ATE92316T1 - Verwendung von l-carnitinderivaten zur herstellung eines arzneimittels zur therapeutischen behandlung von peripheren neuropathien. - Google Patents

Verwendung von l-carnitinderivaten zur herstellung eines arzneimittels zur therapeutischen behandlung von peripheren neuropathien.

Info

Publication number: ATE92316T1
Authority: AT; Austria
Prior art keywords: medication; manufacture; therapeutic treatment; peripheral neuropathies; carnitine derivatives
Prior art date: 1988-12-27

Application number

AT89830544T

Other languages

English (en)

Inventor

Claudio Cavazza

Original Assignee

Sigma Tau Ind Farmaceuti

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-12-27

Filing date

1989-12-13

Publication date

1993-08-15

1989-12-13 Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti

1993-08-15 Application granted granted Critical

1993-08-15 Publication of ATE92316T1 publication Critical patent/ATE92316T1/de

Links

PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical class C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 title 1
229940079593 drug Drugs 0.000 title 1
239000003814 drug Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
208000027232 peripheral nervous system disease Diseases 0.000 title 1
208000033808 peripheral neuropathy Diseases 0.000 title 1
230000001225 therapeutic effect Effects 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
125000003974 3-carbamimidamidopropyl group Chemical group C(N)(=N)NCCC* 0.000 abstract 1
230000004075 alteration Effects 0.000 abstract 1
230000003412 degenerative effect Effects 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 abstract 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
-1 mercaptomethyl Chemical group 0.000 abstract 1
210000000653 nervous system Anatomy 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
125000000547 substituted alkyl group Chemical group 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Emergency Medicine (AREA)
Epidemiology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT89830544T 1988-12-27 1989-12-13 Verwendung von l-carnitinderivaten zur herstellung eines arzneimittels zur therapeutischen behandlung von peripheren neuropathien. ATE92316T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT8848717A IT1224842B (it)	1988-12-27	1988-12-27	Uso di derivati della l-carnitina nel trattamento terapeutico delle alterazioni degenerative del sistema nervoso
EP89830544A EP0376899B1 (de)	1988-12-27	1989-12-13	Verwendung von L-Carnitinderivaten zur Herstellung eines Arzneimittels zur therapeutischen Behandlung von peripheren Neuropathien

Publications (1)

Publication Number	Publication Date
ATE92316T1 true ATE92316T1 (de)	1993-08-15

Family

ID=11268228

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89830544T ATE92316T1 (de)	1988-12-27	1989-12-13	Verwendung von l-carnitinderivaten zur herstellung eines arzneimittels zur therapeutischen behandlung von peripheren neuropathien.

Country Status (9)

Country	Link
US (1)	US5043355A (de)
EP (1)	EP0376899B1 (de)
JP (1)	JP2828293B2 (de)
AT (1)	ATE92316T1 (de)
DE (1)	DE68908145T2 (de)
ES (1)	ES2058596T3 (de)
HK (1)	HK1005849A1 (de)
IT (1)	IT1224842B (de)
ZA (1)	ZA899802B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1245699B (it) *	1991-05-29	1994-10-14	Sigma Tau Ind Farmaceuti	Derivati della l-carnitina quali agenti terapeutici per il trattamento delle miopatie, della degenarazione neuronale e per inibire la proteolisi
IT1254314B (it) *	1992-03-27	1995-09-14	Sigma Tau Ind Farmaceuti	Composizioni farmaceutiche conyenenti l-carnitina e acil- carnitine inassociazione con ace-inibitori per il trattamento di patologie cardiovascolari.
IT1263004B (it) *	1992-10-08	1996-07-23	Sigma Tau Ind Farmaceuti	Impiego della l-carnitina e acil l-carnitine nel trattamento a lungo termine di pazienti diabetici non insulino-dipendenti.
IT1277898B1 (it) *	1995-08-03	1997-11-12	Mendes Srl	Uso di amminoacidi basici, di acil derivati di amminoacidi basici e di loro sali farmaceuticamente accettabili per la profilassi di malattie
IT1276225B1 (it) *	1995-10-17	1997-10-27	Sigma Tau Ind Farmaceuti	Composizioni farmaceutiche contenenti l-carnitina e alcanoil l- carnitine in associazione con resveratrolo o suoi derivati utili per
IT1276253B1 (it)	1995-12-15	1997-10-27	Sigma Tau Ind Farmaceuti	Composizione farmaceutica contenente l-carnitina o alcanoil l-carnitine per la prevenzione ed il trattamento di stati morbosi
IT1283951B1 (it) *	1996-03-15	1998-05-07	Mendes Srl	Uso della acetil l-carnitina o dei suoi sali farmacologicamente accettabili per il trattamento terapeutico o la profilassi di
IT1291113B1 (it) *	1997-03-20	1998-12-29	Sigma Tau Ind Farmaceuti	Composizione nutritiva terapeutica per soggetti affetti da diabete mellito
US6090848A (en) *	1997-12-01	2000-07-18	Sigma-Tau Healthscience S.P.A.	Compositions and methods for increasing the concentration and/or motility of spermatozoa in humans
US5863940A (en)	1997-12-01	1999-01-26	Sigma-Tau Healthscience S.P.A.	Medicament and therapeutical method for treating idiopathic asthenozoospermia
ES2210705T5 (es)	1998-03-19	2011-02-15	Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.	Composición combinada que comprende una l-carnitina o una alcanoil-l-carnitina, un glucosaminoglucano y/o un constituyente del mismo.
US8173618B2 (en) *	2003-07-25	2012-05-08	University Of Massachusetts	Formulations for reducing neuronal degeneration
ITRM20040327A1 (it) *	2004-07-01	2004-10-01	Sigma Tau Ind Farmaceuti	Uso della acetil l-carnitina per la preparazione di un medicamento per il trattamento del dolore neuropatico in pazienti diabetici.
US7842726B2 (en) *	2005-09-30	2010-11-30	Showa Denko K.K.	Carnitine derivative, salt thereof, external skin preparation and cosmetic material
JP5047507B2 (ja) *	2005-09-30	2012-10-10	昭和電工株式会社	カルニチン誘導体及びその塩、皮膚外用剤ならびに化粧料
US8597640B2 (en) *	2007-10-31	2013-12-03	University Of Massachusetts Lowell	Over-the-counter vitamin/nutriceutical formulation that provides neuroprotection and maintains or improves cognitive performance in alzheimer's disease and normal aging
EP3855944A4 (de) *	2018-10-29	2022-06-29	Lonza Consumer Health Inc.	Verfahren und zusammensetzung zur erhöhung der bioverfügbarkeit von carnitin

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2903579A1 (de) *	1978-02-03	1979-08-09	Sigma Tau Ind Farmaceuti	Verwendung von acetylcarnitin und anderen acylderivaten des carnitins zur behandlung der hyperlipoproteinaemie und hyperlimpidaemie sowie arzneimittel
IT1206954B (it) *	1979-02-12	1989-05-17	Sigma Tau Ind Farmaceuti	Agenti terapeutici a base di un acil derivato della carnitina per la cura di vasculopatie periferiche
US4346107A (en) *	1979-02-12	1982-08-24	Claudio Cavazza	Pharmaceutical composition comprising acyl-carnitine for the treatment of impaired cerebral metabolism
IT1116037B (it) *	1979-04-23	1986-02-10	Sigma Tau Ind Farmaceuti	Esteri e ammidi di acil carnitine loro procedimenti di preparazione e loro uso terapeutico
IT1150396B (it) *	1982-12-09	1986-12-10	Sigma Tau Ind Farmaceuti	Impiego di alcanoil l-carnitine per il trattamento terapeutico di miopa tie e distrofie muscolari
IT1181682B (it) *	1985-06-11	1987-09-30	Sigma Tau Ind Farmaceuti	Impiego di alcanoil l-carnitine per il trattamento terapeutico del parkinsonismo idiopatico o indotto
IT1208753B (it) *	1986-07-02	1989-07-10	Sigma Tau Ind Farmaceuti	L-amminoacil derivati della l-carnitina, procedimento per la loro preparazione e composizioni farmaceutiche ad attivita' epatoprotettrice che li contengono
IT1196564B (it) *	1986-08-04	1988-11-16	Sigma Tau Ind Farmaceuti	Impiego di acetil l-carnitina nel trattamento terapeutico delle neuropatie periferiche

1988
- 1988-12-27 IT IT8848717A patent/IT1224842B/it active
1989
- 1989-12-13 ES ES89830544T patent/ES2058596T3/es not_active Expired - Lifetime
- 1989-12-13 DE DE89830544T patent/DE68908145T2/de not_active Expired - Lifetime
- 1989-12-13 EP EP89830544A patent/EP0376899B1/de not_active Expired - Lifetime
- 1989-12-13 AT AT89830544T patent/ATE92316T1/de not_active IP Right Cessation
- 1989-12-15 US US07/451,253 patent/US5043355A/en not_active Expired - Lifetime
- 1989-12-21 ZA ZA899802A patent/ZA899802B/xx unknown
- 1989-12-26 JP JP1338034A patent/JP2828293B2/ja not_active Expired - Lifetime
1998
- 1998-06-05 HK HK98104941A patent/HK1005849A1/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE68908145T2 (de)	1993-11-25
US5043355A (en)	1991-08-27
DE68908145D1 (de)	1993-09-09
JPH02207020A (ja)	1990-08-16
IT8848717A0 (it)	1988-12-27
IT1224842B (it)	1990-10-24
EP0376899A3 (de)	1991-09-18
JP2828293B2 (ja)	1998-11-25
ES2058596T3 (es)	1994-11-01
EP0376899A2 (de)	1990-07-04
EP0376899B1 (de)	1993-08-04
HK1005849A1 (en)	1999-01-29
ZA899802B (en)	1990-11-28

Legal Events

Date	Code	Title	Description
1994-03-15	UEP	Publication of translation of european patent specification
2010-03-15	EELA	Cancelled due to lapse of time

Publication	Publication Date	Title
ATE92316T1 (de)	1993-08-15	Verwendung von l-carnitinderivaten zur herstellung eines arzneimittels zur therapeutischen behandlung von peripheren neuropathien.
DE69201948D1 (de)	1995-05-11	Verwendung von 1,3-oxathiolanalogen von nukleosiden zur herstellung eines arzneimittels zur behandlung von hepatitis-b.
ATE121744T1 (de)	1995-05-15	Neue triazolopyrimidin- und pyrazolopyrimidinderivate zur behandlung von kachexie.
DE3876877D1 (de)	1993-02-04	Verwendung von indolon-derivaten zur herstellung von arzneimitteln zur behandlung des parkinsonismus.
GR3033020T3 (en)	2000-08-31	Amide and urea derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses.
ATE205712T1 (de)	2001-10-15	Verwendung von 2-phenyl-3-aroylbenzothiophen derivaten zur herstellung eines medikaments zur hemmung der angiogenese und angiogene krankheiten
DE3888340D1 (de)	1994-04-14	Verwendung von 1,4-disubstituierten-Piperidinyl-Verbindungen zur Herstellung eines Arzneimittels zur Behandlung von Schlaflosigkeit.
ATE79257T1 (de)	1992-08-15	Verwendung von tetrahydrobenz(c,d>indol-6carboxamiden zur herstellung von arzneimitteln zur behandlung von angstzustaenden.
DE58906387D1 (de)	1994-01-27	Verwendung von Benzimidazolen zur Herstellung eines Arzneimittels mit antiischämischen Wirkungen am Herzen und dessen Kombinationen mit Beta-Blockern oder Bradycardica.
DE59206403D1 (de)	1996-07-04	Verwendung von Xanthinderivaten zur Herstellung eines Arzneimittels zur Behandlung von sekundären Nervenzellschäden und Funktionsstörungen nach Schädel-Hirn-Traumen
EP0342587A3 (de)	1991-05-22	Thienotriazolodiazepine und ihre pharmazeutische Verwendung
ATE135573T1 (de)	1996-04-15	Verwendung von indazol-methoxyalkansäure zur herstellung eines arzneimittels zur behandlung von autoimmunkrankheiten
DE69222570D1 (de)	1997-11-13	Phosphonsäurederivate, Verfahren zur Herstellung und ihre Verwendung
DE69207479D1 (de)	1996-02-22	Verwendung der Ester von Acyl-L-Carnitin mit Gamma-Hydroxy-Buttersäure zur Herstellung von pharmazeutischen Zusammensetzungen zur Behandlung von Lebererkrankungen
DE69906728D1 (de)	2003-05-15	Verwendung von 4-piperidinmethanolderivaten zur behandlung von neuralentwicklungsstörungen
ATE212842T1 (de)	2002-02-15	Quinoxalin-derivate zur behandlung von tinnitus
IE800900L (en)	1980-11-04	Pyrrolidinyl-benzoic acid derivatives.
ATE81466T1 (de)	1992-10-15	Verwendung von 2-oxo-imidazolidin-derivaten zur prophylaxe und zur behandlung von herzinsuffizienz.
DE69532963D1 (de)	2004-06-03	Verwendung von 4-acylaminopyridin derivaten zur Herstellung eines Medikaments für die Behandlung von zerebrovaskulären Erkrankungen
ATE106727T1 (de)	1994-06-15	Verwendung eines benzo(b>thiophen-2- carboximidamid-derivates gegen herzinsuffizienz.