ES2132650T3 - Proceso para la preparacion de un derivado de indazol-3-carboxamida. - Google Patents

Proceso para la preparacion de un derivado de indazol-3-carboxamida.

Info

Publication number
ES2132650T3
ES2132650T3 ES95912187T ES95912187T ES2132650T3 ES 2132650 T3 ES2132650 T3 ES 2132650T3 ES 95912187 T ES95912187 T ES 95912187T ES 95912187 T ES95912187 T ES 95912187T ES 2132650 T3 ES2132650 T3 ES 2132650T3
Authority
ES
Spain
Prior art keywords
indazol
carboxamide
derivative
preparation
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95912187T
Other languages
English (en)
Inventor
Norman J Lewis
Victor W Jacewicz
Neal Ward
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Application granted granted Critical
Publication of ES2132650T3 publication Critical patent/ES2132650T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Saccharide Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)

Abstract

UN PROCESO PARA PREPARAR GRANISETRON (1) O UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO, CUYO PROCESO COMPRENDE DESPROTEGER UN COMPUESTO DE ESTRUCTURA (2), EN DONDE R ES UN GRUPO PROTECTOR DE NITROGENO QUE NO REDUCE SIGNIFICATIVAMENTE LA NUCLEOFILICIDAD DE UN GRUPO AMINO SECUNDARIO, Y QUE FORMA OPCIONALMENTE UNA SAL FARMACEUTICAMENTE ACEPTABLE
ES95912187T 1994-03-03 1995-02-28 Proceso para la preparacion de un derivado de indazol-3-carboxamida. Expired - Lifetime ES2132650T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9404055A GB9404055D0 (en) 1994-03-03 1994-03-03 Novel process

Publications (1)

Publication Number Publication Date
ES2132650T3 true ES2132650T3 (es) 1999-08-16

Family

ID=10751194

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95912187T Expired - Lifetime ES2132650T3 (es) 1994-03-03 1995-02-28 Proceso para la preparacion de un derivado de indazol-3-carboxamida.

Country Status (9)

Country Link
EP (1) EP0748321B1 (es)
JP (1) JP4034339B2 (es)
AT (1) ATE181073T1 (es)
DE (1) DE69510186D1 (es)
ES (1) ES2132650T3 (es)
GB (1) GB9404055D0 (es)
GR (1) GR3031121T3 (es)
MX (1) MX9603818A (es)
WO (1) WO1995023799A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9502583D0 (en) * 1995-02-10 1995-03-29 Smithkline Beecham Plc Novel process
GB9504078D0 (en) * 1995-03-01 1995-04-19 Smithkline Beecham Plc Novel process
GB9504060D0 (en) * 1995-03-01 1995-04-19 Smithkline Beecham Plc Novel process
GB9506119D0 (en) * 1995-03-25 1995-05-10 Smithkline Beecham Plc Chemical process
GB9602862D0 (en) * 1996-02-13 1996-04-10 Smithkline Beecham Plc Novel process
ES2197001B1 (es) * 2002-03-26 2004-11-16 Laboratorios Vita, S.A. Procedimiento de obtencion de un compuesto farmaceuticamente activo.
WO2007088557A1 (en) * 2006-02-01 2007-08-09 Natco Pharma Limited Process for highly pure crystalline granisetron base
US8193217B2 (en) * 2008-08-19 2012-06-05 Scinopharm Taiwan Ltd. Polymorphic form of granisetron hydrochloride and methods of making the same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL59004A0 (en) * 1978-12-30 1980-03-31 Beecham Group Ltd Substituted benzamides their preparation and pharmaceutical compositions containing them
DE3650772T2 (de) * 1985-04-27 2003-04-03 F. Hoffmann-La Roche Ag, Basel Derivate von Indazole-3-carboxamide und -3-carboxylsäure

Also Published As

Publication number Publication date
MX9603818A (es) 1997-03-29
GR3031121T3 (en) 1999-12-31
EP0748321A1 (en) 1996-12-18
WO1995023799A1 (en) 1995-09-08
JP4034339B2 (ja) 2008-01-16
ATE181073T1 (de) 1999-06-15
EP0748321B1 (en) 1999-06-09
DE69510186D1 (de) 1999-07-15
JPH09509673A (ja) 1997-09-30
GB9404055D0 (en) 1994-04-20

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