ES2132536T3 - Derivados de oximas, su preparacion y su utilizacion terapeutica. - Google Patents

Derivados de oximas, su preparacion y su utilizacion terapeutica.

Info

Publication number
ES2132536T3
ES2132536T3 ES95307131T ES95307131T ES2132536T3 ES 2132536 T3 ES2132536 T3 ES 2132536T3 ES 95307131 T ES95307131 T ES 95307131T ES 95307131 T ES95307131 T ES 95307131T ES 2132536 T3 ES2132536 T3 ES 2132536T3
Authority
ES
Spain
Prior art keywords
sup
alkyl
hydrogen
formula
igt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95307131T
Other languages
English (en)
Inventor
Hiroaki Yanagisawa
Takashi Fujita
Koichi Fujimoto
Takao Yoshioka
Kunio Wada
Minoru Oguchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Application granted granted Critical
Publication of ES2132536T3 publication Critical patent/ES2132536T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/44—Two oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

COMPUESTOS DE FORMULA (I) EN LA QUE R 1 ES HIDROGENO O ALQUILO, R{SUP,2} ES ALQUILENO; R{SUP,3} ES HIDROGENO, ALQUILO, ALCOXI, ALQUILTIO, HALOGENO, GRUPO NITRO, GRUPO AMINO, MONOALQUILAMINO, DIALQUILAMINO, ARILO, O ARALQUILO; X ES ARILO O HETEROCICLICO AROMATICO; Y ES OXIGENO, AZUFRE O UN GRUPO DE FORMULA >N-R{SUP,4), DONDE R{SUP,4} ES HIDROGENO, ALQUILO O ACILO; Y Z ES UN GRUPO DE FORMULA (ZA), (ZB), (ZC) O (ZD) Y SUS SALES PUEDEN SER USADA PARA TRATAR O PREVENIR LA HIPERLIPIDEMIA, HIPERGLICEMIA, OBESIDAD, MALA TOLERANCIA DE GLUCOSA (IGT), LA RESISTENCIA A INSULINA DISTINTA DE LA IGT (NGT), TOLERANCIA A LA GLUCOSA NO DIAGNOSTICADA, RESISTENCIA A LA INSULINA, COMPLICACIONES DIABETICAS, HIGADO GRASO, SINDROME DE OVARIOS POLIQUISTICO PCOS) Y DIABETES MELLITUS GESTANTE (GDM); ADEMAS LOS COMPUESTOS DE LA PRESENTE INVENCION TIENEN ACTIVIDAD INHIBIDORA DE LA REDUCTASA ALDOSA.
ES95307131T 1994-10-07 1995-10-09 Derivados de oximas, su preparacion y su utilizacion terapeutica. Expired - Lifetime ES2132536T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP24387694 1994-10-07
JP13678895 1995-06-02

Publications (1)

Publication Number Publication Date
ES2132536T3 true ES2132536T3 (es) 1999-08-16

Family

ID=26470291

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95307131T Expired - Lifetime ES2132536T3 (es) 1994-10-07 1995-10-09 Derivados de oximas, su preparacion y su utilizacion terapeutica.

Country Status (20)

Country Link
US (3) US5703096A (es)
EP (1) EP0708098B1 (es)
KR (1) KR100250175B1 (es)
CN (1) CN1056840C (es)
AT (1) ATE177088T1 (es)
AU (1) AU688573B2 (es)
CA (1) CA2159938A1 (es)
CZ (1) CZ261095A3 (es)
DE (1) DE69508029T2 (es)
DK (1) DK0708098T3 (es)
ES (1) ES2132536T3 (es)
FI (1) FI954763A7 (es)
GR (1) GR3030207T3 (es)
HU (1) HUT72642A (es)
IL (1) IL115536A (es)
MX (1) MX9504261A (es)
NO (1) NO305954B1 (es)
NZ (1) NZ280181A (es)
RU (1) RU2122998C1 (es)
TW (1) TW400329B (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5701896A (en) * 1995-06-02 1996-12-18 Sankyo Company Limited Aromatic oxyimino derivatives
US5798375A (en) * 1995-07-03 1998-08-25 Sankyo Company, Limited Treatment of arteriosclerosis and xanthoma
EP0783888A1 (en) 1995-12-26 1997-07-16 Sankyo Company Limited Use of troglitazone and related thiazolidinediones in the manufacture of a medicament for the treatment and prophylaxis of osteoporosis
IL120443A (en) * 1996-03-18 2000-07-16 Sankyo Co Use of an insulin sensitizer for the manufacture of a medicament for the treatment or prophylaxis of pancreatitis
KR20000005224A (ko) * 1996-04-04 2000-01-25 가와무라 요시부미 페닐알킬카르복실산 유도체_
US5889025A (en) * 1996-05-06 1999-03-30 Reddy's Research Foundation Antidiabetic compounds having hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
ZA973848B (en) * 1996-05-06 1997-12-02 Reddy Research Foundation Novel heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them.
US5919782A (en) * 1996-05-06 1999-07-06 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
CA2257284C (en) * 1996-05-31 2005-10-04 Sankyo Company Limited Remedy for autoimmune diseases
US6114526A (en) * 1996-07-01 2000-09-05 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US6372750B2 (en) 1996-07-01 2002-04-16 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases
USRE39266E1 (en) * 1996-07-01 2006-09-05 Dr. Reddy's Laboratories, Limited Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
BR9711098B1 (pt) 1996-07-01 2011-10-04 compostos heterocìclicos, processo para sua preparação e composições farmacêuticas contendo os mesmos e seu uso no tratamento de diabetes e doenças relacionadas.
WO1998020871A1 (en) * 1996-11-08 1998-05-22 Nippon Chemiphar Co., Ltd. Visceral fat lowering agent
HUP9902721A2 (hu) * 1997-11-25 1999-12-28 The Procter & Gamble Co. Tömény textillágyító készítmény és ehhez alkalmazható magas telítetlenségű textillágyító vegyület
US6019229A (en) * 1997-12-18 2000-02-01 Fleetguard, Inc. Self-centering, floating retainer for spin-on filter
MY123337A (en) 1998-05-11 2006-05-31 Takeda Chemical Industries Ltd Oxyiminoalkanoic acid derivatives.
US6756360B1 (en) 1998-12-24 2004-06-29 Metabasis Therapeutics, Inc. Combination of FBPase inhibitors and insulin sensitizers for the treatment of diabetes
PL351878A1 (en) * 1999-04-07 2003-06-30 Sankyo Co Amino compound derivatives
EP1229026A4 (en) * 1999-11-10 2003-09-24 Takeda Chemical Industries Ltd ALCOXYIMINOALKANOIC ACID DERIVATIVES
US7563774B2 (en) 2000-06-29 2009-07-21 Metabasis Therapeutics, Inc. Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes
US7232828B2 (en) * 2002-08-10 2007-06-19 Bethesda Pharmaceuticals, Inc. PPAR Ligands that do not cause fluid retention, edema or congestive heart failure
US7420083B2 (en) 2003-09-25 2008-09-02 Wyeth Substituted aryloximes
US7342039B2 (en) 2003-09-25 2008-03-11 Wyeth Substituted indole oximes
RU2374239C2 (ru) * 2004-07-28 2009-11-27 Ф.Хоффманн-Ля Рош Аг Производные арилпиридина
CN115887434B (zh) * 2022-11-23 2024-12-24 四川大学 具有抗氧化作用的药物用于制备治疗多囊卵巢综合征药物的用途

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5522636A (en) * 1978-08-04 1980-02-18 Takeda Chem Ind Ltd Thiazoliding derivative
FR2538388B1 (fr) * 1982-12-24 1985-06-21 Pharmuka Lab Nouveaux derives de naphtalene- ou azanaphtalenecarboxamide, leurs procedes de preparation et leur utilisation comme medicaments
JPS6051189A (ja) * 1983-08-30 1985-03-22 Sankyo Co Ltd チアゾリジン誘導体およびその製造法
CN1003445B (zh) * 1984-10-03 1989-03-01 武田药品工业株式会社 噻唑烷二酮衍生物，其制备方法和用途
DK173350B1 (da) * 1985-02-26 2000-08-07 Sankyo Co Thiazolidinderivater, deres fremstilling og farmaceutisk paæparat indeholdende dem
JPH06779B2 (ja) * 1985-06-10 1994-01-05 武田薬品工業株式会社 チアゾリジオン誘導体およびそれを含んでなる医薬組成物
EP0295828A1 (en) * 1987-06-13 1988-12-21 Beecham Group Plc Novel compounds
US4728739A (en) * 1987-06-15 1988-03-01 American Home Products Corporation Hypoglycemic thiazolidinediones
ATE186724T1 (de) * 1987-09-04 1999-12-15 Beecham Group Plc Substituierte thiazolidindionderivate
GB8820389D0 (en) * 1988-08-26 1988-09-28 Beecham Group Plc Novel compounds
WO1991007107A1 (en) * 1989-11-13 1991-05-30 Pfizer Inc. Oxazolidinedione hypoglycemic agents
US5143930A (en) * 1990-02-07 1992-09-01 Sankyo Company, Limited Thiazolidine derivatives with anti-diabetic activity, their preparation and their use
GB9017218D0 (en) * 1990-08-06 1990-09-19 Beecham Group Plc Novel compounds
US5334604A (en) * 1990-08-23 1994-08-02 Pfizer Inc. Hypoglycemic hydroxyurea derivatives
GB9023584D0 (en) * 1990-10-30 1990-12-12 Beecham Group Plc Novel compounds
GB9023585D0 (en) * 1990-10-30 1990-12-12 Beecham Group Plc Novel compounds
GB9023583D0 (en) * 1990-10-30 1990-12-12 Beecham Group Plc Novel compounds
FR2680512B1 (fr) * 1991-08-20 1995-01-20 Adir Nouveaux derives de 2,4-thiazolidinedione, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US5420146A (en) * 1994-05-10 1995-05-30 American Home Products Corporation Di-oxadiazolidine derivatives as antihyperglycemic agents
JPH08143556A (ja) * 1994-11-15 1996-06-04 Terumo Corp ジオキソチアゾリジン誘導体及びそれを含有する医薬組成物
JPH08143568A (ja) * 1994-11-22 1996-06-04 Terumo Corp ピリドピリミジン誘導体及びそれを含有する医薬組成物
JPH08143566A (ja) * 1994-11-25 1996-06-04 Terumo Corp キナゾリン誘導体及びそれを含有する医薬組成物
JP3144624B2 (ja) * 1995-06-02 2001-03-12 杏林製薬株式会社 Ｎ−ベンジルジオキソチアゾリジルベンズアミド誘導体及びその製造法
JP3929512B2 (ja) * 1995-06-02 2007-06-13 杏林製薬株式会社 Ｎ−置換ジオキソチアゾリジルベンズアミド誘導体及びその製造法

Also Published As

Publication number Publication date
US5703096A (en) 1997-12-30
US5972959A (en) 1999-10-26
HK1011974A1 (en) 1999-07-23
NZ280181A (en) 1996-11-26
NO953990D0 (no) 1995-10-06
AU688573B2 (en) 1998-03-12
GR3030207T3 (en) 1999-08-31
IL115536A (en) 1999-07-14
CA2159938A1 (en) 1996-04-08
RU2122998C1 (ru) 1998-12-10
DK0708098T3 (da) 1999-10-04
IL115536A0 (en) 1996-01-19
CN1056840C (zh) 2000-09-27
KR960014124A (ko) 1996-05-22
ATE177088T1 (de) 1999-03-15
MX9504261A (es) 1997-01-31
US5780490A (en) 1998-07-14
HU9502925D0 (en) 1995-11-28
EP0708098A1 (en) 1996-04-24
FI954763A0 (fi) 1995-10-06
DE69508029D1 (de) 1999-04-08
NO305954B1 (no) 1999-08-23
FI954763A7 (fi) 1996-04-08
CZ261095A3 (en) 1996-04-17
KR100250175B1 (ko) 2000-05-01
NO953990L (no) 1996-04-09
DE69508029T2 (de) 1999-10-21
HUT72642A (en) 1996-05-28
TW400329B (en) 2000-08-01
AU3307695A (en) 1996-05-02
CN1143639A (zh) 1997-02-26
EP0708098B1 (en) 1999-03-03

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