE EN SOMETER UN COMPUESTO QUE TIENE LA FORMULA DONDE R SUB 2 ES UN RESIDUO DE ESTER Y PREFERIBLEMENTE UN GRUPO ALQUILO OPCIONALMENTE SUSTITUIDO, A LA ACCION DE UN MICROORGANISMO QUE TIENE LA CAPACIDAD DE PRODUCIR UNA HIDROLISIS ESTEREOSELECTIVA DE UN COMPUESTO (II) A UN COMPUESTO (I), QUE TIENEPOR LO MENOS UN 80 % POR PESO DE LA CONFIGURACION S, Y SI SE DESEA, CONVIRTIENDO EL COMPUESTO (I) EN UNA SAL FARMACEUTICAMENTE ACEPTABLE O UN ESTER DEL MISMO.
ES91200184T 1986-01-07 1987-01-06 Procedimiento para la preparacion de acidos 2-aril-propionicos. Expired - Lifetime ES2131503T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB868600245A GB8600245D0 (en) 1986-01-07 1986-01-07 Preparation of 2-arylpropionic acids

Publications (1)

Publication Number Publication Date
ES2131503T3 true ES2131503T3 (es) 1999-08-01

Family

ID=10590982

Family Applications (2)

Application Number Title Priority Date Filing Date
ES91200184T Expired - Lifetime ES2131503T3 (es) 1986-01-07 1987-01-06 Procedimiento para la preparacion de acidos 2-aril-propionicos.
ES87200008T Expired - Lifetime ES2051727T3 (es) 1986-01-07 1987-01-06 Procedimiento para la preparacion de acidos 2-arilpropionicos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES87200008T Expired - Lifetime ES2051727T3 (es) 1986-01-07 1987-01-06 Procedimiento para la preparacion de acidos 2-arilpropionicos.

Country Status (20)

Country Link
US (2) US4886750A (es)
EP (2) EP0233656B1 (es)
JP (2) JP2702915B2 (es)
KR (1) KR960016868B1 (es)
CN (1) CN87100031A (es)
AT (2) ATE177150T1 (es)
AU (1) AU591541B2 (es)
CA (2) CA1340382C (es)
DE (2) DE3780184T2 (es)
DK (1) DK172862B1 (es)
ES (2) ES2131503T3 (es)
FI (1) FI90565C (es)
GB (1) GB8600245D0 (es)
GR (2) GR3005735T3 (es)
IE (1) IE61983B1 (es)
IL (1) IL81127A (es)
NO (2) NO169498C (es)
NZ (1) NZ218808A (es)
PT (1) PT84060B (es)
ZA (1) ZA8786B (es)

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JPWO2003097851A1 (ja) * 2002-05-15 2005-09-15 小野薬品工業株式会社 光学活性アルキルカルボン酸誘導体の製造方法
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HU231033B1 (hu) 2016-03-22 2019-12-30 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Eljárás 3-as kötést tartalmazó optikailag aktív karbonsavak, karbonsav sók és karbonsav származékok előállítására
CN109706133B (zh) * 2017-10-25 2022-12-27 上海交通大学 一组新型酯酶及其应用

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DE3638758A1 (de) * 1986-11-13 1988-05-26 Schering Ag Racematspaltung von 3-acyloxy-bicyclo(3.3.0)octan-7-on-2- carbonsaeureestern durch stereospezifische enzymatische oder mikrobiologische acylat-hydrolyse

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ES2051727T3 (es) 1994-07-01
EP0426656A2 (en) 1991-05-08
DE3752257D1 (de) 1999-04-08
DK4987A (da) 1987-07-08
IL81127A (en) 1991-07-18
DE3780184D1 (de) 1992-08-13
NO914029D0 (no) 1991-10-14
ATE78054T1 (de) 1992-07-15
PT84060B (pt) 1989-02-28
NO914029L (no) 1987-07-08
GR3030040T3 (en) 1999-07-30
KR870007276A (ko) 1987-08-18
NO870040L (no) 1987-07-08
GR3005735T3 (es) 1993-06-07
US4886750A (en) 1989-12-12
GB8600245D0 (en) 1986-02-12
CA1341324C (en) 2001-12-04
DE3752257T2 (de) 1999-08-05
JPS6345234A (ja) 1988-02-26
EP0233656B1 (en) 1992-07-08
KR960016868B1 (ko) 1996-12-23
US5037751A (en) 1991-08-06
IL81127A0 (en) 1987-03-31
ATE177150T1 (de) 1999-03-15
CA1340382C (en) 1999-02-09
FI90565B (fi) 1993-11-15
EP0233656A1 (en) 1987-08-26
PT84060A (en) 1987-02-01
FI870035A7 (fi) 1987-07-08
NZ218808A (en) 1990-03-27
IE61983B1 (en) 1994-12-14
DK4987D0 (da) 1987-01-06
JP2729044B2 (ja) 1998-03-18
JP2702915B2 (ja) 1998-01-26
DK172862B1 (da) 1999-08-23
EP0426656A3 (en) 1991-06-26
IE870024L (en) 1987-07-07
NO870040D0 (no) 1987-01-06
DE3780184T2 (de) 1992-12-24
AU591541B2 (en) 1989-12-07
NO174350B (no) 1994-01-10
AU6707286A (en) 1987-07-09
FI90565C (fi) 1994-02-25
NO169498C (no) 1992-07-01
ZA8786B (en) 1987-12-30
CN87100031A (zh) 1987-09-09
NO169498B (no) 1992-03-23
EP0426656B1 (en) 1999-03-03
JPH08242853A (ja) 1996-09-24
FI870035A0 (fi) 1987-01-05
NO174350C (no) 1994-04-20

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