ES2136595T3 - Carbonatos activos de oxidos de polialquileno para la modificacion de polipeptidos. - Google Patents

Carbonatos activos de oxidos de polialquileno para la modificacion de polipeptidos.

Info

Publication number
ES2136595T3
ES2136595T3 ES90906698T ES90906698T ES2136595T3 ES 2136595 T3 ES2136595 T3 ES 2136595T3 ES 90906698 T ES90906698 T ES 90906698T ES 90906698 T ES90906698 T ES 90906698T ES 2136595 T3 ES2136595 T3 ES 2136595T3
Authority
ES
Spain
Prior art keywords
polypeptides
modification
polyalkylene oxides
peg
active carbonates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90906698T
Other languages
English (en)
Other versions
ES2136595T5 (es
Inventor
Shmuel Zalipsky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23335516&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2136595(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Application granted granted Critical
Publication of ES2136595T3 publication Critical patent/ES2136595T3/es
Publication of ES2136595T5 publication Critical patent/ES2136595T5/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/38—Albumins
    • A61K38/385—Serum albumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4826—Trypsin (3.4.21.4) Chymotrypsin (3.4.21.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/50—Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Polyethers (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)

Abstract

SE DESCRIBE EL CARBONATO POLI(ETILENO-GLICOL)-N-SUCINIMIDA Y SU PREPARACION. EL POLIETILENO GLICOL (PEC) SE CONVIERTE EN DERIVADOS DEL CARBONATO N-SUCCINIMIDA. ESTA FORMA DE POLIMERO REACCIONA CON LOS GRUPOS AMINO DE PROTEINAS EN BUFFERS ACUOSOS. LAS PROTEINAS MODIFICADAS TIENEN LAS PEG-CADENAS GRABADAS EN LA BASE DEL POLIPEPTIDO POR MEDIO DE ENLACES URETANO (CARBAMATE) ESTABLES, HIDROLISIS-RESISTENTES.
ES90906698T 1989-04-19 1990-04-19 Carbonatos activos de oxidos de polialquileno para la modificacion de polipeptidos. Expired - Lifetime ES2136595T5 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34092889A 1989-04-19 1989-04-19
US340928 1989-04-19

Publications (2)

Publication Number Publication Date
ES2136595T3 true ES2136595T3 (es) 1999-12-01
ES2136595T5 ES2136595T5 (es) 2004-04-01

Family

ID=23335516

Family Applications (2)

Application Number Title Priority Date Filing Date
ES90906698T Expired - Lifetime ES2136595T5 (es) 1989-04-19 1990-04-19 Carbonatos activos de oxidos de polialquileno para la modificacion de polipeptidos.
ES98203166T Expired - Lifetime ES2247656T3 (es) 1989-04-19 1990-04-19 Un proceso para formar un polipeptido modificado que comprende un polipeptido y un oxido de polialquileno.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES98203166T Expired - Lifetime ES2247656T3 (es) 1989-04-19 1990-04-19 Un proceso para formar un polipeptido modificado que comprende un polipeptido y un oxido de polialquileno.

Country Status (10)

Country Link
EP (2) EP0470128B2 (es)
JP (1) JP2875884B2 (es)
AT (2) ATE300519T1 (es)
AU (1) AU5526690A (es)
CA (1) CA2053317C (es)
DE (2) DE69034200T2 (es)
DK (2) DK0470128T4 (es)
ES (2) ES2136595T5 (es)
HU (1) HUT64022A (es)
WO (1) WO1990013540A1 (es)

Families Citing this family (150)

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ES2136595T5 (es) 2004-04-01
DK0470128T4 (da) 2003-12-01
CA2053317C (en) 1996-03-12
WO1990013540A1 (en) 1990-11-15
HUT64022A (en) 1993-11-29
ATE181732T1 (de) 1999-07-15
ES2247656T3 (es) 2006-03-01
JPH04504872A (ja) 1992-08-27
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DE69034200T2 (de) 2006-05-24
DK0470128T3 (da) 2000-01-10
DE69034200D1 (de) 2005-09-01
EP0470128A4 (en) 1992-09-16
JP2875884B2 (ja) 1999-03-31
EP0893439A1 (en) 1999-01-27
DE69033192D1 (de) 1999-08-05
DE69033192T2 (de) 2000-03-09
CA2053317A1 (en) 1990-10-20
AU5526690A (en) 1990-11-29
HU903628D0 (en) 1991-12-30
EP0893439B1 (en) 2005-07-27
DE69033192T3 (de) 2004-05-19
DK0893439T3 (da) 2005-09-05
EP0470128A1 (en) 1992-02-12
EP0470128B1 (en) 1999-06-30

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