ES8105992A1 - Un procedimiento para la preparacion de fenil-quinolicidinas - Google Patents

Un procedimiento para la preparacion de fenil-quinolicidinas

Info

Publication number
ES8105992A1
ES8105992A1 ES493196A ES493196A ES8105992A1 ES 8105992 A1 ES8105992 A1 ES 8105992A1 ES 493196 A ES493196 A ES 493196A ES 493196 A ES493196 A ES 493196A ES 8105992 A1 ES8105992 A1 ES 8105992A1
Authority
ES
Spain
Prior art keywords
phenyl
quinolicidins
procedure
preparation
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES493196A
Other languages
English (en)
Other versions
ES493196A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES8105992A1 publication Critical patent/ES8105992A1/es
Publication of ES493196A0 publication Critical patent/ES493196A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C07D211/76—Oxygen atoms attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DEL RACEMATO O DE LOS ENANTIOMEROS, ASI COMO DE SALES DE ADICION DE ACIDO DE FENILQUINOLICIDINAS DE FORMULA (I), EN LA QUE R4 ES HIDROGENO O UN RADICAL ALQUILICO INFERIOR, Y X, Y, R5 Y R6 PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE UNA FENILENDIAMINA DE FORMULA (II), EN LA QUE X, Y, R5 Y R6 TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), CON TIOFOSGENO, TIOCARBONILDIMIDAZOL O DISULFURO DE CARBONO POR METODOS CONVENCIONALES. SE PUEDE N-ALQUILAR EL COMPUESTO OBTENIDO UTILIZANDO COMO AGENTE N-ALQUILANTE UN HALOGENURO DE ALQUILO INFERIOR. LA MEZCLA RACEMICA SE PUEDE RESOLVER EN SUS ENANTIOMEROS Y FORMAR LA SAL DE ADICION DE ACIDO CORRESPONDIENTE TAMBIEN POR METODOS CONOCIDOS. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD NEUROLEPTICA, DEPRESIVA DEL SISTEMA NERVIOSO CENTRAL, TRANQUILIZANTE Y ANALGESICA. *FORMULA*
ES493196A 1978-10-13 1980-07-08 Un procedimiento para la preparacion de fenil-quinolicidinas Granted ES493196A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1065478 1978-10-13
CH715679 1979-08-03

Publications (2)

Publication Number Publication Date
ES8105992A1 true ES8105992A1 (es) 1981-07-01
ES493196A0 ES493196A0 (es) 1981-07-01

Family

ID=25700857

Family Applications (7)

Application Number Title Priority Date Filing Date
ES484930A Expired ES8200680A1 (es) 1978-10-13 1979-10-11 Un procedimiento para la preparacion de fenil-quinolicidinas
ES493199A Granted ES493199A0 (es) 1978-10-13 1980-07-08 Un procedimiento para la preparacion de fenil-quinolicidinas
ES493202A Expired ES8105993A1 (es) 1978-10-13 1980-07-08 Un procedimiento para la preparacion de fenil-quinolicidinas
ES493198A Expired ES8105997A1 (es) 1978-10-13 1980-07-08 Un procedimiento para la preparacion de fenil-quinolicidinas
ES493196A Granted ES493196A0 (es) 1978-10-13 1980-07-08 Un procedimiento para la preparacion de fenil-quinolicidinas
ES493204A Granted ES493204A0 (es) 1978-10-13 1980-07-08 Un procedimiento para la preparacion de fenil-quinolicidinas
ES493195A Expired ES8105991A1 (es) 1978-10-13 1980-07-08 Un procedimiento para la preparacion de fenil-quinolicidinas

Family Applications Before (4)

Application Number Title Priority Date Filing Date
ES484930A Expired ES8200680A1 (es) 1978-10-13 1979-10-11 Un procedimiento para la preparacion de fenil-quinolicidinas
ES493199A Granted ES493199A0 (es) 1978-10-13 1980-07-08 Un procedimiento para la preparacion de fenil-quinolicidinas
ES493202A Expired ES8105993A1 (es) 1978-10-13 1980-07-08 Un procedimiento para la preparacion de fenil-quinolicidinas
ES493198A Expired ES8105997A1 (es) 1978-10-13 1980-07-08 Un procedimiento para la preparacion de fenil-quinolicidinas

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES493204A Granted ES493204A0 (es) 1978-10-13 1980-07-08 Un procedimiento para la preparacion de fenil-quinolicidinas
ES493195A Expired ES8105991A1 (es) 1978-10-13 1980-07-08 Un procedimiento para la preparacion de fenil-quinolicidinas

Country Status (22)

Country Link
US (6) US4236010A (es)
EP (2) EP0012170B1 (es)
AR (3) AR230637A1 (es)
AT (1) ATE877T1 (es)
AU (1) AU533075B2 (es)
BR (1) BR7906543A (es)
CA (1) CA1140927A (es)
CS (2) CS613879A2 (es)
CU (1) CU35149A (es)
DE (2) DE2962580D1 (es)
DK (1) DK433779A (es)
ES (7) ES8200680A1 (es)
FI (2) FI66611C (es)
GR (1) GR73144B (es)
HU (1) HU180249B (es)
IE (1) IE49082B1 (es)
IL (1) IL58415A (es)
MC (1) MC1289A1 (es)
NO (1) NO152787C (es)
NZ (1) NZ191763A (es)
PH (1) PH16131A (es)
PT (1) PT70309A (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MC1289A1 (fr) * 1978-10-13 1980-07-22 Hoffmann La Roche Phenyl quinolizidines
DK116181A (da) * 1980-04-11 1981-10-12 Hoffmann La Roche Fremgangsmaade til fremstilling af quinolizidinderivater
ZW17385A1 (en) * 1984-11-06 1986-02-19 Hoffmann La Roche Tricyclic pyridine derivatives
US4889848A (en) * 1984-11-06 1989-12-26 Hoffmann-La Roche Inc. Tricyclic pyridine derivatives
CA1317945C (en) * 1985-12-13 1993-05-18 Ulf Fischer Tricyclic pyridazopyridone derivatives
DE3614005A1 (de) * 1986-04-25 1987-10-29 Westfael Elekt Werke Verfahren zur rauchgasentschwefelung
EP0294599A3 (de) * 1987-06-12 1990-05-09 F. Hoffmann-La Roche Ag Tricyclische Pyridonderivate
US6992090B2 (en) * 2003-06-16 2006-01-31 Adolor Corporation Substituted piperidine compounds and methods of their use
US7538110B2 (en) 2005-10-27 2009-05-26 Adolor Corporation Opioid antagonists
US20100311782A1 (en) * 2009-06-08 2010-12-09 Adolor Corporation Substituted piperidinylpropanoic acid compounds and methods of their use
US8143273B2 (en) * 2010-06-22 2012-03-27 Hoffman-La Roche Inc. Quinolizidine and indolizidine derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3031454A (en) * 1962-04-24 Hexahydro quinolizeses
CA668487A (en) * 1963-08-13 H. Tilford Charles Hexahydro quinolizines
GB1096589A (en) * 1964-03-31 1967-12-29 Chugai Pharmaceutical Co Ltd Novel quinolizidine derivatives or salts thereof and process for preparing the same
DE1470084A1 (de) * 1964-08-19 1969-05-29 Merck Ag E Verfahren zur Herstellung von substituierten Piperidin-derivaten
US3394141A (en) * 1965-11-12 1968-07-23 Fabio Sparatore Z-benzyaminobenzimidazoles
US3852452A (en) * 1970-02-10 1974-12-03 Ayerst Mckenna & Harrison Benzocycloheptaisoquinoline derivatives as cns depressants
MC1289A1 (fr) * 1978-10-13 1980-07-22 Hoffmann La Roche Phenyl quinolizidines

Also Published As

Publication number Publication date
ES493195A0 (es) 1981-07-01
US4329467A (en) 1982-05-11
US4316030A (en) 1982-02-16
ES493202A0 (es) 1981-07-01
AR230636A1 (es) 1984-05-31
FI66611B (fi) 1984-07-31
FI70017C (fi) 1986-09-12
US4338444A (en) 1982-07-06
NO793300L (no) 1980-04-15
AR230637A1 (es) 1984-05-31
IL58415A0 (en) 1980-01-31
AU5154579A (en) 1980-04-17
CU35149A (en) 1983-04-06
AU533075B2 (en) 1983-10-27
US4236010A (en) 1980-11-25
MC1289A1 (fr) 1980-07-22
GR73144B (es) 1984-02-09
FI841359A0 (fi) 1984-04-05
FI841359L (fi) 1984-04-05
US4272627A (en) 1981-06-09
ES8105991A1 (es) 1981-07-01
ES493196A0 (es) 1981-07-01
ES493198A0 (es) 1981-07-01
DE2962580D1 (en) 1982-06-03
ES8105994A1 (es) 1981-07-01
ATE877T1 (de) 1982-05-15
IL58415A (en) 1982-11-30
ES8105993A1 (es) 1981-07-01
EP0044573A1 (de) 1982-01-27
IE49082B1 (en) 1985-07-24
FI66611C (fi) 1984-11-12
CS241050B2 (en) 1986-03-13
ES493204A0 (es) 1981-07-01
AR230446A1 (es) 1984-04-30
ES8106304A1 (es) 1981-06-16
EP0044573B1 (de) 1984-02-29
EP0012170B1 (de) 1982-04-21
CS613879A2 (en) 1985-06-13
DE2966740D1 (de) 1984-04-05
ES484930A0 (es) 1981-11-16
IE791943L (en) 1980-04-13
EP0012170A1 (de) 1980-06-25
NO152787C (no) 1985-11-20
NZ191763A (en) 1984-05-31
PT70309A (en) 1979-11-01
DK433779A (da) 1980-04-14
FI70017B (fi) 1986-01-31
US4306067A (en) 1981-12-15
BR7906543A (pt) 1980-07-15
ES493199A0 (es) 1981-06-16
PH16131A (en) 1983-07-08
ES8200680A1 (es) 1981-11-16
FI793182A7 (fi) 1980-04-14
ES8105997A1 (es) 1981-07-01
HU180249B (en) 1983-02-28
NO152787B (no) 1985-08-12
CA1140927A (en) 1983-02-08

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