ES2134926T3 - Derivados vinileno-azaindolicos y su procedimiento de preparacion. - Google Patents

Derivados vinileno-azaindolicos y su procedimiento de preparacion.

Info

Publication number
ES2134926T3
ES2134926T3 ES94903774T ES94903774T ES2134926T3 ES 2134926 T3 ES2134926 T3 ES 2134926T3 ES 94903774 T ES94903774 T ES 94903774T ES 94903774 T ES94903774 T ES 94903774T ES 2134926 T3 ES2134926 T3 ES 2134926T3
Authority
ES
Spain
Prior art keywords
hydrogen
azaindolic
vinylene
derivatives
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94903774T
Other languages
English (en)
Inventor
Franco Buzetti
Angelo Crugnola
Dario Ballinari
Felicita Greco
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Pharmacia and Upjohn SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn SpA filed Critical Pharmacia and Upjohn SpA
Application granted granted Critical
Publication of ES2134926T3 publication Critical patent/ES2134926T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Steroid Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A LOS COMPUESTOS DE LA FORMULA (I) EN LA QUE UNO DE LOS GRUPOS DE X1 A X4 ES N Y LOS OTROS SON CH; R ES UN GRUPO DE FORMULA (A), (B), (C), (D) O (E) EN LAS QUE N ES CERO O UN ENTERO DE 1 A 5; R1 ES HIDROGENO, HALOGENO, ALQUILO C1-C6, ALCOXI C1-C6, NITRO O UN GRUPO -NR4R5 EN EL QUE CADA R4 Y R3 ES INDEPENDIENTEMENTE HIDROGENO O ALQUILO C1-C6; R2 ES HIDROGENO, ALQUILO C1-C6 O ALCANOILO C1-C6; R3 ES HIDROGENO, HALOGENO, HIDROXI, ALCOXI C1-C6, CARBOXI, NITRO O UN GRUPO -NR4R5, EN EL QUE R4 Y R5 SON COMO SE HA DEFINIDO ANTERIORMENTE Y A LAS SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS. LOS COMPUESTOS DE LA FORMULA (I) SON UTILES COMO INHIBIDORES DE LA QUINASA DE TIROSINA.
ES94903774T 1992-12-23 1993-12-15 Derivados vinileno-azaindolicos y su procedimiento de preparacion. Expired - Lifetime ES2134926T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929226855A GB9226855D0 (en) 1992-12-23 1992-12-23 Vinylene-azaindole derivatives and process for their preparation

Publications (1)

Publication Number Publication Date
ES2134926T3 true ES2134926T3 (es) 1999-10-16

Family

ID=10727139

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94903774T Expired - Lifetime ES2134926T3 (es) 1992-12-23 1993-12-15 Derivados vinileno-azaindolicos y su procedimiento de preparacion.

Country Status (24)

Country Link
US (1) US5397787A (es)
EP (1) EP0626963B1 (es)
JP (1) JP3507497B2 (es)
KR (1) KR950700296A (es)
CN (1) CN1093707A (es)
AT (1) ATE181074T1 (es)
AU (1) AU670488B2 (es)
CA (1) CA2126228A1 (es)
DE (1) DE69325262T2 (es)
DK (1) DK0626963T3 (es)
ES (1) ES2134926T3 (es)
FI (1) FI943838A0 (es)
GB (1) GB9226855D0 (es)
GR (1) GR3030941T3 (es)
HU (1) HUT67431A (es)
IL (1) IL108087A (es)
MX (1) MX9400206A (es)
MY (1) MY109695A (es)
NZ (1) NZ259330A (es)
PL (1) PL304894A1 (es)
RU (1) RU94040390A (es)
TW (1) TW296383B (es)
WO (1) WO1994014808A1 (es)
ZA (1) ZA939578B (es)

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