NO973857L - 1-aryl-2-acylamino-etanforbindelser og deres anvnedelse som neurokinin-, spesielt neurokinin-1-antagonister - Google Patents

1-aryl-2-acylamino-etanforbindelser og deres anvnedelse som neurokinin-, spesielt neurokinin-1-antagonister

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Publication number
NO973857L
NO973857L NO973857A NO973857A NO973857L NO 973857 L NO973857 L NO 973857L NO 973857 A NO973857 A NO 973857A NO 973857 A NO973857 A NO 973857A NO 973857 L NO973857 L NO 973857L
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NO
Norway
Prior art keywords
neurokinin
antagonists
aryl
acylamino
pct
Prior art date
Application number
NO973857A
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English (en)
Other versions
NO325605B1 (no
NO973857D0 (no
Inventor
Marc Gerspacher
Andreas Von Sprecher
Silvio Roggo
Robert Mah
Silvio Ofner
Siem Jacob Veenstra
Claudia Betschart
Yves Auberson
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of NO973857D0 publication Critical patent/NO973857D0/no
Publication of NO973857L publication Critical patent/NO973857L/no
Publication of NO325605B1 publication Critical patent/NO325605B1/no

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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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NO19973857A 1995-02-22 1997-08-21 1-aryl-2-acylaminoetanforbindelser, fremgangsmate for fremstilling derav og farmasoytiske sammensetninger omfattende forbindelsene. NO325605B1 (no)

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EP95810117 1995-02-22
PCT/EP1996/000555 WO1996026183A1 (en) 1995-02-22 1996-02-09 1-aryl-2-acylamino-ethane compounds and their use as neurokinin especially neurokinin 1 antagonists

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EP0912178A4 (en) * 1996-05-24 2000-08-16 Lilly Co Eli METHOD FOR TREATING THE HIGH PRESSURE
MY132550A (en) 1996-08-22 2007-10-31 Novartis Ag Acylaminoalkenylene-amide derivatives as nk1 and nk2 antogonists
GB0010958D0 (en) * 2000-05-05 2000-06-28 Novartis Ag Organic compounds
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GB0224788D0 (en) * 2002-10-24 2002-12-04 Novartis Ag Organic compounds
GB2394417A (en) * 2002-10-24 2004-04-28 Novartis Ag Solid dispersion comprising a piperidine substance P antagonist and a carrier
JP5248779B2 (ja) * 2003-12-01 2013-07-31 ケンブリッジ エンタープライズ リミティド 抗炎症剤
US20090156465A1 (en) 2005-12-30 2009-06-18 Sattigeri Jitendra A Derivatives of beta-amino acid as dipeptidyl peptidase-iv inhibitors
JO2630B1 (en) * 2006-04-13 2012-06-17 نوفارتيس ايه جي Organic compounds
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JP4983616B2 (ja) 2008-01-16 2012-07-25 ソニー株式会社 熱転写記録媒体
WO2013004766A1 (en) 2011-07-04 2013-01-10 Ferrari Giulio Nk-1 receptor antagonists for treating corneal neovascularisation
MX2016009939A (es) * 2014-02-18 2017-01-23 Daiichi Sankyo Co Ltd Derivado de aminopirazolona.
RU2020131446A (ru) 2018-02-26 2022-03-28 Оспедале Сан Раффаэле С.Р.Л. Антагонисты nk-1 для применения в лечении глазной боли
RU2697414C1 (ru) * 2018-05-11 2019-08-14 Общество с ограниченной ответственностью "АЙ БИ ДИ Терапевтикс" Новый антагонист тахикининовых рецепторов и его применение
EP3917509A4 (en) * 2019-01-28 2022-11-09 Mitochondria Emotion, Inc. TRANS-4-HYDROXYCYCLOHEXYLPHENYLAMIDE MITOFUSIN ACTIVATORS AND METHODS OF USE THEREOF
WO2021150499A1 (en) 2020-01-20 2021-07-29 Monomer Software LLC Optical device field of view cleaning apparatus
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EA199900385A1 (ru) 1999-10-28
AU4623396A (en) 1996-09-11
FI120304B (fi) 2009-09-15
FI973221A0 (fi) 1997-08-04
HUP9800051A3 (en) 1998-08-28
ES2132882T3 (es) 1999-08-16
ATE178886T1 (de) 1999-04-15
IL117209A (en) 2001-01-11
IL117209A0 (en) 1996-06-18
MX9706394A (es) 1997-11-29
EA002348B1 (ru) 2002-04-25
SK113997A3 (en) 1998-02-04
EP0810991A1 (en) 1997-12-10
US5929067A (en) 1999-07-27
NO325605B1 (no) 2008-06-23
BR9607335A (pt) 1997-11-25
KR19980702391A (ko) 1998-07-15
PL322001A1 (en) 1998-01-05
CY2198B1 (en) 2002-11-08
CZ266297A3 (en) 1997-11-12
KR100389253B1 (ko) 2003-08-19
FI973221L (fi) 1997-10-20
CA2213080A1 (en) 1996-08-29
DE69602087T2 (de) 1999-09-09
NZ300942A (en) 1998-12-23
NO973857D0 (no) 1997-08-21
GR3030626T3 (en) 1999-10-29
EP0810991B1 (en) 1999-04-14
HUP9800051A2 (hu) 1998-05-28
PL184226B1 (pl) 2002-09-30
WO1996026183A1 (en) 1996-08-29
CN1081625C (zh) 2002-03-27
CA2213080C (en) 2007-11-13
DE69602087D1 (de) 1999-05-20
TR199700834T1 (xx) 1998-01-21
DK0810991T3 (da) 1999-10-25
ZA961364B (en) 1996-08-22
CZ288345B6 (en) 2001-05-16
AU701560B2 (en) 1999-01-28
CN1175944A (zh) 1998-03-11
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