ES2134185T3 - Ensayos utilizando esteres, tioesteres y amidas quimioluminiscentes mejorados. - Google Patents
Ensayos utilizando esteres, tioesteres y amidas quimioluminiscentes mejorados.Info
- Publication number
- ES2134185T3 ES2134185T3 ES88121915T ES88121915T ES2134185T3 ES 2134185 T3 ES2134185 T3 ES 2134185T3 ES 88121915 T ES88121915 T ES 88121915T ES 88121915 T ES88121915 T ES 88121915T ES 2134185 T3 ES2134185 T3 ES 2134185T3
- Authority
- ES
- Spain
- Prior art keywords
- ring
- linkage
- ring system
- substituent groups
- heterocyclic ring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001408 amides Chemical class 0.000 title abstract 4
- 150000002148 esters Chemical class 0.000 title abstract 4
- 150000007970 thio esters Chemical class 0.000 title abstract 4
- 125000001424 substituent group Chemical group 0.000 abstract 9
- 125000004122 cyclic group Chemical group 0.000 abstract 8
- 125000000623 heterocyclic group Chemical group 0.000 abstract 6
- 229910052799 carbon Inorganic materials 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 230000007062 hydrolysis Effects 0.000 abstract 3
- 238000006460 hydrolysis reaction Methods 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000006575 electron-withdrawing group Chemical group 0.000 abstract 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 238000003149 assay kit Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910001882 dioxygen Inorganic materials 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- -1 moiety Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 150000002978 peroxides Chemical class 0.000 abstract 1
- 238000000159 protein binding assay Methods 0.000 abstract 1
- 230000009870 specific binding Effects 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
- C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/06—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/10—Aza-phenanthrenes
- C07D221/12—Phenanthridines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Luminescent Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
DE ACUERDO CON LA PRESENTE INVENCION SE DESCRIBEN ENSAYOS DE ENLACE ESPECIFICOS, QUE UTLIZAN UN COMPUESTO QUIMILUMINISCENTE, QUE TIENE ESTABILIDAD MEJORADA EN DISOLUCION ACUOSA. LA PARTE QUIMILUMINISCENTE ES UN ESTER, TIOESTER O AMIDA, EN LA QUE LA UNION ESTER, TIOESTER O AMIDA ESTA ENTRE (1) UN ANILLO O SISTEMA DE ANILLOS HETEROCICLICOS, QUE TIENE UN ATOMO DE CARBONO AL QUE ESTA LIGADO EL ENLACE, DONDE EL HETEROATOMO EN EL ANILLO O SISTEMA DE ANILLOS HETEROCICLICOS SE HALLA EN UN ESTADO DE OXIDACION QUE HACE TAL ATOMO DE CARBONO SUSCEPTIBLE DE ATAQUE POR PEROXIDO U OXIGENO MOLECULAR, PARA FORMAR UN INTERMEDIO QUE SE DESCOMPONE PARA PRODUCIR QUIMILUMINISCENCIA, Y (2) UN ANILLO O SISTEMA DE ANILLOS ARILICO. ESTE CONTIENE POR LO MENOS UN ANILLO DE 6 MIEMBROS SUSTITUIDO. ESTE TIENE DOS O MAS GRUPOS SUSTITUYENTES, DONDE POR LO MENOS DOS DE DICHOS GRUPOS IMPIDEN ESTERICAMENTE LA HIDROLISIS DE DICHO ENLACE. UNO O MAS DE LOS GRUPOS SUSTITUYENTES QUE IMPIDEN ESTERICAMENTE LA HIDROLISIS DEL ENLACEPUEDE SER UN GRUPO APETENTE DE ELECTRONES. EL ANILLO DE 6 MIEMBROS SUSTITUIDO PUEDE TENER UNO O MAS GRUPOS SUSTITUYENTES ADICIONALES, ADEMAS DE LOS GRUPOS SUSTITUYENTES QUE IMPIDEN ESTERICAMENTE LA HIDROLISIS DEL ENLACE. LOS ATOMOS DE CARBONO EN EL ANILLO O SISTEMA DE ANILLOS HETEROCICLICOS, A LOS QUE ESTA UNIDO EL ENLACE, TAMBIEN PUEDEN TENER UN SUSTITUYENTE SECUNDARIO DE FORMULA RNX-, DONDE X SE ELIGE DEL GRUPO QUE CONSTA DE O, N, S Y C; R ES CUALQUIER GRUPO, Y N ES UN NUMERO TAL QUE X TIENE LA VALENCIA ADECUADA. SE DESCRIBEN OTRAS PARTES QUIMILUMINISCENTES QUE SE CARACTERIZAN POR UN ANILLO O SISTEMA DE ANILLOS HETEROCICLICOS Y UN SUSTITUYENTE SECUNDARIO DE FORMULA RNX-, ESTANDO LA UNION ESTER, TIOESTER O AMIDA ENTRE EL ANILLO O SISTEMA DE ANILLOS HETEROCICLICOS Y UN GRUPO SALIENTE. LAS PARTES QUIMILUMINISCENTES DESCRITAS TAMBIEN PUEDEN CONTENER SUSTITUYENTES EN POSICIONES PERI DENTRO DEL ANILLO O SISTEMA DE ANILLOS HETEROCICLICOS. TAMBIEN DE ACUERDO CON LA PRESENTE INVENCION, SE DESCRIBEN COMPOSICIONES QUE CONTIENEN TALES PARTES QUIMILUMINISCENTES Y CONJUNTOS DE ENSAYO QUE LAS INCORPORAN.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14004087A | 1987-12-31 | 1987-12-31 | |
| US140040 | 1987-12-31 | ||
| US29184388A | 1988-12-29 | 1988-12-29 | |
| US291843 | 1988-12-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2134185T3 true ES2134185T3 (es) | 1999-10-01 |
| ES2134185T5 ES2134185T5 (es) | 2004-11-01 |
Family
ID=26837818
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES88121915T Expired - Lifetime ES2134185T5 (es) | 1987-12-31 | 1988-12-30 | Ensayos utilizando esteres, tioesteres y amidas quimioluminiscentes mejorados. |
Country Status (14)
| Country | Link |
|---|---|
| EP (2) | EP0322926B2 (es) |
| JP (1) | JP3172522B2 (es) |
| KR (1) | KR900700888A (es) |
| AT (2) | ATE425970T1 (es) |
| AU (1) | AU635890B2 (es) |
| CA (1) | CA1341613C (es) |
| DE (3) | DE3856597D1 (es) |
| ES (1) | ES2134185T5 (es) |
| GB (4) | GB2232995B (es) |
| GR (1) | GR3031647T3 (es) |
| IE (1) | IE61614B1 (es) |
| IL (1) | IL88848A (es) |
| NZ (1) | NZ227506A (es) |
| WO (1) | WO1989006231A1 (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4918192A (en) * | 1986-10-06 | 1990-04-17 | Ciba Corning Diagnostics Corp. | Polysubstituted aryl acridinium esters |
| DE3750503T2 (de) * | 1986-10-22 | 1995-02-09 | Abbott Lab | Chemilumineszierende Acridinium- und Phenantridiniumsalze. |
| US4950613A (en) * | 1988-02-26 | 1990-08-21 | Gen-Probe Incorporated | Proteted chemiluminescent labels |
| WO1989012232A1 (en) * | 1988-06-08 | 1989-12-14 | London Diagnostics, Inc. | Assays utilizing sensitizer-induced production of detectable signals |
| US5656426A (en) * | 1988-08-01 | 1997-08-12 | Chiron Diagnostics Corporation | Functionaized hydrophilic acridinium esters |
| US5227489A (en) * | 1988-08-01 | 1993-07-13 | Ciba Corning Diagnostics Corp. | Stable hydrophilic acridinium esters suitable for liposome encapsulation |
| CA1339491C (en) * | 1988-09-26 | 1997-10-07 | Say-Jong Law | Nucleophilic polysubstituted aryl acridinium ester and uses thereof |
| US5663074A (en) * | 1988-09-26 | 1997-09-02 | Chiron Diagnostics Corporation | Nucleophilic polysubstituted aryl acridinium ester conjugates and syntheses thereof |
| US5340716A (en) * | 1991-06-20 | 1994-08-23 | Snytex (U.S.A.) Inc. | Assay method utilizing photoactivated chemiluminescent label |
| WO1994002486A1 (en) * | 1992-07-20 | 1994-02-03 | Syntex (U.S.A.) Inc. | Novel chemiluminescent compounds and methods of use |
| US6002000A (en) * | 1992-07-20 | 1999-12-14 | Dade Behring Marburg Gmbh | Chemiluminescent compounds and methods of use |
| CA2141451C (en) * | 1992-07-31 | 2003-10-07 | John S. Pease | Photoactivatable chemiluminescent matrices |
| JP3584379B2 (ja) * | 1993-02-04 | 2004-11-04 | 持田製薬株式会社 | アクリジニウム化合物およびアクリジニウム化合物複合体 |
| US5395752A (en) * | 1993-03-19 | 1995-03-07 | Ciba Corning Diagnostics Corp. | Long emission wavelength chemiluminescent compounds and their use in test assays |
| US5491072A (en) * | 1993-05-17 | 1996-02-13 | Lumigen, Inc. | N-alkylacridan carboxyl derivatives useful for chemiluminescent detection |
| US5393891A (en) * | 1993-06-08 | 1995-02-28 | The Du Pont Merck Pharmaceutical Company | Immunoassay reagents and methods for detecting brequinar and analogs |
| US5731148A (en) * | 1995-06-07 | 1998-03-24 | Gen-Probe Incorporated | Adduct protection assay |
| EP0761652A1 (en) * | 1995-08-01 | 1997-03-12 | Mochida Pharmaceutical Co., Ltd. | Acridinium compound having a plurality of luminescent groups and binding groups, and conjugate thereof |
| PT915851E (pt) * | 1996-07-16 | 2002-09-30 | Staat Nl Verteg Door Min Welzi | Esteres dibenzodihidropiridinecarboxilicos e seu uso no ensaio dos metodos quimiluminiscente |
| US6165800A (en) * | 1997-05-30 | 2000-12-26 | Bayer Corporation | Chemiluminescent energy transfer conjugates and their uses as labels in binding assays |
| JP4838932B2 (ja) * | 1997-08-21 | 2011-12-14 | メイン メディカル センター | 過酸化物に基づく化学発光の検量方法、並びにそのために用いる化合物 |
| US6723851B2 (en) * | 2001-10-31 | 2004-04-20 | Quest Diagnostics Investment Incorporated | Chemiluminescent compounds and use thereof |
| DE102005020384A1 (de) * | 2005-05-02 | 2006-11-09 | Therainvention Gmbh | Spektroskopisches Verfahren zum Nachweis von Analyten |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1461877A (en) * | 1974-02-12 | 1977-01-19 | Wellcome Found | Assay method utilizing chemiluminescence |
| DE3279029D1 (en) * | 1981-12-11 | 1988-10-20 | Welsh Nat School Med | Luminescent labelling materials and procedures |
| US4687747A (en) * | 1984-07-02 | 1987-08-18 | Mallinckrodt, Inc. | Phenanthridinium ester as a labelling compound in luminometric immunoassay |
| JPS6261969A (ja) * | 1985-09-06 | 1987-03-18 | アモコ・コーポレーション | アクリジニウムエステルの合成法 |
| DE3628573C2 (de) * | 1986-08-22 | 1994-10-13 | Hoechst Ag | Chemilumineszierende Acridinderivate, Verfahren zu deren Herstellung und ihre Verwendung in Lumineszenzimmunoassays |
| US4745181A (en) * | 1986-10-06 | 1988-05-17 | Ciba Corning Diagnostics Corp. | Polysubstituted aryl acridinium esters |
| DE3750503T2 (de) * | 1986-10-22 | 1995-02-09 | Abbott Lab | Chemilumineszierende Acridinium- und Phenantridiniumsalze. |
| DE3854029T2 (de) * | 1987-09-21 | 1995-10-26 | Gen Probe Inc | Homogener Abschirmungstest. |
| NL8703075A (nl) † | 1987-12-18 | 1989-07-17 | Nederlanden Staat | Acridiniumverbindingen als chemiluminescentie-merkstof. |
-
1988
- 1988-12-22 NZ NZ227506A patent/NZ227506A/en unknown
- 1988-12-30 GB GB9014479A patent/GB2232995B/en not_active Expired - Lifetime
- 1988-12-30 EP EP88121915A patent/EP0322926B2/en not_active Expired - Lifetime
- 1988-12-30 AT AT98123411T patent/ATE425970T1/de not_active IP Right Cessation
- 1988-12-30 DE DE3856597T patent/DE3856597D1/de not_active Expired - Lifetime
- 1988-12-30 DE DE3856358T patent/DE3856358T3/de not_active Expired - Lifetime
- 1988-12-30 CA CA587320A patent/CA1341613C/en active Active
- 1988-12-30 ES ES88121915T patent/ES2134185T5/es not_active Expired - Lifetime
- 1988-12-30 JP JP50138589A patent/JP3172522B2/ja not_active Expired - Lifetime
- 1988-12-30 IE IE389588A patent/IE61614B1/en not_active IP Right Cessation
- 1988-12-30 DE DE883891212T patent/DE3891212T1/de not_active Withdrawn
- 1988-12-30 WO PCT/US1988/004719 patent/WO1989006231A1/en not_active Ceased
- 1988-12-30 IL IL8884888A patent/IL88848A/en not_active IP Right Cessation
- 1988-12-30 AT AT88121915T patent/ATE183311T1/de not_active IP Right Cessation
- 1988-12-30 AU AU29270/89A patent/AU635890B2/en not_active Expired
- 1988-12-30 EP EP98123411A patent/EP0916658B1/en not_active Expired - Lifetime
-
1989
- 1989-09-01 KR KR1019890701647A patent/KR900700888A/ko not_active Withdrawn
-
1992
- 1992-02-14 GB GB9203180A patent/GB2251942A/en not_active Withdrawn
- 1992-02-14 GB GB9203179A patent/GB2252161A/en not_active Withdrawn
- 1992-02-14 GB GB9203181A patent/GB2252162A/en not_active Withdrawn
-
1999
- 1999-10-27 GR GR990402736T patent/GR3031647T3/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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