ES2135597T3 - Inmunoensayos fluorescentes de canalizacion del oxigeno. - Google Patents

Inmunoensayos fluorescentes de canalizacion del oxigeno.

Info

Publication number
ES2135597T3
ES2135597T3 ES94927258T ES94927258T ES2135597T3 ES 2135597 T3 ES2135597 T3 ES 2135597T3 ES 94927258 T ES94927258 T ES 94927258T ES 94927258 T ES94927258 T ES 94927258T ES 2135597 T3 ES2135597 T3 ES 2135597T3
Authority
ES
Spain
Prior art keywords
immuno assays
oxygen channeling
fluorescent immuno
fluorescent
channeling
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94927258T
Other languages
English (en)
Inventor
Dariush Davalian
Rajendra Singh
Edwin F Ullman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics GmbH Germany
Original Assignee
Dade Behring Marburg GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dade Behring Marburg GmbH filed Critical Dade Behring Marburg GmbH
Application granted granted Critical
Publication of ES2135597T3 publication Critical patent/ES2135597T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/20—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 hydrogenated in the hetero ring
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

SE PRESENTAN METODOS PARA DETERMINAR UNA SUSTANCIA DE ANALISIS EN UN MEDIO QUE SE SOSPECHA CONTIENE LA SUSTANCIA DE ANALISIS. UN METODO CONSISTE EN TRATAR UN MEDIO QUE SE SOSPECHA CONTIENE UNA SUSTANCIA DE ANALISIS BAJO CONDICIONES TALES QUE LA SUSTANCIA DE ANALISIS, DE ENCONTRARSE PRESENTE, HAGA QUE UN FOTOSENSIBILIZADOR Y UNA MOLECULA PRECURSORA INDICADORA FOTOACTIVA SE ACERQUEN. EL FOTOSENSIBILIZADOR GENERA OXIGENO DE SINGELETE QUE ACTIVA EL PRECURSOR INDICADOR FOTOACTIVO PARA GENERAR UNA MOLECULA INDICADORA FOTOACTIVA. TRAS LA RADIACION CON LUZ, LA MOLECULA INDICADORA FOTOACTIVA GENERA LUZ QUE SE MIDE. LA CANTIDAD DE LUZ GENERADA POR EL INDICADOR FOTOACTIVO ESTA RELACIONADA CON LA CANTIDAD DE SUSTANCIA DE ANALISIS EN EL MEDIO. TAMBIEN SE PRESENTAN COMPOSICIONES, KITS Y COMPUESTOS.
ES94927258T 1993-09-03 1994-08-29 Inmunoensayos fluorescentes de canalizacion del oxigeno. Expired - Lifetime ES2135597T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11736593A 1993-09-03 1993-09-03

Publications (1)

Publication Number Publication Date
ES2135597T3 true ES2135597T3 (es) 1999-11-01

Family

ID=22372509

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94927258T Expired - Lifetime ES2135597T3 (es) 1993-09-03 1994-08-29 Inmunoensayos fluorescentes de canalizacion del oxigeno.

Country Status (8)

Country Link
US (2) US5616719A (es)
EP (1) EP0716746B1 (es)
JP (1) JP3498960B2 (es)
AT (1) ATE177842T1 (es)
CA (1) CA2170873A1 (es)
DE (1) DE69417242T2 (es)
ES (1) ES2135597T3 (es)
WO (1) WO1995006877A1 (es)

Families Citing this family (128)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6251581B1 (en) 1991-05-22 2001-06-26 Dade Behring Marburg Gmbh Assay method utilizing induced luminescence
US5578498A (en) 1991-05-22 1996-11-26 Behringwerke Ag Metal chelate containing compositions for use in chemiluminescent assays
US6002000A (en) * 1992-07-20 1999-12-14 Dade Behring Marburg Gmbh Chemiluminescent compounds and methods of use
JPH07509245A (ja) * 1992-07-20 1995-10-12 デイド・ベーリング・マルブルク・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング 新規化学発光化合物およびその使用方法
IT1275571B (it) * 1995-07-19 1997-08-07 Consiglio Nazionale Ricerche Substrati fluorogenici suscettibili di fotoattivazione previa trasformazione per via enzimatica atti alla diagnosi ed alla terapia fotodinamica dei tumori
US5811253A (en) * 1995-09-01 1998-09-22 Johnson & Johnson Clinical Diagnostics, Inc. Use of vanadium bromoperoxidase as a signal-generating enzyme for chemiluminescent systems: test kits and analytical methods
WO1997029636A1 (en) * 1996-02-19 1997-08-21 Schaffer, Moshe Photosensitive composition
EP0852012B1 (en) * 1996-05-01 2006-07-26 Dade Behring Marburg GmbH Chemiluminescent compositions and their use in the detection of hydrogen peroxide
US6432662B1 (en) * 1997-04-15 2002-08-13 Pierce Chemical Company Assay of peroxidase activity
DE69831229T2 (de) 1997-05-14 2006-04-13 Biosite Diagnostics Inc., San Diego Schnelle bestimmung des verhältnisses von biologischen molekülen
DE19756773A1 (de) 1997-12-19 1999-06-24 Dade Behring Marburg Gmbh Neues Verfahren und Diagnosemittel zur Hämostase-Diagnostik
DE19756782A1 (de) 1997-12-19 1999-06-24 Dade Behring Marburg Gmbh Nachweis und Bestimmung festphasenassoziierter Faktoren
US6451526B1 (en) * 1998-01-20 2002-09-17 Mayo Foundation For Medical Education And Research Simplified mutation detection
AU2679899A (en) * 1998-02-18 1999-09-06 Dade Behring Inc. Chemiluminescent compositions for use in detection of multiple analytes
DE19811017A1 (de) * 1998-03-13 1999-09-16 Dade Behring Marburg Gmbh Neues Verfahren zur Bestimmung von Plasmaproteinen und Faktoren der Hämostase sowie ein neues, implantierbares Meßgerät
DE19846148C2 (de) * 1998-10-01 2002-10-10 Igor Popov Verfahren zur Beurteilung der oxidativen Modifikation proteinhaltiger Stoffe mittels Messung ihrer antiradikalen Aktivität
US7759133B2 (en) * 1998-12-22 2010-07-20 Alk-Abello A/S Method of detecting and/or quantifying a specific IgE antibody in a liquid sample
US20040248150A1 (en) * 1999-04-02 2004-12-09 Sharat Singh Methods employing oligonucleotide-binding e-tag probes
US6322980B1 (en) * 1999-04-30 2001-11-27 Aclara Biosciences, Inc. Single nucleotide detection using degradation of a fluorescent sequence
US6627400B1 (en) 1999-04-30 2003-09-30 Aclara Biosciences, Inc. Multiplexed measurement of membrane protein populations
US6673550B2 (en) 1999-04-30 2004-01-06 Aclara Biosciences, Inc. Electrophoretic tag reagents comprising fluorescent compounds
US6649351B2 (en) 1999-04-30 2003-11-18 Aclara Biosciences, Inc. Methods for detecting a plurality of analytes by mass spectrometry
US7037654B2 (en) 1999-04-30 2006-05-02 Aclara Biosciences, Inc. Methods and compositions for enhancing detection in determinations employing cleavable electrophoretic tag reagents
US20030235832A1 (en) * 2000-06-21 2003-12-25 Ahmed Chenna Multiplexed analysis by chromatographic separation of molecular tags
US7001725B2 (en) 1999-04-30 2006-02-21 Aclara Biosciences, Inc. Kits employing generalized target-binding e-tag probes
US6703248B1 (en) * 1999-12-15 2004-03-09 Dade Behring Marburg Gmbh Particles for diagnostic and therapeutic use
ATE395364T1 (de) 1999-12-22 2008-05-15 Dade Behring Marburg Gmbh Gegen procalcitonin gerichtete antikörper, ihre herstellung und verwendung
DE50014159D1 (de) 1999-12-22 2007-04-26 Dade Behring Marburg Gmbh Lösungen von humanem Procalcitonin
EP1267935A2 (en) 2000-01-12 2003-01-02 Light Sciences Corporation Novel treatment for eye disease
WO2001067105A1 (en) 2000-03-06 2001-09-13 Dade Behring Marburg Gmbh Carriers coated with polysaccharides, their preparation and use
US7160735B2 (en) * 2000-04-28 2007-01-09 Monogram Biosciences, Inc. Tagged microparticle compositions and methods
US20030207300A1 (en) * 2000-04-28 2003-11-06 Matray Tracy J. Multiplex analytical platform using molecular tags
US7771929B2 (en) * 2000-04-28 2010-08-10 Monogram Biosciences, Inc. Tag library compounds, compositions, kits and methods of use
US7537938B2 (en) * 2000-04-28 2009-05-26 Monogram Biosciences, Inc. Biomarker detection in circulating cells
WO2001084157A2 (en) 2000-05-04 2001-11-08 Dade Behring Marburg Gmbh Compositions for detection of multiple analytes
US7635571B2 (en) * 2000-12-07 2009-12-22 Siemens Healthcare Diagnostics Products Gmbh Amplified signal in binding assays
DE10064827A1 (de) 2000-12-22 2002-06-27 Dade Behring Marburg Gmbh Nachweisverfahren
US7087395B1 (en) 2001-01-16 2006-08-08 Quest Diagnostics Investments Incorporated Vitamin D assay
CA2442282A1 (en) * 2001-03-29 2002-10-10 Cellect Technologies Corp. Methods devices and systems for sorting and separating particles
WO2002094998A2 (en) 2001-05-21 2002-11-28 Aclara Biosciences, Inc. Analyzing phosphorylated proteins
PL373962A1 (en) * 2001-05-21 2005-09-19 Aclara Biosciences, Inc. Methods and compositions for analyzing proteins
WO2002097112A2 (en) * 2001-05-26 2002-12-05 Aclara Biosciences, Inc. Catalytic amplification of multiplexed assay signals
CN1257408C (zh) 2001-07-02 2006-05-24 北极医疗诊断有限公司 双光子吸收二吡咯亚甲基二氟化硼染料及其应用
US7045311B2 (en) * 2001-10-25 2006-05-16 Monogram Biosciences, Inc. Whole cell assay systems for cell surface proteases
US6949347B2 (en) * 2002-03-05 2005-09-27 Aclara Biosciences, Inc. Multiplex analysis using membrane-bound sensitizers
DE10212960A1 (de) * 2002-03-22 2003-10-23 Gnothis Holding Sa Ecublens Verwendung von Oxazin-Farbstoffen als Markierungsgruppen für die Einzelmolekülanalyse
US7402397B2 (en) * 2002-05-21 2008-07-22 Monogram Biosciences, Inc. Detecting and profiling molecular complexes
US20040229380A1 (en) * 2002-05-21 2004-11-18 Po-Ying Chan-Hui ErbB heterodimers as biomarkers
US20040229293A1 (en) * 2002-05-21 2004-11-18 Po-Ying Chan-Hui Surface receptor complexes as biomarkers
US20040229299A1 (en) * 2002-05-21 2004-11-18 Badal M. Youssouf Intracellular complexes as biomarkers
US20040229294A1 (en) * 2002-05-21 2004-11-18 Po-Ying Chan-Hui ErbB surface receptor complexes as biomarkers
US20030232394A1 (en) * 2002-06-12 2003-12-18 Aventis Pharma Deutschland Gmbh High throughput screening method and assay system for determining the interaction between C-reactive protein and components binding to it
US20030232401A1 (en) * 2002-06-12 2003-12-18 Pugia Michael J. Bacterial test method by glycated label binding
DE10226011A1 (de) * 2002-06-12 2004-01-08 Aventis Pharma Deutschland Gmbh HTS-fähiges Verfahren und Testsystem zur Ermittlung der Wechselwirkung zwischen c-reaktivem Protein und an C-reaktives Protein bindenden Komponenten
US20040175765A1 (en) * 2002-07-05 2004-09-09 Sharat Singh Cell-screening assay and composition
JP4443407B2 (ja) * 2002-07-25 2010-03-31 アクララ バイオサイエンシーズ， インコーポレイテッド レセプターオリゴマー形成の検出
CA2493671A1 (en) * 2002-07-26 2004-02-05 Aclara Biosciences, Inc. Lipophilic electrophoretic probes
US7402398B2 (en) * 2003-07-17 2008-07-22 Monogram Biosciences, Inc. Measuring receptor homodimerization
US7381370B2 (en) 2003-07-18 2008-06-03 Dade Behring Inc. Automated multi-detector analyzer
WO2005019470A2 (en) * 2003-08-11 2005-03-03 Monogram Biosciences, Inc. Detecting and profiling molecular complexes
WO2005085849A2 (en) * 2003-10-24 2005-09-15 U S. Genomics, Inc Biohazard identification by fluorescent immunoassay and single molecule detection
CA2543830A1 (en) * 2003-10-27 2005-05-19 Monogram Biosciences, Inc. Detecting human anti-therapeutic antibodies
EP1695083A1 (de) 2003-12-01 2006-08-30 Dade Behring Marburg GmbH Homogenes nachweisverfahren
DE102005026163A1 (de) 2004-08-24 2006-03-02 Dade Behring Marburg Gmbh Gegen den Marburg I Polymorphismus der Faktor VII aktivierenden Protease (FSAP) gerichtete Antikörper, ihre Herstellung und Verwendung
DE102004042124B4 (de) * 2004-08-30 2006-07-06 Dade Behring Marburg Gmbh Homogenes Verfahren zur Bestimmung eines Analyten in Gegenwart eines Überschusses von kreuzreagierenden Substanzen
US7189582B2 (en) 2005-04-27 2007-03-13 Dade Behring Inc. Compositions and methods for detection of sirolimus
DE102005022047A1 (de) 2005-05-09 2006-11-30 Dade Behring Marburg Gmbh Bindungspartner des Plazentalen Wachstumsfaktors insbesondere gegen den Plazentalen Wachstumsfaktor gerichtete Antikörper, ihre Herstellung und Verwendung
US20060281104A1 (en) * 2005-06-13 2006-12-14 Macevicz Stephen C Leuco dye particles and uses thereof
WO2007008472A2 (en) * 2005-07-08 2007-01-18 Colorado Seminary, Which Owns And Operates The University Of Denver Photoinduced signal amplification through externally sensitized photofragmentation in masked photosensitizers
ES2544236T3 (es) 2005-11-17 2015-08-28 Siemens Healthcare Diagnostics Inc. Reducción de unión no específica en ensayos
WO2007070761A2 (en) * 2005-12-12 2007-06-21 Colorado Seminary, Which Owns And Operates The University Of Denver Method for encoding and screening combinatorial libraries
US7226752B1 (en) * 2006-01-19 2007-06-05 Avago Technologies General Ip (Singapore) Pte. Ltd. Methods for detecting an analyte in a sample
US20080076139A1 (en) 2006-09-21 2008-03-27 Sharat Singh Methods and compositions for detecting the activation states of multiple signal transducers in rare circulating cells
US7790401B2 (en) 2007-08-06 2010-09-07 Siemens Healthcare Diagnostics Methods for detection of immunosuppressant drugs
WO2009026313A1 (en) * 2007-08-20 2009-02-26 Colorado Seminary, Which Owns And Operates The University Of Denver Photoinduced signal amplification through externally sensitized photofragmentation in masked photosensitizers and photoamplified fluorescence turn-off system
EP2065705B1 (en) * 2007-11-30 2011-07-27 Roche Diagnostics GmbH Stabilization of conjugates comprising a thiourea linker
US7910378B2 (en) 2007-12-14 2011-03-22 Siemens Healthcare Diagnostics Inc. Methods for detection of hydrophobic drugs
NZ617520A (en) 2008-02-25 2015-05-29 Nestec Sa Drug selection for breast cancer therapy using antibody-based arrays
US11730407B2 (en) 2008-03-28 2023-08-22 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US8682408B2 (en) 2008-03-28 2014-03-25 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US8583204B2 (en) 2008-03-28 2013-11-12 Dexcom, Inc. Polymer membranes for continuous analyte sensors
DE102008049601A1 (de) 2008-09-30 2010-04-01 Siemens Healthcare Diagnostics Products Gmbh Antikörper zur Bestimmung des Prothrombin-Fragments F2/F1+2 in einem homogenen Immunoassay
AU2010273319B2 (en) 2009-07-15 2015-01-22 Nestec S.A. Drug selection for gastric cancer therapy using antibody-based arrays
JP2013503352A (ja) * 2009-08-31 2013-01-31 エムバイオ ダイアグノスティクス，インコーポレイティド 統合されたサンプル調製及び検体検出
MX337666B (es) 2009-10-20 2016-03-14 Nestec Sa Ensayos regulados mediante proximidad para detectar proteinas de fusion oncogenicas.
CN102822676B (zh) 2010-01-12 2015-02-18 雀巢产品技术援助有限公司 用于预测三阴性乳腺癌对疗法的应答的方法
EP2395354A1 (de) * 2010-06-10 2011-12-14 Siemens Healthcare Diagnostics Products GmbH Homogener Aktivitätstest zur Bestimmung von enzymatischen Reaktionen
US20110306148A1 (en) 2010-06-14 2011-12-15 Siemens Healthcare Diagnostics Inc. Composition for use as an assay reagent
US8329424B2 (en) 2010-06-25 2012-12-11 Siemens Healthcare Diagnostics Reduction in false results in assay measurements
EP2656077A1 (en) 2010-12-23 2013-10-30 Nestec S.A. Drug selection for malignant cancer therapy using antibody-based arrays
EP2471945A1 (de) 2010-12-30 2012-07-04 Siemens Healthcare Diagnostics Products GmbH Verfahren zur Bestimmung von Inhibitoren der Gerinnung
WO2012119113A2 (en) 2011-03-02 2012-09-07 Nestec Sa Prediction of drug sensitivity of lung tumors based on molecular and genetic signatures
EP2694972B8 (en) 2011-04-04 2017-08-16 Pierian Holdings, Inc. Methods for predicting and improving the survival of gastric cancer patients
ES2671238T3 (es) 2011-08-12 2018-06-05 Siemens Healthcare Diagnostics Inc. Detección de esteroides sexuales
JP6186575B2 (ja) 2011-09-02 2017-08-30 ダイアテック ホールディングス， インコーポレイテッドＤｉａＴｅｃｈ Ｈｏｌｄｉｎｇｓ， Ｉｎｃ． 治療有効性を判定するためのシグナル経路タンパク質のプロファイリング
EP2788752B1 (en) 2011-12-05 2018-10-03 Pierian Holdings, Inc. Method of therapy selection for patients with lung cancer
CN102735833B (zh) * 2012-07-09 2015-01-21 沃克(天津)生物科技有限公司 甲状腺过氧化物酶抗体均相发光免疫分析试剂盒及其检测方法
CN102798725B (zh) * 2012-08-13 2015-03-18 沃克(天津)生物科技有限公司 血清总IgE测定诊断试剂盒及制备和使用方法
KR101933620B1 (ko) * 2012-09-18 2018-12-28 삼성전자주식회사 소포를 검출하기 위한 조성물, 키트 및 이를 이용하여 소포를 분석하는 방법
US9121859B2 (en) 2012-12-04 2015-09-01 Siemens Healthcare Diagnostics Inc. Compounds and methods for determination of FKBP-binding immunosuppressant drugs
EP2954328A1 (en) 2013-02-05 2015-12-16 Nestec S.A. Drug selection for colorectal cancer therapy using receptor tyrosine kinase profiling
WO2014122600A1 (en) 2013-02-05 2014-08-14 Nestec S.A. Methods of selecting combination therapy for colorectal cancer patients
EP2954068B8 (en) 2013-02-05 2018-10-31 Pierian Holdings, Inc. Drug selection for non-small cell lung cancer therapy
WO2014151590A1 (en) 2013-03-15 2014-09-25 Siemens Healthcare Diagnostics Inc. Heterogeneous luminescent oxygen channeling immunoassays and methods of production and use thereof
DK2972245T3 (da) * 2013-03-15 2020-09-07 Siemens Healthcare Diagnostics Inc Heterogene luminescerende oxygenkanaliserende immunoassays
WO2014188363A1 (en) 2013-05-21 2014-11-27 Nestec S.A. Methods for predicting and improving the survival of colorectal cancer patients
KR20160026909A (ko) 2013-07-09 2016-03-09 네스텍 소시에테아노님 미세유체 협동 효소 증강 반응성(ceer) 면역검정
WO2015028974A2 (en) 2013-08-30 2015-03-05 Nestec S.A. Polyp recurrence
WO2015083085A1 (en) 2013-12-03 2015-06-11 Nestec S.A. Signaling pathways in tissues from inflammatory bowel disease patients
ES2740851T3 (es) 2013-12-13 2020-02-06 Siemens Healthcare Diagnostics Inc Agente de tratamiento previo en ensayos sin aglutinación
EP2919013B1 (de) 2014-03-11 2016-11-02 Siemens Healthcare Diagnostics Products GmbH Verfahren zur Detektion von Modulatoren der GPIb-Thrombin-Interaktion
EP2955517A1 (de) 2014-06-10 2015-12-16 Siemens Healthcare Diagnostics Products GmbH Verfahren zur Stabilisierung von Körperflüssigkeitsproben durch die Zugabe von Detergenz
HK1254374A1 (zh) 2015-10-02 2019-07-19 Tgr生物科学私人有限公司 使用多基质的分析物检测
CN106093391A (zh) * 2016-05-31 2016-11-09 南方医科大学 一种基于单线态氧通道发光量子点传感器
US11369964B2 (en) 2016-07-18 2022-06-28 Siemens Healthcare Diagnostics Inc. Sample analyzer system with a sample vessel having opaque and translucent portions
EP3413051B1 (de) 2017-06-09 2020-07-29 Siemens Healthcare Diagnostics Products GmbH Aktivierungstest zur diagnose einer heparin-induzierten thrombozytopenie
ES2862434T3 (es) 2017-08-02 2021-10-07 Siemens Healthcare Diagnostics Products Gmbh Prueba de unión para el diagnóstico de trombocitopenia inducida por heparina
US20200264188A1 (en) 2017-09-13 2020-08-20 Progenity, Inc. Preeclampsia biomarkers and related systems and methods
EP3514541A1 (de) 2018-01-17 2019-07-24 Siemens Healthcare Diagnostics Products GmbH Verfahren zur quantitativen bestimmung eines therapeutischen tnf-alpha inhibitors
EP3788330B1 (en) 2018-05-04 2024-06-26 Siemens Healthcare Diagnostics, Inc. Spectral sample analyzer with an illumination unit having multiple light sources
AU2019278927A1 (en) 2018-06-01 2020-12-24 Bt Bidco, Inc. Devices and systems for gastrointestinal microbiome detection and manipulation
CA3102114A1 (en) * 2018-06-01 2019-12-05 University Of Oregon Compounds for thiol-triggered cos and/or h2s release and methods of making and using the same
EP4070113A4 (en) 2019-12-04 2023-12-20 Biora Therapeutics, Inc. ASSESSMENT OF PREECLAMPSIA USING FREE AND DISSOCIATE PLACENTAL GROWTH FACTOR TESTS
CN112679518B (zh) * 2020-12-29 2022-11-08 华东理工大学 基于硫代色满酮衍生物的纯有机室温磷光材料及其制备方法和应用
EP4239338A1 (de) 2022-03-03 2023-09-06 Siemens Healthcare Diagnostics Products GmbH Globaltest zur feststellung des status des blutgerinnungssystems
EP4325224A1 (de) 2022-08-18 2024-02-21 Siemens Healthcare Diagnostics Products GmbH Thrombozytenaktivierungstest zur diagnose einer heparin-induzierten thrombozytopenie
EP4571417A1 (en) * 2023-12-14 2025-06-18 Arkema France Process of curing ethylenically unsaturated compounds with coumarin thioester photoinitiators
EP4585926A1 (de) 2024-01-09 2025-07-16 Siemens Healthcare Diagnostics Products GmbH Verfahren und kit zur reduzierung von interferenzen in immunoassays

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4013528A (en) * 1974-03-26 1977-03-22 Xerox Corporation Process for preparation of solid phase dispersion of photoconductive materials
US4233402A (en) * 1978-04-05 1980-11-11 Syva Company Reagents and method employing channeling
US4650770A (en) * 1981-04-27 1987-03-17 Syntex (U.S.A.) Inc. Energy absorbing particle quenching in light emitting competitive protein binding assays
CA1180647A (en) * 1981-07-17 1985-01-08 Cavit Akin Light-emitting polynucleotide hybridization diagnostic method
CA1190838A (en) * 1981-07-17 1985-07-23 Cavit Akin Homogeneous nucleic acid hybridization diagnostics by non-radiative energy transfer
CA1294285C (en) * 1983-03-13 1992-01-14 Robert T. Buckler Optical indicator chalcogen compounds and methods for their preparation and use
US4599303A (en) * 1983-12-12 1986-07-08 Hri Associates, Inc. Nucleic acid hybridization assay employing probes crosslinkable to target sequences
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4822733A (en) * 1985-05-28 1989-04-18 Amoco Corporation Lifetime-resolved assay procedures
US4908307A (en) * 1986-12-19 1990-03-13 Karin D. Rodland Hybridization method and probe for detecting nucleic acid sequences
US4891324A (en) * 1987-01-07 1990-01-02 Syntex (U.S.A.) Inc. Particle with luminescer for assays
US4806485A (en) * 1987-02-27 1989-02-21 Cooperative Institute For Research In Environmental Sciences Univers. Of Colorado Method of improving the detection limits of UV-VIS absorbing compounds in HPLC by the use of a singlet oxygen trap
AU636110B2 (en) * 1988-06-08 1993-04-22 Nichols Institute Diagnostics Assays utilizing sensitizer-induced production of detectable signal
US5019496A (en) * 1989-02-17 1991-05-28 Gerald Oster Photopolymerization diagnostic test composition and method for immunoassay and nucleic acid assay
CA2035029C (en) * 1989-09-06 2001-12-18 Applied Biosystems, Llc Synthesis of stable water-soluble chemiluminescent 1,2-dioxetanes and intermediates therefor
EP0476556A3 (en) * 1990-09-18 1992-11-19 Takeda Chemical Industries, Ltd. Method for determination of a light sensitive substance
EP0984281B1 (en) * 1991-05-22 2007-01-03 Dade Behring Marburg GmbH A homogeneous assay for determining analyte
US5340716A (en) * 1991-06-20 1994-08-23 Snytex (U.S.A.) Inc. Assay method utilizing photoactivated chemiluminescent label
ATE162892T1 (de) * 1992-07-31 1998-02-15 Behringwerke Ag Photoaktivierbare chemiluminizierende matrices

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US5616719A (en) 1997-04-01
EP0716746B1 (en) 1999-03-17
ATE177842T1 (de) 1999-04-15
DE69417242D1 (de) 1999-04-22
EP0716746A1 (en) 1996-06-19
JP3498960B2 (ja) 2004-02-23
CA2170873A1 (en) 1995-03-09
WO1995006877A1 (en) 1995-03-09
DE69417242T2 (de) 1999-07-08
US5807675A (en) 1998-09-15

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